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Start Over Author "A. M. Sidoti" Publisher elsevier bv
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2. Cytomegalovirus and Epstein-Barr Virus DNA Kinetics in Whole Blood and Plasma of Allogeneic Hematopoietic Stem Cell Transplantation Recipients

Author

Lazzarotto T, Chiereghin A, Piralla A, Piccirilli G, Girello A, Campanini G, Gabrielli L, Costa C, Prete A, Bonifazi F, Busca A, Cairoli R, Colombo AA, Zecca M, Sidoti F, Bianco G, Paba P, Perno CF, Cavallo R, Baldanti F, AMCLI-GLaIT working group., Lazzarotto T, Chiereghin A, Piralla A, Piccirilli G, Girello A, Campanini G, Gabrielli L, Costa C, Prete A, Bonifazi F, Busca A, Cairoli R, Colombo AA, Zecca M, Sidoti F, Bianco G, Paba P, Perno CF, Cavallo R, Baldanti F, AMCLI-GLaIT working group., Tiziana, L, Angela, C, Antonio, P, Giulia, P, Alessia, G, Giulia, C, Liliana, G, Cristina, C, Arcangelo, P, Francesca, B, Alessandro, B, Cairoli, R, Anna Amelia, C, Marco, Z, Francesca, S, Gabriele, B, Pierpaolo, P, Carlo Federico, P, Rossana, C, and Fausto, B

Subjects
Adult, Male, 0301 basic medicine, Herpesvirus 4, Human, medicine.medical_specialty, medicine.medical_treatment, 030106 microbiology, Congenital cytomegalovirus infection, Allogeneic hematopoietic stem cell transplantation, CMV and EBV DNA kinetics, Plasma, Whole blood, Hematology, Transplantation, Cytomegalovirus, Hematopoietic stem cell transplantation, Virus Replication, Virus, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Humans, Aged, Retrospective Studies, CMV and EBV DNA kinetic, business.industry, Hematopoietic Stem Cell Transplantation, virus diseases, Middle Aged, Allografts, medicine.disease, Virology, Transplant Recipients, Kinetics, Blood, 030104 developmental biology, chemistry, Viral replication, DNA, Viral, Female, business, DNA
Abstract

Currently, no consensus has been reached on the optimal blood compartment to be used for surveillance of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNAemia. Although several comparative studies have been performed correlating CMV and EBV DNA loads in whole blood (WB) versus plasma, to our knowledge, no studies to date have analyzed the kinetics of both viruses in the 2 blood compartments. In this retrospective noninterventional multicenter cohort study, the kinetics of CMV and EBV DNA in 121 hematopoietic stem cell transplantation (HSCT) recipients were investigated by analyzing in parallel 569 and 351 paired samples from 80 and 58 sequential episodes of CMV and EBV DNAemia, respectively. Unlike previous studies, this study used a single automated molecular method that was CE-marked and Food and Drug Administration-approved for use in quantifying CMV and EBV DNA in both plasma and WB. Furthermore, the complete viral replication kinetics of all episodes (including both the ascending and the descending phases of the active infection) was examined in each patient. The previously observed overall correlation between CMV DNA levels in WB and plasma was confirmed (Spearman's ρ =.85; P

Published
2018
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