Search

In order to improve the bioavailability of paclitaxel, hemicellulose fractions from hot water pretreatment liquor were the first time to design new amphiphilic polymers through the Maillard reaction. Structural characteristics, emulsifying and drug release behaviors of the amphiphilic polymers were then investigated in detail. Results showed that the amphiphilic polymers with degrees of substitution ranging from 0.31 to 1.65 were obtained by reacting hemicellulose fractions with dodecylamine. Furthermore, the nanometer paclitaxel emusion was successfully preparaed. The amphiphilic polymer provided excellent emulsifying properties and desired storage stability. The average particle sizes of emulsion stayed in the range of 235–266 nm, even after 90 days of storage. Besides, the amphiphilic polymer also proved considerable paclitaxel preservation ability and released performance of pH-responsive. The controlled release of paclitaxel was better at pH 5.0, and thus the new amphiphilic polymer can be used as a delivery carrier of hydrophobic drugs. • A new insight to combine hot water pretreatment with Maillard reaction • New amphiphilic polymers were first designed through hydrophobic modification. • Excellent emulsifying properties and desired storage stability • Considerable drug preservation ability and release performance of pH-responsive • The delivery carrier was expected to improve bioavailability of hydrophobic drugs. [ABSTRACT FROM AUTHOR]

Highlights • Nano SiO 2 modified with TMES was covered a layer of hydrophobic methyl groups on the surface. • Super hydrophobic surface was prepared by building micro/nano structure with nano SiO 2. • Effects of nano SiO 2 content on the nanocomposite films properties were studied. • Thermal properties of the nanocomposite films were enhanced by incorporating nano SiO 2. Abstract Nanocomposite films with super hydrophobic surface were prepared by building rough micro/nano structure on the surface of siloxane-modified two-component waterborne polyurethane (2K-WPU) with hydrophobic nano SiO 2. Firstly, nano SiO 2 prepared by StÖber method with tetraethoxysilane (TEOS) as precursor was modified with trimethylethoxysilane (TMES), in order to cover a layer of hydrophobic methyl groups on the surface of nano SiO 2. Then, a series of nanocomposite films with different water contact angles were obtained by adding different contents of TMES modified SiO 2 into the siloxane-modified 2K-WPU. The effects of the content of nano SiO 2 on the morphology and hydrophobicity of film surface were investigated. The results showed that the surface structures of the nanocomposite films became rougher and the water contact angle of nanocomposite films was increased obviously with the increase of the content of hydrophobic nano SiO 2. Super hydrophobic nanocomposite film with water contact angle over 150° was successfully fabricated by using polysiloxane as low surface energy material and hydrophobic nano SiO 2 as micro/nano rough structure builder on the polymer surface. Moreover, incorporating nano SiO 2 into the 2K-WPU matrix could increase the glass transition temperature and thermal stability of the nanocomposite films. [ABSTRACT FROM AUTHOR]