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Start Over Author "A. Verheem" Publisher elsevier bv
26 results on '"A. Verheem"'

1. Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer

Author

Küçükköse, Emre, primary, Laoukili, Jamila, additional, Gorelick, Alexander N., additional, Degner, Sebastian, additional, Laclé, Miangela M., additional, van den Bent, Lotte, additional, Peters, Niek A., additional, Verheem, André, additional, Hung, Wei-Ting, additional, Frenkel, Nicola C., additional, Wassenaar, Emma C.E., additional, Lansu, Nico, additional, Lenos, Kristiaan J., additional, Vermeulen, Louis, additional, Koopman, Miriam, additional, Roodhart, Jeanine M.L., additional, Kops, Geert J.P.L., additional, Borel Rinkes, Inne H.M., additional, Hagendoorn, Jeroen, additional, Naxerova, Kamila, additional, and Kranenburg, Onno, additional

Published
2023
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2. Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer

Author

Emre Küçükköse, Jamila Laoukili, Alexander N. Gorelick, Sebastian Degner, Miangela Lacle, Lotte van den Bent, Niek A. Peters, André Verheem, Wei-Ting Hung, Nicola C. Frenkel, Emma Wassenaar, Nico Lansu, Kristiaan J. Lenos, Louis Vermeulen, Miriam Koopman, Jeanine M.L. Roodhart, Geert J.P.L. Kops, Inne H.M. Borel Rinkes, Jeroen Hagendoorn, Kamila Naxerova, and Onno Kranenburg

Subjects
Hepatology, Gastroenterology
Published
2023
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6. Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis

Author

Hein G. Gooszen, Marguerite E.I. Schipper, Harro M. Timmerman, Alfons B.A. Kroese, Louis M. A. Akkermans, L. Paul van Minnen, Jakub Rychter, Ger T. Rijkers, Andre Verheem, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Male, Pathology, medicine.medical_specialty, Pancreatic disease, Ileum, Pharmacology, Mice, medicine, Animals, Lung, Pancreas, Ceruletide, Barrier function, Bifidobacterium, biology, Ileal Diseases, business.industry, Probiotics, medicine.disease, biology.organism_classification, Lactobacillus acidophilus, Lactococcus lactis, Lacticaseibacillus casei, medicine.anatomical_structure, Pancreatitis, Evaluation of complex medical interventions [NCEBP 2], International, Bacterial Translocation, Acute pancreatitis, Surgery, business
Abstract

Background Intestinal barrier failure during acute pancreatitis (AP) is associated with translocation of luminal bacteria, resulting in infectious complications. We examined the effects of multispecies probiotics on the intestinal barrier impairment in a murine model of AP. Methods Mice were injected with cerulein to induce AP and were sacrificed 11 (early AP) or 72 hours (late AP) after start of induction. AP and associated systemic effects were confirmed by histology of pancreas and lung. Animals received daily probiotics starting 2 days prior to AP induction (pretreatment) or at the moment of AP induction (treatment). Mucosal barrier function of the distal ileum was assessed in Ussing chambers by measurement of the epithelial electrical resistance and the permeability to Na-fluorescein. Results Histological analysis revealed pancreatic injury in both phases of AP, and lung damage in the early phase. Epithelial resistance of the ileum was reduced and permeability increased in both phases of AP, indicating impairment of the intestinal barrier. Pretreatment had no effect on resistance or permeability in the early phase of AP. In the late phase of AP, pretreatment but not treatment abolished the AP induced resistance decrease and permeability increase. Administration of probiotics as such (ie, without induction of AP) had no effect on intestinal barrier function. Conclusion Pretreatment with multispecies probiotics for 2 days abolishes intestinal barrier dysfunction in the late phase of AP, while treatment does not. The effectiveness of probiotics in this model depends on the timing of administration. Clinical trials with probiotics should seek conditions where treatment can be started prior to onset of disease or elective surgical intervention.

Published
2009
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8. Atypical findings in a rat model for parenteral nutrition–induced cholestasis

Author

Andre Verheem, Louis M. A. Akkermans, Judith M. Deckers-Kocken, Roderick H. J. Houwen, and Peter G. J. Nikkels

Subjects
medicine.medical_specialty, Nutrition and Dietetics, Common bile duct, business.industry, Endocrinology, Diabetes and Metabolism, Histology, medicine.disease, Gastroenterology, Pathophysiology, Endocrinology, medicine.anatomical_structure, Parenteral nutrition, Cholestasis, Internal medicine, Jugular vein, medicine, Abnormal Liver Function Test, Steatosis, business
Abstract

The pathophysiology of parenteral nutrition–associated cholestasis (PNAC) in young children is poorly understood. The composition of the total parenteral nutrition (TPN) is reported to be of importance for the occurrence of PNAC. In this study, the effects of parenteral nutrition with different caloric loads and different amounts of lipids were studied in a rat model for PNAC. Four different groups of male Wistar rats were used. In 3 groups, a central catheter was placed in the right jugular vein. The first group (group A) received NaCl 0.9% and had free access to food and water; the other two (groups C and D) received TPN, containing 1142 and 1611 J kg −1 d −1 , respectively. In group B, the common bile duct was ligated. Animals were killed after 7 or 14 days; at these points, liver enzymes were measured, and liver histology was assessed. In the bile duct ligation group, all liver enzymes significantly increased compared with baseline. Liver enzymes did not significantly change in the other groups. Histology showed cholestatic changes in the bile duct ligation group. In the parenteral nutrition groups, significant steatotic changes were found, and in the high caloric TPN group, more so than in the TPN group. In this study, TPN was not associated with abnormal liver function tests or with histological evidence of cholestasis. Total parenteral nutrition was associated with steatosis in this rat model, which is a finding commonly reported in the literature. Therefore, it is questionable whether the rat is a good model for TPN-associated cholestasis.

Published
2006
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13. Differentiated Human Colorectal Cancer Cells Protect Tumor-Initiating Cells From Irinotecan

Author

Emmink, Benjamin L., primary, Van Houdt, Winan J., additional, Vries, Robert G., additional, Hoogwater, Frederik J.H., additional, Govaert, Klaas M., additional, Verheem, Andre, additional, Nijkamp, Maarten W., additional, Steller, Ernst J.A., additional, Jimenez, Connie R., additional, Clevers, Hans, additional, Borel Rinkes, Inne H.M., additional, and Kranenburg, Onno, additional

Published
2011
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15. T1820 Altered Expression of Fibroblast Growth Factor 15 (FGF15) in Acute Pancreatitis: Potential Consequences for Bacterial Translocation and Infection Risk

Author

Nijmeijer, Rian M., primary, Akkermans, Louis M., additional, Schaap, Frank G., additional, Jansen, Peter L., additional, ter Linde, Jose J., additional, Verheem, Andre, additional, Kroese, Alfons B., additional, Besselink, Marc G., additional, Schipper, Marguerite E.I., additional, Gooszen, Hein G., additional, and Van Erpecum, Karel J., additional

Published
2009
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19. T1820 Altered Expression of Fibroblast Growth Factor 15 (FGF15) in Acute Pancreatitis: Potential Consequences for Bacterial Translocation and Infection Risk

Author

Marguerite E.I. Schipper, Frank G. Schaap, Alfons B.A. Kroese, Louis M. A. Akkermans, Marc G. Besselink, Hein G. Gooszen, Peter L.M. Jansen, Rian M. Nijmeijer, Andre Verheem, Jose J. ter Linde, and Karel J. van Erpecum

Subjects
Infection risk, Hepatology, business.industry, FGF15, Immunology, Gastroenterology, Medicine, Acute pancreatitis, Bacterial translocation, business, medicine.disease, Fibroblast growth factor
Published
2009
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20. Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis

Author

van Minnen, L. Paul, primary, Timmerman, Harro M., additional, Lutgendorff, Femke, additional, Verheem, André, additional, Harmsen, Wil, additional, Konstantinov, Sergey R., additional, Smidt, Hauke, additional, Visser, Maarten R., additional, Rijkers, Ger T., additional, Gooszen, Hein G., additional, and Akkermans, Louis M.A., additional

Published
2007
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22. W1769 Pretreatment But Not Treatment with Probiotics Abolishes Mouse Intestinal Barrier Dysfunction in Acute Pancreatitis

Author

Hein G. Gooszen, Jakub Rychter, Marguerite E.I. Schipper, Harro M. Timmerman, Alfons B.A. Kroese, Louis M. A. Akkermans, Andre Verheem, Ger T. Rijkers, and Paul L. van Minnen

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Acute pancreatitis, medicine.disease, business
Published
2008
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