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Adenoid cystic carcinoma (AdCC) is a salivary gland-type of cancer that may also occur in the breast. Breast AdCC shows the same morphological spectrum as is observed in salivary glands, with recognition of individual subtypes that may differ in their clinical behaviour. AdCC classic variant (C-AdCC) is a slowly growing tumour, with a low rate of axillary node and distant metastases. Local recurrences may develop as a consequence of incomplete surgical excision. C-AdCC should be differentiated from the solid-basaloid variant of AdCC (SB-AdCC) that is characterized by nuclear atypia, frequent mitotic figures and necrosis, in addition to the solid architecture. SB-AdCC is a more aggressive tumour, with higher rates of axillary node and distant metastases. AdCC may also co-exist with more aggressive types of carcinoma including metaplastic and neuroendocrine carcinoma, referred to as AdCC with high grade transformation (HG-AdCC). This paper reviews the key diagnostic criteria of the different subtypes of breast AdCC with emphasis on differential diagnosis and prognostic parameters. [ABSTRACT FROM AUTHOR]

Adenomyoepithelioma of the breast is a rare tumor consisting of both epithelial and myoepithelial cells. Malignant transformation of either cell line can occur. We describe the imaging features, clinical presentation, and management of seven cases of biopsy-proven adenomyoepithelioma at our institution. • Adenomyoepithelioma (AME) of the breast is a rare tumor in which malignant transformation can occur. • Diagnosis of AMEs on imaging is challenging due to variable presentations, necessitating biopsy or excision for diagnosis.. • Wide surgical excision is recommended for definitive diagnosis and treatment of AMEs. [ABSTRACT FROM AUTHOR]

• Adenomyoepithelioma is a rare tumor of the breast characterized by a biphasic proliferation. • Variable spectrum of behavior ranging from benign to malignant, with tendency to local recurrence. • Combine sentinel lymph node dissection (SLND), with simple mastectomy. • Hematogenous spread is the more common means of spread. • Adjuvant chemotherapy for malignant AME cases is recommended. Adenomyoepithelioma is a rare tumor of the breast characterized by a dual/biphasic proliferation of two cell populations: the epithelial cells and the myoepithelial cells. The first case was reported in 1970. The majority of the cases are benign, but few malignant cases were reported in literature. A case of a 66-year-old lady presenting with an asymptomatic breast mass, of 18 × 17 × 15 mm size with irregular borders and negative metastatic workup. The patient was operated for wide local excision of the tumor, with a confirmed negative margins intraoperatively. The final pathology was Adenomyoepithelioma. We report this rare case to encourage physicians to keep this etiology in mind as part of the differential diagnosis of breast mass. [ABSTRACT FROM AUTHOR]

• Adenomyoepithelioma is an uncommon benign disease that occurs in the breast. • Although not common, adenomyoepithelioma is associated with metastasis with malignant changes. • Total mastectomy is known to be the best treatment method, and the effect of chemotherapy or radiation therapy is not known clearly. Adenomyoepithelioma of the breast is a rarely reported and mostly benign disease that seldom undergoes malignant transformation. Here, we present a case of malignant adenomyoepithelioma of the breast in a patient who initially presented with pain following an excision procedure at local clinic. The condition was finally diagnosed after a third surgical procedure, pathologic analysis with hematoxylin and eosin staining, and immunohistochemistry analysis to detect smooth muscle actin and S100 expression. The patient developed no complications or recurrences after a total mastectomy with sentinel node dissection. [ABSTRACT FROM AUTHOR]

Summary Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur ( Lemur catta ) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal–epithelial and basal–myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm. A low mitotic count, low Ki67 labelling index, expression of oestrogen receptor-α, lack of expression of human epidermal growth factor receptor and a 3-year disease-free period without recurrence supported the benign nature of the tumour. Macroscopically, histologically and immunohistochemically this neoplasm resembled benign adenomyoepithelioma of the breast in women. This is the first complete report of a naturally occurring mammary tumour in a ring-tailed lemur. [ABSTRACT FROM AUTHOR]

We describe an unusual case of multifocal breast adenoid cystic carcinoma (AdCC) with adenomyoepitheliomatous morphology. Most breast AdCCs are unifocal and only four cases of multifocal AdCC have been reported previously, however, to our best knowledge, multifocality in AdCC confirmed by molecular analysis has not been reported, so this report adds to the literature on this unique presentation. An 80-year-old woman presented with a left breast mass at 1 o'clock and non-mass enhancement lesion at 5 o'clock on imaging. Incisional biopsy at 1 o'clock showed AdCC based on histopathological features and MYB rearrangement by fluorescent in situ hybridization (FISH). As AdCC involved the margins and the non-mass enhancing lesion remained, mastectomy was performed. Microscopically, the lesion at 5 o'clock demonstrated multinodularity and a biphasic epithelial-basaloid/myoepithelial pattern. Although histological features resembled adenomyoepithelioma, MYB rearrangement was identified on FISH, so the 5 o'clock lesion was also diagnosed as AdCC showing an adenomyoepitheliomatous pattern. This unusual presentation is a potential diagnostic pitfall, so pathologists should consider AdCC as a possible differential diagnosis of multifocal basaloid breast tumors with adenomyoepitheliomatous features. [ABSTRACT FROM AUTHOR]

Adenomyoepithelial tumors of the breast are very rare tumors comprising of - fibroepithelial and myoepithelial components We present the case of a 66 years old lady who presented with a right breast lump 5 cm in size, diagnosed as an atypical adenomyoepithelioma who underwent successful excision and returned two and half years later with a recurrence These tumors present a diagnostic dilemma needing histopathology for definitive diagnosis. Recurrence is not uncommon Adenomyoepitheliomas demand regular surveillance for early detection of any recurrence. • Adenomyoepithelial tumors of the breast are very rare tumors of the breast. • These tumors present a diagnostic dilemma. • Recurrence is not uncommon. • Adenomyoepitheliomas demand regular surveillance for early detection of any recurrence. [ABSTRACT FROM AUTHOR]

The 2012 World Health Organization (WHO) classification of breast tumors distinguishes adenomyoepitheliomas (AMEs) as benign tumors composed of a biphasic proliferation of phenotypically variable myoepithelial cells around small epithelial lined spaces. Many AMEs have demonstrated benign behavior and are often cured with excision with negative margins, but some have exhibited malignant transformation of the myoepithelial cells, ductal epithelial cells, or both. When one of the components is histologically malignant, it is termed AME with carcinoma. Due to the rarity, the literature correlating imaging, histology, and clinical outcome is limited. A retrospective review was undertaken. A review of an institutional pathology database identified 14 cases with AME or malignant AME. Most AMEs had nonspecific imaging findings and were categorized as Bi-Rads 4. Histologic features of AME did not correlate with prior or concurrent breast malignancies or any radiographic features. Clinical follow up could be obtained for all but one case (mean follow up time = 75 months). 5 cases had no known treatment post-biopsy and 5 patients received mastectomy. No recurrences were noted. 3/13 cases of benign AME had associated breast malignancies including invasive ductal adenocarcinoma and ductal carcinoma in-situ. 1 case of malignant AME had a synchronous separate malignant phyllodes tumor. Given the unclear and unpredictable propensity for malignant transformation, conservative excision with negative margins currently seems appropriate. [ABSTRACT FROM AUTHOR]

Adenomyoepitheliomas of breast are rare tumors. We report for the first time a case of an adenomyoepithelioma of the breast with associated lobular neoplasia. A 53-year-old woman had an annual screening mammogram, which identified areas of asymmetry in her left breast at 4-5-o'clock position. Resection of the masses revealed a well-circumscribed, gray-white, firm discrete nodule (0.8 × 0.4 × 0.3 cm). The tumor was composed of both adenomyoepithelial cell hyperplasia and focal atypical lobular hyperplasia. The 2 cell populations had some overlapping histologic features. Immunohistochemical analysis demonstrated a biphasic proliferation with approximately equal parts of luminal epithelial cells with clear and rounded appearance and myoepithelial cells. The myoepithelial component of the proliferation expressed myosin, p63, CK5/6, S-100, and dimly expressed E-cadherin. The epithelial component of the proliferation strongly expressed E-cadherin. In the areas of atypical lobular hyperplasia, there was distinct loss E-cadherin expression. Awareness of this association is highly important to provide these patients adequate follow-up and treatment. [ABSTRACT FROM AUTHOR]

Summary: Pulmonary epithelial-myoepithelial carcinomas are rare low-grade malignant neoplasms with histologic features similar to their salivary gland counterparts. We report a series of 5 cases and describe their clinical, morphological, and immunohistochemical features. The patients included 3 men and 2 women whose ages ranged from 38 to 56 years. All patients had obstructing endobronchial lesions that ranged from 2.5 to 5.0 cm in greatest dimension. The tumors were completely resected by simple lobectomy or pneumonectomy. In one patient, the tumor infiltrated perinodal soft tissue of a peribronchial lymph node with intranodal extension and metastasis within the same lymph node. The follow-up in these patients ranged from 4 to 12 months. The histologic appearance of these tumors varied, but all shared the common feature of a biphasic proliferation of epithelial (strong cytokeratin-positive; actin and S-100–negative) and myoepithelial (strong actin and S-100 and focal weak cytokeratin-positive) cells with formation of bilayered ductlike structures. The focal resemblance to other salivary gland-type tumors may cause diagnostic difficulties, particularly in small endobronchial biopsies. Although little is known about their biologic potential due to limited follow-up data, these tumors when in the lung clearly have the capacity to infiltrate and metastasize and therefore should be designated as epithelial-myoepithelial carcinoma. At present, it appears that treatment by complete surgical resection with negative margins alone is appropriate and adequate. [Copyright &y& Elsevier]

Abstract: Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, tubes and cords formed by neoplastic epithelial cells were separated by bundles of neoplastic myoepithelial cells in a clear and partially mucinous matrix. The tumor displayed characteristics of a benign neoplastic proliferation with a compressive growth pattern, and moderate cellular pleomorphism and mitotic index. At immunohistochemistry, the epithelial cells were strongly cytokeratin positive; the myoepithelial cells were weakly cytokeratin positive and strongly smooth muscle actin positive. This is to our knowledge, the first report of a mammary gland adenomyoepithelioma in a C57BL/6 mouse. [Copyright &y& Elsevier]

Abstract: In the case presented here, a lesion in the breast showed many features of malignancy at contrast-enhanced magnetic resonance (MR) imaging. The histologic specimen was removed by means of MR-guided vacuum assisted biopsy and histology demonstrated a benign adenomyoepithelioma. To our knowledge, this is the first case of benign adenomyoepithelioma characterized by MR mammography and confirmed by MR-guided vacuum assisted biopsy. [Copyright &y& Elsevier]

Abstract: Adenomyoepithelioma of the breast is a rare tumor, having a bicellular pattern of proliferation which consists of epithelial and myoepithelial cells. Though generally considered a benign tumor, removal of the primary tumor may occasionally be followed by local recurrence and rarely distant metastasis. We describe a case of a 60-year-old woman with adenomyoepithelioma of the breast who developed lung, bone, and kidney metastases 5 years after removal of the primary tumor. [Copyright &y& Elsevier]