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Background: Hyperuricemia is associated with a higher risk of death in patients with coronary artery disease (CAD). In contrast, overweight or obesity was associated with survival benefits in this population. However, the relation of body mass index (BMI) and serum uric acid (SUA) to mortality has not been clarified in this population. Methods: We studied a cohort of 1202 patients with angiographic CAD from the ET-CHD registry during 1997-2003 in Taiwan. To evaluate the relation of BMI and SUA on mortality, the subjects were categorized into 4 groups by BMI ≥ 25kg/m² (overweight or obesity) or BMI<25kg/m² (normal- or under-weight), and SUA levels higher or lower than the median of 6.6mg/dl. At a median follow-up of 5.4 years, cardiac and all-cause deaths were the primary end points Results: Multivariate analyses demonstrated that high SUA group had a significantly higher cardiac mortality [hazard ratio (HR): 1.79, 95% confidence interval (CI): 1.14-2.82, p=0.023] and overall mortality (HR: 1.68, 95% CI: 1.19-2.36, p=0.003) than low SUA group only in overweight or obese patients. Additionally, high BMI was associated with a significantly lower cardiac mortality (HR: 0.58, 95% CI: 0.38-0.99, p=0.023) and overall mortality (HR: 0.62, 95% CI: 0.41-0.82, p=0.003) than low BMI in patients with low SUA levels. Furthermore, normal-low weight and underweight patients (BMI<21kg/m²) were found to have a higher risk of mortality regardless of SUA levels. Conclusions: Among patients with established CAD, SUA may be a potent predictor to mortality in overweight or obese patients. Moreover, the obesity-mortality paradox phenomenon was mainly driven by higher mortality risk in underweight patients and lower mortality risk in overweight and obese patients with low SUA. [ABSTRACT FROM AUTHOR]

Background: Low estimated glomerular filtration rate (eGFR) and body mass index (BMI) have been known as poor prognostic factors in patients with coronary artery disease (CAD). Besides, high BMI was associated with higher survival rate in patients on dialysis as well. However, the relation of eGFR and BMI to mortality has not been clarified in non-dialysis CAD patients. Methods: We studied a cohort of 1243 non-dialysis patients with angiographic CAD from the ET-CHD registry during 1997-2003 in Taiwan. To evaluate the relation of eGFR and BMI to mortality, the subjects were categorized into 4 groups by BMI higher or lower than 25kg/m² and eGFR higher or lower than 60mL/min/1.73m², a cut-off value for chronic kidney disease (CKD). At a mean follow-up of 5.4 years, cardiac and all-cause deaths were the primary end points. Results: In the high BMI group, CKD was a strong predictor of cardiac and overall mortality [hazard ratio (HR): 1.63 (95% CI: 1.05-2.53) and 2.17 (95% CI: 1.54-3.07), respectively]. Besides, CKD marginally elevated the mortality risk in the low BMI group. Among CKD patients, BMI was not associated with mortality except for a high death rate in patients with BMI lower than 21kg/m². In contrast, in non-CKD patients, high BMI group had a lower cardiac and overall mortality than the low BMI group [HR: 0.75 (95% CI: 0.48-1.16) and 0.55 (95% CI: 0.39-0.77), respectively]. Conclusions: Among non-dialysis CAD patients in eastern Taiwan, lower eGFR was associated with worse prognosis regardless of BMI levels. Notably, in patients with high BMI, the relationship between CKD and mortality was extremely remarkable. Moreover, the obesity-mortality paradox phenomenon was not present in non-dialysis CKD patients. [ABSTRACT FROM AUTHOR]

Examines the effect of Taiwanese vegetarian diets on B-vitamin status and plasma homocysteine levels. Dietary assessment, anthropometric measurements and blood collection of subjects; Comparison of the levels of plasma folate and vitamin B-12; Independent determinants of homocysteine variation.