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Due to lack of reliable and generalizable datasets, knowledge about the real-world treatment of advanced non-small-cell lung cancer (aNSCLC) patients is still limited. The objective of this study was to assess progression-free survival (PFS) and overall survival (OS) of aNSCLC patients since start of a first-line (1L) systemic treatment in German clinical practice. We analyzed patients included in a new electronic medical record databank targeting German oncology patients (INGRESS-Indivumed Liquid Biopsy RWE oncology database). [Extracted from the article]

Patients' disease and treatment knowledge has a positive influence on patients' adherence to treatment and, consequently, positively influences the course of the disease as well as patients' quality of life. Out of these, 72.4% were able to report their MS subtype, with RRMS as most reported subtype (244 patients, 72.2%) followed by SPMS and CIS (37 patients each, 10.9%) and PPMS as least reported subtype (20 patients, 5.9%). Even if there might be a positive selection of patients using a novel mobile application, our data show that both disease and treatment knowledge of MS patients needs improvement. [Extracted from the article]

Especially in oncology, a better understanding of the real-world treatment of patients is needed, both to compare RWE with clinical trial results and to identify unmet needs in the real-world (RW) treatment of patients. We aimed to describe the RW treatment of patients included in a new electronic medical record databank targeting German oncology patients (INGRESS-Indivumed Liquid Biopsy RWE oncology database). The Indivumed Liquid Biopsy RWE oncology database has the potential to provide valuable insights into RW data on the treatment and treatment-associated outcomes of German oncology patients. [Extracted from the article]

Due to lack of reliable and generalizable datasets, knowledge about the real-world treatment of metastatic breast cancer (mBC) patients is still limited. The objective of this study was to assess progression-free survival (PFS) and overall survival (OS) of mBC patients since start of a first-line (1L) systemic treatment in German clinical practice. We analyzed patients included in a new electronic medical record databank targeting German oncology patients (INGRESS-Indivumed Liquid Biopsy RWE oncology database). [Extracted from the article]

Although vaccine preventable, the incidence of tick-borne encephalitis (TBE) increased in Germany from 2001 to 2021 by on average 2% each year, with a peak of more than 700 TBE infections documented in 2020. TBE-risk areas, as designated by district based on incidence of human cases, expanded north- and northeastward, present in 11 of the 16 Federal States as of 2022. Using claims data from a German statutory health insurance in the Federal States of Saxony and Thuringia (AOK PLUS), we aimed to assess whether official assignment of a district to a risk area had an impact on vaccination rates in Germany. The data covered the period from 01/01/2010 to 31/12/2018 and included information on vaccine administrations from outpatient physicians. Yearly incident vaccination rates were reported overall and by district. To investigate the association between a new designation of an incident TBE-risk area and vaccination rates, a difference-in-difference analysis was conducted. Overall, the incident vaccination rates increased from 6.2 to 9.5 per 1,000 person-years between 2012 and 2018, with a peak of 12.2 in 2015. While districts that had been risk-areas for the whole study period had always a higher vaccination rate compared to districts that were never categorized as risk areas, the increase between 2012 and 2018 was comparable in the two groups (3.0 and 3.2 per 1,000 person-years, respectively). In contrast, districts that were newly designated risk districts during the study period experienced a significantly larger increase in vaccination rates, going from 5.8 to 14.7 per 1,000 person-years between 2012 and 2018, with a peak of 19.6 in 2015. The results suggest that the new designation of a district as risk area has a significant positive impact on vaccination rates, which is strongest immediately after designation of risk area. [ABSTRACT FROM AUTHOR]

INVESTIGATING THE WEEKLY PATTERN OF STROKES This work investigates factors affecting weekly patterns in stroke hospitalizations. Stress factors may play a major role in weekly stroke patterns, calling for stroke care readiness measures in hospitals after weekends and public holidays, and strategies for a gradual transition into the working week. [Extracted from the article]

The objective of this medical chart review (MCR) was to describe the clinical characteristics of elderly patients with community-acquired invasive Escherichia coli disease (IED), as well as their treatment, clinical outcomes, and the associated medical resource use in Germany. This retrospective MCR study utilized data documented from 11 hospitals across Germany. Hospitals searched their in-house electronic medical record system to identify IED cases (E. coli mono-infection, age ≥60) hospitalized between January 2018 and February 2020. Two mutually exclusive groups were identified through a clinical case definition (CCD): E. coli in blood or other sterile sites (Group B) or E. coli in urine, with the presence of urosepsis and without identifiable other sources of infection (Group U). Cases were subsequently excluded if the infection was hospital-acquired or if they did not meet the CCD. Of 221 documented IED cases, 134 (60.60%) were ultimately eligible (mean age: 77.98 ± 8.52, females: 47.01%). Of these, 107 (79.85%) were in group B and 27 (20.15%) in group U. Across both groups, the average length of hospitalization was 13.07 ± 11.37 days, and most patients were admitted as emergencies (91.79%). The most common encoded main diagnoses were sepsis due to E. coli (ICD-10: A41.51; 38.06%) and unspecified urinary tract infection (ICD-10: N39.0; 11.94%). The patients' average sepsis-related organ failure assessment score was 3.21 ± 2.43 at admission; 8.96% of patients had a septic shock, and 29.85% were in the intensive care unit during their hospitalization. In total, 10.45% of the patients died during their index hospitalization; of the surviving patients, 18.33% had at least one readmission within 90-days after discharge. In elderly patients (age ≥60) with IED, severe courses associated with increased health care resource utilization and sometimes fatal outcomes were observed. Therefore, advances in recognition and treatment seem to be necessary. [ABSTRACT FROM AUTHOR]