172 results on '"Worek, Franz"'
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2. Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
3. Determination of tissue distribution of VX and its metabolites EMPA and EA-2192 in various rat tissues by LC-ESI-MS/MS after phosphotriesterase treatment
4. Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents
5. The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms – Structure optimization
6. Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
7. Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication
8. Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor
9. Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships
10. Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption
11. MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor
12. AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning
13. The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds
14. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
15. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
16. Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
17. Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample
18. Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks
19. A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds
20. Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by 31P-NMR spectroscopy
21. Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl
22. Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM
23. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
24. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis
25. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism
26. Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
27. Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor
28. The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study
29. Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models
30. Alteration of miRNA expression in a sulfur mustard resistant cell line
31. Development of a sensitive, generic and easy to use organophosphate skin disclosure kit
32. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning
33. Blaptica dubia as sentinels for exposure to chemical warfare agents – a pilot study
34. Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes – Possible therapeutic implications
35. Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study
36. Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability
37. Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies
38. GC–MS and LC–MS analysis of nerve agents in body fluids: Intra-laboratory verification test using spiked plasma and urine samples
39. Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC–ESI-MS/MS and flow-injection-ESI-MS/MS
40. Development and validation of a sensitive gas chromatography–ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species
41. Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples
42. Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples
43. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study
44. Suitability of human HepaRG cells and liver spheroids as in vitro model to investigate the bioactivation of the organothiophosphate pesticide parathion.
45. Improved determination of acetylcholinesterase activity in human whole blood
46. Oximes in organophosphate poisoning: 60 years of hope and despair.
47. Bispyridinium non-oximes: An evaluation of cardiac effects in isolated hearts and smooth muscle relaxing effects in jejunum.
48. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit—Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds.
49. Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
50. Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord—skeletal muscle cocultures.
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