1. Native Valve Aspergillus Endocarditis Complicating Lung Transplantation
- Author
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Gilles D. Dreyfus, Martin Carby, Margaret Burke, Nicholas R. Banner, Anne V. Hall, and Toby M. Maher
- Subjects
Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Antifungal Agents ,Heart disease ,medicine.medical_treatment ,Aspergillus fumigatus ,Fatal Outcome ,medicine ,Humans ,Endocarditis ,Lung transplantation ,Ultrasonography ,Transplantation ,Aspergillus ,Lung ,biology ,business.industry ,Aspergillosis, Allergic Bronchopulmonary ,biology.organism_classification ,medicine.disease ,Heart Valves ,Surgery ,medicine.anatomical_structure ,Female ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Lung Transplantation - Abstract
We present 2 cases of Aspergillus endocarditis occurring in lung transplant recipients, both of whom were treated with early surgical intervention and triazole anti-fungal agents. Neither had evidence of airway colonization/infection with Aspergillus post-transplant, suggesting hematogenous spread of fungi at the time of surgery as a possible mechanism of infection. One case was successfully treated and discharged from the hospital, but, despite initial recovery, death occurred 10 months later due to a recurrence of Aspergillus endocarditis. Aspergillus endocarditis should be considered a relapsing disease and survivors of the condition should receive ongoing anti-fungal therapy.
- Published
- 2008
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