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"Food Is Medicine" (FIM) represents a spectrum of food-based interventions integrated into health care for patients with specific health conditions and often social needs. Programs include medically tailored meals, groceries, and produce prescriptions, with varying levels of nutrition and culinary education. Supportive advances include expanded care pathways and payment models, e-screening for food and nutrition security, and curricular and accreditation requirements for medical nutrition education. Evidence supports positive effects of FIM on food insecurity, diet quality, glucose control, hypertension, body weight, disease self-management, self-perceived physical and mental health, and cost-effectiveness or cost savings. However, most studies to date are quasiexperimental or pre/post interventions; larger randomized trials are ongoing. New national and local programs and policies are rapidly accelerating FIM within health care. Remaining research gaps require rigorous, iterative evaluation. Successful incorporation of FIM into health care will require multiparty partnerships to assess, optimize, and scale these promising treatments to advance health and health equity., Competing Interests: Funding Support and Author Disclosures This work was supported by the National Heart, Lung, and Blood Institute, National Institutes of Health (2R01 HL115189). The funder had no role in study conception or design, data analysis or interpretation, manuscript drafting or editing, or the decision to submit the manuscript for publication. Dr Mozaffarian has received research funding from the National Institutes of Health, the Gates Foundation, the Rockefeller Foundation, and the Kaiser Permanente East Bay Community Foundation; has received personal fees from Acasti Pharma and Barilla; has served on the scientific advisory board of Beren Therapeutics, Brightseed, Calibrate, Elysium Health, Filtricine, HumanCo, Instacart Health, January, Perfect Day, Season Health, and Validation Institute; has stock ownership in Calibrate and HumanCo; and receives chapter royalties from UpToDate. Dr Aspry has received research funding from Amgen, Ionis, Novartis, Regeneron, and the American College of Cardiology; and has received speaker honoraria or travel funding from the American College of Cardiology, National Lipid Association, and MedScape. Ms Garfield has received research funding from the Rockefeller Foundation, the Kaiser Permanente East Bay Community Foundation, the M·A·C VIVA GLAM Fund, the Point32Health Foundation, and the Bristol Myers Squibb Foundation; and has received organizational funding from the Food is Medicine Coalition. Dr Seligman has received funding from the Centers for Disease Control and Prevention, the United States Department of Agriculture, the National Institutes of Health, and Feeding America; and her voucher program receives funding from numerous additional sources, including government programs, private donors, and foundations. Dr Yang has received research grants from Amgen and Microsoft Research; has received consultant fees or honoraria from the American College of Cardiology and Genentech; and has ownership interest, partnership, or principal in Clocktree, Measure Labs, and TenPoint7. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)