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Purposes The objective of the study was to identify the trends and relations between antimicrobial resistance (AMR) and antibiotic use in the Xinjiang Uyghur Autonomous Region in Western China from 2014 to 2016. Methods A retrospective, descriptive analysis of AMR prevalence, and trends and relations between AMR and antibiotic use during the 3-year period was performed. Results Third-generation cephalosporin-resistant Escherichia coli was the most prevalent resistant pathogen in terms of both resistance density and resistance proportion. A significant correlation was found between resistance density of third-generation cephalosporin-resistant Klebsiella pneumoniae and the use of beta-lactam–beta-lactamase inhibitor combinations (cc = 0.63, p = 0.03), quinolones (cc = 0.60, p = 0.04), and carbapenems (cc = 0.76, p = 0.004), among which only beta-lactam–beta-lactamase inhibitor combinations showed a significant correlation with third-generation cephalosporin-resistant E. coli (cc = 0.63, p = 0.03). For carbapenem-resistant Pseudomonas aeruginosa , not only carbapenem use (cc = 0.65, p = 0.02) but also penicillin (cc = 0.76, p = 0.004) and quinolone (cc = 0.69, p = 0.01) use showed significant correlation. A strong correlation was observed between the resistant proportion of third-generation cephalosporin-resistant E. coli and only the use of beta-lactam–beta-lactamase inhibitor combinations (cc = 0.61, p = 0.03). Conclusion The association between antibiotic use and AMR, especially the implication of the difference in resistance density and resistance proportion, is crucial for local physicians and decision-makers to better use of antibiotics and allocate healthcare resources more effectively, as well as to better implement antimicrobial stewardship and effective infection control strategies. [ABSTRACT FROM AUTHOR]

Abstract: For the magnetic levitation system consisting of a high-Tc superconductor and permanent magnet, the relation curve of magnetic force with gap between these two components is known as a hysteresis loop, that is, the approaching and departing portions envelop a complete one, and generally these two portions do not cross each other. However, in some special cases this crossing arises, and makes the complete loop broken. In this paper, by the numerical simulation of the magnetic force-gap curve in large numbers of physical and geometrical parameters, two typical crossings were found. To investigate the crossing and explore its physical causes, for one of the crossings, the current density in the superconductor was further calculated and its magnitude and vector distribution at the gaps nearby where the crossing arises were obtained. Based on these calculation results and an adequate discussion, the conclusion was induced that the crossing in the magnetic force-gap hysteresis curve results from applied magnetic field’s incomplete and insufficient penetrating in superconductor. [Copyright &y& Elsevier]

Abstract: One new metal-organic polymer formulated as [Fe2(μ10-btc)0.5(μ2-ox)0.5(μ2-O)1.5] n 1 (btc=1,2,4,5-benzenetetracarboxylate, pyramellitate; ox=oxalate) has been synthesized by low-temperature solid-state reaction and characterized by single-crystal X-ray diffraction, elemental analyses, TGA, IR spectra and UV–visible spectra. Complex 1 presents the first 3D coordination network structure constructed by bridging btc, ox and O mixed ligands. In 1, carboxyl groups of btc are all deprotonated and they have a new type of μ10-btc coordination mode. The third-order non-linear optical (NLO) properties of the title compound 1 were also investigated and they exhibit the reverse saturable absorption and self-defocusing performance with modulus of the hyperpolarizability (γ) 5.98×10−30 esu for 1 in a 7.45×10−4 moldm−3 DMF solution. [Copyright &y& Elsevier]

Abstract: The homometal cluster [Fe(DMF)6][W2(μ2-S)2S4] 1 (DMF=dimethylformamide) was successfully synthesized by low-temperature solid-state reactions. X-ray single-crystal diffraction studies reveal that compound 1 is dinuclear anion cluster. The compound was characterized by elemental analyses, IR spectra and UV–vis spectra. The third-order non-linear optical (NLO) properties of the cluster were also investigated and exhibited non-linear rare saturation absorption (α 2 <0) and self-defocusing performance with modulus of the hyperpolarizabilities 9.547×10−31 esu for 1. [Copyright &y& Elsevier]

Abstract: The homometal cluster [Fe(DMF)6][Mo2(μ2-S)2S4] 1 (DMF=dimethylformamide) was successfully synthesized by low-temperature solid-state reactions. X-ray single-crystal diffraction studies suggest that compound 1 is dinuclear anion cluster. The compound was characterized by elemental analyses, IR spectra and UV–vis spectra. The third-order non-linear optical (NLO) properties of the cluster were also investigated and exhibited nice non-linear absorption and self-defocusing performance with modulus of the hyperpolarizabilities 4.20×10−30 esu for 1. [Copyright &y& Elsevier]

Abstract: The heterometallic cluster [WM2S4(Pph3)3]·DMF (M2=1.25Ag+0.75Cu) 1 has been synthesized by low-temperature solid-state reaction. Single crystal X-ray analyses reveal that compound 1 possesses a linear skeleton with a W center slightly distorted from the tetrahedron. The compound was characterized by elemental analyses, IR spectra and UV–visible spectra. The third-order nonlinear optical (NLO) properties were also investigated and they exhibit nice nonlinear absorption and self-defocusing performance with modulus of the hyperpolarizability 9.8×10−30esu for 1. [Copyright &y& Elsevier]

Objective: We attempt to investigate the role of TNFRSF1A and its underlying mechanism in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in rat pheochromocytoma PC12 cells.Methods: Public datasets GSE61616 and GSE106680 were downloaded from GEO database. PC12 cells were used to construct OGD/R models. QRT-PCR and western blot were implemented to test the relative mRNA and protein levels, respectively. The miRNA online prediction website TargetScan was used to predict TNFRSF1A upstream regulated miRNAs, which were then confirmed by luciferase reporter assay. The changes in cell viability and apoptosis were evaluated using cell counting kit 8 (CCK-8), lactose dehydrogenase (LDH), and flow cytometry assays.Results: Bioinformatics analysis demonstrated that the expression of TNFRSF1A was upregulated in CI/RI and middle cerebral artery occlusion models compared with control, respectively. And a significant upregulation was also observed in OGD/R-damaged PC12 cells. Depletion of TNFRSF1A can notably enhance the cells proliferation after OGD/R treatment, while enlargement of TNFRSF1A presented the opposite outcomes. Moreover, miR-29a-3p was shown to be the upstream regulatory miRNA of TNFRSF1A. The levels of TNFRSF1A were inversely mediated by miR-29a-3p. Overexpression of miR-29a-3p can raise the cell viability, decrease the LDH activity, and reduce the apoptotic ratio in OGD/R-treated cells. Besides, TNFRSF1A can attenuate the protective effect of miR-29a-3p on OGD/R-treated cells. Furthermore, miR-29a-3p mimic inhibited, while overexpression of TNFRSF1A promoted the activation of NF-κB signaling pathway, and TNFRSF1A can attenuate the suppressive effect of miR-29a-3p on the NF-κB pathway.Conclusion: Our research illustrated that the potential regulatory role of miR-29a-3p/TNFRSF1A axis in neurons cells suffered from OGD/R, and their effects on NF-κB signaling pathway, providing a possible bio-target for protecting cells from OGD/R damage . [ABSTRACT FROM AUTHOR]