Search

Your search keyword '"thalidomide analogues"' showing total 2 results
Start Over Descriptor "thalidomide analogues" Publisher elsevier b.v.
2 results on '"thalidomide analogues"'

1. Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide

Author

Machado, Alexandre Légora, Lima, Lı́dia Moreira, Araújo-Jr, João Xavier, Fraga, Carlos Alberto M., Gonçalves Koatz, Vera Lúcia, and Barreiro, Eliezer J.

Subjects
*ANTI-inflammatory agents, *ANTIPYRETICS, *INFLAMMATION, *ACETANILIDE
Abstract

Abstract: As part of an ongoing effort to develop new thalidomide analogues as antiinflammatory lead-candidates, this paper describes the synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized derivatives (4a–d, 5a,b, 6a,b). The target compounds were assayed in an acute lung inflammatory model and all compounds were able to inhibit TNF-α production and subsequent neutrophil recruitment in the LPS-acute lung inflammatory model. [Copyright &y& Elsevier]

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results