1. Serological response in health care workers after a single dose of SARS-CoV-2 vaccine using six automated SARS-CoV-2 antibody assays.
- Author
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Cuykx M, Mortelé O, Jansens H, Schouwers S, Meskal A, Hoffbauer I, and Peeters B
- Subjects
- Antibodies, Viral immunology, COVID-19 diagnosis, COVID-19 prevention & control, COVID-19 Serological Testing, Coronavirus Nucleocapsid Proteins immunology, Health Personnel, Humans, Phosphoproteins immunology, SARS-CoV-2 isolation & purification, Spike Glycoprotein, Coronavirus immunology, Vaccination, Antibodies, Viral blood, COVID-19 immunology, COVID-19 Vaccines immunology, SARS-CoV-2 immunology
- Abstract
Spike (S)- and nucleocapsid (N)-specific serological assay responses were determined before and/or after first dose SARS-CoV-2 vaccination in 22 individuals. S-specific assays quantified antibodies after vaccination with significant higher levels in participants with a previous infection. Be cautious combining N-/S-specific assay results, potentially differentiating post-infection/vaccination immunization as assay-specific N-antibody waning was observed., Competing Interests: Declaration of competing interest Matthias Cuykx: Declarations of interest: none.Olivier Mortelé: Declarations of interest: none. Hilde Jansens: Declarations of interest: none. Sofie Schouwers: Declarations of interest: none. Anissa Meskal: Declarations of interest: none. Ilse Hoffbauer: Declarations of interest: none. Bart Peeters: Roche, Siemens and DiaSorin provided the S-specific assay kits for this study. Roche, Siemens or DiaSorin played no role in the design of study, choice of enrolled patients, review and interpretation of data, preparation of manuscript, or final approval of manuscript., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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