1. Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague–Dawley rats
- Author
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Prins, Gail S., Ye, Shu-Hua, Birch, Lynn, Ho, Shuk-mei, and Kannan, Kurunthachalam
- Subjects
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BISPHENOL A , *PHARMACOKINETICS , *SPRAGUE Dawley rats , *PROSTATE cancer , *NEWBORN infants , *ESTROGEN , *BODY weight , *DRUG administration , *ORAL drug administration , *SERUM - Abstract
Abstract: The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10μg BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC–MS–MS. Free and total BPA at C max were 1.77 and 2.0ng/ml, respectively following injection and 0.26 and 1.02ng/ml, respectively following oral exposure. The AUC0–2 for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. vs. oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10μg BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels. [Copyright &y& Elsevier]
- Published
- 2011
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