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Cognitive deficits and neuroinflammation are significant complications associated with metabolic diseases induced by a high-fat, high-cholesterol (HFHC) diet. Although tomato juice (TJ) has shown potential benefits for brain health, its specific interventional role remains unclear. This research examined the capability of TJ to mitigate HFHC-induced cognitive deficits and delineated TJ's specific mechanisms against neuroinflammation. The results demonstrated that TJ effectively ameliorated cognitive impairments triggered by HFHC diets, improving spatial working memory, novel object recognition, and reducing anxiety-like behaviors in open space and elevated maze tests. Moreover, TJ mitigated neuronal damage, decreased the activity of immune cells, and diminished the level of COX-2 and iNOS in the hippocampus. Additionally, TJ decreased serum TNF-α and lipopolysaccharide levels, reduced liver inflammation, and improved intestinal barrier markers Claudin-1 and Mucin-2 expression. Fecal metabolomics demonstrated that TJ significantly upregulated bile acid metabolism-related pathways. TJ also altered the profile of serum bile acids, elevating the levels of Takeda G protein-coupled receptor 5 (TGR5)-activating bile acids, including deoxycholic acid, ursodeoxycholic acid, and tauroursodeoxycholic acid. TJ upregulated TGR5 protein expression and inhibited the phosphorylation of protein kinase B and nuclear factor kappa B proteins in the hippocampus. Notably, the positive effects of TJ on cognition and TGR5 activation were nullified in an antibiotic-treated mouse model, underscoring the essential role of the gut-brain axis in mediating TJ's neuroprotective effects. These findings propose that bile acid-TGR5 signaling may be associated with the anti-neuroinflammatory effects of TJ, which may represent a novel approach for neurogenic disease prevention. [Display omitted] [ABSTRACT FROM AUTHOR]

Abstract: In an effort to further advance our understanding of the evolution of the Sulu–Dabie orogen and its complex interactions with the Tanlu fault, and to tackle non-unique geophysical interpretations, we characterize the 3D geological structures and dynamics of the Sulu–Dabie orogen and its environs using various data processing and interpretation of a very large suite of gravimetric, magnetic, magnetotelluric, geothermal, and seismic data. We have modeled regional geothermal field of the lithosphere by incorporating both surface heat flow and Curie-point depths inverted from magnetic anomalies. This gives better constraints on regional thermal lithospheric thicknesses, which are found to be small (mostly between 55 and 95km), conformable to other geophysical results, and supportive of lithospheric de-rooting. From regional geotherms and Bouguer gravity anomalies, we assess depths, temperatures and heat flow of the Moho, and find that mantle contributes a little over 70% of the total surface heat flow. Large differences in thermal lithospheric thicknesses and geothermal activities are found between the Sulu and the Dabie segments of the Sulu–Dabie orogen. These differences result, at least partially, from large vertical differential movement at the lithospheric scale across the Tanlu fault, as seen from both reflection seismic sections and gravity anomalies. Within the Sulu–Dabie orogenic belt, reduction to the pole and 3D analytic signal analysis on magnetic anomalies reveal that positive magnetic anomalies associated with this belt are most due to gneiss, migmatite and Mesozoic granites, whereas ultrahigh-pressure metamorphic zones show weak or negative magnetic anomalies. This interesting magnetic contrast between ultrahigh-pressure metamorphic rocks and surrounding rocks suggests that ultrahigh-pressure metamorphic minerals are either only weakly magnetized, or possibly retrograded and remagnetized over a long time span or in a period of reversed magnetization. High-pressure metamorphic minerals of blueschist facies appear to be less susceptive than ultrahigh-pressure metamorphic minerals. [Copyright &y& Elsevier]