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Your search keyword '"Wang Hongcheng"' showing total 161 results
Start Over Author "Wang Hongcheng" Publisher elsevier b.v.
161 results on '"Wang Hongcheng"'

33. A highly stable optical humidity sensor

Author

Chen, Mingyu, Xue, Sheng, Liu, Liu, Li, Zongbao, Wang, Haiyan, Tan, Chunlin, Yang, Jianxin, Hu, Xiaowen, Jiang, Xiao-Fang, Cheng, Yupeng, Wang, Hongcheng, Xing, Xiaobo, and He, Sailing

Published
2019
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46. Evaluating the multi-seasonal impacts of urban blue-green space combination models on cooling and carbon-saving capacities.

Author

Yang, Fei, Yang, Dongdong, Zhang, Ying, Guo, Ru, Li, Jiaying, and Wang, Hongcheng

Subjects
PUBLIC spaces, CITIES & towns, CLIMATE change, URBAN planners, SMART cities
Abstract

The impacts of global climate change on cities are increasing, especially in high-density cities. Urban blue-green spaces can regulate the microclimate of the surroundings through providing shade and transpiration while saving the energy use of residents. Under changing climate conditions, accurately assessing urban blue-green spaces' cooling and carbon-saving capacities is a prerequisite for the smart growth of the city. However, little attention has been paid to the cooling and carbon-saving potential of different blue-green spaces in mid and high latitude regions. Based on this, we selected Tianjin, a typical high-density city in northern China, as the study area and quantified the cooling intensity, cooling distance, and carbon-saving by cooling of the green space, the river-green space, and the lake-green space's samples under different seasons. The results show that: (1) the average background temperature can significantly affect the cooling and carbon-saving capacities of blue-green spaces and the intensity of the influencing factors on them. (2) Among the three types of urban blue-green space, the river-green space has the highest overall cooling and carbon-saving potential. The carbon-saving of the green space is better than the lake-green space but the cooling intensity of the green space is weaker. (3) The improved method of calculating "threshold value of efficiency" is more able to match the location of the inflexion points, and it can help planners obtain more accurate optimal blue-green space patch sizes. The contribution of this study is mainly in revealing the thermal sensitivity of the existence of cooling and carbon-saving functions under different background temperatures. The results of this study will serve as a tool for urban planners to configure the appropriate size and type of UBGS for different scenarios to achieve efficient cooling and carbon-saving in high-density by the urban blue-green space, which are in urgent need of smart growth strategies. • Three combinations of UBGS were selected to explore cooling and carbon-saving functions. • The model for estimating UBGS' carbon-saving by cooling was updated. • The carbon-saving efficiency thresholds are related to the background temperature. • The differences in the influencing factors of cooling and carbon-saving functions under different seasons are explored. • Optimization suggestions for the cooling and carbon-saving functions of three types of UBGS were proposed. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice.

Author

Wang, Hongcheng, Ming, Xin, Zhang, Shengnan, Chen, Ji, Liu, Xinli, Wu, Xiaoqing, Zhang, Shangrong, Zhang, Yunhai, Cui, Wei, Li, Wenyong, and Liu, Yong

Subjects
*SMALL nuclear RNA, *EMBRYOLOGY, *DNA damage, *CAENORHABDITIS elegans, *CELL cycle
Abstract

The target of EGR1 protein 1 (TOE1) is evolutionarily conserved from Caenorhabditis elegans to mammals, which plays a critical role in the maturation of a variety of small nuclear RNAs. Mutation in human TOE1 has been reported to cause pontocerebellar hypoplasia type 7, a severe neurodegenerative syndrome. However, the role of TOE1 in early embryonic development remains unclear. Herein, we found that Toe1 mRNA and protein were expressed in mouse preimplantation embryos. Silencing Toe1 by siRNA led to morula-to-blastocyst transition failure. This developmental arrest can be rescued by Toe1 mRNA microinjection. EdU incorporation assay showed a defect in blastomere proliferation within developmentally arrested embryos. Further studies revealed that Toe1 knockdown caused increased signals for γH2AX and micronuclei, indicative of sustained DNA damage. Moreover, mRNA levels of cell cycle inhibitor p21 were significantly upregulated in Toe1 knockdown embryos before developmental arrest. Together, these results suggest that TOE1 is indispensable for mouse early embryo development potentially through maintaining genomic integrity. Our findings provide further insight into the role of TOE1 in mouse preimplantation embryonic development. • The expression pattern of Toe1 and its role in early embryogenesis is characterized. • Loss of TOE1 suppresses proliferation and induces apoptosis. • Knockdown of Toe1 activates cell cycle inhibitor p21. • Silencing Toe1 triggers DNA damage. [ABSTRACT FROM AUTHOR]

Published
2022
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