1. Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives.
- Author
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Undare, Santosh S., Valekar, Navanath J., Patravale, Ajinkya A., Jamale, Dattatraya K., Vibhute, Sunil S., Walekar, Laxman S., Kolekar, Govind B., Deshmukh, M.B., and Anbhule, Prashant V.
- Subjects
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DRUG synthesis , *ANTI-inflammatory agents , *CYCLOOXYGENASES , *PYRIMIDINE derivatives , *CARRAGEENANS , *DICLOFENAC - Abstract
Objective of the present work was to evaluate the anti-inflammatory, ulcerogenicity and cyclooxygenase activity of indenopyrimidine derivatives. Anti-inflammatory activity of the tested compounds is investigated by carrageenan-induced rat paw edema assay. Compounds A1 , A6 , A7 and A12 exhibit the comparable anti-inflammatory activity (79.33–81.33%) to the standard drug diclofenac sodium (85.33%), while A6 , A7 , A9 , A12 and A14 show better ulcer index than the reference standard diclofenac sodium. To rationalize the anti-inflammatory activity, docking experiments are performed to study the ability of these compounds to bind into the active site of COX-2 enzyme. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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