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Your search keyword '"Xue, Xin"' showing total 243 results
Start Over Author "Xue, Xin" Publisher elsevier b.v.
243 results on '"Xue, Xin"'

34. Impact of body mass index elevation, Vitamin D receptor polymorphisms and antipsychotics on the risk of Vitamin D deficiency in schizophrenia patients.

Author

Goh, Xue Xin, Tee, Shiau Foon, Tang, Pek Yee, Chee, Kok Yoon, and Loh, Kenny Kien Woon

Subjects
*VITAMIN D receptors, *SINGLE nucleotide polymorphisms, *VITAMIN D, *VITAMIN D deficiency, *WEIGHT gain
Abstract

Antipsychotics with weight gain as side effect and vitamin D receptor dysfunction associated with single nucleotide polymorphisms (VDR SNPs) may have different effects on vitamin D status. Hence, present study aimed to investigate the relationship between vitamin D with body mass index (BMI), antipsychotics and VDR SNPs (rs2228570, rs1544410, rs7975232 and rs731236) in Malaysian patients with schizophrenia. Serum vitamin D level was measured using competitive enzyme–linked immunosorbent assay kit. VDR SNPs were analyzed using polymerase chain reaction–restriction fragment length polymorphism. We found significantly lower serum vitamin D level in patients with schizophrenia (p < 0.01), especially those taking atypical antipsychotics (p = 0.02) and combined antipsychotics (p = 0.02) and obese (BMI ≥27.5 kg/m2) patients (p = 0.04) after adjustment for covariates. For VDR SNPs, the CT genotype of rs1544410, CA genotype of rs7975232, and AA and AG genotypes of rs731236 may contribute to the significant decreased serum vitamin D level in patients (p < 0.05). Nevertheless, these relationships may differ by populations or medical conditions. The hypotheses of volumetric dilution and sequestration of vitamin D may explain the lower vitamin D level in obese patients. In addition, lifestyle factors such as poor diet and lack of physical activity with less sunlight exposure may cause reduced vitamin D level among patients. As patients in present study were prescribed with various antipsychotics, the effect of each antipsychotic on vitamin D level could not be determined. Thus, future studies should investigate the effect of different types of antipsychotics and obesity on vitamin D level in schizophrenia. • Patients with schizophrenia were having significant reduced serum vitamin D level. • Atypical and combined antipsychotics may be linked with decreased vitamin D level. • Obese patients were having lower vitamin D level after covariate adjustment. • Certain genotypes of VDR SNPs may contribute to lower vitamin D level in patients. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China.

Author

SONG, Yun, HE, Ying, LU, Xue Xin, ZHANG, Xiao Mei, JIANG XIAO, Lin, SONG, Qing, HUANG, Xue Yong, MA, Hong Xia, YU, Peng Cheng, and ZHU, Wu Yang

Subjects
RABIES vaccines, IMMUNE response, VIRAL antibodies, RABIES virus, COMPARATIVE studies, PLANT protection
Abstract

This study aimed to compare the current Essen rabies post-exposure immunization schedule (0-3-7-14-28) in China and the simple 4-dose schedule (0-3-7-14) newly recommended by the World Health Organization in terms of their safety, efficacy, and protection. Mice were vaccinated according to different immunization schedules, and blood was collected for detection of rabies virus neutralizing antibodies (RVNAs) on days 14, 21, 28, 35, and 120 after the first immunization. Additionally, different groups of mice were injected with lethal doses of the CVS-11 virus on day 0, subjected to different rabies immunization schedules, and assessed for morbidity and death status. In a clinical trial, 185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule, and blood was collected for RVNAs detection on days 28 and 42 after the first immunization. A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day (P < 0.05). The groups 0-3-7-14, 0-3-7-21, and 0-3-7-28 showed no statistically significant difference (P > 0.05) in RVNAs levels at any time point. The post-exposure immune protective test showed that the survival rate of mice in the control group was 20%, whereas that in the immunization groups was 40%. In the clinical trial, the RVNAs positive conversion rates on days 28 (14 days after 4 doses) and 42 (14 days after 5 doses) were both 100%, and no significant difference in RVNAs levels was observed (P > 0.05). The simple 4-dose schedule can produce sufficient RVNAs levels, with no significant effect of a delayed fourth vaccine dose (14–28 d) on the immunization potential. [ABSTRACT FROM AUTHOR]

Published
2024
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