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Copper-catalyzed radical methylation of 1,3-diketones with tert -butyl peroxybenzoate in air is described, providing a general pathway to α -methyl 1,3-diketones in moderate to good yields. This protocol has been scaled up to 50 g, and one of the synthesized products can be used in the synthesis of medicine, Rosuvastatin. [ABSTRACT FROM AUTHOR]

A facile and efficient protocol of oxythiocyanation of styrenes with ammonium thiocyanate has been developed. The reaction proceeded at room temperature using oxygen as sole oxidant to afford the α-oxothiocyanates via radical pathway in moderate to good yields. This method is straightforward, green and cost-effective, requires no catalyst and additives. [ABSTRACT FROM AUTHOR]

Abstract: Simple and efficient Ga(OTf)3-catalyzed [4+3] cycloaddition of 1,3-diarylpropynones and o-phenylenediamines is developed for the preparation of 2,4-disubstituted-3H-benzo[b][1,4]diazepines. The reaction has advantages of using a green solvent, generating a minimal amount of waste, and easy catalyst recycle. [Copyright &y& Elsevier]

A novel copper-catalyzed sp3-carbon radical/carbamoyl radical cross-coupling protocol for the construction of C(sp3)-C(O) bond is described. This provides a straightforward method for synthesis of 2-carbamoyl-1,3-dicarbonyl compounds in good to excellent yields under mild conditions. Mechanistic studies confirms the generation of both carbamoyl and C(sp3)-centered radicals directly from oxidation of C(sp3)-H bond of formamides and 1,3-dicarbonyl compounds, respectively. Image 1 • The reaction of 1,3-dicarbonyl compounds and formamides afforded the 2-carbamoyl-1,3-dicarbonyl compounds. • This protocol provided an efficient construction of C(sp3)−C(O) bond strategy. • Mechanistic studies confirm that the products were formed through radical-radical cross-coupling process. [ABSTRACT FROM AUTHOR]