1. Limiting factors for autologous transplantation among transplant-eligible multiple myeloma patients: Lesson from a Tertiary Cancer Centre in rural India.
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Nair, Chandran K., Selvaraj, Kalaiselvi, Raghavan, Vineetha, A, Manuprasad, Shenoy, Praveen Kumar, Kurup, Anju R., Duraisamy, Karthickeyan, Shringarpure, Kalpita, and Venugopal, Vinayagamoorthy
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AUTOTRANSPLANTATION , *MULTIPLE myeloma , *MIDDLE-income countries , *LOW-income countries , *PROGRESSION-free survival - Abstract
• Only 26% of transplant eligible Myeloma patients could undergo the procedure. • Most common reasons for no transplant were fear (47%) and financial (46%). • The transplanted group had better PFS compared against non-transplanted group. There is limited data from low and middle income countries on the exact proportion of Myeloma patients undergoing transplant even if they are eligible for the same. In this retrospective analysis of all newly diagnosed transplant eligible Myeloma treated between January 2011 to June 2017, number of patients undergoing transplant were recorded and among those not opting for transplant, reasons for the same were noted. Among 89 eligible patients, 23 (26%) patients could undergo transplantation. Most common reasons for not undergoing transplant were fear of the complications in 42 (47%) and financial reasons in 41 (46%) of patients. The transplanted group had better progression free survival when compared against the non-transplanted group (3 year PFS of 80% versus 36%, HR = 0.09, 95%CI 0.02–0.4, p = 0.001). Future studies may be conducted to arrive at measures, for correcting the transplant related concerns and fears, through psycho-social interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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