1. New agents in post-remission therapy.
- Author
-
Stone, Richard M.
- Subjects
ACUTE myeloid leukemia treatment ,CELLULAR signal transduction ,IMMUNOTHERAPY ,DRUG dosage ,STEM cell transplantation ,DRUG therapy ,AGE factors in disease - Abstract
The choice of post-remission therapy for patients with acute myeloid leukemia (AML) depends on age, response to initial therapy, and on disease-related biology. High-dose ara-C (HIDAC) is the standard chemotherapy-based post-remission treatment for younger AML patients, but diagnostic cytogenetics and genetic features may mandate an allogeneic stem cell transplant. While intensive chemotherapy has little utility, the optimal post-remission therapy for older adults remains unclear, though reduced-intensity conditioning allogeneic stem cell transplant is being used with increasing frequency. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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