617 results on '"A. Charron"'
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2. Synchronization modulo P in dynamic networks
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Louis Penet de Monterno, Bernadette Charron-Bost, and Stephan Merz
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General Computer Science ,Theoretical Computer Science - Published
- 2023
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3. Active Retrieval Improves Procedural Learning in Orthopedic Surgery
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Silvio Ndoja, Charles-Antoine Dion, Ali Ahmadi Pirshahid, Brynn Petras Charron, Alexandra Durocher, Alexander McCarton, and Marie-Eve LeBel
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Writing ,Mental Recall ,Humans ,Learning ,Orthopedic Procedures ,Surgery ,Curriculum ,Education - Abstract
Tests are shown to enhance learning: this is known as the "testing effect". The benefit of testing is theorized to be through "active retrieval", which is the effortful process of recalling stored knowledge. This differs from "passive studying", such as reading, which is a low effort process relying on recognition. The testing effect is commonly studied in random word list scenarios and is thought to disappear as complexity of material increases. Little is known about the testing effect in complex situations such as procedural learning. Therefore, we investigated if testing improves procedural learning of fracture fixation as compared to "passive studying".Fifty participants watched an instructional video of an open reduction internal fixation of a Sawbones™ femur. Participants then performed the procedure under guided supervision (pretest). After randomization, they either read the steps (passive studying group), or wrote down the steps from memory (active retrieval group) for a period of 15 minutes. After a washout period, all participants performed the procedure without guidance (posttest) and then once more, 1 week after the initial testing (retention test). The participants were assessed using the Objective Structured Assessment of Technical Skill. Each performance was video recorded for data analysis purposes.Participants in the passive studying group had significantly higher Objective Structured Assessment of Technical Skill scores during immediate assessment compared to the active retrieval group (p = 0.001), especially with respect to remembering the correct order of the steps (p = 0.002). The percentage of information forgotten was significantly less in the active retrieval group (p = 0.02) at the retention test.We demonstrated that, compared to passive studying, testing with active retrieval through writing resulted in better retention of fracture fixation knowledge (i.e., less forgetting). These findings can easily be applied and incorporated in existing curricula. Future studies are needed to determine the effects of different kinds of active retrieval methods such as verbal retrieval (e.g., dictating) in surgical practice.
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- 2022
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4. Croyances périnatales : mécanismes neurocognitifs et spécificités culturelles
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Hugo Bottemanne, Morgane Charron, and Lucie Joly
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Reproductive Medicine ,Obstetrics and Gynecology - Published
- 2022
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5. Functional Epicardial Conduction Disturbances Due to a SCN5A Variant Associated With Brugada Syndrome
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Estelle Renard, Richard D. Walton, David Benoist, Fabien Brette, Gilles Bru-Mercier, Sébastien Chaigne, Sabine Charron, Marion Constantin, Matthieu Douard, Virginie Dubes, Bastien Guillot, Thomas Hof, Julie Magat, Marine E. Martinez, Cindy Michel, Néstor Pallares-Lupon, Philippe Pasdois, Alice Récalde, Fanny Vaillant, Frédéric Sacher, Louis Labrousse, Julien Rogier, Florence Kyndt, Manon Baudic, Jean-Jacques Schott, Julien Barc, Vincent Probst, Marine Sarlandie, Céline Marionneau, Jesse L. Ashton, Mélèze Hocini, Michel Haïssaguerre, and Olivier Bernus
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- 2023
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6. Impact of COVID‐19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID‐19 patients with acute ischemic stroke
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Jean‐Philippe Desilles, Mialitiana Solo Nomenjanahary, Arturo Consoli, Véronique Ollivier, Dorothée Faille, Marie‐Charlotte Bourrienne, Mylène Hamdani, Sébastien Dupont, Lucas Di Meglio, Simon Escalard, Benjamin Maier, Raphael Blanc, Michel Piotin, Bertrand Lapergue, Nadine Ajzenberg, Marc Vasse, Mikael Mazighi, Benoît Ho‐Tin‐Noé, Jean‐Philippe Désilles, Hocine Redjem, Stanislas Smajda, Pierre Seners, Francois Delvoye, Solene Hebert, Malek Ben Maacha, Mylene Hamdani, Candice Sabben, Michael Obadia, Catherine Deschildre, Georges Rodesch, Federico Maria, Okuzan Coskun, Delphine Lopez, Romain Bourcier, Lili Detraz, Hubert Desal, Monica Roy, Delphine Clavier, Gaultier Marnat, Florent Gariel, Ludovic Lucas, Igor Sibon, Francois Eugene, Stéphane Vannier, Jean‐Christophe Ferre, Anthony LeBras, Hélène Raoult, Christophe Paya, Jean‐Yves Gauvrit, Sébastien Richard, Benjamin Gory, Charlotte Barbier, Denis Vivien, Emmanuel Touze, Maxime Gauberti, Gaetane Blaizot, Héloïse Ifergan, Denis Herbreteau, Richard Bibi, Kevin Janot, Vladimir Charron, and Grégoire Boulouis
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Cohort Studies ,Stroke ,SARS-CoV-2 ,Fibrinolysis ,Tissue Plasminogen Activator ,Humans ,Thrombolytic Therapy ,Thrombosis ,Hematology ,Brain Ischemia ,Ischemic Stroke ,COVID-19 Drug Treatment - Abstract
Resistance to fibrinolysis, levels of procoagulant/antifibrinolytic neutrophil extracellular traps (NETs), and the severity of acute ischemic stroke (AIS) are increased by COVID-19. Whether NETs are components of AIS thrombi from COVID-19 patients and whether COVID-19 impacts the susceptibility of these thrombi to thrombolytic treatments remain unknown, however.We aimed to characterize AIS thrombi from COVID-19 patients by immunohistology and to compare their response to thrombolysis to that of AIS thrombi from non-COVID-19 patients.For this monocentric cohort study, 14 thrombi from COVID-19 AIS patients and 16 thrombi from non-COVID-19 patients, all recovered by endovascular therapy, were analyzed by immunohistology or subjected to ex vivo thrombolysis by tissue-type plasminogen (tPA)/plasminogen.COVID-19 AIS thrombi were rich in neutrophils and contained NETs, but not spike protein. Thrombolysis assays revealed a mean resistance profile to tPA/plasminogen of COVID-19 AIS thrombi similar to that of non-COVID-19 AIS thrombi. The addition of DNase 1 successfully improved thrombolysis by potentiating fibrinolysis irrespective of COVID-19 status. Levels of neutrophil, NETs, and platelet markers in lysis supernatants were comparable between AIS thrombi from non-COVID-19 and COVID-19 patients.These results show that COVID-19 does not impact NETs content or worsen fibrinolysis resistance of AIS thrombi, a therapeutic hurdle that could be overcome by DNase 1 even in the context of SARS-CoV-2 infection.
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- 2022
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7. Study of a new device for washing and concentrating cryopreserved hematopoietic stem cells and mononuclear cells: a single center experience
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Mathieu Mercier, Catherine Chesnel Santurette, Steven Binninger, Sabrina Bouyer, Mickaël Charron, Christine Giraud, Alexis Lavergne, and Pascal Houzé
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Cancer Research ,Cell Survival ,Immunology ,CD34 ,Antigens, CD34 ,Peripheral blood mononuclear cell ,Cryopreservation ,Donor lymphocyte infusion ,Andrology ,chemistry.chemical_compound ,Cryoprotective Agents ,Extracorporeal Photopheresis ,Humans ,Immunology and Allergy ,Dimethyl Sulfoxide ,Centrifugation ,Genetics (clinical) ,Transplantation ,Dimethyl sulfoxide ,Hematopoietic Stem Cell Transplantation ,Cell Biology ,Hematopoietic Stem Cells ,Oncology ,chemistry ,Stem cell - Abstract
Background aims Cryopreserved cellular products, as parts of hematopoietic progenitor cell (HPC) transplants, mononuclear cell reinjections for donor lymphocyte infusion or extracorporeal photopheresis, can be washed before being reinjected into the patient or infused directly, depending on local practices. The aim of washing is to reduce the incidence and severity of adverse reactions (ARs) due to the dimethyl sulfoxide (DMSO) used as a cryoprotective agent and other factors, such as dead cell debris. At the authors’ cell therapy laboratory (CTL) in Poitiers, France, as in 76% of Etablissement Francais du Sang (EFS) CTLs, all cryopreserved products undergo thawing in a water bath followed by washing with the COBE 2991. As this device will soon cease to be available, an alternative process needs to be assessed. Methods The authors compared two closed systems: the authors’ semi-automatic system using the traditional centrifugation method (COBE 2991) and an automated device using spinning membrane filtration (Lovo). A total of 72 HPC bags available for research were used. The authors first performed a paired comparison, processing one or two HPC bags washed by each device. A second study was carried out to compare two different washing solutions generally used by EFS CTLs along with variable storage conditions. Finally, the authors studied the efficiency of the Lovo with three or four thawed bags. The main parameters studied were viable CD34+ cell recovery and viability, CD3+ cell recovery, stability up to 6 h after washing, DMSO elimination and center feasibility. Results The Lovo device showed better CD34+ cell recovery compared with the COBE 2991 while maintaining CD34+ viability and stability over 6 h. Moreover, Lovo efficiency seemed to be independent of the number of thawed bags processed and washing solution used in the authors’ study. CD3+ cell recovery met the authors’ internal specifications (cell recovery >50%), with similar results seen when processing with either the COBE 2991 or Lovo. Additionally, on average, 97% of DMSO was removed after washing with Lovo, minimizing the risk of ARs. The storage conditions post-processing indicated preferred storage conditions of 7 ± 3°C. Finally, if processing time seemed shorter using COBE 2991 for one bag washed, the Lovo device required only one staff member regardless of the number of HPC bags processed. Conclusions The Lovo device seems to provide an opportunity to standardize HPC processing, ensuring patient safety, with, on average, 97% of DMSO removed, while improving recovery of cells of interest and maintaining viability over time in case of delayed transplant. The Lovo device consequently seems to be a serious alternative to the COBE 2991.
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- 2022
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8. CE-452775-4 LONG-TERM ARRHYTHMIC FOLLOW-UP AND PERFORMANCE OF MODERN RISK STRATIFICATION TOOLS IN LARGE COHORT OF PATIENTS WITH DESMOPLAKIN ARRHYTHMOGENIC CARDIOMYOPATHY
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Alessio Gasperetti, Richard Carrick, Alexander Protonotarios, Mikael Laredo, Iris van der Schaaf, Petros Syrris, Brittney Murray, Crystal Tichnell, Chiara Cappelletto, Marta Gigli, Kristen Medo, Peter Crabtree, Ardan Saguner, Firat Duru, Robyn Hylind, Dominic J. Abrams, Neal Lakdawala, Charles Massie, Julia Cadrin-Tourigny, Mattia Targetti, Iacopo Olivotto, Maddalena Graziosi, Moniek Cox, Elena Biagini, Philippe Charron, Michela Casella, Claudio Tondo, Momina Yazdani, James S. Ware, Sanjay Prasad, Leonardo Caló, Eric D. Smith, Adam Helms, Sophie Hespe, Jodie Ingles, Harikrishna Tandri, Flavie Ader, Luisa Mestroni, Arthur A. Wilde, Marco Merlo, Estelle Gandjbakhch, Hugh Calkins, Anneline te Riele, Peter van Tintelen, Perry Elliott, and Cynthia A. James
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
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9. Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis
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Johannie Beaucage-Charron, Justine Rinfret, Richard Coveney, and David Williamson
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Psychiatry and Mental health ,Clinical Psychology - Published
- 2023
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10. A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS
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Brenda Toscano Márquez, Tsz Chui Sophia Leung, Jeanette Hui, François Charron, R. Anne McKinney, and Alanna J. Watt
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Neurology - Published
- 2023
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11. Functional MRI of a conductor in action
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Charles Mellerio, Anne Isabelle de Parcevaux, Sylvain Charron, Pierre Etevenon, and Catherine Oppenheim
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) - Published
- 2023
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12. Opioid prescriptions during pregnancy by race and ethnicity in utah’s urban and rural counties, 2014-2017
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Marcela Smid, Elizabeth Charron, Michelle P. Debbink, Amanda A. Allshouse, Kristine Campbell, Adam G. Gordon, and Gerald Cochran
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Obstetrics and Gynecology - Published
- 2023
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13. Cluster analysis to identify patient profiles and substance use patterns among pregnant persons with opioid use disorder
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Elizabeth Charron, Ziji Yu, Brad Lundahl, John Silipigni, Akiko Okifuji, Adam J. Gordon, Jacob D. Baylis, Ashley White, Kristi Carlston, Walitta Abdullah, Benjamin Haaland, Elizabeth E. Krans, Marcela C. Smid, and Gerald Cochran
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Psychiatry and Mental health ,Clinical Psychology ,Medicine (miscellaneous) ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) - Published
- 2023
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14. Analyse comparative de deux outils de mesure de la force de préhension
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P. Fayemendy, T. Vernier, C. De Rouvray, M. Migolatiev, K. Prémaud, F. Mérigaud, L. Charron, P. Jésus, and B. Misset
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Published
- 2023
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15. Machine learned coarse-grained protein force-fields: Are we there yet?
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Aleksander E.P. Durumeric, Nicholas E. Charron, Clark Templeton, Félix Musil, Klara Bonneau, Aldo S. Pasos-Trejo, Yaoyi Chen, Atharva Kelkar, Frank Noé, and Cecilia Clementi
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Structural Biology ,Molecular Biology - Published
- 2023
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16. Barriers to and facilitators of hormonal and long-acting reversible contraception access and use in the US among reproductive-aged women who use opioids: A scoping review
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Elizabeth Charron, Jacqueline Kent-Marvick, Tyler Gibson, Eliza Taylor, Kelsey Bouwman, Gelina M. Sani, Sara E. Simonsen, Rebecca H. Stone, Jennifer E. Kaiser, and Mary M. McFarland
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Epidemiology ,Public Health, Environmental and Occupational Health - Published
- 2023
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17. Female representation and electoral clientelism: New insights from South African municipal electionss
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Amy Alexander, Nicholas Charron, and Mogens K. Justesen
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Female representation ,South Africa ,Local government ,Political Science and International Relations ,Elections ,Clientelism ,Vote buying - Abstract
Do citizens experience less electoral clientelism in polities with more elected female representatives? The current literature is remarkably silent on the role of gender and female political representation for electoral clientelism. Due to gender differences in issue priorities, targeted constituent groups, networks and resources, we argue that voters experience less clientelism in municipalities with a higher proportion of female politicians because either female politicians are likely to engage less in clientelism or women are less likely to be viable candidates in more clientelist settings. Through either mechanism, we expect all voters – and female voters in particular – to experience less exposure to clientelism in municipalities with higher female representation. We examine this idea using survey data from the 2016 municipal elections in South Africa – a country with high levels of female representation in politics but increasing problems of corruption and patronage in the political system. Our findings are consistent with the argument that municipalities with more elected female councilors have considerably lower rates of electoral clientelism and that this mostly affects whether female voters are targeted by clientelist distribution. These findings shed new light on how women's representation in elected political office shapes the incidence and use of clientelist distribution during elections.
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- 2023
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18. Impact de la Covid-19 sur les situations de burn-out parental
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Astrid Lebert-Charron
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Government ,2019-20 coronavirus outbreak ,education.field_of_study ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,media_common.quotation_subject ,Population ,Burnout ,Pediatrics ,Developmental psychology ,Feeling ,education ,Psychology ,media_common - Abstract
The various measures taken by the government to counter the spreading of Covid-19 have confronted parents with major challenges in managing and caring for their children. They are therefore considered a population at risk of developing burn-out. While current studies show that the health crisis has not contributed to the explosion in the number of people experiencing parental burn-out in France, many parents report feelings of exhaustion.
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- 2021
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19. Adolescent Latinas’ with Diabetes and Their Mothers’ Understanding of Diabetes and Reproductive Health: Converging Themes to Inform a Culturally Sensitive Preconception Counseling Program
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Robynn Zender, Ellen Olshansky, Frances M. Peterson-Burch, Dara H. Sorkin, Keirsten Montgomery, Hiba Abujaradeh, and Denise Charron-Prochownik
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Counseling ,Adolescent ,media_common.quotation_subject ,Population ,Mothers ,Stigma (botany) ,Fertility ,Human sexuality ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,030225 pediatrics ,Diabetes Mellitus ,medicine ,Humans ,030212 general & internal medicine ,education ,media_common ,Reproductive health ,education.field_of_study ,business.industry ,Hispanic or Latino ,medicine.disease ,Reproductive Health ,Family planning ,Family Planning Services ,Pediatrics, Perinatology and Child Health ,Female ,Psychology ,business ,Dyad - Abstract
Introduction Latinas are at an increased risk for diabetes and reproductive health (RH) complications with sexuality and pregnancy. This study explored the understanding of diabetes related to RH, pregnancy, unplanned pregnancies, preconceptioncounseling, tight-control, and family planning among Latina adolescents with diabetes and their mothers and explored converging themes. Method The qualitative descriptive study used written open-ended questions (English or Spanish) with Latina mothers (n = 13) and daughters (n = 21). Responses were transcribed. Content analysis was used by four researchers who coded and discussed themes and reached consensus. Converging themes were confirmed using Atlas.ti software. Results Seven themes emerged from the mother–daughter dyad: communication (awkwardness, ambivalence, styles); control (being controlled vs. controlling); consequences (fertility, complications); planning (pregnancy, being healthy, life plan, RH); support; danger, risk, and safety; and stigma. Discussion Many mother–daughter dyads were not ready to discuss RH among themselves. Cultural and familial perspectives should be considered when providing care and preconception counseling to this population.
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- 2021
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20. Fecal Bacteria as Biomarkers for Predicting Food Intake in Healthy Adults
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Janet A. Novotny, Leila Shinn, Colleen Bushell, Hannah D. Holscher, David J. Baer, Yutong Li, Aditya Mansharamani, Ruoqing Zhu, Michael Welge, Craig S. Charron, Naiman A. Khan, and Loretta Auvil
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Adult ,dietary intake biomarker ,Food intake ,multiclass ,Medicine (miscellaneous) ,Urine ,Microbial biomarkers ,Biology ,Whole grains ,AcademicSubjects/MED00060 ,Eating ,Feces ,Young Adult ,Humans ,Microbiome ,Food science ,Methodology and Mathematical Modeling ,Aged ,gastrointestinal microbiota ,Nutrition and Dietetics ,Gastrointestinal microbiota ,food and beverages ,Middle Aged ,Diet ,Gastrointestinal Microbiome ,Fecal coliform ,Editor's Choice ,fidelity measures ,machine learning ,AcademicSubjects/SCI00960 ,Biomarkers - Abstract
Background Diet affects the human gastrointestinal microbiota. Blood and urine samples have been used to determine nutritional biomarkers. However, there is a dearth of knowledge on the utility of fecal biomarkers, including microbes, as biomarkers of food intake. Objectives This study aimed to identify a compact set of fecal microbial biomarkers of food intake with high predictive accuracy. Methods Data were aggregated from 5 controlled feeding studies in metabolically healthy adults (n = 285; 21–75 y; BMI 19–59 kg/m2; 340 data observations) that studied the impact of specific foods (almonds, avocados, broccoli, walnuts, and whole-grain barley and whole-grain oats) on the human gastrointestinal microbiota. Fecal DNA was sequenced using 16S ribosomal RNA gene sequencing. Marginal screening was performed on all species-level taxa to examine the differences between the 6 foods and their respective controls. The top 20 species were selected and pooled together to predict study food consumption using a random forest model and out-of-bag estimation. The number of taxa was further decreased based on variable importance scores to determine the most compact, yet accurate feature set. Results Using the change in relative abundance of the 22 taxa remaining after feature selection, the overall model classification accuracy of all 6 foods was 70%. Collapsing barley and oats into 1 grains category increased the model accuracy to 77% with 23 unique taxa. Overall model accuracy was 85% using 15 unique taxa when classifying almonds (76% accurate), avocados (88% accurate), walnuts (72% accurate), and whole grains (96% accurate). Additional statistical validation was conducted to confirm that the model was predictive of specific food intake and not the studies themselves. Conclusions Food consumption by healthy adults can be predicted using fecal bacteria as biomarkers. The fecal microbiota may provide useful fidelity measures to ascertain nutrition study compliance.
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- 2021
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21. Influence of information sources on vaccine hesitancy and practices
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Christine Jestin, Arnaud Gautier, and Jalal Charron
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Parents ,Health Knowledge, Attitudes, Practice ,Vaccines ,0303 health sciences ,medicine.medical_specialty ,Health professionals ,030306 microbiology ,business.industry ,Health Personnel ,Vaccination ,Patient Acceptance of Health Care ,Logistic regression ,03 medical and health sciences ,Infectious Diseases ,Family medicine ,medicine ,Humans ,The Internet ,Child ,Psychology ,business ,Quality information - Abstract
Many factors influence vaccination practices and attitudes. This study aimed to identify vaccine information sources used by parents of children aged 1-15 years to get a better understanding of the relation between vaccine information sources, practices for two vaccines (MMR, HBV), vaccine acceptance, and vaccine hesitancy.A total of 3938 parents, drawn by random sampling, were interviewed by telephone as part of the "2016 health barometer" survey. Vaccine information sources were described and analyzed according to socio-demographic variables. Multivariate logistic regression models were then built to explain vaccine information sources usage, vaccination practices and attitudes.Healthcare professionals (HCP), the Internet, and relatives were the three main vaccine information sources. Vaccination practices and acceptance were better when parents were getting information from HCPs compared with parents getting information from the Internet or relatives. Besides, getting information from the three different types of sources was associated with the highest rate of vaccine hesitancy: 70.9% (OR=4.6; P0.0001) versus 34.6% among parents getting information from HCPs only.Those results suggest an interest in providing quality information about vaccination on the Internet. The primary role of HCPs in vaccination decision is once again demonstrated.
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- 2020
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22. The myth of price convergence under economic integration: A proposed explanation for the difference in food prices across European countries
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Jaime Romero, Jean-Philippe Charron, and Ignacio Cruz-Roche
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Market integration ,Economic integration ,Strategy and Management ,05 social sciences ,Food prices ,Convergence (economics) ,Monetary economics ,Market concentration ,Globalization ,0502 economics and business ,Price dispersion ,Economics ,050211 marketing ,Productivity ,050203 business & management - Abstract
Conventional globalization theory states that regional economic integration will precede price standardization across participating countries due to the increased buying power of large retail groups and parallel imports. The resulting price corridor should merely reflect differences in logistic costs and short-term, local competitive actions. Yet, this study uses panel data from 25 European countries to examine how hefty food and beverage price differentials between regions remained constant over the last decade. Income, store productivity, and market concentration all contribute to the explanation for regional price differences. These findings suggest that, contrary to straight-line globalization theory, large European retailers’ decisions can influence price convergence and maintain important price dispersion between economically integrated countries. We provide recommendations to enhance market integration.
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- 2020
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23. Sex-Related Exacerbation of Injury-Induced Mechanical Hypersensitivity in GAD67 Haplodeficient Mice
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Aude Charron, Lucie Pepino, Pascale Malapert, Vincent Debrauwer, Francis Castets, Chiara Salio, and Aziz Moqrich
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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24. Epidemiological Characterisation of Omicron Variant Cases in the APHP Critical Care Units
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Antoine Vieillard-Baron, Remi Flicoteaux, Maud Salmona, djillali annane, Soufia Ayed, Elie Azoulay, Raphael Bellaiche, Sadek Beloucif, Enora Berti, Astrid Bertier, Sebastien Besset, Marlène Bret, Alain Cariou, Christophe Carpentier, Oussama Chaouch, Cyril Charron, Julien Charpentier, Cherifa Cheurfa, Bernard Cholley, Sebastien Clerc, Alain Combes, Benjamin Chousterman, Yves Cohen, Jean Michel Constantin, Charles Damoisel, Michael Darmon, Vincent Degos, Bertrand De Maupeou D'Ableiges, Sophie Demeret, Etienne De Montmollin, Alexandre Demoule, François depret, Jean-Luc Diehl, Michel Djibré, Do Chung-Hi, Emmanuel Dudoignon, Jacques Duranteau, Muriel Fartoukh, Fabienne Fieux, Etienne Gayat, Mael Gennequin, Bertrand Guidet, Christophe Gutton, Sophie HAMADA, Nicholas Heming, Romain Jouffroy, Hawa Keita-Meyer, Olivier Langeron, Brice Lortat-Jacob, Jonathan Marey, Alexandre Mebazaa, Bruno Megarbane, Armand Mekontso Dessap, Jean-Paul Mira, Julie Molle, Philippe Montravers, Capucine Morelot-Panzini, Safaa Nemlaghi, Bao-long Nguyen, Antoine Parrot, Romain Pasqualotto, Nicolas Peron, Lucile Picard, marc Pineton de Chambrun, Benjamin Planquette, Benoit Plaud, Pons Stephanie, Christophe Quesnel, Jean-Herle Raphalen, Keyvan Razazi, Jean-Damien Ricard, Anne Roche, Benjamin Rohaut, Damien Roux, Laurent Savale, Jennifer Sobotka, Jean-Louis Teboul, Jean-Francois Timsit, Guillaume Voiriot, Emmanuel Weiss, Lucille Wildenberg, Elie Zogheib, Bruno Riou, and Frederic Batteux
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- 2022
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25. The effect of pulp production times on the characteristics and properties of hemp-based paper
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Lydia Axelrod, Patrick Charron, Irfan Tahir, Steven Kostell, and Rachael Floreani
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Mechanics of Materials ,Materials Chemistry ,General Materials Science - Published
- 2023
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26. Experimental investigation of the forces dictating polymer translocation through solid-state nanopores
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Martin Charron, Breeana Elliott, and Vincent Tabard-Cossa
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Biophysics - Published
- 2023
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27. Toward protein fingerprinting with a solid-state nanopore
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Breeana Elliott, Martin Charron, Dmytro Lomovtsev, Emily Majaesic, Walid A. Houry, and Vincent Tabard-Cossa
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Biophysics - Published
- 2023
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28. ALPK3 gene in cardiomyopathies: Which phenotypes? Which mode of inheritance?
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F. Ader, M. Bensalah, G. Millat, A. Janin, C. Cazeneuve, N. Roux-Buisson, P. Charron, and P. Richard
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Cardiology and Cardiovascular Medicine - Published
- 2023
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29. Incidence and survival of transthyretin amyloid cardiomyopathy from a French nationwide study of in- and out-patient databases
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T. Damy, G. Bourel, M. Slama, V. Algalarrondo, O. Lairez, P. Fournier, J. Costa, F. Pelcot, A. Farrugia, I. Durand Zaleski, H. Lilliu, M. Bartoli, S. Fievez, J. Rudant, A. Coste, C. Noirot Cosson, P.A. Squara, M. Narbeburu, B. De Neuville, and P. Charron
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Cardiology and Cardiovascular Medicine - Published
- 2023
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30. Interpol Review Paper of Marks and Impression Evidence 2019-2022
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Jonathan Charron, Catherine Currier, Philip Hess, Patrick Jacobs, and Jeremy Zerbe
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Law ,Pathology and Forensic Medicine - Published
- 2023
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31. Trends in outpatient opioid prescriptions during pregnancy by clinician specialty in utah, 2014-2017
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Marcela Smid, Elizabeth Charron, Amanda A. Allshouse, Kristine Campbell, Michelle P. Debbink, Adam G. Gordon, and Gerald Cochran
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Obstetrics and Gynecology - Published
- 2023
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32. NEXN-mediated cardiomyopathies: Prevalence, phenotypic expression, and prognosis
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A. Hermida, F. Ader, G. Millat, P. Chevalier, G. Clerici, X. Le Guillou, A. Milhem, P.A. Catalan, P. Maury, P. Charron, and E. Gandjbakhch
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Cardiology and Cardiovascular Medicine - Published
- 2023
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33. Regional estimation of river water temperature at ungauged locations
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Taha B.M.J. Ouarda, Christian Charron, and André St-Hilaire
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Water Science and Technology - Published
- 2022
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34. VP.70 OPALE: a patient registry for laminopathies and emerinopathies in France
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R. Ben Yaou, F. Anselme, A. De Sande-Giovannoli, E. Campanna-Salort, P. Charron, C. Chikhaoui, I. Jeru, F. Labombarda, F. Leturcq, S. Quijano-Roy, C. Stalens, P. Richard, C. Vigouroux, G. Bonne, and K. Wahbi
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Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Genetics (clinical) - Published
- 2022
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35. Integrating hereditary breast and ovarian cancer genetic counselling and testing into mainstream clinical practice: Legal and ethical challenges
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Marilou Charron, Beatrice Kaiser, Aurélie Dauge, Hortense Gallois, Julie Lapointe, Michel Dorval, Hermann Nabi, and Yann Joly
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Adult ,Ovarian Neoplasms ,Oncology ,Humans ,Female ,Genetic Counseling ,Genetic Testing ,Hematology ,Carcinoma, Ovarian Epithelial ,Confidentiality - Abstract
Health professionals not specialized in genetics are expected to take an increasing role in genetic services delivery. This article aims to identify legal and ethical challenges related to a collaborative oncogenetics service model, where non-genetic health professionals provide genetic services to patients. Through a scoping literature review, we identified issues to the provision of hereditary breast and ovarian cancer, or other hereditary adult cancers, genetic testing under this model. Concerns that arose in the literature were informed consent, lack of adherence to best practice guidelines, lack of education of non-genetic health professionals on the provision of genetic services, psychological impacts of genetic testing, continuity of care, the complexity of genetic test results, confidentiality, risks of medical mismanagement, and the associated medical responsibility liabilities. Despite these challenges, there is a growing consensus towards the feasibility of cancer genetic testing being undertaken by non-genetic healthcare professionals in a collaborative oncogenetics service model.
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- 2022
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36. Correction to 'Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study'
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Naïm Ouldali, Haleh Bagheri, Francesco Salvo, Denise Antona, Antoine Pariente, Claire Leblanc, Martine Tebacher, Joëlle Micallef, Corinne Levy, Robert Cohen, Etienne Javouhey, Brigitte Bader-Meunier, Caroline Ovaert, Sylvain Renolleau, Veronique Hentgen, Isabelle Kone-Paut, Nina Deschamps, Loïc De Pontual, Xavier Iriart, Christelle Gras-Le Guen, Francois Angoulvant, Alexandre Belot, Aurelie Donzeau, Layal El Aridi, Sophie Lety, Bertrand Leboucher, Agnes Baur, Lucas Jeusset, Maelle Selegny, Cristian Fedorczuk, Marion Lajus, Philippe Bensaid, Yacine Laoudi, Charlotte Pons, Anne-Cécile Robert, Camille Beaucourt, Muriel Richard, Etienne Goisque, Olivier Brissaud, Pierre Segretin, Julie Molimard, Marie-Clothilde Orecel, Gregoire Benoit, Lucille Bongiovanni, Margaux Guerder, Robin Pouyau, Jean-Marie De Guillebon De Resnes, Ellia Mezgueldi, Fleur Cour-Andlauer, Come Horvat, Pierre Poinsot, Cecile Frachette, Antoine Ouziel, Yves Gillet, Catherine Barrey, Jacques Brouard, Florence Villedieu, Vathanaksambath Ro, Narcisse Elanga, Vincent Gajdos, Romain Basmaci, Hadile Mutar, Sébastien Rouget, Elodie Nattes, Isabelle Hau, Sandra Biscardi, Houmam El Jurdi, Camille Jung, Denis Semama, Frederic Huet, Anne-Marie Zoccarato, Mayssa Sarakbi, Guillaume Mortamet, Cécile Bost-Bru, Joachim Bassil, Caroline Vinit, Véronique Hentgen, Pascal Leroux, Valérie Bertrand, Caroline Parrod, Irina Craiu, Philippe Durand, Pierre Tissiere, Caroline Claude, Guillaume Morelle, Tamazoust Guiddir, Charlotte Borocco, Frédérique Delion, Camille Guillot, Stéphane Leteurtre, François Dubos, Mylene Jouancastay, Alain Martinot, Valentine Voeusler, Jeanne Languepin, Nathalie Garrec, Arnaud Chalvon Demersay, Aurélie Morand, Emmanuelle Bosdure, Noémie Vanel, Fabrice Ughetto, Fabrice Michel, Marie Caujolle, Renaud Blonde, Jacqueline Nguyen, Olivier Vignaud, Caroline Masserot-Lureau, François Gouraud, Carine Araujo, Tara Ingrao, Sanaa Naji, Mohammed Sehaba, Christine Roche, Aurelia Carbasse, Christophe Milesi, Mustapha Mazeghrane, Sandrine Haupt, Cyril Schweitzer, Benedicte Romefort, Elise Launay, Christèle Gras-Le Guen, Ahmed Ali, Nathalie Blot, Antoine Tran, Anne Rancurel, Mickael Afanetti, Sophie Odorico, Deborah Talmud, Anais Chosidow, Anne-Sophie Romain, Emmanuel Grimprel, Marie Pouletty, Jean Gaschignard, Olivier Corseri, Albert Faye, Isabelle Melki, Camille Ducrocq, Cherine Benzoïd, Johanna Lokmer, Stéphane Dauger, Maryline Chomton, Anna Deho, Fleur Lebourgeois, Fabrice Lesage, Florence Moulin, Laurent Dupic, Yael Pinhas, Agathe Debray, Martin Chalumeau, Véronique Abadie, Pierre Frange, Jeremie F Cohen, Slimane Allali, William Curtis, Zahra Belhadjer, Johanne Auriau, Mathilde Méot, Lucile Houyel, Damien Bonnet, Christophe Delacourt, Brigitte Bader Meunier, Pierre Quartier, Youssef Shaim, Laurence Baril, Samuel Crommelynck, Baptiste Jacquot, Philippe Blanc, Natacha Maledon, Blandine Robert, Camille Loeile, Clémence Cazau, Gauthier Loron, Simona Gaga, Cécile Vittot, Loubna El Nabhani, François Buisson, Muriel Prudent, Hugues Flodrops, Fadhila Mokraoui, Simon Escoda, Laurent Bonnemains, Sarah-Louisa Mahi, Clara Mertes, Joelle Terzic, Julie Helms, Charlotte Idier, Soraya Chenichene, Nicoleta Magdolena Ursulescu, Gladys Beaujour, Abdelhak Hakim, Alice Miquel, Agnès Rey, Arnaud Wiedermann, Anne Charbonneau, Agnès Veauvy-Juven, Alexandrine Ferry, Alexis Mandelcwajg, Alix Rousseau, Amandine Prenant, Anne-Laure Bourneuf, Anne Filleron, Audrey Robine, Arthur Félix, Aude Parizel, Aurélie Labarre, Aymeric Cantais, Barbara Ros, Basile Coulon, Blandine Biot, Bérengère Dalichoux, Benjamin Fournier, Benoit Cagnard, Blandine Vanel, David Brossier, Bruno Ménager, Bruno Ozanne, Carole Marie-Jeanne, Camille Bergerot, Camille Chavy, Camille Guidon, Candice Fabre, Caroline Galeotti, Catherine Baker, Claire Ballot-Schmit, Céline Belleau, Céline Charasse, Caroline Favel, Chadia Toumi, Charlène Ferrandiz, Charlotte Couturier, Charlotte Pouchoux, Maryline Chomton-Cailliez, Charlotte Kevorkian-Verguet, Clément Brunet, Céline Manteau, Clémence Mougey, Coline Santy, Coralie Fitament, Charlotte Petriat, Charlotte Rebelle, Cyril Charron, Maxime Dartus, David Toulorge, Cécile Guillou-Debuisson, Dorann Bartebin, Valérie Klein, E Broustal, E. Desselas, Elodie Marteau, Emmanuelle Bouvrot, Elise Delacroix, Edeline Coinde, Loubna Elnabhani, Elsa Amouyal, Emilie Chaillou, Emeline Gabilly-Bernard, Emilie Ruiz, Emilie Thibault, Emilie Robin, Etienne Darrieux, Eva Blondel, Floriane Socchi, François Cazassus, Fanny Bajolle, Fatma Lacin, Fouad Madhi, Franck Zekre, François Guerin, Gerald Boussicault, Henri Ginies, Gnansounou Magloire, Guilhem Arnold, Ines Coulognon, Iona Sicard-Cras, Jean-Emmanuel Kahn, Jeanne Bordet, Jeanne-Lise Fausser, Jean-François Baleine, Josephine Brice, Julie Gendras, Kaan Pekin, Karine Norbert, Clément Karsenty, Léa Savary, Laurence Martinat, Léa Lesniewski, Lorelei Charbonnier, Louise Alexandre, Lucas Percheron, Marie Vincenti, Manon Lanzini, Margot Grisval, Marianne Mercy, Marie-Emilie Lampin, Marie Desgranges, Marie Duperril, Marie-Clothilde Orcel, Marion Audier, Marion Favier, Mathieu Carpentier, Mathilde Balcean, Mathilde Bonnet, Maurine Jouret, Marie Delattre, Michael Levy, Michael Valensi, Mickael Shum, Morgane Dumortier, Morgane Gelin, Morgane Nemmouchi, Morgane Williaume, M. Sebaha, Nicoleta Genetay-Stanescu, Nathan Giroux, Nicolas Crassard, Neil Derridj, Noemie Lachaume, Oscar Werner, Olivier Guilluy, Olivier Richer, Olivier Tirel, Aurianne Pauvert, Paul Casha, Noémie Perez, Pauline Gras, Pierre-Louis Leger, Marion Pinchou, Pierre Mornand, Prisca Largo, Ramona-Christina Ibanez, Charlotte Roulland, Salam Hadah Albarazi, Said Bichali, Sarah Faton, Amandine Schott, Sébastien Walser, Severine Guillaume, Solene Vincent, Sophie Galene-Gromez, Stanislas Kozisek, Thierry Maugard, Thierry Blanc, Thierry Navarro, Thomas Lauvray, Tamas Kovacs, Valérie Launay, Véronique Despert, Victoria Lhostis, Virginie Gall, Xavier Micaelli, Yasmine Benadjaoud, Zied Matoussi, Hélène Géniaux, Anthony Facile, Tessa Pietri, Pascale Palassin, Sylvine Pinel, Laurent Chouchana, Delphine Callot, and Charlène Boulay
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Oncology ,Health Policy ,Internal Medicine - Published
- 2022
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37. Performance and interaction quality variations of a collaborative Cable-Driven Parallel Robot
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Marceau Métillon, Camilo Charron, Kévin Subrin, Stéphane Caro, Robots and Machines for Manufacturing, Society and Services (LS2N - équipe RoMas), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Nantes Université (Nantes Univ), Perception, Action, Cognition pour la Conception et l’Ergonomie (LS2N - équipe PACCE), Université de Rennes 2 (UR2), Institut Universitaire de Technologie - Nantes (Nantes Univ - IUT Nantes), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), ANR-18-CE10-0004,CRAFT,Robots Parallèles à Câbles pour des Opérations Industrielles Agiles(2018), and ANR-21-ESRE-0015,TIRREX,Infrastructure technologique pour la recherche d'excellence en robotique(2021)
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Performance variations ,Control and Systems Engineering ,Mechanical Engineering ,Cable Driven Parallel Robots ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,Electrical and Electronic Engineering ,Physical Human-Robot interactions ,Transparency ,[SPI.MECA.GEME]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph] ,[SPI.AUTO]Engineering Sciences [physics]/Automatic ,Computer Science Applications - Abstract
International audience; In the field of large scale robotic, which is often remotely operated, having direct interaction can be disruptive for applications such as moving heavy loads or 3D printing. A Cable-Driven Parallel Robot (CDPR) is used here in physical Human–Robot Interactions (pHRI) with an admittance-based control strategy to physically interact with a user in tele-operation or in co-manipulation mode. A user experiment involving participants is designed to assess the performance of the human–robot team in a given task completion. Task performance and interaction quality metrics are defined and recorded during experiments with different robot configurations. The novelty is to provide a methodology to compare the configurations based on the performance metrics. The methodology accounts for variations of the metrics along time of use and assert a training effect leading to a progression or a regression of the performances. The experiment apparatus includes a CDPR, a user task composed of targets to reach with the robot and a handle equipped with a force sensor acting as a control input of a fixed admittance control strategy of the robot. Collected data show that the task performances and the interaction quality vary during the experiments and denote different variation profiles among the user population. Distribution of these profiles among configurations are analysed to determine the configuration that has the best training effect on users.
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- 2022
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38. Ethnic differences in CD1E, but not CD1A, gene polymorphisms between Sub-Saharan Africans, West Asians and Europeans
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Ryad Tamouza, Samia Zertal-Zidani, Rajendranath Ramasawmy, Landry Erik Mombo, Dominique Charron, Physiopathologie et pharmacogénomique du traitement de la drépanocytose (PHATMAH (U_458 / U_763)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Réponses immunes : régulation et développement, and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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0301 basic medicine ,Sub saharan ,[SDV]Life Sciences [q-bio] ,Immunology ,Ethnic group ,Black People ,Biology ,White People ,Antigens, CD1 ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Gene Frequency ,Polymorphism (computer science) ,parasitic diseases ,Genotype ,Asia, Western ,Humans ,Immunology and Allergy ,Allele ,Gene ,Allele frequency ,Africa South of the Sahara ,Alleles ,Genetics ,Polymorphism, Genetic ,integumentary system ,General Medicine ,Europe ,Genetics, Population ,030104 developmental biology ,030215 immunology - Abstract
The five closely linked CD1A-E genes encode the human CD1 family of proteins. Few studies of the allele frequencies of these genes in African populations have been published so far. This study aimed to genotype CD1A and CD1E variants and to compare their frequencies in Sub-Saharan Africans from Gabon and Ivory Coast, and Non-Africans from Syria and France. A restriction analysis of DNA fragments generated by PCR was performed to detect CD1A and CD1E alleles in 105 subjects from Gabon, 169 subjects from Ivory Coast, 107 subjects from Syria and 181 subjects from France. The frequencies of the CD1E*02 allele were high among Sub-Saharan Africans (87%) and low in West Asians (44%) and Europeans (36%), whereas the contrary was obtained for the CD1E*01 allele (7%, 55% and 64% respectively). Frequencies of CD1A alleles were similar between all groups, the CD1A*02 allele was most prevalent (91%). The high frequency of the CD1E*02 allele in Sub-Saharan Africans suggest that future work should investigate the relationship between CD1 polymorphism and infectious diseases.
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- 2019
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39. Broccoli consumption affects the human gastrointestinal microbiota
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Hannah D. Holscher, Sharon A. Ross, Kelly S. Swanson, Xiaoji Liu, Harold E. Seifried, Jennifer L Kaczmarek, Elizabeth H. Jeffery, Michael J. Miller, Craig S. Charron, and Janet A. Novotny
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Adult ,Male ,0301 basic medicine ,Firmicutes ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Brassica ,Biochemistry ,Article ,Body Mass Index ,Feces ,03 medical and health sciences ,chemistry.chemical_compound ,Humans ,Microbiome ,Food science ,Molecular Biology ,Aged ,030109 nutrition & dietetics ,Nutrition and Dietetics ,biology ,Bacteroidetes ,Cruciferous vegetables ,food and beverages ,Middle Aged ,biology.organism_classification ,Crossover study ,Gastrointestinal Microbiome ,030104 developmental biology ,chemistry ,Glucosinolate ,Female ,Bacteroides ,Body mass index - Abstract
The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and phytonutrients, including glucosinolates, which can be metabolized by gastrointestinal microbes. This study aimed to determine the impact of broccoli consumption on the gastrointestinal microbiota of healthy adults. A controlled feeding, randomized, crossover study consisting of two 18-day treatment periods separated by a 24-day washout was conducted in healthy adults (n=18). Participants were fed at weight maintenance with the intervention period diet including 200 g of cooked broccoli and 20 g of raw daikon radish per day. Fecal samples were collected at baseline and at the end of each treatment period for microbial analysis. Beta diversity analysis indicated that bacterial communities were impacted by treatment (P=0.03). Broccoli consumption decreased the relative abundance of Firmicutes by 9% compared to controls (P=0.05), increased the relative abundance of Bacteroidetes by 10% compared to controls (P=0.03), and increased Bacteroides by 8% relative to controls (P=0.02). Furthermore, the effects were strongest among participants with BMI < 26 kg/m(2), and within this group there were associations between bacterial relative abundance and glucosinolate metabolites. Functional prediction revealed that broccoli consumption increased the pathways involved in the functions of the endocrine system (P=0.05), transport and catabolism (P=0.04), and energy metabolism (P=0.01). These results reveal that broccoli consumption affects the composition and function of the human gastrointestinal microbiota.
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- 2019
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40. Regional thermal analysis approach: A management tool for predicting water temperature metrics relevant for thermal fish habitat
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Olfa Abidi, André St-Hilaire, Taha B.M.J. Ouarda, Christian Charron, Claudine Boyer, and Anik Daigle
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Computational Theory and Mathematics ,Ecology ,Applied Mathematics ,Ecological Modeling ,Modeling and Simulation ,Ecology, Evolution, Behavior and Systematics ,Computer Science Applications - Published
- 2022
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41. Comprehensive evaluation of self-healing of concrete with different admixtures under laboratory and long-term outdoor expositions
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K.-S. Lauch, J.-P. Charron, and C. Desmettre
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Mechanics of Materials ,Architecture ,Building and Construction ,Safety, Risk, Reliability and Quality ,Civil and Structural Engineering - Published
- 2022
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42. MICRA : Microstructural image compilation with repeated acquisitions
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Erika P. Raven, Mark Drakesmith, C. John Evans, Kristin Koller, David R. Owen, Maxime Chamberland, Chantal M. W. Tax, Derek K. Jones, Fabrizio Fasano, Cyril Charron, Umesh S. Rudrapatna, Garin Hughes, and Greg D. Parker
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Adult ,Male ,Relaxometry ,Computer science ,Cognitive Neuroscience ,Article ,050105 experimental psychology ,lcsh:RC321-571 ,White matter ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Brain White Matter ,Image Processing, Computer-Assisted ,medicine ,Humans ,0501 psychology and cognitive sciences ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,business.industry ,05 social sciences ,Brain ,Pattern recognition ,Magnetic Resonance Imaging ,White Matter ,Healthy Volunteers ,medicine.anatomical_structure ,Neurology ,Female ,Artificial intelligence ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
We provide a rich multi-contrast microstructural MRI dataset acquired on an ultra-strong gradient 3T Connectom MRI scanner comprising 5 repeated sets of MRI microstructural contrasts in 6 healthy human participants. The availability of data sets that support comprehensive simultaneous assessment of test-retest reliability of multiple microstructural contrasts (i.e., those derived from advanced diffusion, multi-component relaxometry and quantitative magnetisation transfer MRI) in the same population is extremely limited. This unique dataset is offered to the imaging community as a test-bed resource for conducting specialised analyses that may assist and inform their current and future research. The Microstructural Image Compilation with Repeated Acquisitions (MICRA) dataset includes raw data and computed microstructure maps derived from multi-shell and multi-direction encoded diffusion, multi-component relaxometry and quantitative magnetisation transfer acquisition protocols. Our data demonstrate high reproducibility of several microstructural MRI measures across scan sessions as shown by intra-class correlation coefficients and coefficients of variation. To illustrate a potential use of the MICRA dataset, we computed sample sizes required to provide sufficient statistical power a priori across different white matter pathways and microstructure measures for different statistical comparisons. We also demonstrate whole brain white matter voxel-wise repeatability in several microstructural maps. The MICRA dataset will be of benefit to researchers wishing to conduct similar reliability tests, power estimations or to evaluate the robustness of their own analysis pipelines.
- Published
- 2021
43. Early echocardiography by treating physicians and outcome in the critically ill: An ancillary study from the prospective multicenter trial FROG-ICU
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Koji Takagi, Eiichi Akiyama, Alexis Paternot, Òscar Miró, Cyril Charron, Etienne Gayat, Nicolas Deye, Alain Cariou, Xavier Monnet, Samir Jaber, Bertrand Guidet, Charles Damoisel, Romain Barthélémy, Elie Azoulay, Antoine Kimmoun, Marie-Céline Fournier, Bernard Cholley, Christopher Edwards, Beth A. Davison, Gad Cotter, Antoine Vieillard-Baron, and Alexandre Mebazaa
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Intensive Care Units ,Heart Diseases ,Echocardiography ,Critical Illness ,Physicians ,Humans ,Stroke Volume ,Prospective Studies ,Critical Care and Intensive Care Medicine ,Ventricular Function, Left - Abstract
This study aimed to investigate the association between the use of early echocardiography performed by the treating physician certified in critical care ultrasound and mortality in ICU patients.FROG-ICU was a multi-center cohort designed to investigate the outcome of critically ill patients. Of the 1359 patients admitted to centers where echocardiography was available, 372 patients underwent echocardiography during the initial 3 days.Of the ICU patients admitted for cardiac disease, 47.4% underwent echocardiography, and those patients had the lowest left ventricular ejection fraction 40 [31-58] % and the lowest cardiac output 4.2 [3.2-5.7] L/min compared to patients admitted for other causes (p0.001 for both). One-year mortality was 36.8% and 39.9% in patients with and without echocardiography, respectively [HR 0.92 (95% CI 0.75-1.11)]. This result was confirmed after multivariable Cox regression analysis [HR 0.88 (95% CI 0.71-1.08)]. Subgroup analyses suggest that among patients admitted to ICU for cardiac disease, those managed with echocardiography had a lower risk of one-year mortality [HR 0.65 (95% CI 0.43-0.98)].Early echocardiography by treating physicians was not associated with short- or long-term survival in ICU patients. In subgroups, early echocardiography improved survival in ICU patients admitted for cardiac disease.clinicaltrials.gov Identifier: NCT01367093.
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- 2022
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44. AAV-driven human BAG3 overexpression unexpectedly exacerbate heart failure in a LMNAH222P DCM mice model
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Océane Piedallu, Perrine Devos, Nathalie Mougenot, Laetitia Duboscq-Bidot, Tiphaine Héry, Nicolas Vignier, Philippe Charron, Gisèle Bonne, and Eric Villard
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Cardiology and Cardiovascular Medicine - Published
- 2022
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45. Effect of percutaneous pulmonary valve replacement on ventricular electrophysiological remodeling in a porcine model of repaired tetralogy of Fallot
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Virginie Dubes, Sabine Charron, Estibaliz Valdeolmillos, Mélody Schena, Amandine Martin, Dounia El Hamrani, Jérôme Naulin, Cindy Michel, Marion Constantin, François Roubertie, Bruno Quesson, Olivier Bernus, Jean-Benoit Thambo, Zakaria Jalal, and David Benoist
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Cardiology and Cardiovascular Medicine - Published
- 2022
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46. Corrigendum to: A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling✰
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Gavin M. Meade, Lily S. Charron, Lantz W. Kilburn, Zhe Pei, Hoau-Yan Wang, and Siobhan Robinson
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Behavioral Neuroscience ,Experimental and Cognitive Psychology - Published
- 2022
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47. EP1068: GENETIC SUSCEPTIBILITY TO IBD IMPACTS ON EPITHELIAL BARRIER INTEGRITY
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Isabelle Hébert-Milette, Chloé Lévesque, Marie-Ève Rivard, Jean Paquette, Philippe Goyette, Guy Charron, and John D. Rioux
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Hepatology ,Gastroenterology - Published
- 2022
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48. Risky alcohol use among patients dispensed opioid medications: A clinical community pharmacy study
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Gerald Cochran, Elizabeth Charron, Jennifer L. Brown, Alina Cernasev, Kenneth C. Hohmeier, and T. John Winhusen
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Adult ,Analgesics, Opioid ,Male ,Pharmacies ,Pharmacology ,Psychiatry and Mental health ,Cross-Sectional Studies ,Odds Ratio ,Humans ,Pharmacology (medical) ,Drug Overdose ,Toxicology ,Article - Abstract
BACKGROUND. Included among the significant risk factors for opioid overdose is concomitant use of other central nervous system depressants, particularly alcohol. Given the continued expansion of community pharmacy in the continuum of care, it is imperative to characterize alcohol use among pharmacy patients dispensed opioids in order to establish a foundation for identification and intervention in these settings. METHODS. This secondary analysis utilized data from a one-time, cross-sectional health assessment conducted among patients dispensed opioid medications in 19 community pharmacies in Indiana and Ohio. Adult, English speaking, patients not receiving cancer care who were dispensed opioid medications were asked to self-report alcohol and substance use, behavioral and physical health, and demographic information. Descriptive and logistic regression analyses were employed to characterize alcohol use/risky alcohol use and patient characteristics associated therewith. RESULTS. The analytical sample included 1,494 individuals. Participants were on average 49 years of age (Standard Deviation=14.9)—with 6% being persons of color (n=89). Weekly drinking was reported by 18.1% (n=204) and daily drinking was reported by 6.8% (n=77) of the study sample, with a total of 143 (9.6%) participants reporting moderate/high risk drinking. Males (Adjusted Odds Ratio [AOR]=1.94, 95% CI=1.3,2.9), those with higher pain interference (AOR=1.44, 95% CI=1.0,2.0), overdose history (AOR=1.93, 95% CI=1.1,3.5), sedative use (AOR=2.11, 95% CI=1.3,3.5), and tobacco use (AOR=2.41, 95% CI=1.6,3.7) had increased likelihood of moderate/high risk alcohol use (all p
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- 2022
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49. IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation
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Virginie Mercier, Gabrielle Boucher, Dominic Devost, Kyla Bourque, Azadeh Alikashani, Claudine Beauchamp, Alain Bitton, Sylvain Foisy, Philippe Goyette, Guy Charron, Terence E. Hébert, and John D. Rioux
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Inflammation ,HEK293 Cells ,Inflammasomes ,Interleukin-1beta ,NLR Family, Pyrin Domain-Containing 3 Protein ,Humans ,Cell Biology ,Inflammatory Bowel Diseases ,Article ,Receptors, G-Protein-Coupled - Abstract
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBD) result in chronic inflammation of the gastrointestinal tract. Genetic studies have shown that the GPR65 gene, as well as its missense coding variant, GPR65*Ile231Leu, is associated with IBD. We aimed to define the signalling and biological pathways downstream of GPR65 activation and evaluate the impact of GPR65*231Leu on these. METHODS: We used HEK 293 cells stably expressing GPR65 and deficient for either Gα(s), Gα(q/11) or Gα(12/13), to define GPR65 signalling pathways, IBD patient biopsies and a panel of human tissues, primary immune cells and cell lines to determine biologic context, and genetic modulation of human THP-1-derived macrophages to examine the impact of GPR65 in bacterial phagocytosis and NLRP3 inflammasome activation. RESULTS: We confirmed that GPR65 signals via the Gα(s) pathway, leading to cAMP accumulation. GPR65 can also signal via the Gα(12/13) pathway leading to formation of stress fibers, actin remodelling and RhoA activation; all impaired by the IBD-associated GPR65*231Leu allele. Gene expression profiling revealed greater expression of GPR65 in biopsies from inflamed compared to non-inflamed tissues from IBD patients or control individuals, potentially explained by infiltration of inflammatory immune cells. Decreased GPR65 expression in THP-1-derived macrophages leads to impaired bacterial phagocytosis, increased NLRP3 inflammasome activation and IL-1β secretion in response to an inflammatory stimulus. CONCLUSIONS: We demonstrate that GPR65 exerts its effects through Gα(s)- and Gα(12/13)-mediated pathways, that the IBD-associated GPR65*231Leu allele has compromised interactions with Gα(12/13) and that KD of GPR65 leads to impaired bacterial phagocytosis and increased inflammatory signaling via the NLRP3 inflammasome. This work identifies a target for development of small molecule therapies.
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- 2022
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50. SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics
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Bruce D. Uhal, Xavier Soehnlen, Jacob Bauss, Jared Painter, Joseph A. Carcillo, Olivia Sirpilla, Caleb Bupp, Taylor W Cook, Jacob G Charron, Cynthia L. Stenger, Xiaopeng Li, Surender Rajasekaran, Ruchir Gupta, William Faber, Hunter Steward, David A. Hinds, Neil E. Lamb, Adam Underwood, Austin Frisch, Michele I. Morris, Jeremy W. Prokop, and Eric Lind
- Subjects
0301 basic medicine ,030102 biochemistry & molecular biology ,biology ,viruses ,RNA virus ,Computational biology ,Cell Biology ,Protein structure prediction ,biology.organism_classification ,Genome ,Biochemistry ,Human genetics ,03 medical and health sciences ,030104 developmental biology ,Protein structure ,Molecular evolution ,Viral entry ,Proteome ,Molecular Biology - Abstract
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged the speed at which laboratories can discover the viral composition and study health outcomes. The small ∼30-kb ssRNA genome of coronaviruses makes them adept at cross-species spread while enabling a robust understanding of all of the proteins the viral genome encodes. We have employed protein modeling, molecular dynamics simulations, evolutionary mapping, and 3D printing to gain a full proteome- and dynamicome-level understanding of SARS-CoV-2. We established the Viral Integrated Structural Evolution Dynamic Database (VIStEDD at RRID:SCR_018793) to facilitate future discoveries and educational use. Here, we highlight the use of VIStEDD for nsp6, nucleocapsid (N), and spike (S) surface glycoprotein. For both nsp6 and N, we found highly conserved surface amino acids that likely drive protein-protein interactions. In characterizing viral S protein, we developed a quantitative dynamics cross-correlation matrix to gain insights into its interactions with the angiotensin I-converting enzyme 2 (ACE2)-solute carrier family 6 member 19 (SLC6A19) dimer. Using this quantitative matrix, we elucidated 47 potential functional missense variants from genomic databases within ACE2/SLC6A19/transmembrane serine protease 2 (TMPRSS2), warranting genomic enrichment analyses in SARS-CoV-2 patients. These variants had ultralow frequency but existed in males hemizygous for ACE2. Two ACE2 noncoding variants (rs4646118 and rs143185769) present in ∼9% of individuals of African descent may regulate ACE2 expression and may be associated with increased susceptibility of African Americans to SARS-CoV-2. We propose that this SARS-CoV-2 database may aid research into the ongoing pandemic.
- Published
- 2020
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