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This paper considers the first order consensus problem of multi-agent systems. A new kind of distributed control protocol is constructed for achieving distributed consensus. Based on linear matrix inequalities and the Lyapunov function method, the sufficient conditions for the achievement of the distributed consensus are obtained. Illustrative examples are provided to show the effectiveness of this method. [ABSTRACT FROM AUTHOR]

Abstract: This paper investigates adaptive synchronization for dynamical networks of neutral type with time-delay. In comparison with those of the existing synchronization of dynamical networks of neutral type with time-delay, we assume that the given neutral type expression can be linear function, nonlinear function, or even any elementary transformation. Based on the Lyapunov stability theorem, the adaptive control law is derived to make the state of two dynamical networks of neutral type synchronized. Some numerical are also given to show the effectiveness of the proposed method. [Copyright &y& Elsevier]

In this paper, the impulsive synchronization problem of Lü chaotic systems is investigated by using a novel hybrid controller. The proposed hybrid controller is composed of a single controller and impulsive controller. Using the impulsive theory and the novel hybrid controller, some sufficient conditions are derived for the synchronization of Lü chaotic systems. Numerical simulation example is provided to verify the effectiveness of the proposed approach. The simulation results show that the proposed control scheme has a fast convergence rate compared with the conventional single controller method and impulsive controller method. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) has emerged as one of the most common malignancies worldwide. It is associated with a high mortality rate, as evident from its increasing incidence and extremely poor prognosis. The deubiquitinating enzyme 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) has been reported to act as an oncogene in several human cancers. The present study aimed to reveal the functional significance of PSMD14 in HCC progression and the underlying mechanisms. We found that PSMD14 was significantly upregulated in HCC tissues. Overexpression of PSMD14 correlated with vascular invasion, tumor number, tumor recurrence, and poor tumor-free and overall survival of patients with HCC. Knockdown and overexpression experiments demonstrated that PSMD14 promoted proliferation, migration, and invasion in HCC cells in vitro, and facilitated tumor growth and metastasis in vivo. Mechanistically, we identified PSMD14 as a novel post-translational regulator of GRB2. PSMD14 inhibits degradation of GRB2 via deubiquitinating this oncoprotein in HCC cells. Furthermore, pharmacological inhibition of PSMD14 with O-phenanthroline (OPA) suppressed the malignant behavior of HCC cells in vitro and in vivo. In conclusion, our findings suggest that PSMD14 could serve as a novel promising therapeutic candidate for HCC. [ABSTRACT FROM AUTHOR]

This paper is concerned with finite-time synchronization for a class of the complex dynamical network with non-derivative and derivative coupling. Different from the existing related results, a new finite-time synchronization theory is proposed to investigate finite-time synchronization of the complex dynamical network with non-derivative and derivative coupling, several new and effective criteria are derived to realize synchronization in finite time of the addressed complex dynamical network with non-derivative and derivative coupling. Finally, some numerical examples are provided to verify the theoretical results established in this paper. [ABSTRACT FROM AUTHOR]

Retinoid X receptor alpha (RXRα), a nuclear receptor of transcription factor, controls various physiological and pathological pathways including cellular growth, proliferation, differentiation, and apoptosis. Here, we report that RXRα is phosphorylated at its N-terminal A/B domain by cyclin-dependent kinase 1 (Cdk1) at the onset of mitosis, triggering its translocation to the centrosome, where phosphorylated-RXRα (p-RXRα) interacts with polo-like kinase 1 (PLK1) through its N-terminal A/B domain by a unique mechanism. The interaction promotes PLK1 activation, centrosome maturation, and mitotic progression. Levels of p-RXRα are abnormally elevated in cancer cell lines, during carcinogenesis in animals, and in clinical tumor tissues. An RXRα ligand XS060, which specifically inhibits p-RXRα/PLK1 interaction but not RXRα heterodimerization, promotes mitotic arrest and catastrophe in a tumor-specific manner. These findings unravel a transcription-independent action of RXRα at the centrosome during mitosis and identify p-RXRα as a tumor-specific vulnerability for developing mitotic drugs with improved therapeutic index. • Cdk1 phosphorylation of RXRα induces its translocation to centrosome during mitosis • Centrosomal RXRα modulates mitosis by interacting with PLK1 • Cdk1-phosphorylated RXRα confers tumor cells with vulnerability to RXRα inhibitors • An RXRα ligand promotes mitotic catastrophe by inhibiting p-RXRα/PLK1 interaction Xie and Zhou et al. report a transcription-independent function of RXRα. Upon phosphorylation by Cdk1 at the onset of mitosis, RXRα translocates to the centrosome, where it interacts with PLK1 to promote centrosome maturation and mitotic progression. The authors also identify Cdk1-phosphorylated RXRα as a tumor-specific vulnerability to an RXRα inhibitor. [ABSTRACT FROM AUTHOR]