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Abstract: Chemical investigation of the soft coral Lobophytum durum resulted in the isolation of seven new cembranolides, durumolides F–L (1–7), as well as one previously characterized cembranolides, sinularolide D (8). The molecular structures of these isolated metabolites were determined mainly through NMR techniques and HRESIMS analysis. Moreover, the absolute configurations of 1 and 5 were established by application of modified Mosher’s method. The antibacterial activities, anti-inflammatory effects, and anti-HCMV (Human cytomegalovirus) endonuclease activity of metabolites 1–8 were also evaluated in vitro. Anti-inflammatory activity of metabolites 1 and 6 (10μM) significantly reduced the levels of the iNOS protein to 0.8±0.6% and 5.7±2.2%, respectively, and COX-2 protein to 47.8±9.0% and 71.6±5.8%, respectively. Metabolites 1–8 (100μg/disk) exhibited weak antibacterial activity against Salmonella enteritidis. [Copyright &y& Elsevier]

Abstract: A preliminary study dealing with the feasibility of ring closing metathesis and ene-yne ring closing metathesis to construct the central bicyclic cores of uprolides D and E was investigated. [Copyright &y& Elsevier]