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Two new oxidovanadium(V) complexes with formula [VOLL′], (L = L 1 = 2-ethyl-3-hydroxy-4H-pyran-4-one for 1 , L = L 2 = 2-methyl-3-hydroxy-4H-pyran-4-one for 2 , and L′ = (E)-N′-(2-hydroxy-3-methoxybenzylidene)pivalohydrazide) have been prepared. The complexes have been characterized by single crystal X-ray determination. The V atom in each complex is coordinated by the NOO donor atoms of L′ and the OO donor atoms of L, and one oxido group, forming octahedral coordination. The complexes were administered intragastrically to both normal and STZ-diabetic mices for two weeks. The biological activity results show that the complexes at doses of 10.0 and 5.0 mg V·kg −1 , can significantly decrease the blood glucose level in STZ-diabetic mices, but the blood glucose level in the treated normal mices was not altered. [ABSTRACT FROM AUTHOR]

Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental analysis, single crystal X-ray diffraction，UV/Vis and IR spectra. Complex 1 : [VOL1X] (H 2 L1 = (E)-N′-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL2(CH 3 O)(CH 3 OH)], (H 2 L2 = C 16 H 16 N 2 O 4 = (E)-N′-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CH 3 OH = methanol), Complex 3 : [VOL3X] (H 2 L3 = (E)-N′-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Both normal and streptozotocin (STZ)-diabetic mice were administered intragastrically for two weeks. It was found that the complexes at doses of 10.0 and 5.0 mg V·kg−1 can significantly decrease the blood glucose level in STZ-diabetic mice, and the blood glucose level in the treated normal mice was not altered. The lesions of kidney and liver caused by diabetes have varying degrees of improvement. Unlabelled Image • The complexes have fine insulin-like activity on streptozotocin diabetic mice. • The complexes have protective effects on the lesions of kidney and liver caused by diabetes. [ABSTRACT FROM AUTHOR]