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1,232 results on '"A. PARENTI"'

3. Measurement of the K+ → π+γγ decay

Author

Cortina Gil, E., primary, Kleimenova, A., additional, Minucci, E., additional, Padolski, S., additional, Petrov, P., additional, Shaikhiev, A., additional, Volpe, R., additional, Numao, T., additional, Petrov, Y., additional, Velghe, B., additional, Wong, V.W.S., additional, Bryman, D., additional, Fu, J., additional, Hives, Z., additional, Husek, T., additional, Jerhot, J., additional, Kampf, K., additional, Zamkovsky, M., additional, De Martino, B., additional, Perrin-Terrin, M., additional, Döbrich, B., additional, Lezki, S., additional, Akmete, A.T., additional, Aliberti, R., additional, Khoriauli, G., additional, Kunze, J., additional, Lomidze, D., additional, Peruzzo, L., additional, Vormstein, M., additional, Wanke, R., additional, Dalpiaz, P., additional, Fiorini, M., additional, Mazzolari, A., additional, Neri, I., additional, Norton, A., additional, Petrucci, F., additional, Soldani, M., additional, Wahl, H., additional, Bandiera, L., additional, Cotta Ramusino, A., additional, Gianoli, A., additional, Romagnoni, M., additional, Sytov, A., additional, Iacopini, E., additional, Latino, G., additional, Lenti, M., additional, Lo Chiatto, P., additional, Panichi, I., additional, Parenti, A., additional, Bizzeti, A., additional, Bucci, F., additional, Antonelli, A., additional, Georgiev, G., additional, Kozhuharov, V., additional, Lanfranchi, G., additional, Martellotti, S., additional, Moulson, M., additional, Spadaro, T., additional, Tinti, G., additional, Ambrosino, F., additional, Capussela, T., additional, Corvino, M., additional, D'Errico, M., additional, Di Filippo, D., additional, Fiorenza, R., additional, Giordano, R., additional, Massarotti, P., additional, Mirra, M., additional, Napolitano, M., additional, Rosa, I., additional, Saracino, G., additional, Anzivino, G., additional, Brizioli, F., additional, Imbergamo, E., additional, Lollini, R., additional, Piandani, R., additional, Santoni, C., additional, Barbanera, M., additional, Cenci, P., additional, Checcucci, B., additional, Lubrano, P., additional, Lupi, M., additional, Pepe, M., additional, Piccini, M., additional, Costantini, F., additional, Di Lella, L., additional, Doble, N., additional, Giorgi, M., additional, Giudici, S., additional, Lamanna, G., additional, Lari, E., additional, Pedreschi, E., additional, Sozzi, M., additional, Cerri, C., additional, Fantechi, R., additional, Pontisso, L., additional, Spinella, F., additional, Mannelli, I., additional, D'Agostini, G., additional, Raggi, M., additional, Biagioni, A., additional, Cretaro, P., additional, Frezza, O., additional, Leonardi, E., additional, Lonardo, A., additional, Turisini, M., additional, Valente, P., additional, Vicini, P., additional, Ammendola, R., additional, Bonaiuto, V., additional, Fucci, A., additional, Salamon, A., additional, Sargeni, F., additional, Arcidiacono, R., additional, Bloch-Devaux, B., additional, Boretto, M., additional, Menichetti, E., additional, Migliore, E., additional, Soldi, D., additional, Biino, C., additional, Filippi, A., additional, Marchetto, F., additional, Briano Olvera, A., additional, Engelfried, J., additional, Estrada-Tristan, N., additional, Reyes Santos, M.A., additional, Rodriguez Rivera, K.A., additional, Boboc, P., additional, Bragadireanu, A.M., additional, Ghinescu, S.A., additional, Hutanu, O.E., additional, Bician, L., additional, Blazek, T., additional, Cerny, V., additional, Kucerova, Z., additional, Bernhard, J., additional, Ceccucci, A., additional, Ceoletta, M., additional, Danielsson, H., additional, De Simone, N., additional, Duval, F., additional, Federici, L., additional, Gamberini, E., additional, Gatignon, L., additional, Guida, R., additional, Hahn, F., additional, Holzer, E.B., additional, Jenninger, B., additional, Koval, M., additional, Laycock, P., additional, Lehmann Miotto, G., additional, Lichard, P., additional, Mapelli, A., additional, Marchevski, R., additional, Massri, K., additional, Noy, M., additional, Palladino, V., additional, Pinzino, J., additional, Ryjov, V., additional, Schuchmann, S., additional, Venditti, S., additional, Bache, T., additional, Brunetti, M.B., additional, Duk, V., additional, Fascianelli, V., additional, Fry, J.R., additional, Gonnella, F., additional, Goudzovski, E., additional, Henshaw, J., additional, Iacobuzio, L., additional, Kenworthy, C., additional, Lazzeroni, C., additional, Lurkin, N., additional, Newson, F., additional, Parkinson, C., additional, Romano, A., additional, Sanders, J., additional, Sergi, A., additional, Sturgess, A., additional, Swallow, J., additional, Tomczak, A., additional, Heath, H., additional, Page, R., additional, Trilov, S., additional, Angelucci, B., additional, Britton, D., additional, Graham, C., additional, Protopopescu, D., additional, Carmignani, J., additional, Dainton, J.B., additional, Jones, R.W.L., additional, Ruggiero, G., additional, Fulton, L., additional, Hutchcroft, D., additional, Maurice, E., additional, Wrona, B., additional, Conovaloff, A., additional, Cooper, P., additional, Coward, D., additional, Rubin, P., additional, Baeva, A., additional, Baigarashev, D., additional, Emelyanov, D., additional, Enik, T., additional, Falaleev, V., additional, Fedotov, S., additional, Gorshanov, K., additional, Gushchin, E., additional, Kekelidze, V., additional, Kereibay, D., additional, Kholodenko, S., additional, Khotyantsev, A., additional, Korotkova, A., additional, Kudenko, Y., additional, Kurochka, V., additional, Kurshetsov, V., additional, Litov, L., additional, Madigozhin, D., additional, Medvedeva, M., additional, Mefodev, A., additional, Misheva, M., additional, Molokanova, N., additional, Movchan, S., additional, Obraztsov, V., additional, Okhotnikov, A., additional, Ostankov, A., additional, Polenkevich, I., additional, Potrebenikov, Yu., additional, Sadovskiy, A., additional, Semenov, V., additional, Shkarovskiy, S., additional, Sugonyaev, V., additional, Yushchenko, O., additional, and Zinchenko, A., additional

Published
2024
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5. Menke-Hennekam syndrome; delineation of domain-specific subtypes with distinct clinical and DNA methylation profiles

Author

Haghshenas, Sadegheh, primary, Bout, Hidde J., additional, Schijns, Josephine M., additional, Levy, Michael A., additional, Kerkhof, Jennifer, additional, Bhai, Pratibha, additional, McConkey, Haley, additional, Jenkins, Zandra A., additional, Williams, Ella M., additional, Halliday, Benjamin J., additional, Huisman, Sylvia A., additional, Lauffer, Peter, additional, de Waard, Vivian, additional, Witteveen, Laura, additional, Banka, Siddharth, additional, Brady, Angela F., additional, Galazzi, Elena, additional, van Gils, Julien, additional, Hurst, Anna C.E., additional, Kaiser, Frank J., additional, Lacombe, Didier, additional, Martinez-Monseny, Antonio F., additional, Fergelot, Patricia, additional, Monteiro, Fabíola P., additional, Parenti, Ilaria, additional, Persani, Luca, additional, Simarro, Fernando Santos, additional, Simpson, Brittany N., additional, Alders, Mariëlle, additional, Robertson, Stephen P., additional, Sadikovic, Bekim, additional, and Menke, Leonie A., additional

Published
2024
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10. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Yun-Feng Liang, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Ming-Sheng Cai, Elisabetta Casilli, Enrico Catanzani, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Ming-Yang Cui, Tian-Shu Cui, Yu-Xing Cui, Hao-Ting Dai, Antonio De Benedittis, Ivan De Mitri, Francesco de Palma, Maksym Deliyergiyev, Margherita Di Santo, Qi Ding, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, David Droz, Jing-Lai Duan, Kai-Kai Duan, Domenico D’Urso, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Piergiorgio Fusco, Min Gao, Fabio Gargano, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Wei Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Shang Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Chuan-Ning Luo, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta, Dan Mo, Maria Muñoz Salinas, Xiao-Yang Niu, Xu Pan, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Rui Qiao, Jia-Ning Rao, Arshia Ruina, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Mikhail Stolpovskiy, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Shu-Xin Wang, Xiao-Lian Wang, Ying Wang, Yan-Fang Wang, Yuan-Zhu Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Li-Bo Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, En-Heng Xu, Hai-Tao Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Guan-Wen Yuan, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Yi Zhang, Yong-Jie Zhang, Yun-Long Zhang, Ya-Peng Zhang, Yong-Qiang Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Yan Zhu, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato , Paolo Bernardini , Xiao-Jun Bi , Ming-Sheng Cai , Elisabetta Casilli , Enrico Catanzani , Jin Chang , Deng-Yi Chenj , Jun-Ling Chen , Zhan-Fang Chen , Ming-Yang Cui , Tian- Shu Cuin , Yu-Xin Cui , Hao-Ting Dai , Antonio De Benedittis , Ivan De Mitri , Francesco de Palma , Maksym Deliyergiyev Margherita Di Santo , Qi Ding , Tie-Kuan Dong , Zhen-Xing Dong , Giacinto Donvito , David Droz, Jing-Lai Duan , Kai-Kai Duan , Domenico D’Urso , Rui-Rui Fan , Yi-Zhong Fan , Fan Fang , Kun Fang, Chang-Qin Feng , Lei Feng , Piergiorgio Fusco, Min Gao , Fabio Gargano , Ke Gong , Yi-Zhong Gong , Dong- Ya Guo , Jian-Hua Guo , Shuang-Xue Han, Yi-Ming Hu , Guang- Shun Huang , Xiao-Yuan Huang , Yong-Yi Huang , Maria Ionica , Wei Jiang , Jie Kong , Andrii Kotenko , Dimitrios Kyratzis , Shi- Jun Lei, Shang Li , Wen-Hao Li , Wei-Liang Li , Xiang Li , Xian Qiang Li , Yao-Ming Lian , Cheng-Ming Liu , Hao Liu , Jie Liu , Shu-Bin Liu , Yang Liu , Francesco Loparco , Chuan-Ning Luo , Miao Ma , Peng-Xiong Ma , Tao Ma , Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta , Dan Mo , Maria Muñoz Salinas , Xiao-Yang Niu , Xu Pan , Andrea Parenti , Wen-Xi Peng , Xiao- Yan Peng , Chiara Perrina , Rui Qiao , Jia-Ning Rao , Arshia Ruina , Zhi Shangguan , Wei-Hua Shen , Zhao-Qiang Shen , Zhong-Tao Shen , Leandro Silveri, Jing-Xing Song , Mikhail Stolpovskiy Hong Su , Meng Su , Hao-Ra Sun , Zhi-Yu Sun , Antonio Surdo , Xue-Jian Teng , Andrii Tykhonov , Jin-Zhou Wang , Lian-Guo Wang , Shen Wang , Shu-Xin Wang , Xiao-Lian Wang , Ying Wang , Yan-Fang Wang , Yuan-Zhu Wang , Da-Ming Wei , Jia-Ju Wei , Yi-Feng Wei , Di Wu , Jian Wu , Li-Bo Wu , Sha-Sha Wun , Xin Wu , Zi-Qing Xi , En-Heng Xu , Hai-Tao Xu , Zhi-Hui Xu , Zun-Lei Xu , Zi-Zong Xu , Guo-Feng Xuen , Hai-Bo Yang , Peng Yang , Ya-Qing Yang , Hui-Jun Yao , Yu-Hong Yu , Guan-Wen Yuan , Qiang Yuan , Chuan Yue , JingJing Zang Sheng-Xi Zhang , Wen-Zhang Zhang , Yan Zhang, Yi Zhangj, Yong-Jie Zhang , Yun-Long Zhang , Ya-Peng Zhang , Yong-Qiang Zhang , Zhe Zhang , Zhi-Yong Zhang , Cong Zhao , Hong-Yun Zhao , Xun-Feng Zhao , Chang-Yi Zhou , and Yan Zhu, Alemanno, Francesca, An, Qi, Azzarello, Philipp, Carla Tiziana Barbato, Felicia, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xin, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, DE PALMA, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D’Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrio, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Lian, Yao-Ming, Liu, Cheng-Min, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Nicola Mazziotta, Mario, Mo, Dan, Muñoz Salinas, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Ra, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zann, Jing-Jing, Zhan, Sheng-Xia, Zhan, Wen-Zhang, Zhan, Yan, Zhan, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, and Yan Zhu, And

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Line-like structure, High Energy Physics - Experiment (hep-ex), Multidisciplinary, Astrophysics::High Energy Astrophysical Phenomena, DAMPE, Dark matter, Gamma-ray, Line-like structure, Settore FIS/01 - Fisica Sperimentale, DAMPE, Dark matter, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version

Published
2022
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11. Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

Author

Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, and Gangqing Hu

Subjects
Biomaterials, Biomedical Engineering, Biotechnology
Abstract

Articular cartilage has a limited capacity to self-heal once damaged. Tissue-specific stem cells are a solution for cartilage regeneration; however

Published
2023
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12. ACR Appropriateness Criteria® Workup of Noncerebral Systemic Arterial Embolic Source

Author

Vincent G. Parenti, Kanupriya Vijay, Christopher D. Maroules, Bill S. Majdalany, Lynne M. Koweek, Minhajuddin S. Khaja, Brian B. Ghoshhajra, Prachi P. Agarwal, Benjamin N. Contrella, Nicole A. Keefe, Bruce M. Lo, Sachin B. Malik, Devaki Shilpa Surasi, Kathleen Waite, Eric E. Williamson, Suhny Abbara, and Karin E. Dill

Subjects
Radiology, Nuclear Medicine and imaging
Published
2023
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13. Search for K+ decays into the π+e+e−e+e− final state

Author

Cortina Gil, E., primary, Kleimenova, A., additional, Minucci, E., additional, Padolski, S., additional, Petrov, P., additional, Shaikhiev, A., additional, Volpe, R., additional, Numao, T., additional, Petrov, Y., additional, Velghe, B., additional, Wong, V.W.S., additional, Bryman, D., additional, Fu, J., additional, Hives, Z., additional, Husek, T., additional, Jerhot, J., additional, Kampf, K., additional, Zamkovsky, M., additional, De Martino, B., additional, Perrin-Terrin, M., additional, Akmete, A.T., additional, Aliberti, R., additional, Khoriauli, G., additional, Kunze, J., additional, Lomidze, D., additional, Peruzzo, L., additional, Vormstein, M., additional, Wanke, R., additional, Dalpiaz, P., additional, Fiorini, M., additional, Mazzolari, A., additional, Neri, I., additional, Norton, A., additional, Petrucci, F., additional, Soldani, M., additional, Wahl, H., additional, Bandiera, L., additional, Cotta Ramusino, A., additional, Gianoli, A., additional, Romagnoni, M., additional, Sytov, A., additional, Iacopini, E., additional, Latino, G., additional, Lenti, M., additional, Lo Chiatto, P., additional, Panichi, I., additional, Parenti, A., additional, Bizzeti, A., additional, Bucci, F., additional, Antonelli, A., additional, Georgiev, G., additional, Kozhuharov, V., additional, Lanfranchi, G., additional, Martellotti, S., additional, Moulson, M., additional, Spadaro, T., additional, Tinti, G., additional, Ambrosino, F., additional, Capussela, T., additional, Corvino, M., additional, D'Errico, M., additional, Di Filippo, D., additional, Fiorenza, R., additional, Giordano, R., additional, Massarotti, P., additional, Mirra, M., additional, Napolitano, M., additional, Rosa, I., additional, Saracino, G., additional, Anzivino, G., additional, Brizioli, F., additional, Imbergamo, E., additional, Lollini, R., additional, Piandani, R., additional, Santoni, C., additional, Barbanera, M., additional, Cenci, P., additional, Checcucci, B., additional, Lubrano, P., additional, Lupi, M., additional, Pepe, M., additional, Piccini, M., additional, Costantini, F., additional, Di Lella, L., additional, Doble, N., additional, Giorgi, M., additional, Giudici, S., additional, Lamanna, G., additional, Lari, E., additional, Pedreschi, E., additional, Sozzi, M., additional, Cerri, C., additional, Fantechi, R., additional, Pontisso, L., additional, Spinella, F., additional, Mannelli, I., additional, D'Agostini, G., additional, Raggi, M., additional, Biagioni, A., additional, Cretaro, P., additional, Frezza, O., additional, Leonardi, E., additional, Lonardo, A., additional, Turisini, M., additional, Valente, P., additional, Vicini, P., additional, Ammendola, R., additional, Bonaiuto, V., additional, Fucci, A., additional, Salamon, A., additional, Sargeni, F., additional, Arcidiacono, R., additional, Bloch-Devaux, B., additional, Boretto, M., additional, Menichetti, E., additional, Migliore, E., additional, Soldi, D., additional, Biino, C., additional, Filippi, A., additional, Marchetto, F., additional, Briano Olvera, A., additional, Engelfried, J., additional, Estrada-Tristan, N., additional, Reyes Santos, M.A., additional, Boboc, P., additional, Bragadireanu, A.M., additional, Ghinescu, S.A., additional, Hutanu, O.E., additional, Bician, L., additional, Blazek, T., additional, Cerny, V., additional, Kucerova, Z., additional, Bernhard, J., additional, Ceccucci, A., additional, Ceoletta, M., additional, Danielsson, H., additional, De Simone, N., additional, Duval, F., additional, Döbrich, B., additional, Federici, L., additional, Gamberini, E., additional, Gatignon, L., additional, Guida, R., additional, Hahn, F., additional, Holzer, E.B., additional, Jenninger, B., additional, Koval, M., additional, Laycock, P., additional, Lehmann Miotto, G., additional, Lichard, P., additional, Mapelli, A., additional, Marchevski, R., additional, Massri, K., additional, Noy, M., additional, Palladino, V., additional, Pinzino, J., additional, Ryjov, V., additional, Schuchmann, S., additional, Venditti, S., additional, Bache, T., additional, Brunetti, M.B., additional, Duk, V., additional, Fascianelli, V., additional, Fry, J.R., additional, Gonnella, F., additional, Goudzovski, E., additional, Henshaw, J., additional, Iacobuzio, L., additional, Kenworthy, C., additional, Lazzeroni, C., additional, Lurkin, N., additional, Newson, F., additional, Parkinson, C., additional, Romano, A., additional, Sanders, J., additional, Sergi, A., additional, Sturgess, A., additional, Swallow, J., additional, Tomczak, A., additional, Heath, H., additional, Page, R., additional, Trilov, S., additional, Angelucci, B., additional, Britton, D., additional, Graham, C., additional, Protopopescu, D., additional, Carmignani, J., additional, Dainton, J.B., additional, Jones, R.W.L., additional, Ruggiero, G., additional, Fulton, L., additional, Hutchcroft, D., additional, Maurice, E., additional, Wrona, B., additional, Conovaloff, A., additional, Cooper, P., additional, Coward, D., additional, Rubin, P., additional, Baeva, A., additional, Baigarashev, D., additional, Emelyanov, D., additional, Enik, T., additional, Falaleev, V., additional, Fedotov, S., additional, Gorshanov, K., additional, Gushchin, E., additional, Kekelidze, V., additional, Kereibay, D., additional, Kholodenko, S., additional, Khotyantsev, A., additional, Korotkova, A., additional, Kudenko, Y., additional, Kurochka, V., additional, Kurshetsov, V., additional, Litov, L., additional, Madigozhin, D., additional, Medvedeva, M., additional, Mefodev, A., additional, Misheva, M., additional, Molokanova, N., additional, Movchan, S., additional, Obraztsov, V., additional, Okhotnikov, A., additional, Ostankov, A., additional, Polenkevich, I., additional, Potrebenikov, Yu., additional, Sadovskiy, A., additional, Semenov, V., additional, Shkarovskiy, S., additional, Sugonyaev, V., additional, Yushchenko, O., additional, and Zinchenko, A., additional

Published
2023
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16. Integration and first operation of the Gotthard-II detector at European XFEL

Author

Ramilli, Marco, primary, Ahmed, Karim, additional, de Wijin, Raphael, additional, Dietze, Thomas, additional, Fernandes, Bruno, additional, Hammer, David, additional, Jiang, Yifeng, additional, Khakhulin, Dmitry, additional, Koliyadu, Jayanath C.P., additional, Letrun, Romain, additional, Liu, Jia, additional, Lopez-Cuenca, Carlos, additional, Mezza, Davide, additional, Milne, Christopher, additional, Mozzanica, Aldo, additional, Parenti, Andrea, additional, Sato, Tokushi, additional, Schmidt, Philipp, additional, Schmitt, Bernd, additional, Sikorski, Marcin, additional, Turcato, Monica, additional, Uemura, Yohei, additional, Wang, Hao, additional, Yousef, Hazem, additional, and Zhang, Jiaguo, additional

Published
2023
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17. Leaving child and adolescent mental health services in the MILESTONE cohort: a longitudinal cohort study on young people's mental health indicators, care pathways, and outcomes in Europe

Author

Suzanne E Gerritsen, Larissa S van Bodegom, Mathilde M Overbeek, Athanasios Maras, Frank C Verhulst, Dieter Wolke, Dimitris Rizopoulos, Giovanni de Girolamo, Tomislav Franić, Jason Madan, Fiona McNicholas, Moli Paul, Diane Purper-Ouakil, Paramala J Santosh, Ulrike M E Schulze, Swaran P Singh, Cathy Street, Sabine Tremmery, Helena Tuomainen, Gwendolyn C Dieleman, Rebecca Appleton, Nikolina Davidović, Sabrina Ferrari, Federico Fiori, Charlotte Gatherer, Gaëlle Hendrickx, Ingrid Holme, Renaud Jardri, Alfred Kolozsvari, Kate Lievesley, Mathilde Mastroianni, Virginie Maurice, Giorgia Morini, Aesa Parenti, Frédérick Russet, Melanie Saam, Ilyas Sagar-Ouriaghli, Anne Sartor, Giulia Signorini, Jatinder Singh, Priya Tah, Amanda Tuffrey, Therese AMJ van Amelsvoort, Pamela Varvara, Stefano Vicari, Leanne Walker, Anna Wilson, Helena Jerkovic, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Mental Health, Child and Adolescent Psychiatry / Psychology, and Epidemiology

Subjects
Adult, Male, Mental Health Services, Adolescent, Infant, Cohort Studies, Europe, Young Adult, Psychiatry and Mental health, Mental Health, SDG 3 - Good Health and Well-being, Critical Pathways, Humans, Female, Longitudinal Studies, Child, Europe-epidemiology, Biological Psychiatry
Abstract

Background: The configuration of having separate mental health services by age, namely child and adolescent mental health services (CAMHS) and adult mental health services (AMHS), might be a barrier to continuity of care that adversely affects young people's mental health. However, no studies have investigated whether discontinuity of care in the transition period affects mental health. We aimed to discern the type of care young people receive after reaching the upper age limit of their CAMHS and examine differences in outcomes at 24-month follow-up between young people receiving different types of care. Methods: To assess mental health in young people from 39 CAMHS in eight European countries (Belgium, Croatia, France, Germany, Italy, Ireland, the Netherlands, and the UK), we did a longitudinal cohort study. Eligible young people were CAMHS users up to 1 year younger than the upper age limit of their CAMHS or up to 3 months older, if they were still in CAMHS. Information on mental health service use, mental health problems (ie, using the Health of the Nation Outcome Scale for Children and Adolescents, Youth Self-Report and Adult Self-Report, DSM-5, and ICD-10), and sociodemographic characteristics were collected using self-reported, parent-reported, and clinician-reported interviews and questionnaires. Mixed models were applied to assess relationships between baseline characteristics, mental health service use, and outcomes. Findings: The MILESTONE cohort included 763 young people. The participants were 60·0% female (n=458) and 40·0% male (n=305), 90·3% White (n=578), and had a mean age of 17·5 years (range 15·2–19·6 years). Over the 24-month follow-up period, 48 young people (6·3%) actively withdrew from the study. For young people, the higher their scores on the Health of the Nation Outcome Scale for Children and Adolescents (p=0·0009) and Youth Self-Report and Adult Self-Report (p=0·046), and who had a clinical classification of severe mental illness (p=0·0033), had suicidal thoughts or behaviours or self-harm (p=0·034), used psychotropic medication (p=0·0014), and had a self-reported or parent-reported need for continued treatment (p

Published
2022
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18. Inflammasome activation and assembly in Huntington’s disease

Author

Tiago, de Oliveira Furlam, Isadora Gonçalves, Roque, Ewelin Wasner, Machado da Silva, Pedro Parenti, Vianna, Priscila Aparecida, Costa Valadão, Cristina, Guatimosim, Antônio Lúcio, Teixeira, and Aline Silva, de Miranda

Subjects
Huntington Disease, Inflammasomes, Leucine, Nucleotides, Caspases, Interleukin-1beta, NLR Family, Pyrin Domain-Containing 3 Protein, Immunology, Interleukin-18, Humans, Neurodegenerative Diseases, Molecular Biology
Abstract

Huntington's disease (HD) is a rare neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. Inflammasomes are multiprotein complexes capable of sensing pathogen-associated and damage-associated molecular patterns, triggering innate immune pathways. Activation of inflammasomes results in a pro-inflammatory cascade involving, among other molecules, caspases and interleukins. NLRP3 (nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3) is the most studied inflammasome complex, and its activation results in caspase-1 mediated cleavage of the pro-interleukins IL-1β and IL-18 into their mature forms, also inducing a gasdermin D mediated form of pro-inflammatory cell death, i.e. pyroptosis. Accumulating evidence has implicated NLRP3 inflammasome complex in neurodegenerative diseases. The evidence in HD is still scant and mostly derived from pre-clinical studies. This review aims to present the available evidence on NLRP3 inflammasome activation in HD and to discuss whether targeting this innate immune system complex might be a promising therapeutic strategy to alleviate its symptoms.

Published
2022
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19. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia

Author

Angeli, Andrea, primary, Micheli, Laura, additional, Turnaturi, Rita, additional, Pasquinucci, Lorella, additional, Parenti, Carmela, additional, Alterio, Vincenzo, additional, Di Fiore, Anna, additional, De Simone, Giuseppina, additional, Monti, Simona Maria, additional, Carta, Fabrizio, additional, di Cesare Mannelli, Lorenzo, additional, Ghelardini, Carla, additional, and Supuran, Claudiu T., additional

Published
2023
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20. De novo missense variants in phosphatidylinositol kinase PIP5KIγ underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling

Author

Morleo, Manuela, primary, Venditti, Rossella, additional, Theodorou, Evangelos, additional, Briere, Lauren C., additional, Rosello, Marion, additional, Tirozzi, Alfonsina, additional, Tammaro, Roberta, additional, Al-Badri, Nour, additional, High, Frances A., additional, Shi, Jiahai, additional, Putti, Elena, additional, Ferrante, Luigi, additional, Cetrangolo, Viviana, additional, Torella, Annalaura, additional, Walker, Melissa A., additional, Tenconi, Romano, additional, Iascone, Maria, additional, Mei, Davide, additional, Guerrini, Renzo, additional, van der Smagt, Jasper, additional, Kroes, Hester Y., additional, van Gassen, Koen L.I., additional, Bilal, Muhammad, additional, Umair, Muhammad, additional, Pingault, Veronica, additional, Attie-Bitach, Tania, additional, Amiel, Jeannine, additional, Ejaz, Resham, additional, Rodan, Lance, additional, Zollino, Marcella, additional, Agrawal, Pankaj B., additional, Del Bene, Filippo, additional, Nigro, Vincenzo, additional, Sweetser, David A., additional, Franco, Brunella, additional, Acosta, Maria T., additional, Adam, Margaret, additional, Adams, David R., additional, Alvarez, Raquel L., additional, Alvey, Justin, additional, Amendola, Laura, additional, Andrews, Ashley, additional, Ashley, Euan A., additional, Bacino, Carlos A., additional, Bademci, Guney, additional, Balasubramanyam, Ashok, additional, Baldridge, Dustin, additional, Bale, Jim, additional, Bamshad, Michael, additional, Barbouth, Deborah, additional, Bayrak-Toydemir, Pinar, additional, Beck, Anita, additional, Beggs, Alan H., additional, Behrens, Edward, additional, Bejerano, Gill, additional, Bellen, Hugo J., additional, Bennett, Jimmy, additional, Berg-Rood, Beverly, additional, Bernstein, Jonathan A., additional, Berry, Gerard T., additional, Bican, Anna, additional, Bivona, Stephanie, additional, Blue, Elizabeth, additional, Bohnsack, John, additional, Bonner, Devon, additional, Botto, Lorenzo, additional, Boyd, Brenna, additional, Brown, Gabrielle, additional, Burke, Elizabeth A., additional, Burrage, Lindsay C., additional, Butte, Manish J., additional, Byers, Peter, additional, Byrd, William E., additional, Carey, John, additional, Carrasquillo, Olveen, additional, Cassini, Thomas, additional, Chang, Ta Chen Peter, additional, Chanprasert, Sirisak, additional, Chao, Hsiao-Tuan, additional, Clark, Gary D., additional, Coakley, Terra R., additional, Cobban, Laurel A., additional, Cogan, Joy D., additional, Coggins, Matthew, additional, Cole, F. Sessions, additional, Colley, Heather A., additional, Cooper, Cynthia M., additional, Cope, Heidi, additional, Corona, Rosario, additional, Craigen, William J., additional, Crouse, Andrew B., additional, Cunningham, Michael, additional, D’Souza, Precilla, additional, Dai, Hongzheng, additional, Dasari, Surendra, additional, Davis, Joie, additional, Dayal, Jyoti G., additional, Dell'Angelica, Esteban C., additional, Dipple, Katrina, additional, Doherty, Daniel, additional, Dorrani, Naghmeh, additional, Doss, Argenia L., additional, Douine, Emilie D., additional, Earl, Dawn, additional, Eckstein, David J., additional, Emrick, Lisa T., additional, Eng, Christine M., additional, Falk, Marni, additional, Fieg, Elizabeth L., additional, Fisher, Paul G., additional, Fogel, Brent L., additional, Forghani, Irman, additional, Gahl, William A., additional, Glass, Ian, additional, Gochuico, Bernadette, additional, Goddard, Page C., additional, Godfrey, Rena A., additional, Golden-Grant, Katie, additional, Grajewski, Alana, additional, Hadley, Don, additional, Hahn, Sihoun, additional, Halley, Meghan C., additional, Hamid, Rizwan, additional, Hassey, Kelly, additional, Hayes, Nichole, additional, High, Frances, additional, Hing, Anne, additional, Hisama, Fuki M., additional, Holm, Ingrid A., additional, Hom, Jason, additional, Horike-Pyne, Martha, additional, Huang, Alden, additional, Hutchison, Sarah, additional, Introne, Wendy, additional, Isasi, Rosario, additional, Izumi, Kosuke, additional, Jamal, Fariha, additional, Jarvik, Gail P., additional, Jarvik, Jeffrey, additional, Jayadev, Suman, additional, Jean-Marie, Orpa, additional, Jobanputra, Vaidehi, additional, Karaviti, Lefkothea, additional, Ketkar, Shamika, additional, Kiley, Dana, additional, Kilich, Gonench, additional, Kobren, Shilpa N., additional, Kohane, Isaac S., additional, Kohler, Jennefer N., additional, Korrick, Susan, additional, Kozuira, Mary, additional, Krakow, Deborah, additional, Krasnewich, Donna M., additional, Kravets, Elijah, additional, Lalani, Seema R., additional, Lam, Byron, additional, Lam, Christina, additional, Lanpher, Brendan C., additional, Lanza, Ian R., additional, LeBlanc, Kimberly, additional, Lee, Brendan H., additional, Levitt, Roy, additional, Lewis, Richard A., additional, Liu, Pengfei, additional, Liu, Xue Zhong, additional, Longo, Nicola, additional, Loo, Sandra K., additional, Loscalzo, Joseph, additional, Maas, Richard L., additional, Macnamara, Ellen F., additional, MacRae, Calum A., additional, Maduro, Valerie V., additional, Maghiro, AudreyStephannie, additional, Mahoney, Rachel, additional, Malicdan, May Christine V., additional, Mamounas, Laura A., additional, Manolio, Teri A., additional, Mao, Rong, additional, Maravilla, Kenneth, additional, Marom, Ronit, additional, Marth, Gabor, additional, Martin, Beth A., additional, Martin, Martin G., additional, Martínez-Agosto, Julian A., additional, Marwaha, Shruti, additional, McCauley, Jacob, additional, McConkie-Rosell, Allyn, additional, McCray, Alexa T., additional, McGee, Elisabeth, additional, Mefford, Heather, additional, Merritt, J. Lawrence, additional, Might, Matthew, additional, Mirzaa, Ghayda, additional, Morava, Eva, additional, Moretti, Paolo, additional, Mulvihill, John, additional, Nakano-Okuno, Mariko, additional, Nelson, Stanley F., additional, Newman, John H., additional, Nicholas, Sarah K., additional, Nickerson, Deborah, additional, Nieves-Rodriguez, Shirley, additional, Novacic, Donna, additional, Oglesbee, Devin, additional, Orengo, James P., additional, Pace, Laura, additional, Pak, Stephen, additional, Pallais, J. Carl, additional, Palmer, Christina G.S., additional, Papp, Jeanette C., additional, Parker, Neil H., additional, Phillips III, John A., additional, Posey, Jennifer E., additional, Potocki, Lorraine, additional, Pusey Swerdzewski, Barbara N., additional, Quinlan, Aaron, additional, Rao, Deepak A., additional, Raper, Anna, additional, Raskind, Wendy, additional, Renteria, Genecee, additional, Reuter, Chloe M., additional, Rives, Lynette, additional, Robertson, Amy K., additional, Rodan, Lance H., additional, Rosenfeld, Jill A., additional, Rosenwasser, Natalie, additional, Rossignol, Francis, additional, Ruzhnikov, Maura, additional, Sacco, Ralph, additional, Sampson, Jacinda B., additional, Saporta, Mario, additional, Schaechter, Judy, additional, Schedl, Timothy, additional, Schoch, Kelly, additional, Scott, Daryl A., additional, Scott, C. Ron, additional, Shashi, Vandana, additional, Shin, Jimann, additional, Silverman, Edwin K., additional, Sinsheimer, Janet S., additional, Sisco, Kathy, additional, Smith, Edward C., additional, Smith, Kevin S., additional, Solnica-Krezel, Lilianna, additional, Solomon, Ben, additional, Spillmann, Rebecca C., additional, Stoler, Joan M., additional, Sullivan, Kathleen, additional, Sullivan, Jennifer A., additional, Sun, Angela, additional, Sutton, Shirley, additional, Sybert, Virginia, additional, Tabor, Holly K., additional, Tan, Queenie K.-G., additional, Tan, Amelia L.M., additional, Tekin, Mustafa, additional, Telischi, Fred, additional, Thorson, Willa, additional, Tifft, Cynthia J., additional, Toro, Camilo, additional, Tran, Alyssa A., additional, Ungar, Rachel A., additional, Urv, Tiina K., additional, Vanderver, Adeline, additional, Velinder, Matt, additional, Viskochil, Dave, additional, Vogel, Tiphanie P., additional, Wahl, Colleen E., additional, Walker, Melissa, additional, Wallace, Stephanie, additional, Walley, Nicole M., additional, Wambach, Jennifer, additional, Wan, Jijun, additional, Wang, Lee-kai, additional, Wangler, Michael F., additional, Ward, Patricia A., additional, Wegner, Daniel, additional, Weisz Hubshman, Monika, additional, Wener, Mark, additional, Wenger, Tara, additional, Westerfield, Monte, additional, Wheeler, Matthew T., additional, Whitlock, Jordan, additional, Wolfe, Lynne A., additional, Worley, Kim, additional, Xiao, Changrui, additional, Yamamoto, Shinya, additional, Yang, John, additional, Zhang, Zhe, additional, Zuchner, Stephan, additional, Morleo, Manuela, additional, Spampanato, Carmine, additional, Pinelli, Michele, additional, Banfi, Sandro, additional, Varavallo, Alessandra, additional, Selicorni, Angelo, additional, Mariani, Milena, additional, Massimello, Marta, additional, Daolio, Cecilia, additional, Capra, Valeria, additional, Accogli, Andrea, additional, Scala, Marcello, additional, Leuzzi, Vincenzo, additional, Nardecchia, Francesca, additional, Galosi, Serena, additional, Mastrangelo, Mario, additional, Milani, Donatella, additional, Vitiello, Giuseppina, additional, Piluso, Giulio, additional, Romano, Corrado, additional, Failla, Pinella, additional, Greco, Donatella, additional, Pantaleoni, Chiara, additional, Ciaccio, Claudia, additional, D’Arrigo, Stefano, additional, Brunetti Pierri, Nicola, additional, Parenti, Giancarlo, additional, Coppola, Antonietta, additional, Mattina, Teresa, additional, Amenta, Simona, additional, Tummolo, Albina, additional, Santoro, Claudia, additional, Grandone, Anna, additional, De Brasi, Daniele, additional, Varone, Antonio, additional, Garavelli, Livia, additional, Marini, Carla, additional, Bigoni, Stefania, additional, Piscopo, Carmelo, additional, Trabacca, Antonio, additional, De Rinaldis, Marta, additional, and Peron, Angela, additional

Published
2023
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21. Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity

Author

Barbaraci, Carla, primary, di Giacomo, Viviana, additional, Maruca, Annalisa, additional, Patamia, Vincenzo, additional, Rocca, Roberta, additional, Dichiara, Maria, additional, Di Rienzo, Annalisa, additional, Cacciatore, Ivana, additional, Cataldi, Amelia, additional, Balaha, Marwa, additional, Rapino, Monica, additional, Zagni, Chiara, additional, Zampieri, Daniele, additional, Pasquinucci, Lorella, additional, Parenti, Carmela, additional, Amata, Emanuele, additional, Rescifina, Antonio, additional, Alcaro, Stefano, additional, and Marrazzo, Agostino, additional

Published
2023
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24. Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial

Author

Sheela Sitaraman, Richard Roxburgh, Kristina Gutschmidt, Ela Stefanescu, Drago Bratkovic, Thomas Burrow, Kornblum Cornelia, Kristl Claeys, Miriam Freimer, Ozlem Goker-Alpan, Srilakshmi Kuchipudi, Alan Pestronk, Wolfgang Löscher, Francoise Bouhour, Maria Judit Molnar, Ans T. van der Ploeg, Halina Bartosik-Psujek, Mitchell Goldman, Robert D. Henderson, Stephanie Dearmey, Colin Quinn, Paula R. Clemens, Priya S. Kishnani, Jennifer B Avelar, Nicola Longo, Shahram Attarian, Robert Hopkin, Tomo Sawada, Blaž Koritnik, George Konstantinos Papadimas, Hideaki Shiraishi, Christopher Lindberg, Jin-Hong Shin, Ivaylo Tarnev, Tahseen Mozaffar, Heather Lau, Michel Tchan, Jozsef Janszky, Tobias Ruck, Sabrina Sacconi, Benedikt Schoser, Hashiguchi Akihiro, Patrick Deegan, Ernest Butler, Nuria Vidal-Fernandez, Antonio Toscano, Tarekegn Hiwot, Gee Kim, Emmanuelle Salort-Campana, Jeff Castelli, Pascal Laforet, Céline Tard, Crystal Eldridge, Aneal Khan, Stephan Wenninger, Simona Fecarotta, Jordi Díaz-Manera, Jorge Alonso-Pérez, Yin-Hsiu Chien, Mark Tarnopolsky, Olimpia Musumeci, Hiroshi Kobayashi, Helio Pedro, Jonathan Cauci, Agnes Sebok, Cynthia Bodkin, Hai Jiang, Julie Berthy, Vescei Laszlo, Derralynn Hughes, David Reyes-Leiva, Aleksandra Dominovic-Kovacevic, Mazen M. Dimachkie, Hernan Amartino, Hani Kushlaf, Barry J. Byrne, Giancarlo Parenti, Henning Andersen, Mark Roberts, Marie Wencel, Jaime Vengoechea, Schoser, B., Roberts, M., Byrne, B. J., Sitaraman, S., Jiang, H., Laforet, P., Toscano, A., Castelli, J., Diaz-Manera, J., Goldman, M., van der Ploeg, A. T., Bratkovic, D., Kuchipudi, S., Mozaffar, T., Kishnani, P. S., Sebok, A., Pestronk, A., Dominovic-Kovacevic, A., Khan, A., Koritnik, B., Tard, C., Lindberg, C., Quinn, C., Eldridge, C., Bodkin, C., Reyes-Leiva, D., Hughes, D., Stefanescu, E., SALORT-CAMPANA, E., Butler, E., Bouhour, F., Kim, G., Konstantinos Papadimas, G., Parenti, G., Bartosik-Psujek, H., Kushlaf, H., Akihiro, H., Lau, H., Pedro, H., Andersen, H., Amartino, H., Shiraishi, H., Kobayashi, H., Tarnev, I., Vengoechea, J., Avelar, J., Shin, J. -H., Cauci, J., Alonso-Perez, J., Janszky, J., Berthy, J., Cornelia, K., Gutschmidt, K., Claeys, K., Judit Molnar, M., Wencel, M., Tarnopolsky, M., Dimachkie, M., Tchan, M., Freimer, M., Longo, N., Vidal-Fernandez, N., Musumeci, O., Goker-Alpan, O., Deegan, P., Clemens, P. R., Roxburgh, R., Henderson, R., Hopkin, R., Sacconi, S., Fecarotta, S., Attarian, S., Wenninger, S., Dearmey, S., Hiwot, T., Burrow, T., Ruck, T., Sawada, T., Laszlo, V., Loscher, W., Chien, Y. -H., and Pediatrics

Subjects
education.field_of_study, medicine.medical_specialty, 1-Deoxynojirimycin, Adolescent, Glycogen Storage Disease Type II, business.industry, Population, alpha-Glucosidases, Enzyme replacement therapy, Placebo, Treatment Outcome, Double-Blind Method, SDG 3 - Good Health and Well-being, Internal medicine, Miglustat, medicine, Clinical endpoint, Humans, Respiratory function, Neurology (clinical), Adverse effect, education, business, Alglucosidase alfa, medicine.drug
Abstract

Summary Background Pompe disease is a rare disorder characterised by progressive loss of muscle and respiratory function due to acid α-glucosidase deficiency. Enzyme replacement therapy with recombinant human acid α-glucosidase, alglucosidase alfa, is the first approved treatment for the disease, but some patients do not respond, and many do not show a sustained benefit. We aimed to assess the safety and efficacy of an investigational two-component therapy (cipaglucosidase alfa, a novel recombinant human acid α-glucosidase, plus miglustat, an enzyme stabiliser) for late-onset Pompe disease. Methods We did a randomised, double-blind, parallel-group, phase 3 trial at 62 neuromuscular and metabolic medical centres in 24 countries in the Americas, Asia-Pacific, and Europe. Eligible participants were aged 18 years or older with late-onset Pompe disease, and had either been receiving alglucosidase alfa for at least 2 years or were enzyme replacement therapy-naive. Participants were randomly assigned (2:1) using interactive response technology software, stratified by 6-min walk distance and previous enzyme replacement therapy status, to intravenous cipaglucosidase alfa (20 mg/kg) plus oral miglustat or to intravenous alglucosidase alfa (20 mg/kg) plus oral placebo once every 2 weeks for 52 weeks. Patients, investigators, and outcome assessors were masked to treatment assignment. The primary endpoint was change from baseline to week 52 in 6-min walk distance, assessed using a mixed-effect model for repeated measures analysis for comparison of superiority in the intention-to-treat population (all patients who received at least one dose of study drug). This study is now complete and is registered with ClinicalTrials.gov , NCT03729362 . Findings Between Dec 3, 2018, and Nov 26, 2019, 130 patients were screened for eligibility and 125 were enrolled and randomly assigned to receive cipaglucosidase alfa plus miglustat (n=85) or alglucosidase alfa plus placebo (n=40). Two patients in the alglucosidase alfa plus placebo group did not receive any dose due to absence of genotype confirmation of late-onset Pompe disease and were excluded from analysis. Six patients discontinued (one in the alglucosidase alfa plus placebo group, five in the cipaglucosidase alfa plus miglustat group), and 117 completed the study. At week 52, mean change from baseline in 6-min walk distance was 20·8 m (SE 4·6) in the cipaglucosidase alfa plus miglustat group versus 7·2 m (6·6) in the alglucosidase alfa plus placebo group using last observation carried forward (between-group difference 13·6 m [95% CI −2·8 to 29·9]). 118 (96%) of 123 patients experienced at least one treatment-emergent adverse event during the study; the incidence was similar between the cipaglucosidase alfa plus miglustat group (n=81 [95%]) and the alglucosidase alfa plus placebo group (n=37 [97%]). The most frequently reported treatment-emergent adverse events were fall (25 [29%] patients in the cipaglucosidase alfa plus miglustat group vs 15 [39%] in the alglucosidase alfa plus placebo group), headache (20 [24%] vs 9 [24%]), nasopharyngitis (19 [22%] vs 3 [8%]), myalgia (14 [16%] vs 5 [13%]), and arthralgia (13 [15%]) vs 5 [13%]). 12 serious adverse events occurred in eight patients in the cipaglucosidase alfa plus miglustat group; only one event (anaphylaxis) was deemed related to study drug. One serious adverse event (stroke) occurred in the alglucosidase alfa plus placebo group, which was deemed unrelated to study drug. There were no deaths. Interpretation Cipaglucosidase alfa plus miglustat did not achieve statistical superiority to alglucosidase alfa plus placebo for improving 6-min walk distance in our overall population of patients with late-onset Pompe disease. Further studies should investigate the longer-term safety and efficacy of cipaglucosidase alfa plus miglustat and whether this investigational two-component therapy might provide benefits, particularly in respiratory function and in patients who have been receiving enzyme replacement therapy for more than 2 years, as suggested by our secondary and subgroup analyses. Funding Amicus Therapeutics.

Published
2021
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25. High-rate, high-capacity electrochemical energy storage in hydrogen-bonded fused aromatics

Author

Chen, Tianyang, Banda, Harish, Yang, Luming, Li, Jian, Zhang, Yugang, Parenti, Riccardo, Dincă, Mircea, Chen, Tianyang, Banda, Harish, Yang, Luming, Li, Jian, Zhang, Yugang, Parenti, Riccardo, and Dincă, Mircea

Abstract

Designing materials for electrochemical energy storage with short charging times and high charge capacities is a longstanding challenge. The fundamental difficulty lies in incorporating a high density of redox couples into a stable material that can efficiently conduct both ions and electrons. We report all-organic, fused aromatic materials that store up to 310 mAh g−1 and charge in as little as 33 s. This performance stems from abundant quinone/imine functionalities that decorate an extended aromatic backbone, act as redox-active sites, engage in hydrogen bonding, and enable a delocalized high-rate energy storage with stability upon cycling. The extended conjugation and hydrogen-bonding-assisted bulk charge storage contrast with the surface-confined or hydration-dependent behavior of traditional inorganic electrodes., QC 20230713

Published
2023
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26. Theta synchronization as a neural marker of flexible (re-)use of socio-cognitive mechanisms for a new category of (artificial) interaction partners

Author

Parenti, L, Navare, U, Marchesi, S, Roselli, C, Wykowska, A, Navare, UP, Parenti, L, Navare, U, Marchesi, S, Roselli, C, Wykowska, A, and Navare, UP

Abstract

Previous work shows that in some instances artificial agents, such as robots, can elicit higher-order socio-cognitive mechanisms, similar to those elicited by humans. This suggests that these socio-cognitive mechanisms, such as mentalizing processes, originally developed for interaction with other humans, might be flexibly (re-)used, or "hijacked", for approaching this new category of interaction partners (Wykowska, 2020). In this study, we set out to identify neural markers of such flexible reuse of socio-cognitive mechanisms. We focused on fronto-parietal theta synchronization, as it has been proposed to be a substrate of cognitive flexibility in general (Fries, 2005). We analyzed EEG data from two experiments (Bossi et al., 2020; Roselli et al., submitted), in which participants completed a test measuring their individual likelihood to adopt the intentional stance towards robots, the intentional stance (IST) test. Our results show that participants with higher scores on the IST, indicating that they had higher likelihood of adopting the intentional stance towards a robot, had a significantly higher theta synchronization value, relative to participants with lower scores on the IST. These results suggest that long-range synchronization in the theta band might be a marker sociocognitive process that can be flexibly applied towards non-human agents, such as robots. (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Published
2023

29. ACR Appropriateness Criteria® Workup of Noncerebral Systemic Arterial Embolic Source

Author

Parenti, Vincent G., primary, Vijay, Kanupriya, additional, Maroules, Christopher D., additional, Majdalany, Bill S., additional, Koweek, Lynne M., additional, Khaja, Minhajuddin S., additional, Ghoshhajra, Brian B., additional, Agarwal, Prachi P., additional, Contrella, Benjamin N., additional, Keefe, Nicole A., additional, Lo, Bruce M., additional, Malik, Sachin B., additional, Surasi, Devaki Shilpa, additional, Waite, Kathleen, additional, Williamson, Eric E., additional, Abbara, Suhny, additional, and Dill, Karin E., additional

Published
2023
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30. Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

Author

Pei, Ming, primary, Pei, Yixuan Amy, additional, Zhou, Sheng, additional, Mikaeiliagah, Elmira, additional, Erickson, Christopher, additional, Giertych, Benjamin, additional, Akhter, Halima, additional, Wang, Lei, additional, Stewart, Amanda, additional, Parenti, Joshua, additional, Wang, Bin, additional, Wen, Sijin, additional, Sim, Sotcheadt, additional, Quenneville, Eric, additional, Hansen, Kirk C., additional, Frisch, Steven, additional, and Hu, Gangqing, additional

Published
2023
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33. APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility

Author

Capitini, Claudia, primary, Bigi, Alessandra, additional, Parenti, Niccolò, additional, Emanuele, Marco, additional, Bianchi, Niccolò, additional, Cascella, Roberta, additional, Cecchi, Cristina, additional, Maggi, Laura, additional, Annunziato, Francesco, additional, Pavone, Francesco Saverio, additional, and Calamai, Martino, additional

Published
2023
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40. Potential Biomarkers of Impulsivity in Mild Traumatic Brain Injury: A Pilot Study

Author

Cardoso, Maíra Glória de Freitas, primary, de Barros, João Luís Vieira Monteiro, additional, de Queiroz, Rafael Alves Bonfim, additional, Rocha, Natalia Pessoa, additional, Silver, Carlisa, additional, da Silva, Agnes Stéphanie, additional, da Silva, Ewelin Wasner Machado, additional, Roque, Isadora Gonçalves, additional, Carvalho, Júlia de Lima, additional, dos Santos, Laura Ferreira, additional, Cota, Letícia Bitencourt, additional, Lemos, Lucas Miranda, additional, Miranda, Mariana Figueiredo, additional, Miranda, Millena Figueiredo, additional, Vianna, Pedro Parenti, additional, Oliveira, Rafael Arantes, additional, de Oliveira Furlam, Tiago, additional, Soares, Túlio Safar Sarquis, additional, Pedroso, Vinicius Sousa Pietra, additional, Faleiro, Rodrigo Moreira, additional, Vieira, Érica Leandro Marciano, additional, Teixeira, Antônio Lúcio, additional, de Souza, Leonardo Cruz, additional, and de Miranda, line Silva, additional

Published
2023
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43. Développement et mise en ligne d’un questionnaire du sommeil destiné aux adolescents

Author

Royant-Parola, Sylvie, primary, Hartley, Sarah, additional, Colas des Francs, Claire, additional, Aussert, Frédérique, additional, Tobie, Catherine, additional, Bioulac-Rogier, Stéphanie, additional, Putois, Benjamin, additional, Brion, Agnès, additional, Parenti, Aesa, additional, Mazza, Stéphanie, additional, Plancoulaine, Sabine, additional, Franco, Patricia, additional, and Schröde, Carmen, additional

Published
2023
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45. A search for the K+ → μ−νe+e+ decay

Author

Cortina Gil, E., primary, Kleimenova, A., additional, Minucci, E., additional, Padolski, S., additional, Petrov, P., additional, Shaikhiev, A., additional, Volpe, R., additional, Numao, T., additional, Petrov, Y., additional, Velghe, B., additional, Wong, V.W.S., additional, Bryman, D., additional, Fu, J., additional, Husek, T., additional, Jerhot, J., additional, Kampf, K., additional, Zamkovsky, M., additional, Aliberti, R., additional, Khoriauli, G., additional, Kunze, J., additional, Lomidze, D., additional, Peruzzo, L., additional, Vormstein, M., additional, Wanke, R., additional, Dalpiaz, P., additional, Fiorini, M., additional, Neri, I., additional, Norton, A., additional, Petrucci, F., additional, Wahl, H., additional, Cotta Ramusino, A., additional, Gianoli, A., additional, Iacopini, E., additional, Latino, G., additional, Lenti, M., additional, Parenti, A., additional, Bizzeti, A., additional, Bucci, F., additional, Antonelli, A., additional, Georgiev, G., additional, Kozhuharov, V., additional, Lanfranchi, G., additional, Martellotti, S., additional, Moulson, M., additional, Spadaro, T., additional, Tinti, G., additional, Ambrosino, F., additional, Capussela, T., additional, Corvino, M., additional, Di Filippo, D., additional, Fiorenza, R., additional, Massarotti, P., additional, Mirra, M., additional, Napolitano, M., additional, Saracino, G., additional, Anzivino, G., additional, Brizioli, F., additional, Imbergamo, E., additional, Lollini, R., additional, Piandani, R., additional, Santoni, C., additional, Barbanera, M., additional, Cenci, P., additional, Checcucci, B., additional, Lubrano, P., additional, Lupi, M., additional, Pepe, M., additional, Piccini, M., additional, Costantini, F., additional, Di Lella, L., additional, Doble, N., additional, Giorgi, M., additional, Giudici, S., additional, Lamanna, G., additional, Lari, E., additional, Pedreschi, E., additional, Sozzi, M., additional, Cerri, C., additional, Fantechi, R., additional, Pontisso, L., additional, Spinella, F., additional, Mannelli, I., additional, D'Agostini, G., additional, Raggi, M., additional, Biagioni, A., additional, Cretaro, P., additional, Frezza, O., additional, Leonardi, E., additional, Lonardo, A., additional, Turisini, M., additional, Valente, P., additional, Vicini, P., additional, Ammendola, R., additional, Bonaiuto, V., additional, Fucci, A., additional, Salamon, A., additional, Sargeni, F., additional, Arcidiacono, R., additional, Bloch-Devaux, B., additional, Boretto, M., additional, Menichetti, E., additional, Migliore, E., additional, Soldi, D., additional, Biino, C., additional, Filippi, A., additional, Marchetto, F., additional, Engelfried, J., additional, Estrada-Tristan, N., additional, Bragadireanu, A.M., additional, Ghinescu, S.A., additional, Hutanu, O.E., additional, Baeva, A., additional, Baigarashev, D., additional, Emelyanov, D., additional, Enik, T., additional, Falaleev, V., additional, Kekelidze, V., additional, Korotkova, A., additional, Litov, L., additional, Madigozhin, D., additional, Misheva, M., additional, Molokanova, N., additional, Movchan, S., additional, Polenkevich, I., additional, Potrebenikov, Yu., additional, Shkarovskiy, S., additional, Zinchenko, A., additional, Fedotov, S., additional, Gushchin, E., additional, Khotyantsev, A., additional, Kudenko, Y., additional, Kurochka, V., additional, Medvedeva, M., additional, Mefodev, A., additional, Kholodenko, S., additional, Kurshetsov, V., additional, Obraztsov, V., additional, Ostankov, A., additional, Semenov, V., additional, Sugonyaev, V., additional, Yushchenko, O., additional, Bician, L., additional, Blazek, T., additional, Cerny, V., additional, Kucerova, Z., additional, Bernhard, J., additional, Ceccucci, A., additional, Danielsson, H., additional, De Simone, N., additional, Duval, F., additional, Döbrich, B., additional, Federici, L., additional, Gamberini, E., additional, Gatignon, L., additional, Guida, R., additional, Hahn, F., additional, Holzer, E.B., additional, Jenninger, B., additional, Koval, M., additional, Laycock, P., additional, Lehmann Miotto, G., additional, Lichard, P., additional, Mapelli, A., additional, Marchevski, R., additional, Massri, K., additional, Noy, M., additional, Palladino, V., additional, Perrin-Terrin, M., additional, Pinzino, J., additional, Ryjov, V., additional, Schuchmann, S., additional, Venditti, S., additional, Bache, T., additional, Brunetti, M.B., additional, Duk, V., additional, Fascianelli, V., additional, Fry, J.R., additional, Gonnella, F., additional, Goudzovski, E., additional, Henshaw, J., additional, Iacobuzio, L., additional, Lazzeroni, C., additional, Lurkin, N., additional, Newson, F., additional, Parkinson, C., additional, Romano, A., additional, Sergi, A., additional, Sturgess, A., additional, Swallow, J., additional, Tomczak, A., additional, Heath, H., additional, Page, R., additional, Trilov, S., additional, Angelucci, B., additional, Britton, D., additional, Graham, C., additional, Protopopescu, D., additional, Carmignani, J., additional, Dainton, J.B., additional, Jones, R.W.L., additional, Ruggiero, G., additional, Fulton, L., additional, Hutchcroft, D., additional, Maurice, E., additional, Wrona, B., additional, Conovaloff, A., additional, Cooper, P., additional, Coward, D., additional, and Rubin, P., additional

Published
2023
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46. Status of the plastic scintillator detector for the HERD experiment

Author

Alemanno, F., primary, Altomare, C., additional, Barbato, F.C.T., additional, Bernardini, P., additional, Bissaldi, E., additional, Casilli, E., additional, Cattaneo, P.W., additional, De Mitri, I., additional, de Palma, F., additional, De Vecchi, C., additional, Di Giovanni, A., additional, Di Santo, M., additional, Di Venere, L., additional, Fusco, P., additional, Gargano, F., additional, Guerrisi, C., additional, Kyratzis, D., additional, Licciulli, F., additional, Loparco, F., additional, Marsella, G., additional, Mazziotta, M.N., additional, Pantaleo, F.R., additional, Parenti, A., additional, Pillera, R., additional, Pullia, M., additional, Rappoldi, A., additional, Raselli, G., additional, Rossella, M., additional, Serini, D., additional, Silveri, L., additional, Suma, A., additional, and Surdo, A., additional

Published
2023
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47. A deeper understanding of the qualitative consequences of food pumping: A case study of wine

Author

Alessandro Parenti, Luca Calamai, Piernicola Masella, Francesco Maioli, Agnese Spadi, Lorenzo Guerrini, and Giulia Angeloni

Subjects
Wine, Piston pump, Suction, business.industry, General Chemical Engineering, media_common.quotation_subject, Flexible impeller, Peristaltic pump, Lobe pump, Biochemistry, Racking, law.invention, law, Environmental science, Quality (business), Process engineering, business, Food Science, Biotechnology, media_common
Abstract

The consequences of pumping on food quality are poorly understood, and wine is a good example. Therefore, the present paper examines the use of four pumps and the application of inertization on wine quality. We develop a novel, physical qualitative index (PQI), which is the ratio between pumping specific energy and the net positive suction head, and examine the correlation with wine quality characteristics. Four pumps (a flexible impeller pump, a lobe pump, a peristaltic pump, and a rotary piston pump) that are widely-used in wine cellars were compared over a wide array of chemical-physical variables, during conventional racking, with and without inertization. The analysis found a correlation between the PQI and some quality variables, and this finding was confirmed by a conventional statistical analysis (ANOVA-GLM). Overall, the flexible impeller pump performed slightly differently compared to the other pumps with respect to some color-related parameters. All pumps behave differently as a function of inertization (or not). Inertization was effective in minimizing volatile losses.

Published
2022
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48. High-Rate, High-Capacity Electrochemical Energy Storage in Hydrogen-Bonded Fused Aromatics

Author

Tianyang Chen, Harish Banda, Luming Yang, Jian Li, Yugang Zhang, Riccardo Parenti, and Mircea Dincă

Subjects
General Energy
Abstract

Designing materials for electrochemical energy storage with short charging times and high charge capacities is a longstanding challenge. The fundamental difficulty lies in installing a high density of redox couples into a stable material that can efficiently conduct both ions and electrons. Here, we report all-organic, fused aromatic materials that store up to 310 mAh g–1 and charge in as little as 33 seconds. This performance stems from abundant quinone/imine functionalities that act as redox-active sites, engage in hydrogen bonding for outstanding stability upon cycling, and enable bulk electronic delocalization for high-rate energy storage. The hydrogen bonding-assisted bulk charge storage here contrasts with the surface-confined or hydration-dependent behavior of traditional inorganic electrodes. These materials outperform state-of-the-art faradaic and capacitive electrodes in both capacity and power capability.

Published
2023
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