10 results on '"Whitaker, Jennifer A."'
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2. Risk of COVID-19 after natural infection or vaccination
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Scott, Lane, Dakotah C., Wald, Anna, James, Frank, Duke, Elizabeth, Hauge, Kirsten, Heimonen, Jessica, Goecker, Erin A., Huang, Yunda, Fong, Youyi, Kauffman, Carol, Linder, Kathleen, Nofz, Kimberly, McConnell, Andrew, Buynak, Robert J., Webb, Angella, Petty, Taryn, Andree, Stephanie, Sanchez, Erica, Mackey, Nolan, Baudelaire, Clarisse, Dzigiel, Sarah, Marquez, Adrienna, Quillin, Kim, King, Michelle, Abad, Vanessa, Knowles, Jennifer, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Tovar, Dalia, Shaw, Marian E., Turner, Mark A., Huffine, Cory J., Huffine, Esther S., Ake, Julie A., Secord, Elizabeth, McGrath, Eric, Levy, Phillip, Stewart, Brittany, Cromer, Charnell, Walters, Ayanna, Ellsworth, Grant, Greene, Caroline, Galloway, Sarah, Kapadia, Shashi, DeHaan, Elliot, Wilson, Clint, Milligan, Jason, Raley, Danielle, Bocchini, Joseph, McClenathan, Bruce, Hussain, Mary, Lomasney, Evelyn, Hall, Evelyn, Lamberth, Sherry, Schmeck, Christy, Leathers, Vickie, Theodore, Deborah A., Branche, Angela R., Graciaa, Daniel S., Hatlen, Timothy J., Miller, Jacqueline, Sadoff, Jerald, Falsey, Ann R., Sobieszczyk, Magdalena E., Rick, Anne-Marie, Laurens, Matthew B., Huang, Ying, Yu, Chenchen, Martin, Thomas C.S., Rodriguez, Carina A., Rostad, Christina A., Maboa, Rebone M., Baden, Lindsey R., El Sahly, Hana M., Grinsztejn, Beatriz, Gray, Glenda E., Gay, Cynthia L., Gilbert, Peter B., Janes, Holly E., Kublin, James G., Leav, Brett, Hirsch, Ian, Struyf, Frank, Dunkle, Lisa M., Neuzil, Kathleen M., Corey, Lawrence, Goepfert, Paul A., Follmann, Dean, and Kotloff, Karen L.
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- 2023
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3. The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL).
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Whitaker, Jennifer A., Parikh, Sameer A., Shanafelt, Tait D., Kay, Neil E., Kennedy, Richard B., Grill, Diane E., Goergen, Krista M., Call, Timothy G., Kendarian, Saad S., Ding, Wei, and Poland, Gregory A.
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FLU vaccine efficacy , *HUMORAL immunity , *CHRONIC lymphocytic leukemia , *LYMPHOCYTOSIS , *VACCINE effectiveness , *VIRAL antibodies , *INFLUENZA - Abstract
• First published vaccine responses in those with monoclonal B cell lymphocytosis (MBL). • High-dose influenza vaccine responses in MBL and chronic lymphocytic leukemia (CLL). • Seroprotection: 63% (A/H1N1); 91% (A/H3N2); and 43% (B) for cohort (MBL and CLL). • Higher seroprotection rates for influenza B seen were in those with MBL than CLL. Limited data are available regarding the immunogenicity of high-dose influenza vaccine among persons with chronic lymphocytic leukemia (CLL) and monoclonal B cell lymphocytosis (MBL). A prospective pilot study of humoral immune responses to 2013–2014 and 2014–2015 high-dose trivalent influenza vaccine (HD IIV; Fluzone® High-Dose; Sanofi Pasteur) was conducted among individuals with MBL and previously untreated CLL. Serum hemagglutination inhibition (HAI) antibody titers were measured at baseline and Day 28 after vaccination; seroprotection and seroconversion rates were determined. Memory B cell responses were assessed by B-cell enzyme-linked immune absorbent spot assays. Thirty subjects (17 CLL and 13 MBL) were included. Median age was 69.5 years. Day 28 seroprotection rates for the cohort were 19/30 (63.3%) for A/H1N1; 21/23 (91.3%) for A/H3N2; and 13/30 (43.3%) for influenza B. Those with MBL achieved higher day 28 HAI geometric mean titers (54.1 [4.9, 600.1] vs. 12.1 [1.3, 110.1]; p = 0.01) and higher Day 28 seroprotection rates (76.9% vs. 17.6%; p = 0.002) against the influenza B-vaccine strain virus than those with CLL. Immunogenicity of the HD IIV3 in patients with CLL and MBL is lower than reported in healthy adults. Immunogenicity to influenza B was greater in those with MBL than CLL. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. Strategies to maximize influenza vaccine impact in older adults.
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Whitaker, Jennifer A., von Itzstein, Mitchell S., and Poland, Gregory A.
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INFLUENZA , *MORTALITY , *VACCINATION , *IMMUNIZATION , *PUBLIC health - Abstract
Abstract Older adults are disproportionately affected by influenza morbidity and mortality. In most high income countries, influenza vaccine policies target persons age ≥65 years for influenza vaccination. Many low-resource settings do not utilize seasonal influenza vaccination. Barriers to influenza prevention among older adults around the globe are multiple and some vary between high- and low-resource settings. To maximize influenza prevention in the older adult population, gaps in influenza vaccination coverage and improvements in vaccine efficacy are needed. The focus of this article is on the data for currently available vaccine strategies to maximize influenza vaccine impact, with a focus on high-resource settings. We also discuss novel influenza vaccine strategies needed for older adults worldwide. [ABSTRACT FROM AUTHOR]
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- 2018
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5. Immunization education for internal medicine residents: A cluster-randomized controlled trial.
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Whitaker, Jennifer A., Poland, Caroline M., Beckman, Thomas J., Bundrick, John B., Chaudhry, Rajeev, Grill, Diane E., Halvorsen, Andrew J., Huber, Jill M., Kasten, Mary J., Mauck, Karen F., Mehta, Ramila A., Olson, Timothy, Thomas, Kris G., Thomas, Matthew R., Virk, Abinash, Wingo, Majken T., and Poland, Gregory A.
- Subjects
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IMMUNIZATION , *INTERNAL medicine , *RANDOMIZED controlled trials , *VACCINE effectiveness , *VACCINATION ,SOCIAL aspects - Abstract
Purpose The aims of this study are to evaluate the impact of a novel immunization curriculum based on the Preferred Cognitive Styles and Decision Making Model (PCSDM) on internal medicine (IM) resident continuity clinic patient panel immunization rates, as well as resident immunization knowledge, attitudes, and practices (KAP). Methods A cluster-randomized controlled trial was performed among 143 IM residents at Mayo Clinic to evaluate the PCSDM curriculum plus fact-based immunization curriculum (intervention) compared to fact-based immunization curriculum alone (control) on the outcomes of resident continuity clinic patient panel immunization rates for influenza, pneumococcal, tetanus, pertussis, and zoster vaccines. Pre-study and post-study immunization KAP surveys were administered to IM residents. Results Ninety-nine residents participated in the study. Eighty-two residents completed pre-study and post-study surveys. Influenza and pertussis immunization rates improved for both intervention and control groups. There was no significant difference in immunization rate improvement between the groups. Influenza immunization rates improved significantly by 33.4% and 32.3% in the intervention and control groups, respectively. The odds of receiving influenza immunization at the end of the study relative to pre-study for the entire study cohort was 4.6 (p < 0.0001). The odds of having received pertussis immunization at the end of the study relative to pre-study for the entire study cohort was 1.2 (p = 0.0002). Both groups had significant improvements in immunization knowledge. The intervention group had significant improvements in multiple domains that assessed confidence in counseling patients on immunizations. Conclusions Fact-based immunization education was useful in improving IM resident immunization rates for influenza and pertussis. The PCSDM immunization curriculum did not lead to increases in immunization rates compared with the fact-based curriculum, but it did significantly increase resident confidence in communicating with patients about vaccines. [ABSTRACT FROM AUTHOR]
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- 2018
- Full Text
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6. Vaccinology in the third millennium: scientific and social challenges.
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Poland, Gregory A, Whitaker, Jennifer A, Poland, Caroline M, Ovsyannikova, Inna G, and Kennedy, Richard B
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The epidemiology of deaths due to vaccine-preventable diseases has been significantly and positively altered through the use of vaccines. Despite this, significant challenges remain in vaccine development and use in the third millennium. Both new (Ebola, Chikungunya, Zika, and West Nile) and re-emerging diseases (measles, mumps, and influenza) require the development of new or next-generation vaccines. The global aging of the population, and accumulating numbers of immunocompromised persons, will require new vaccine and adjuvant development to protect large segments of the population. After vaccine development, significant challenges remain globally in the cost and efficient use and acceptance of vaccines by the public. This article raises issues in these two areas and suggests a way forward that will benefit current and future generations. [ABSTRACT FROM AUTHOR]
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- 2016
- Full Text
- View/download PDF
7. Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1
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Whitaker, Jennifer A, Rouphael, Nadine G, Edupuganti, Srilatha, Lai, Lilin, and Mulligan, Mark J
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HEPATITIS B vaccines , *HIV infections , *ADULTS , *HIV , *HEPATITIS B virus , *MORTALITY , *COMPARATIVE studies , *HEALTH planning - Abstract
Summary: HIV and hepatitis B virus co-infection leads to substantially increased morbidity and mortality compared with either infection alone. Immunisation with hepatitis B virus vaccine is the most effective way to prevent the infection in people with HIV; however, these patients have decreased vaccine responses and a short duration of protection compared with immunocompetent individuals. Control of HIV replication with highly active antiretroviral therapy and increased CD4 cell counts are associated with improved immune responses to hepatitis B vaccination. New vaccination strategies, such as increased vaccine dose, use of the intradermal route, and addition of adjuvants, could improve response rates in adults with HIV. [ABSTRACT FROM AUTHOR]
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- 2012
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8. Measles and mumps outbreaks in the United States: Think globally, vaccinate locally.
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Whitaker, Jennifer A. and Poland, Gregory A.
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- 2014
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9. Vaccinating donors for hematopoietic cell transplantation: A systematic review and future perspectives.
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Muhsen, Ibrahim N., Aljurf, Mahmoud, Wingard, John R., Poland, Gregory A., Komanduri, Krishna V., Whitaker, Jennifer A., and Hashmi, Shahrukh K.
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HEMATOPOIETIC stem cell transplantation , *MEDLINE , *DIPHTHERIA vaccines , *PNEUMOCOCCAL vaccines , *ENZYME-linked immunosorbent assay - Abstract
Abstract Allogeneic hematopoietic cell transplantation (Allo-HCT) recipients are at an increased risk of infectious complications, which is a major cause of morbidity and mortality post-transplant. Vaccination of donors is one of the strategies that has been studied to improve immune reconstitution post-transplant, however the efficacy and safety of this strategy is not well reviewed in the literature. In this systematic review we sought to evaluate the current strategies of donor vaccination along with their immunogenicity, effectiveness and safety. Utilizing strict selection criteria with defined MeSH terminology, an electronic search was conducted from the following databases: Medline, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Scopus. Abstracts of various professional society meetings were also screened and hand searching of various reviews and guideline articles was carried out. The full text of 52 articles were reviewed, from which 5 articles satisfied the inclusion/exclusion criteria for effectiveness and immunogenicity trials and 1 article was included for safety data. Jadad score was used to assess the quality of included studies. The results of the included studies were inconsistent, and the studies were generally of suboptimal methodological quality. Most of the included studies (n = 3) investigated the use of more than one vaccine, however not all commonly used vaccines in HCT were investigated. None of the studies reported any long-term benefits for HCT recipients of vaccinated donors. Only one study reported safety data of using vaccination in donors. Given the suboptimal quality of the studies, and questionable effectiveness, donor vaccination cannot be recommended for all. Prospective high-quality vaccine trials in HCT donors are needed. [ABSTRACT FROM AUTHOR]
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- 2018
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10. Variability in Humoral Immunity to Measles Vaccine: New Developments.
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Haralambieva, Iana H., Kennedy, Richard B., Ovsyannikova, Inna G., Whitaker, Jennifer A., and Poland, Gregory A.
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HUMORAL immunity , *MEASLES vaccines , *VACCINE effectiveness , *SYSTEMS biology , *HEALTH outcome assessment - Abstract
Despite the existence of an effective measles vaccine, resurgence in measles cases in the USA and across Europe has occurred, including in individuals vaccinated with two doses of the vaccine. Host genetic factors result in inter-individual variation in measles vaccine-induced antibodies, and play a role in vaccine failure. Studies have identified HLA (human leukocyte antigen) and non-HLA genetic influences that individually or jointly contribute to the observed variability in the humoral response to vaccination among healthy individuals. In this exciting era, new high-dimensional approaches and techniques including vaccinomics, systems biology, GWAS, epitope prediction and sophisticated bioinformatics/statistical algorithms provide powerful tools to investigate immune response mechanisms to the measles vaccine. These might predict, on an individual basis, outcomes of acquired immunity post measles vaccination. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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