29 results on '"Vanjani, Nisheka"'
Search Results
2. The Current Status of Awake Endoscopic Surgery: A Systematic Review and Meta-Analysis.
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Jadczak, Caroline N., Vanjani, Nisheka N., Pawlowski, Hanna., Cha, Elliot D.K., Lynch, Conor P., Prabhu, Michael C., Hartman, Timothy J., Nie, James W., MacGregor, Keith R., Zheng, Eileen., Oyetayo, Omolabake O., and Singh, Kern.
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LOCAL anesthesia , *ENDOSCOPIC surgery , *SPINAL surgery , *CONSCIOUS sedation , *GENERAL anesthesia , *SATISFACTION , *CERVICAL vertebrae - Abstract
To examine the use of local anesthesia and/or conscious sedation in endoscopic spine procedures within the past decade. This systematic review abided by PRISMA guidelines. Embase, PubMed, Google Scholar, and Cochrane databases were searched for post-2011 articles with patients >18 years old, lumbar/cervical percutaneous endoscopic spine procedures using local/awake anesthesia, and patient/surgical outcomes. Reviews, book chapters, single case reports, or small case series (n ≤15 patients) were excluded. Scoring systems of the National Institutes of Health quality assessment tool, Newcastle-Ottawa Scale, and Cochrane Risk of Bias evaluated interventional case series, comparative studies, and randomized control trials, respectively. Twenty-six articles were included, with 4 studies comparing general and local anesthesia. Of 2113 total patients, 1873 patients received local anesthesia. Significant improvements were seen in pain and disability scores. Studies that included MacNab scores showed that 96% of patients rated their postoperative satisfaction as excellent to good. Subanalysis of comparative studies showed a reduced risk of surgical/major medical complications and a slight increased risk for minor medical complications among awake spine patients. Length of stay was shorter for patients receiving local anesthesia. The current systematic review and meta-analysis shows that use of local anesthesia is a safe and effective alternative to general anesthesia among different endoscopic spinal procedures. Although awake spine surgery is associated with a decreased risk of severe complications, lower revision rates, and higher postoperative satisfaction, more robust studies involving larger cohorts of patients are needed to evaluate the true impact of awake spine surgery on outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Comparing Patient-Reported Outcomes in Patients Undergoing Lumbar Fusion for Isthmic Spondylolisthesis with Predominant Back Pain versus Predominant Leg Pain Symptoms.
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Jacob, Kevin C., Patel, Madhav R., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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SPONDYLOLISTHESIS , *LEG pain , *BACKACHE , *SPINAL fusion , *PATIENT reported outcome measures , *SPINAL surgery , *SYMPTOMS , *VISUAL analog scale - Abstract
To compare patient-reported outcome measures (PROMs) and minimum clinically important difference (MCID) achievement following anterior or transforaminal lumbar interbody fusion for isthmic spondylolisthesis in patients presenting with predominant back pain versus predominant leg pain symptoms. A single-surgeon database was reviewed for anterior or transforaminal lumbar interbody fusion procedures for isthmic spondylolisthesis. Patient demographics, perioperative characteristics, postoperative complications, and PROMs were collected. Demographic/perioperative characteristics were compared among groups using χ2 and Student t tests for categorical and continuous variables, respectively. Mean PROM scores were compared using an unpaired Student t test. Postoperative improvement from preoperative baseline within each cohort was assessed with paired-samples t test. MCID achievement rates were compared with χ2 analysis. In total, 143 patients were included with 65 patients in the predominant back pain and 78 patients in the predominant leg pain cohort. Preoperative visual analog scale (VAS) leg was noted to be significantly greater in predominant leg pain cohort (P < 0.001). Cohorts demonstrated significant mean postoperative differences for the following PROMs at the following postoperative time points: significant differences were noted between cohorts for rate of achievement of MCID for the following PROMs at the following time points: VAS back at 2 years and VAS leg at 6 weeks/12 weeks/6 months/overall (P < 0.036, all). Compared with patients presenting for surgery with predominant leg pain symptoms, patients undergoing lumbar fusion at L4–L5 and L5–S1 for isthmic spondylolisthesis with predominant back pain symptoms may demonstrate improved long-term clinical outcomes for reported back pain, leg pain, and disability and reduced postoperative length of stay and narcotic consumption. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Severe Comorbidity Burden Does Not Influence Postoperative Clinical Outcomes and Trajectory for Back Pain, Leg Pain, Physical Function, or Disability in Patients Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion: Cohort-Matched Analysis
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Jacob, Kevin C., Patel, Madhav R., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., Park, Grant J., Collins, Andrew P., and Singh, Kern
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LEG pain , *PHYSICAL mobility , *BACKACHE , *SPINAL fusion , *PROPENSITY score matching , *VISUAL analog scale - Abstract
To compare perioperative outcomes, patient-reported outcome measures (PROMs), and minimum clinically important difference achievement after single-level transforaminal lumbar interbody fusion (TLIF) in patients stratified by preoperative comorbidity burden. PROMs were administered preoperatively/postoperatively and included Patient-Reported Outcomes Measurement Information System–Physical Function (PROMIS-PF), visual analog scale (VAS), Oswestry Disability Index (ODI), and 12-Item Short-Form Physical Composite Score (SF-12 PCS). Patients were grouped according to preoperative Charlson Comorbidity Index (CCI) <5 (mild to moderate comorbidity) or preoperative CCI ≥5 (severe preoperative comorbidity). A 3:1 propensity score match for age, gender, insurance status, smoking status, and preoperative spinal disease was used to control for significant demographic differences between cohorts. After propensity score matching, 255 patients were included (135 in the CCI <5 cohort; 120 in the CCI ≥5 cohort). The CCI ≥5 cohort showed significantly reduced postoperative VAS back pain score on the day of surgery (P < 0.001, all). Mean PROM differences were noted for postoperative PROMs: VAS back and ODI 6 months, both instances favoring the CCI ≥5 cohort (P < 0.038). The CCI <5 cohort improved from baseline to 1 year for all postoperative PROMs except SF-12 PCS 6 weeks and 12 weeks and SF-12 Mental Composite Score 6 weeks (P < 0.034, all). The CCI ≥5 cohort reported significant improvement from preoperative baseline to 1 year for all postoperative PROMs except ODI 6 weeks, SF-12 Mental Composite Score 6 weeks and 1 year, SF-12 PCS 6 weeks, and PROMIS-PF 6 weeks (P < 0.017, all). Both cohorts reported >50% overall minimum clinically important difference achievement rate for VAS leg, VAS back, ODI, SF-12 PCS, and PROMIS-PF. The results suggest that patients undergoing MIS TLIF with severe comorbidities can expect a similar postoperative trajectory for disability, leg and back pain, and physical function. However, long-term (1 year) mental health improvement from preoperative baseline was noted only in the mild to moderate comorbidity group. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Does an Author's Social Media Presence Affect Dissemination of Spine Literature?
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Patel, Madhav R., Jacob, Kevin C., Vanjani, Nisheka N., Prabhu, Michael C., Lynch, Conor P., Cha, Elliot D.K., Pawlowski, Hanna, Rush III, Augustus J., and Singh, Kern
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SOCIAL media , *SPINE , *DESCRIPTIVE statistics - Abstract
Our study assesses the impact of an author's social media presence on citation rates and readership of spine literature. The Altmetric database was queried for spine-related articles between 2016 and 2021; the top 100 by Altmetric Attention Score (AAS) were assessed. Public profile presence, number of followers, number of posts, and promotion of articles were assessed for Twitter/Instagram. Social media profiles were identified by searching for the author's name followed by "Twitter" or "Instagram" on Google.com or searching each platform. Descriptive statistics assessed social media use and attention metrics. Negative binomial regression assessed presence/promotion/number of followers/number of posts on Twitter/Instagram as predictors of Dimensions citation rates/AAS/Mendeley reader counts, while accounting for time passed since publication. Twitter promotion was noted for 9.0% of articles and Instagram promotion for 1.0%. Mean number of Twitter and Instagram followers was 447.9 ± 1406.1(range: 0–9079) and 173.2 ± 1097.1(range: 0:10,700), respectively. Mean number of Twitter and Instagram posts was 411.6 ± 1210.5 and 18.4 ± 96.4, respectively. Dimensions citations ranged from 0–641, AAS from 79–2257, and Mendeley readers from 2–1854. Following negative binomial regression, Instagram presence was identified as a significant predictor of Mendeley readers (P = 0.043), number of Twitter posts was a significant predictor of AAS (P = 0.008). Additionally, Twitter presence was identified as a negative predictor of Mendeley readers (P = 0.005) and Twitter promotion was identified as a negative predictor of AAS (P = 0.003). Activity on Twitter and Instagram may have variable associations with altmetrics of literature visibility and readership but with citation rates. Interestingly, presence/promotion on Twitter predicted less attention/readership, while Instagram presence predicted higher Mendeley readership. [ABSTRACT FROM AUTHOR]
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- 2022
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6. P137. Preliminary analysis on the influence of workers' compensation status on outcomes of anterior lumbar interbody fusion at L5-S1.
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Patel, Madhav, Jacob, Kevin, Vanjani, Nisheka, Pawlowski, Hanna, Prabhu, Michael, and Singh, Kern
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WORKERS' compensation , *PATIENT reported outcome measures , *SPINAL fusion , *VISUAL analog scale , *POSTOPERATIVE period , *HISPANIC Americans - Abstract
Few studies have focused on outcomes among Workers' Compensation (WC) claimants undergoing anterior lumbar interbody fusion (ALIF). To determine the influence of WC on perioperative outcomes, patient-reported outcome measures (PROMs) and attainment rates of minimal clinically important difference (MCID) among patients undergoing single-level ALIF at L5S1. Retrospective. A retrospective surgical database of an attending spine surgeon was utilized to identify patients with WC insurance undergoing single-level ALIF at L5S1. One-hundred and nine patients were included, with 82 in the non-WC and 27 in the WC cohort. PROM data for visual analog scale (VAS) back/leg, Oswestry Disability Index (ODI), 12-Item Short Form (SF-12) Physical Composite Score (PCS) and Patient Reported Outcome Measurement Information System physical function (PROMIS-PF) was obtained preoperatively and at 6-weeks, 12-weeks, 6-months, 1-year and 2-years following ALIF. Patients were divided into groups based on insurance status: WC vs non-WC (including patients with private insurance or Medicare/Medicaid). Demographic and perioperative information was evaluated between insurance groups using student's t-test for independent samples for continuous variables and chi-squared test for categorical variables. Mean PROMs were compared with student's t-test for independent samples. Comparisons of preoperative and postoperative PROM values were evaluated with paired sample t-tests. Patients who achieved an improvement in PROM score greater than or equal to established threshold values were marked as achieving MCID. WC and non-WC groups were compared in MCID attainment rates across PROMs with chi-squared analyses. A greater proportion of the non-WC cohort were Caucasian, while a significantly greater proportion of the WC cohort were African American and Hispanic (p=0.001). Significantly more patients in the WC cohort were smokers (p<0.001). Non-WC patients improved significantly from preoperative to postoperative timepoints of 6-months through 2-years for PROMIS-PF and SF-12 PCS, 6 weeks through 1 year for VAS back, 6 months/1 year for VAS leg and 12 weeks through 1-year for ODI (p≤0.048, all). WC patients improved significantly at postoperative timepoints for PROMIS-PF at 6 weeks (p=0.029), SF-12 PCS at 12 weeks (p=0.018), VAS back from 6 weeks to 6 months, and VAS leg at 6 months, only (p≤0.029, all). Mean VAS back scores were significantly greater in the WC cohort at 6 months and 1 year (p≤0.013, both), mean VAS leg scores were significantly greater in the WC cohort at 1 year (p=0.029), and mean ODI scores were significantly higher in the WC cohort at preoperative through 1 year (p≤0.040, all). With the exception of higher MCID achievement for VAS back at 12 weeks (p=0.037), no other differences in attainment rates were observed for any PROM at any time point or for the overall postoperative period. Among patients receiving ALIF, WC insurance was more prevalent among patients identifying as Hispanic and African American, along with smokers. While physical function scores were similar between groups, long-term pain and disability (throughout the entire postoperative period) were significantly higher among patients with WC. MCID achievement, however, was largely comparable for all PROMs between WC and non-WC study groups. This abstract does not discuss or include any applicable devices or drugs. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Minimally Invasive Transforaminal versus Anterior Lumbar Interbody Fusion in Patients Undergoing Revision Fusion: Clinical Outcome Comparison.
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Nie, James W., Hartman, Timothy J., Jacob, Kevin C., Patel, Madhav R., Vanjani, Nisheka N., MacGregor, Keith R., Oyetayo, Omolabake O., Zheng, Eileen, and Singh, Kern
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SPINAL fusion , *PATIENT reported outcome measures , *VISUAL analog scale , *TREATMENT effectiveness , *PHYSICAL mobility , *LEG pain - Abstract
We aim to compare perioperative/postoperative clinical outcomes between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and anterior lumbar interbody fusion (ALIF) in patients presenting for revision surgery. A retrospective database was reviewed for procedures between November 2005 and December 2021. Revision MIS-TLIF/ALIFs were included, whereas primary fusions or diagnosis of infection/malignancy/trauma were excluded. Patients were grouped into MIS-TLIF/ALIF cohorts. Preoperatively/postoperatively collected patient-reported outcome measures (PROMs) included visual analog scale back/leg score, Oswestry Disability Index, Patient-Reported Outcome Measurement Information System–Physical Function (PROMIS-PF), and Short-Form 12-Item Survey Mental/Physical Composite Scores. A total of 164 patients were eligible, with 84 patients in the MIS-TLIF cohort. The presence of degenerative spondylolisthesis and central stenosis, narcotic consumption on postoperative day 0/1, and postoperative urinary retention rates was greater in the MIS-TLIF cohort (P ≤ 0.036, all). Preoperative PROMs between cohorts did not significantly differ. Significantly favorable postoperative PROM scores were shown in the MIS-TLIF cohort with PROMIS-PF at 12 weeks/6 months (P ≤ 0.033, all). Most patients in both cohorts achieved overall minimum clinically important difference for visual analog scale back/leg score, Oswestry Disability Index, Short-Form 12-Item Survey Physical Composite Score, and PROMIS-PF. No differences were noted between cohorts within rates of MCID achievement. Patients undergoing revision fusion via MIS-TLIF or ALIF reported similar 1-year postoperative mean outcomes and rates of meaningful clinical achievement for physical function, mental health, disability, and back/leg pain. However, patients undergoing revision MIS-TLIF reported improved physical function at 12 weeks and 6 months. Perioperatively, patients undergoing revision MIS-TLIF were noted to consume significantly greater quantities of narcotics. [ABSTRACT FROM AUTHOR]
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- 2022
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8. The Effect of the Severity of Preoperative Leg Pain on Patient-Reported Outcomes, Minimum Clinically Important Difference Achievement, and Patient Satisfaction After Minimally Invasive Transforaminal Lumbar Interbody Fusion.
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Jacob, Kevin C., Patel, Madhav R., Collins, Andrew P., Parsons, Alexander W., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, and Singh, Kern
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PATIENT satisfaction , *LEG pain , *PATIENT reported outcome measures , *SPONDYLOLISTHESIS , *VISUAL analog scale , *EPIDURAL injections , *SATISFACTION , *SPINAL fusion - Abstract
To compare patient-reported outcome measures (PROMs), satisfaction, and minimum clinically important difference (MCID) achievement after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in patients stratified by preoperative leg pain. Patients undergoing MIS-TLIF were collected through retrospective review of a prospectively maintained single-surgeon database. PROMs administered preoperatively/postoperatively included Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF), visual analog scale (VAS) back/leg pain, Oswestry Disability Index (ODI), and 12-Item Short Form (SF-12) Physical/Mental Component Score (PCS/MCS). Patients were grouped based on preoperative VAS leg scores: VAS leg ≤7 or VAS leg >7. Inferential statistics were used to compare PROMs, MCID achievement rates, and postoperative satisfaction between groups. A total of 562 patients were eligible (168 VAS leg score ≤7; 394 VAS leg score >7). Significant differences between cohorts in postoperative mean PROMs were noted for PROMIS-PF at 6 weeks/2 years, SF-12 PCS at 6 weeks/2 years, SF-12 MCS at 6 weeks/12 weeks/6 months/1 year, VAS back score at 6 weeks/12 weeks/6 months, VAS leg score at 6 weeks/12 weeks/6 months/2 years and ODI at all postoperative time points (P < 0.045, all). In the VAS leg score >7 cohort, a greater proportion achieving MCID for VAS leg score at all postoperative time points and ODI at 12 weeks (P < 0.010, all). Postoperative satisfaction was greater in VAS back score ≤7 cohort for VAS leg score at 6 weeks/12 weeks/6 months/2 years, VAS back score at 12 weeks/2 years, and ODI at 6 weeks/12 weeks/6 months/2 years (P < 0.046, all). Patients with severe preoperative leg pain showed worse postoperative PROM scores and patient satisfaction for disability and back/leg pain. MCID achievement rates across cohorts were similar. Patients with severe leg pain may have expectations for surgical benefits incongruent with their postoperative outcomes, and physicians may seek to manage the preoperative expectations of their patients to reflect likely outcomes after MIS-TLIF. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Impact of Ambulatory Setting for Workers' Compensation Patients Undergoing One-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion and Review of the Literature.
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Nie, James W., Hartman, Timothy J., Pawlowski, Hanna, Prabhu, Michael C., Vanjani, Nisheka N., Oyetayo, Omolabake O., and Singh, Kern
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WORKERS' compensation , *PATIENT reported outcome measures , *VISUAL analog scale , *LITERATURE reviews , *PROPENSITY score matching , *BACK exercises , *AMBULATORY surgery - Abstract
To compare perioperative characteristics and patient-reported outcome measures (PROMs) in workers' compensation (WC) patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in either the inpatient/outpatient setting. Patients with WC undergoing 1-level MIS-TLIF were included. Patients were separated into inpatient/outpatient groups and demographically propensity score matched. PROMs included visual analog scale (VAS) back/VAS leg/Oswestry Disability Index (ODI)/12-item Short Form Physical Composite Score (SF-12 PCS)/Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF) preoperatively and 6 weeks, 12 weeks, 6 months, and 1 year postoperatively. Results were compared preoperatively and postoperatively and between cohorts. Minimum clinically important difference (MCID) achievement was determined through comparison with values established in the literature. A total of 216 patients were included (184 inpatient). The inpatient cohort (IC) showed worse perioperative outcomes in multiple measures (P < 0.034; all). The IC improved in all PROMs (P < 0.038; all), besides ODI at 6 weeks, SF-12 PCS at 6 weeks/6 months/1 year, and PROMIS-PF at 6 weeks. The outpatient cohort (OC) improved in VAS back at all time points and VAS leg at 6 months (P < 0.033; all). Between cohorts, the OC showed better scores with VAS leg/ODI/SF-12 PCS/PROMIS-PF at multiple time points (P < 0.031; all). Most of the IC achieved MCID, aside from ODI, whereas the OC achieved MCID in SF-12 PCS. MCID achievement between cohorts was higher in the IC at PROMIS-PF at 1 year and VAS back overall (P < 0.034; all). Despite more comorbidities and worse perioperative measures, the IC showed improved PROMs from preoperative to ≥1 follow-up visit, whereas the OC had improvement with only VAS back and leg. The IC showed multiple MCID achievements, whereas the OC showed MCID in only SF-12 PCS. These findings may help guide a surgeon's decision making between inpatient/outpatient lumbar surgery in the WC population. [ABSTRACT FROM AUTHOR]
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- 2022
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10. The Effect of the Preoperative Severity of Neck Pain on Patient-Reported Outcome Measures and Minimum Clinically Important Difference Achievement After Anterior Cervical Discectomy and Fusion.
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Patel, Madhav R., Jacob, Kevin C., Nie, James W., Hartman, Timothy J., Vanjani, Nisheka, Pawlowski, Hanna, Prabhu, Michael, Amin, Kanhai S., and Singh, Kern
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PATIENT reported outcome measures , *NECK pain , *DISCECTOMY , *VISUAL analog scale , *PHYSICAL mobility , *EDUCATIONAL attainment , *LONGITUDINAL ligaments , *NECK muscles - Abstract
To compare patient-reported outcome measure (PROM) scores and minimum clinically important difference (MCID) achievement rates among patients undergoing single-level anterior cervical discectomy and fusion (ACDF) in patients with varying severity of preoperative visual analog scale (VAS) neck score. Patients with ACDF were grouped: severity of preoperative VAS neck score ≤8 or >8. Demographic/perioperative variables and PROMs (Patient-Reported Outcomes Measurement Information System Physical Function [PROMIS PF] score, 12-Item Short Form [SF-12] Mental Component Score [MCS], VAS neck/arm score, and Neck Disability Index [NDI]) were collected preoperatively/postoperatively. MCID attainment comparison by grouping was evaluated using χ2 analysis. A total of 137 patients were included (103 VAS neck preoperative score ≤8; 34 VAS neck preoperative score >8). The VAS neck preoperative score ≤8 cohort did not improve: 6 weeks PROMIS-PF score, 6 weeks SF-12 Physical Component Score [PCS], 12 weeks/1 year/2 years SF-12 MCS, 2 years VAS neck score, and 1 years/2 years VAS arm score (P ≤ 0.015, all). VAS neck preoperative score >8 did not improve: 6 weeks/12 weeks/2 years PROMIS-PF score, all time points SF-12 PCS, 6 weeks/12 weeks/1 year/2 years SF-12 MCS, and 2 years VAS arm score (P ≤ 0.013, all). VAS neck preoperative score >8 had inferior PROMIS-PF scores all time points except 1 year (P ≤ 0.036, all), lower SF-12 PCS 6 weeks/6 months (P ≤ 0.043, both), inferior SF-12 MCS at preoperative to 6 months (P ≤ 006, all), higher VAS neck score from preoperative to 6 months (P ≤ 0.018), higher VAS arm score preoperative/12 weeks/6 months (P ≤ 0.020, all), and higher NDI at preoperative/12 weeks/6 months (P ≤ 0.030, all). MCID attainment rates for VAS neck preoperative score >8 were greater for NDI 2 years (P = 0.040), lower for PROMIS-PF score 2 years, and overall (P = 0.018), lower for SF-12 MCS 12 weeks (P = 0.046), lower for VAS neck score 12 weeks to 1 year and overall (P ≤ 0.032, all), and lower for VAS arm score 6 weeks/1 year (P ≤ 0.030, both). Patients with single-level ACDF presenting with greater baseline neck pain showed poorer physical function/pain/disability/mental health at preoperative/intermediate postoperative time points, but had comparable long-term PROMs by 2 years. MCID attainment was lower among patients with greater preoperative neck pain; MCID among the VAS neck score >8 cohort were only significantly inferior for neck pain. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Patient Satisfaction Following Lumbar Decompression: What is the Role of Mental Health?
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Patel, Madhav R., Jacob, Kevin C., Hartman, Timothy J., Nie, James W., Shah, Vivek P., Chavez, Frank A., Vanjani, Nisheka N., Lynch, Conor P., Cha, Elliot D.K., Prabhu, Michael C., Pawlowski, Hanna, and Singh, Kern
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PATIENT satisfaction , *PATIENTS' attitudes , *LEG pain , *MENTAL health , *PATIENT reported outcome measures , *ONE-way analysis of variance - Abstract
To determine the association between patient-reported depressive symptoms and patient satisfaction following minimally invasive lumbar decompression. Primary, single-level/multilevel minimally invasive lumbar decompression was identified. Patient-reported outcome measures (PROMs) collected preoperatively/postoperatively included visual analog scale back/leg, Oswestry Disability Index, 9-Item Patient Health Questionnaire (PHQ-9), and 12-Item Short Form Mental Composite Score (SF-12 MCS). Patients rated current satisfaction level (0–10) with back/leg pain and disability. A paired Student's t-test compared each postoperative PROM score to its preoperative baseline. At each timepoint, patients were categorized by PHQ-9 and SF-12 MCS scores. One-way analysis of variance compared patient satisfaction with back/leg pain and disability among PHQ-9 subgroups. The Student's t-test for independent samples compared patient satisfaction between SF-12 MCS subgroups. Analysis of covariance (ANCOVA) assessed differences in satisfaction between depression subgroups while controlling for preoperative/postoperative values in corresponding PROMs. 193 patients were included. All PROMs demonstrated significant postoperative improvement from 6-weeks through 2-years (P < 0.001, all), except PHQ at 9 2-years (P = 0.874). Mean satisfaction scores ranged from 6.9–7.9 (back pain), 7.3–8.0 (leg pain), and 7.6–8.0 (disability). Satisfaction with back/leg pain and disability significantly differed among PHQ-9 subgroups at all postoperative timepoints (P < 0.001, all). Accounting for baseline and current pain/disability values, ANCOVA revealed differences between PHQ-9 subgroups only in satisfaction with back pain at 2 years (P < 0.001), leg pain at 12 weeks/1 year/2 years (P ≤ 0.047, all), and disability at 6 months/2 years (P ≤ 0.049, both). Satisfaction differed between SF-12 MCS subgroups at all timepoints (P ≤ 0.047), except back pain 6 months (P = 0.263). Accounting for baseline and postoperative pain/disability, ANCOVA revealed differences in satisfaction between SF-12 MCS groups only for back/leg pain at 2 years (P ≤ 0.001, both). Independent effect of depression at long-term follow-up was significant. This highlights the importance of understanding the interaction between physical and mental health outcomes to optimize patients' perceptions of surgical outcomes. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Presenting Mental Health Influences Postoperative Clinical Trajectory and Long-Term Patient Satisfaction After Lumbar Decompression.
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Jacob, Kevin C., Patel, Madhav R., Nie, James W., Hartman, Timothy J., Ribot, Max A., Parsons, Alexander W., Pawlowski, Hanna, Prabhu, Michael C., Vanjani, Nisheka N., and Singh, Kern
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PATIENT satisfaction , *MENTAL health , *VISUAL analog scale , *MINIMALLY invasive procedures , *PHYSICAL mobility , *BACK exercises , *SPINAL surgery - Abstract
To compare patient-reported outcomes (PROMs), postoperative patient-reported satisfaction, and minimum clinically important difference (MCID) achievement after minimally invasive surgery lumbar decompression (MIS-LD) in patients stratified by their preoperative 12-Item Short-Form Mental Component Score (SF-12 MCS). Patients who underwent single-level/multilevel MIS-LD were included. PROMs were administered preoperatively and 6 weeks/12 weeks/6 months/1 year postoperatively. Patients were grouped by preoperative SF-12 MCS. Demographic/perioperative characteristics were compared among groups using a χ2 and Student t test for categorical and continuous variables, respectively. Mean PROM and postoperative satisfaction scores were compared using an unpaired Student t test. PROM improvement within cohorts was assessed with paired-samples t test. MCID achievement rates were compared using χ2 analysis. A total of 297 patients were included: 111 patients in SF-12 MCS <48.9 and 186 patients in the SF-12 MCS ≥48.9 cohort. Cohorts showed mean postoperative differences for visual analog scale (VAS) back score at 12 weeks, VAS leg score at 6 weeks/12 weeks, Oswestry Disability Index (ODI) at 6 weeks/12 weeks, SF-12 MCS at all postoperative time points, and 12-Item Short-Form Physical Component Score at 6 weeks/12 weeks (P < 0.022, all). Of patients in the SF-12 MCS <48.9 cohort, more achieved MCID for SF-12 MCS at all postoperative time points and ODI at 1 year (P < 0.023, all). More patients in the SF-12 MCS ≥48.9 cohort achieved MCID for VAS leg score at 12 weeks and 12-Item Short-Form Physical Component Score at 6 weeks (P < 0.038). Patients in the SF-12 MCS <48.9 cohort showed inferior postoperative satisfaction for VAS leg score at 6 weeks/12 weeks/1 year, VAS back score at 12 weeks, and ODI at all postoperative time points. Patients with inferior mental health preoperatively showed worse mean short-term postoperative clinical outcome for leg/back pain, physical function and disability, short-term and long-term postoperative satisfaction for leg pain and disability, and long-term satisfaction for sleeping/lifting/walking/standing/sex/travel. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Lateral Lumbar Interbody Fusion: Single Surgeon Learning Curve.
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Jacob, Kevin C., Patel, Madhav R., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, Munim, Mohammed A., and Singh, Kern
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FEMORAL nerve , *SPINAL fusion , *PHYSICAL mobility , *MUSCLE strength , *ILIOPSOAS muscle , *LEG pain , *MUSCLE strength testing , *BACKACHE - Abstract
To characterize lateral lumbar interbody fusion surgical learning curve and investigate changes in perioperative and postoperative clinical parameters associated with increased operative experience. In a case series, surgical learning curve was defined using 3-parameter asymptotic regression and piecewise linear regression, yielding learning phase (patients 1–53) and proficient phase (patients 54–179) cohorts. Using a 5-point grading scale, ipsilateral iliopsoas (hip-flexion) and quadriceps (knee-extension) muscle strength and thigh and groin sensory disturbances were compared for differences preoperatively versus postoperatively using χ2 test. Patient-reported outcome measures were collected preoperatively and postoperatively and compared between cohorts with unpaired t test. The proficient phase cohort demonstrated significantly reduced operative time, estimated blood loss, postoperative length of stay, and narcotic consumption on postoperative days 0 and 1. The proficient phase cohort displayed decreased disability at 6 weeks and 6 months and demonstrated significant improvement at all time points for disability, pain, and physical function except for 6 weeks and 2 years for physical function, whereas the learning phase cohort demonstrated improvement in disability beginning at 6 months, leg pain at all time points, and back pain through 6 months. Ipsilateral groin and thigh sensory disturbances and iliopsoas and quadriceps weakness improved with increasing operative experience. The proficient phase cohort demonstrated significantly improved perioperative profile, reduced complication rate, and reduced rates of iliopsoas and quadriceps weakness. While the proficient phase cohort demonstrated earlier improvement in disability and physical function scores compared with the learning phase cohort, 2-year outcome measures did not differ. Long-term clinical outcomes suggest that patient safety and quality of life are not compromised during the learning phase, but patients may be particularly susceptible to femoral nerve injury early in a surgeon's practice. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Obesity and Workers' Compensation in the Setting of Minimally Invasive Lumbar Decompression.
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Patel, Madhav R., Jacob, Kevin C., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, Amin, Kanhai, and Singh, Kern
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WORKERS' compensation , *SURGICAL decompression , *VISUAL analog scale , *NUCLEUS pulposus , *BODY mass index , *OBESITY - Abstract
To investigate the influence of body mass index (BMI) on perioperative outcomes, postoperative patient-reported outcome measures (PROMs), and minimal clinically important difference (MCID) achievement among workers' compensation (WC) claimants undergoing minimally invasive lumbar decompression (MIS-LD). WC patients diagnosed with herniated nucleus pulposus undergoing single-level MIS-LD were identified. Patients were divided into 3 groups: Non-obese (<30 kg/m2), Obese I (≥30 and <35 kg/m2), and Obese II/III (≥35 kg/m2). PROMs were collected preoperatively and at 6 weeks, 12 weeks, 6 months, 1 year, and 2 years postoperatively. The predictive influence of BMI grouping on mean PROM scores was computed using simple linear regression. To compare PROMs between groups, post hoc pairwise comparisons of adjusted means were utilized. MCID achievement was compared between groups with χ2 analysis. A total of 81 patients were in the Non-obese cohort, and 43 and 45 in the Obese I and Obese II/III cohorts, respectively. Visual analog scale (VAS) leg, Oswestry Disability Index (ODI), and 12-Item Short Form Physical Composite Score (SF-12 PCS) were worse in the Obese I cohort at 12 weeks, and SF-12 PCS was lower in the Obese I vs. Obese II/III subgroup analysis (P ≤ 0.045, all). MCID achievement rates for ODI were higher for the Non-obese group at 12 weeks and overall (P ≤ 0.049, both). MCID attainment for VAS back was higher among the Non-obese cohort at 6-weeks (P = 0.022). Patients with higher levels of obesity were more likely to experience longer length of stay and delayed discharge following MIS-LD. Increasing BMI was generally not a significant predictor of postoperative pain, disability, or physical health PROMs at most timepoints. MCID achievement rates for disability relief were significantly higher for non-obese patients. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Systematic Review: Applications of Intraoperative Ultrasonography in Spinal Surgery.
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Patel, Madhav R., Jacob, Kevin C., Parsons, Alexander W., Chavez, Frank A., Ribot, Max A., Munim, Mohammed A., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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SPINAL surgery , *OPERATIVE ultrasonography , *INTERVERTEBRAL disk , *FLUOROSCOPY , *NERVE tissue , *STATISTICAL power analysis , *DATABASE searching - Abstract
As a result of increased practicality and decreased costs and radiation, interest has increased in intraoperative ultrasonography (iUS) in spinal surgery applications; however, few studies have provided a robust overview of its use in spinal surgery. We synthesize findings of existing literature on use of iUS in navigation, pedicle screw placement, and identification of anatomy during spinal interventions. PRISMA guidelines were used in this systematic review. Studies were identified through PubMed, Scopus, and Google Scholar databases using the search string. Abstracts mentioning iUS in spine applications were included. On full-text review, exclusion criteria were implemented, including outdated studies or those with weak topic relevance or statistical power. On elimination of duplicates, multireviewer screening for eligibility, and citation search, 44 articles were analyzed. Navigation using iUS is safe, effective, and economical. iUS registration accuracy and success are within clinically acceptable limits for image-guided navigation. Pedicle screw instrumentation with iUS is precise, with a favorable safety profile. Anatomic landmarks are reliably identified with iUS, and surgeons are overwhelmingly successful in neural or vascular tissue identification with iUS modalities, including standard B mode, Doppler, and contrast-enhanced ultrasonography. iUS use in traumatic reduction of fractures properly identifies anatomic structures, intervertebral disc space, and vasculature. iUS eliminates radiation, decreases costs, and provides sufficient accuracy and reliability in identification of anatomic and neurovascular structures in various spinal surgery settings. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Neck Disability at Presentation Influences Long-Term Clinical Improvement for Neck Pain, Arm Pain, Disability, and Physical Function in Patients Undergoing Anterior Cervical Discectomy and Fusion.
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Jacob, Kevin C., Patel, Madhav R., Ribot, Max A., Pawlowski, Hanna, Prabhu, Michael C., Vanjani, Nisheka N., Collins, Andrew P., and Singh, Kern
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NECK pain , *PHYSICAL mobility , *BLOOD loss estimation , *PATIENT reported outcome measures , *DISCECTOMY , *VISUAL analog scale - Abstract
To compare perioperative characteristics, patient-reported outcome measures (PROMs) and minimum clinically important difference (MCID) achievement after anterior cervical discectomy and fusion (ACDF) in patients stratified by preoperative neck disability. The Neck Disability Index (NDI) assesses a patient's self-perceived neck disability and is often used to assess the efficacy of cervical surgical intervention. Our study (a retrospective cohort study) evaluates how preoperative severity of patient neck disability influences postoperative clinical improvement after ACDF. Primary, single-level, or multilevel ACDF procedures were included. PROMs were administered at preoperative/6 week/12 week/6 month/1 year/2 year time points and included Patient-Reported Outcome Measurement Information System–Physical Function (PROMIS-PF), visual analog scale (VAS) for neck and arm pain, NDI, and 12-Item Short-Form (SF-12) Physical Composite Score (PCS). Patients were grouped according to preoperative NDI <50 (mild to moderate neck disability) or NDI ≥50 (severe neck disability). Demographics/perioperative characteristics/postoperative complications/mean PROMs/MCID achievement rates were compared using χ2 or Student t test. Postoperative improvement from preoperative baseline within each cohort was assessed with paired-samples t test. MCID achievement was determined by comparing ΔPROMs with established thresholds. A total of 225 patients were included, 150 NDI <50 and 75 NDI ≥50. The NDI ≥50 cohort was significantly younger (P = 0.002). Cohorts did not differ for spinal disease/operative duration/estimated blood loss/postoperative length of stay/postoperative narcotic consumption/adjacent segment disease rate/1-year arthrodesis rate/6-month pseudarthrosis rate. Postoperative VAS pain score on postoperative day 0 and 1 was significantly increased in the NDI ≥50 cohort (P < 0.048, all). Postoperative complication rates did not differ. All mean PROMs differed at all time points (P < 0.043, all). The NDI <50 patient cohort significantly improved from preoperative baseline for all PROMs and time points except SF-12 PCS/Patient-Reported Outcome Measurement Information System–Physical Function at 6 weeks. The NDI ≥50 cohort significantly improved for all PROMs and time points except SF-12 PCS at 6 weeks. The NDI ≥50 cohort showed a greater proportion achieving MCID for NDI at 6 weeks/2 years/overall (P < 0.037, all). Both cohorts showed significant long-term clinical improvement for neck pain/arm pain/physical function/neck disability, although patients with severe preoperative neck disability reported inferior mean scores for these outcomes at all time points. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Meeting Patient Expectations and Achieving a Minimal Clinically Important Difference for Back Disability, Back Pain, and Leg Pain May Provide Predictive Utility for Achieving Patient Satisfaction Among Lumbar Decompression Patients.
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Jacob, Kevin C., Patel, Madhav R., Collins, Andrew P., Park, Grant J., Vanjani, Nisheka N., Prabhu, Michael C., Pawlowski, Hanna, Parsons, Alexander W., and Singh, Kern
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PATIENT satisfaction , *LEG pain , *BACKACHE , *SURGICAL decompression , *SPINAL surgery , *PEARSON correlation (Statistics) , *EXPECTATION (Psychology) - Abstract
Our study evaluates minimum clinically important difference (MCID) achievement for back pain/leg pain/disability and meeting preoperative expectations as predictors of patient satisfaction after minimally invasive lumbar decompression (MIS-LD) surgery. Single/multilevel MIS-LD procedures were identified. Patient-reported outcome measures (preoperative/postoperative), expectations (preoperative), and satisfaction (postoperative) were collected for visual analog scale (VAS) back/VAS leg/Oswestry Disability Index (ODI). Student's t -test assessed patient-reported outcome measure improvement from preoperative baseline. Correlations between outcome and satisfaction scores were evaluated using the Pearson correlation coefficient and categorized according to strength of relationship. MCID achievement and meeting expectations were evaluated as predictors of postoperative patient satisfaction with simple linear regression. Comparison of meeting expectations or achieving MCID as predictors of satisfaction scores was performed using a post hoc Suest test comparison of standardized β-coefficients. A total of 329 patients were included. All outcomes improved from baselines (P < 0.001, all) at all postoperative time points and demonstrated strong and negative correlations with satisfaction scores (P < 0.001, all). Majority of patients had their expectations met for ODI/VAS back/VAS leg and achieved MCID for ODI/VAS back/VAS leg at all time points and overall. Both MCID achievement and meeting preoperative expectations demonstrated significant associations with satisfaction scores at all time points for ODI/VAS back/VAS leg. Post hoc analysis of predictors of patient satisfaction in pain and disability demonstrated that MCID achievement was an equivalent predictor to meeting patient preoperative expectations at all postoperative time points. Pain/disability improved after MIS-LD; improvement was strongly correlated with postoperative satisfaction. Meeting expectations/MCID achievement is associated with satisfaction. MCID achievement was equivalent to meeting expectations in predicting satisfaction at all postoperative time points for pain/disability. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Mental Health as a Predictor of Preoperative Expectations for Pain and Disability Following Lumbar Fusion.
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Jacob, Kevin C., Patel, Madhav R., Park, Grant J., Cha, Elliot D.K., Lynch, Conor P., Collins, Andrew P., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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LEG pain , *MENTAL health , *VETERANS , *EXPECTATION (Psychology) , *DISABILITIES , *BACKACHE , *VISUAL analog scale - Abstract
To evaluate impact of preoperative mental health on expectations in patients undergoing transforaminal, anterior, or lateral lumbar interbody fusion. Demographics, perioperative characteristics, duration of preoperative symptoms, and preoperative mental health scores were collected. Pain and disability were recorded using preoperative visual analog scale (VAS) for back and leg pain and Oswestry Disability Index scores. Patients' expectations were recorded. Preoperative mental health was recorded using Patient Health Questionnaire-9 (PHQ-9), 12-Item Short Form Health Survey (SF-12) mental component score (MCS), and Veterans RAND 12-Item Health Survey (VR-12) MCS. PHQ-9 scores were categorized by severity of depressive symptoms. Simple linear regression evaluated impact of preoperative mental health on patient expectations for pain and disability; multiple linear regression evaluated the same while accounting for preoperative scores. In 181 patients, PHQ-9 and increasing severity of depressive symptoms significantly predicted VAS back pain expectations (P ≤ 0.006); significance was lost after accounting for preoperative VAS back pain. All mental health outcomes significantly predicted VAS leg pain expectations (P ≤ 0.040); only PHQ-9 retained significance after accounting for preoperative VAS leg pain. All mental health scores significantly predicted ODI expectations (P < 0.001); none retained significance after accounting for preoperative ODI. PHQ-9, SF-12, and VR-12 significantly predicted all ODI domains except personal care and pain intensity (P ≤ 0.045). PHQ-9 significantly predicted patient expectations for lifting, walking, standing, sleeping, sex life, and social life. SF-12 MCS significantly predicted expectations for lifting, walking, standing, sleeping, and social life after accounting for preoperative domain scores. VR-12 MCS significantly predicted expectations for lifting, walking, standing, sleeping, sex life, and social life (P ≤0.050, all), even after accounting for preoperative scores. Mental health scores impact expectations regarding improvement in more active areas of a patient's life. Poor mental health scores may be associated with lower expectations for preoperative symptom improvement. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Influence of Self-Identified Gender on Clinical Outcomes and Postoperative Patient Satisfaction After Lumbar Decompression: Cohort-Matched Analysis.
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Jacob, Kevin C., Patel, Madhav R., Park, Grant J., Ribot, Max A., Parsons, Alexander W., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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PATIENT satisfaction , *SURGICAL decompression , *LEG pain , *PROPENSITY score matching , *TREATMENT effectiveness , *BACKACHE - Abstract
We compared the patient-reported outcomes (PROs), minimal clinically important difference (MCID) achievement, and perceived postoperative satisfaction after minimally invasive lumbar decompression of patients stratified by self-identified gender. Patients who had undergone single minimally invasive lumbar decompression were identified. The PRO measures were administered preoperatively and postoperatively and included the PRO measurement information system–physical function, visual analog scale (VAS) for back and leg pain, Oswestry disability index (ODI), and 12-item short form physical and mental component scores. The patients were grouped by self-identified gender. Propensity score matching was performed. The mean PROs and postoperative satisfaction scores were compared between cohorts using a 2-sample t test. The postoperative PRO improvement within each cohort was calculated using a paired t test. MCID achievement was determined by comparison to previously established threshold values. The MCID achievement rates were compared among the groups using simple logistic regression. A total of 128 propensity score-matched patients were included: 44 in the female group and 84 in the male group. The male group demonstrated worse VAS scores for back pain at 12 weeks and a worse ODI at 6 weeks (P < 0.046 for all). The female cohort had achieved greater rates of a MCID for the ODI at 6 months (P < 0.049). Patients in the self-identified female group demonstrated higher levels of postoperative satisfaction for the VAS score for leg pain at 6 and 12 weeks), the VAS score for back pain at 12 weeks, and the ODI at 6 and 12 weeks (P < 0.028 for all). Additionally, patients in the self-identified female group demonstrated greater levels of satisfaction for lifting at 6 and 12 weeks (P < 0.014 for all). Despite the similar preoperative baseline values, postoperative improvement, and clinical outcomes, our results suggest that the self-identified male patients will have poorer short-term satisfaction for disability, leg pain, back pain, and lifting versus patients in the self-identified female group. Self-identified gender might influence patient satisfaction and could be attributed to differing preoperative expectations at baseline for short-term recovery. [ABSTRACT FROM AUTHOR]
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- 2022
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20. Impact of Time to Surgery for Patients Using Workers' Compensation Insurance Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Preliminary Analysis of Clinical Outcomes.
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Patel, Madhav R., Jacob, Kevin C., Lynch, Conor P., Cha, Elliot D.K., Patel, Saajan D., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, and Singh, Kern
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SPINAL fusion , *WORKERS' compensation , *NUCLEUS pulposus , *VISUAL analog scale , *TREATMENT effectiveness - Abstract
To conduct a preliminary analysis on the impact of time to surgery (TTS) and duration of symptoms (DOS) on clinical outcomes in workers' compensation patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Patients using workers' compensation insurance undergoing primary, single-level MIS TLIF were identified. Patient-reported outcome measures (PROMs) were administered at preoperative/6-week/12-week/6-month postoperative time points and included visual analog scale (VAS) back/VAS leg/Oswestry Disability Index/12-Item Short-Form Physical Composite Score/12-Item Short-Form Mental Composite Score. Patients were grouped by TTS: <90 days, 90–179 days, and ≥180 days. Demographics were compared by χ2; perioperative characteristics, mean PROMs, and postoperative improvement (ΔPROM) were compared using 1-way analysis of variance. Minimum clinically important difference (MCID) achievement rates were compared using simple logistic regression. A secondary analysis was performed by grouping patients by DOS: <180 days, 180–364 days, and ≥365 days. Mean PROMs, ΔPROMs, and MCID achievement were similarly compared between DOS groups using 1-way analysis of variance and logistic regression. A total of 193 patients were included. Prevalence of herniated nucleus pulposus and initial appointment type were significantly associated with TTS (P < 0.042, all). No significant differences in mean PROMs or ΔPROMs were observed among TTS groups. MCID achievement was significantly lower for VAS back at 6 months in the longest TTS group. Mean PROMs were significantly different based on DOS for VAS leg at 6 weeks only. MCID achievement was significantly lower for the longest DOS group for VAS leg at 6 months only. ΔPROMs did not significantly differ among DOS groups. Neither TTS nor DOS was significantly associated with MIS TLIF outcomes. Workers' compensation patients may achieve similar clinical improvement even with longer symptom burden and substantial delays in operative treatment. [ABSTRACT FROM AUTHOR]
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- 2022
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21. Influence of Predominant Neck versus Arm Pain on Anterior Cervical Discectomy and Fusion Outcomes: A Follow-Up Study.
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Patel, Madhav R., Jacob, Kevin C., Shah, Vivek P., Prabhu, Michael C., Pawlowski, Hanna, Vanjani, Nisheka N., and Singh, Kern
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NECK pain , *NECK , *DISCECTOMY , *PATIENT reported outcome measures , *VISUAL analog scale , *PHYSICAL mobility - Abstract
To assess differences in postoperative patient-reported outcome measures (PROMs) and minimal clinically important difference (MCID) attainment following single-level anterior cervical discectomy and fusion based on predominant preoperative pain symptom. Patients undergoing primary, single-level anterior cervical discectomy and fusion were identified. PROMs included visual analog scale (VAS) arm and neck, 12-item short-form physical component summary (SF-12 PCS), Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF), and Neck Disability Index, collected preoperatively and postoperatively. Patients were placed in preoperative predominant arm pain (pAP) and preoperative predominant neck pain groups. χ2 test compared demographic and perioperative characteristics, and MCID attainment rates. Student t test evaluated change from preoperative to postoperative PROM values and compared PROMs between groups. There were 110 patients assessed (52 neck pain, 58 arm pain). Patients with preoperative predominant neck pain improved significantly from preoperative to postoperative at 12 weeks to 1 year for PROMIS-PF, 6 months and 1 year for SF-12 PCS, 6 weeks to 1 year for VAS neck, 6 weeks to 6 months for VAS arm, and 6 weeks to 2 years for Neck Disability Index (all P ≤ 0.035). Patients with pAP improved significantly from preoperative to all postoperative time points for PROMIS-PF, 6 months to 2 years for SF-12 PCS, 6 weeks to 1 year for VAS neck, 6 weeks to 1 year for VAS arm, and 6 weeks to 6 months for Neck Disability Index (all P ≤ 0.040). Mean PROMIS-PF was higher at 6 weeks, preoperative VAS neck was lower, and preoperative VAS arm was higher for pAP patients (all P ≤ 0.013). MCID attainment was significantly higher in pAP patients for PROMIS-PF from 6 weeks to 6 months, SF-12 PCS 6 weeks, and VAS arm 12 weeks. Predominant pain symptom demonstrated little effect on perioperative characteristics and postoperative PROMs. Anterior cervical discectomy and fusion candidates will likely experience similar clinically meaningful postoperative improvements in physical function, disability, and pain. [ABSTRACT FROM AUTHOR]
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- 2022
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22. The Effect of the Severity of Preoperative Disability on Patient-Reported Outcomes and Patient Satisfaction Following Minimally Invasive Transforaminal Lumbar Interbody Fusion.
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Jacob, Kevin C., Patel, Madhav R., Collins, Andrew P., Ribot, Max A., Pawlowski, Hanna, Prabhu, Michael C., Vanjani, Nisheka N., and Singh, Kern
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SPINAL fusion , *PATIENT satisfaction , *PATIENT reported outcome measures , *VISUAL analog scale , *PHYSICAL mobility , *TREATMENT effectiveness , *PEOPLE with disabilities - Abstract
To compare patient-reported outcomes (PROMs), satisfaction, and minimum clinically important difference (MCID) achievement following minimally invasive transforaminal lumbar interbody fusion stratified by preoperative disability. Minimally invasive transforaminal lumbar interbody fusions were grouped by preoperative Oswestry Disability Index (ODI) score: ODI <41 or ODI ≥41. PROMs administered pre/postoperatively included Patient-Reported Outcomes Measurement Information System physical function (PROMIS-PF), visual analog scale (VAS) back/leg, ODI, and 12-Item Short-Form Physical Composite Score (SF-12 PCS)/12-Item Short-Form Mental Composite Score (SF-12 MCS). Satisfaction scores were collected for VAS back/leg and ODI. Coarsened exact match controlled for differences between cohorts. T tests compared mean PROMs and postoperative improvement/satisfaction between cohorts. Simple logistic regression compared MCID achievement. After coarsened exact matching, there were 118 patients in the ODI ≤41 and 377 patients in the ODI >41 cohort. The ODI >41 cohort saw greater postoperative inpatient VAS pain score and narcotic consumption on days 0/1 (P < 0.018, all). PROMs differed between cohorts: PROMIS-PF, SF-12 PCS, ODI, VAS back/leg at all postoperative time points and SF-12 MCS at 6 weeks/12 weeks/6 months/1 year (P < 0.045, all). Patients in the ODI >41 cohort demonstrated greater proportion achieving MCID for ODI at all postoperative time points and for SF-12 MCS 6-week/12-week/6-month/1-year (P < 0.040, all). The ODI ≤41 cohort demonstrated greater MCID achievement for overall PROMIS-PF and SF-12 PCS 6 months (P < 0.047, all). Postoperative satisfaction was greater in the ODI ≤41 cohort for VAS leg 6 weeks/12 weeks, VAS back 6 weeks/12 weeks, and ODI all postoperative time points (P < 0.048, all). Preoperative disability associated with worse postoperative PROMs and patient satisfaction for disability, back/leg pain at multiple time points. MCID achievement rates across cohorts were similar for most PROMs at most postoperative time points. Patients with severe disability may have unrealistic expectations for surgical benefits, influencing corresponding postoperative satisfaction. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Influence of Preoperative 12-Item Short Form Mental Composite Score on Clinical Outcomes in an Isthmic Spondylolisthesis Population Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion.
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Patel, Madhav R., Jacob, Kevin C., Patel, Saajan D., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, and Singh, Kern
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SPINAL fusion , *SPONDYLOLISTHESIS , *VISUAL analog scale , *TREATMENT effectiveness , *PHYSICAL mobility , *INFORMATION measurement - Abstract
To determine preoperative 12-Item Short Form Health Survey (SF-12) Mental Component Summary (MCS) influence on minimally important clinical difference (MCID) and patient-reported outcome measures in patients with isthmic spondylolisthesis receiving minimally invasive transforaminal lumbar interbody fusion. Patients with isthmic spondylolisthesis undergoing primary, single-level minimally invasive transforaminal lumbar interbody fusion at L5-S1 were retrospectively identified and divided into preoperative SF-12 MCS <50 and SF-12 MCS ≥50 groups. Visual analog scale (VAS) back/leg, Oswestry Disability Index (ODI), SF-12 Physical Composite Score (PCS), and Patient-Reported Outcome Measurement Information System physical function (PROMIS-PF) were assessed. Improvements from preoperative score were analyzed via paired samples t test. Patient-reported outcome measures and MCID attainment between groups were evaluated using linear regression and χ2, respectively. SF-12 MCS <50 and SF-12 MCS ≥50 groups included 35 and 26 patients, respectively. SF-12 MCS < 50 group had inferior scores for all VAS back time points except 6 weeks, all VAS leg time points except 6 weeks/1 year, all ODI time points, SF-12 PCS at 6 months/2 years, and PROMIS-PF at preoperative/6 months (all P ≤ 0.049). SF-12 MCS <50 group improved for VAS back/leg to 1 year, ODI and SF-12 PCS from 12 weeks to 1 year, and PROMIS-PF at 1 year only (all P ≤ 0.047). SF-12 MCS ≥50 group improved for VAS back from 12 weeks to 1 year, SF-12 PCS 6 months to 2 years, and VAS leg, ODI, and PROMIS-PF 12 weeks to 2 years (all P ≤ 0.018). MCID attainment differed for ODI at 6 weeks and PROMIS-PF at 12 weeks only (both P ≤ 0.035). Patients with SF-12 MCS <50 demonstrated fewer long-term improvements from preoperative to 2 years and inferior patient-reported outcome measures at most time points for pain and disability following minimally invasive transforaminal lumbar interbody fusion. MCID attainment largely did not differ by preoperative mental functioning. [ABSTRACT FROM AUTHOR]
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- 2022
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24. How Do Patient-Reported Outcomes Vary Between Lumbar Fusion Patients with Complete Versus Incomplete Follow-Up?
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Patel, Madhav R., Jacob, Kevin C., Parsons, Alexander W., Vanjani, Nisheka N., Cha, Elliot D.K., Lynch, Conor P., Hijji, Fady, Prabhu, Michael C., Pawlowski, Hanna, and Singh, Kern
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SPINAL fusion , *PATIENT reported outcome measures , *VISUAL analog scale , *SPONDYLOLISTHESIS , *PHYSICAL mobility - Abstract
We sought to assess differences in patient-reported outcome measures (PROMs) between patients who do and do not follow up for 2 years after lumbar fusion. Primary, elective, single-level anterior lumbar interbody fusion, lateral lumbar interbody fusion, or transforaminal lumbar interbody fusion procedures were identified. Patients were grouped by 2-year PROM follow-up completion. Mean and delta PROM scores for visual analog scale (VAS) back and leg, Oswestry Disability Index (ODI), short-form (SF)-12 Physical Composite Score (PCS), and Mental Composite Score (MCS) were computed for both groups preoperatively and postoperatively. Minimum clinically important difference (MCID) achievement was determined for PROM scores using established threshold values. Linear and logistic regression assessed mean and ΔPROM scores as predictors of 2-year follow-up completion and compared MCID achievement between groups, respectively. We included 316 lumbar fusion patients. PROM scores were more favorable for complete follow-up patients for 6-month VAS back (P = 0.003), 6-month and 1-year ODI (P ≤ 0.027, both), and 6-week and 6-month SF-12 PCS (P ≤ 0.015, both). Six-month VAS back (P = 0.007); 6-month and 1-year ODI (P ≤ 0.028, both); 6-week, 6-month, and 1-year SF-12 PCS (P ≤ 0.041, all); and 6-week SF-12 MCS (P ≤ 0.028, both) significantly predicted 2-year follow-up. ΔPROMs significantly differed between groups at 1 year for ΔVAS leg (P = 0.029), ΔODI (P = 0.013), and ΔSF-12 MCS (P = 0.004). One-year ΔVAS leg (P = 0.035), ΔODI (P = 0.011), and ΔSF-12 MCS (P = 0.003) significantly predicted follow-up. MCID achievement for ΔPROMs significantly differed between groups for 6-week VAS leg (P = 0.035), overall ODI (P = 0.034), and SF-12 PCS from 12 weeks through 1 year (P ≤ 0.011, all) and overall (P < 0.001). Patients with full follow-up demonstrated significantly more favorable outcome scores and improvement in pain, disability, and physical function at several postoperative time points. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion versus Anterior Lumbar Interbody Fusion with Posterior Instrumentation at L5/S1.
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Jacob, Kevin C., Patel, Madhav R., Ribot, Max A., Parsons, Alexander W., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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SPINAL fusion , *BACK muscles , *VISUAL analog scale , *PHYSICAL mobility , *EDUCATIONAL attainment , *LEG pain - Abstract
To compare outcomes between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and anterior lumbar interbody fusion (ALIF) at L5/S1. Primary, elective, single, MIS-TLIF, or ALIF with posterior fixation at L5/S1 were identified. Patient-reported outcome measures (PROMs) were collected. Coarsened exact matching was used to control for significant differences. Achievement of minimum clinically important difference [MCID] was determined by comparing ΔPROM scores with threshold values. Demographic/perioperative characteristics were compared between MIS-TLIF and ALIF cohorts using χ2 Student t tests. Differences in mean PROM scores, MCID rates, and postoperative complications were evaluated using an unpaired t test. After coarsened exact matching, 93 patients received MIS-TLIF and 50 received ALIF. Cohorts differed in operative time, estimated blood loss, and postoperative narcotic consumption on postoperative day 0 (P < 0.034, all). Mean PROMs differed significantly on 12-Item Short-Form Physical Component Summary at 6 weeks and 1 year, Patient-Reported Outcomes Measurement Information System Physical Function at 6 weeks, Oswestry Disability Index at 6 weeks, and visual analog scale (VAS) back at 6 weeks, with the ALIF cohort showing significantly improved mean PROMs (P ≤ 0.044, all). Significantly greater rates were reported of MCID achievement for PROMs for the ALIF cohort: VAS back at 6 weeks, Oswestry Disability Index at 12 weeks, 12-Item Short-Form Physical Component Summary at 6 weeks, and Patient-Reported Outcomes Measurement Information System Physical Function at 12 weeks (P ≤ 0.047, all). A greater rate of MCID achievement for the MIS-TLIF cohort was seen for 6-week and overall VAS leg (P < 0.046, all). Postoperative fever was greater in the TLIF cohort (9.6% vs. 2.0%; P < 0.047). Patients undergoing ALIF showed significantly improved rates of MCID achievement for disability, physical function, and back pain during the early postoperative period. However, the overall MCID achievement rate for leg pain was higher for the MIS-TLIF cohort. [ABSTRACT FROM AUTHOR]
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- 2022
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26. The Effect of the Severity of Preoperative Back Pain on Patient-Reported Outcomes, Recovery Ratios, and Patient Satisfaction Following Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF).
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Jacob, Kevin C., Patel, Madhav R., Parsons, Alexander W., Vanjani, Nisheka N., Pawlowski, Hanna, Prabhu, Michael C., and Singh, Kern
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PATIENT satisfaction , *BACKACHE , *PATIENT reported outcome measures , *SPINAL fusion , *VISUAL analog scale , *LEG pain - Abstract
Limited literature has addressed impact of preoperative back pain severity on patient-reported outcome measures (PROMs), recovery ratios (RRs), and patient satisfaction following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). MIS TLIFs were retrospectively identified and grouped: preoperative visual analog scale (VAS) back ≤7 or VAS back >7. PROMs, including PROMIS-PF, VAS back and leg, Oswestry Disability Index (ODI), and SF-12 Physical Composite Score and Mental Composite Score (MCS), were collected pre- and postoperatively. A PROM's RR was calculated as proportion of postoperative improvement to overall potential improvement. In total, 740 patients were included: 359 patients with VAS back ≤7 and 381 patients with VAS back >7. The VAS back >7 cohort reported significantly greater postoperative inpatient pain (P ≤.003, both). All preoperative and the following postoperative PROMs favored the VAS back ≤7 cohort: PROMIS-PF 2-years, VAS back overall, SF-12 Physical Composite Score 12 weeks and 1 year, SF-12 MCS 6 weeks/12 weeks, VAS leg 6 weeks, 12 weeks, 6 months, and 2 years, and ODI overall (P ≤ 0.048, all). The VAS back >7 cohort demonstrated greater delta PROMs for all VAS back and ODI except 2 years (P ≤ 0.021, all). A greater proportion of patients in the VAS back >7 group achieved minimal clinically important difference for VAS back overall, ODI 6 weeks/12 weeks, PROMIS-PF 6 weeks, and SF-12 MCS 6 weeks/6 months (P ≤ 0.044, all). The VAS back>7 cohort RR was significantly greater for VAS back 6 months and VAS leg 6 months/2 years (P ≤ 0.034, all). The VAS back ≤7 cohort's postoperative satisfaction was significantly greater for VAS back 12 weeks, VAS leg 12 weeks, and ODI 6 weeks/12 weeks (P ≤ 0.046, all). Patients with greater preoperative back pain demonstrated significantly worse postoperative scores for most PROMs at most time points and significantly worse patient satisfaction for disability, back and leg pain at multiple time points. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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27. 212. ALIF as a salvage procedure for TLIF pseudarthrosis: a clinical outcome study.
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Jacob, Kevin, Patel, Madhav, Prabhu, Michael, Vanjani, Nisheka, Pawlowski, Hanna, and Singh, Kern
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ARTHRODESIS , *PSEUDARTHROSIS , *URINARY tract infections , *ACUTE kidney failure , *LENGTH of stay in hospitals , *TREATMENT effectiveness - Abstract
Lumbar fusion procedures are at risk for pseudarthrosis as a complication. Despite its relative prevalence, few studies have characterized the clinical efficacy of salvage procedures. To characterize clinical outcomes following anterior lumbar interbody fusion (ALIF) as a salvage procedure for pseudarthrosis of transforaminal lumbar interbody fusion (TLIF). Retrospective. Thirty-four ALIF patients. VAS back and leg, ODI, SF-12 PCS, VR-12 PCS. A retrospective review of a surgical database of eligible procedures between November 2010 and June 2020 was performed. Inclusion criteria were as follows: single-level revision ALIF procedures performed at the index level for pseudarthrosis of TLIF. Patients were excluded if procedures were primary or performed for infectious, malignant or traumatic etiologies. Demographic and perioperative characteristics were collected. Additionally, time to revision, rates of 1-year arthrodesis, 6-month pseudarthrosis and postoperative complications were calculated. Radiographic measurements were performed to evaluate sagittal alignment and disc height at the preoperative, immediate postoperative and final postoperative timepoint. Differences between preoperative and final postoperative radiographic measurements were evaluated using a Student's t-test. Visual analog scale (VAS) for back and leg pain, Oswestry Disability Index (ODI), 12-Item Short Form physical composite score (SF-12 PCS and VR-12 PCS) were collected preoperatively and postoperatively. Overall achievement of a minimum clinically important difference (MCID) was calculated using the following established values: 1.2 (VAS Back), 1.6 (VAS leg), 12.8 (ODI), 4.0 (SF-12 PCS). A total of 34 patients who underwent an ALIF revision procedure at the index level were identified. Mean age was 46.7 years with 81.1% being male and 64.9% obese (body mass index: 30 kg/m2). A total of 83.8% had an ASA < 2 and 75.5% carried a CCI > 1. Mean time from index TLIF to salvage ALIF procedure was 21.3 months. Mean operative time was 135.3 minutes with an average blood loss of 75.0mL and hospital length of stay of 49.5 hours. The majority of procedures were performed at the L5-S1 level (73.5%). Patients demonstrated a one-year arthrodesis rate of 100.0% with 2/34 patients requiring an additional revision procedure at the index level for neuroforaminal bone growth. A total of six postoperative complications were observed with one patient suffering from a mild urinary tract infection, one with acute renal failure, one with a venous thromboembolism, one with altered mental status, and two with fever of unknown origin. Following ALIF salvage, there was a significant increase in segmental lordosis, mean anterior and posterior disc height, as well as average disc height (p≤0.037, all). Mean preoperative outcome scores were 7.2 ± 1.9 for VAS back, 6.8 ± 2.8 for VAS leg, 56.7 ± 16.5 for ODI, and 28.1 ± 10.9 for SF-12 PCS. Clinically relevant improvement of PROMs as measured by MCID achievement rates by one-year were 67.1% for VAS back, 57.1% for VAS leg, 40.0% for ODI and 37.5% for SF-12 PCS. Use of ALIF as a salvage procedure at either the L4-5 or L5-S1 level for TLIF pseudoarthrosis demonstrated a high arthrodesis rate at one-year. Patients demonstrated high rates of MCID achievement for back and leg pain, as well as ODI. These results support the use of ALIF as a salvage procedure for failed TLIFs at the L4-5 and L5-S1 levels. This abstract does not discuss or include any applicable devices or drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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28. 106. Usage trends and safety profile of recombinant human bone morphogenetic protein-2 for spinal column tumor surgery: a national matched analysis.
- Author
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Munim, Mohammed, Federico, Vincent, Nolte, Michael T., Berlinberg, Elyse, Prabhu, Michael, Vanjani, Nisheka, Pawlowski, Hanna, and Colman, Matthew
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SPINAL fusion , *SPINE , *SURGICAL site , *SPINAL surgery , *SURGICAL site infections ,TUMOR surgery - Abstract
Achieving arthrodesis after spinal tumor surgery remains a significant challenge. Patients in this vulnerable cohort commonly experience poor bone quality, malnutrition and concurrent use of chemotherapy or radiotherapy—all of which interfere with proper bone formation and healing. To augment fusion efforts, recombinant human bone morphogenetic protein-2 (rhBMP-2) emerged as a powerful osteogenic factor after its FDA approval in 2002 but its use has remained a persistent concern. Although most recent evidence does not seem to suggest significantly increased rates of complications or carcinogenicity due to rhBMP-2 use, these findings remain poorly defined in the spinal oncology subcohort. To investigate national rates of rhBMP-2 utilization in spinal tumor surgery and examine its association with postoperative complications, revisions, and carcinogenicity. Retrospective national database analysis. All patients diagnosed with primary or metastatic spinal tumors who underwent subsequent surgical intervention involving a spinal fusion recorded in Medicare, Medicaid, and commercial administrate claims databases in PearlDiver from 2005-2020. Utilization rates; postoperative rates of complications, revisions, and failures; survivorship. Patients were organized into two cohorts according to rhBMP-2 usage and 1:1 matched based on age, gender, and Charlson Comorbidity Index. rhBMP-2 utilization trends were compared via a Pearson correlation across calendar years. Postoperative complications and revisions were examined at 1 month, 3 months, 6 months, and 1 year after spinal fusion. New cancer incidence following spinal tumor surgery was assessed until 5 years postoperatively. Post hoc comparisons were characterized using chi-squared analysis, and threshold for significance was established at P < 0.05. A total of 11,198 patients underwent fusion surgery after resection of spinal tumors between 2005 and 2020, with 909 cases reporting the use of rhBMP-2 (8.1%). An annualized analysis revealed that the proportion of spine tumor fusion procedures utilizing rhBMP-2 has been significantly decreasing (R2 = 0.859, P < 0.001), with the most recent annual utilization rate at 1.1%. The final matched cohorts each comprised 894 patients. At least 6 months after surgery, significantly increased incidences of surgical site (7.3% vs 1.6%, P = 0.05) and systemic infections (13.8% vs 4.1%, P = 0.01) were observed in patients who underwent fusion with rhBMP-2. Across all time points, no significant differences were observed between the groups in survival, implant removal, or revision rates. In addition, incidence of new cancer diagnoses after fusion surgery was comparable between the two groups. rhBMP-2 has been widely used off-label to promote arthrodesis; however. its role in spinal fusion procedures involving spinal tumors remains controversial. This analysis demonstrated significantly declining national utilization rates, and while rhBMP-2 usage was not associated with new cancer incidence postoperatively, its impact on local and metastatic progression remains unknown and requires further investigation. Compared with nonusers, spinal tumor cases utilizing rhBMP-2 sustained greater rates of surgical site and systemic infections. Furthermore, rhBMP-2 usage did not significantly reduce the risk of mortality, implant failure, or reoperation–suggesting it may not be essential to fulfilling the needs of this specific patient population. BMP-2: not approved for this indication. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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29. Baseline Risk Factors for Prolonged Opioid Use Following Spine Surgery: Systematic Review and Meta-Analysis.
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Mohan, Shruthi, Lynch, Conor P., Cha, Elliot D.K., Jacob, Kevin C., Patel, Madhav R., Geoghegan, Cara E., Prabhu, Michael C., Vanjani, Nisheka N., Pawlowski, Hanna, and Singh, Kern
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SPINAL surgery , *PREOPERATIVE risk factors , *LUMBAR pain , *OPIOIDS , *DRUG addiction , *TOBACCO use - Abstract
To conduct a comprehensive systematic review and meta-analysis of current retrospective cohort studies to identify significant preoperative risk factors for prolonged postoperative opioid use following spine surgery. Studies were identified according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses through a search of PubMed, Google Scholar, Scopus, and Cochrane databases. Unique articles were screened by 2 independent reviewers. Primary research articles reporting odds ratios of risk factors for prolonged opioid use following spine surgery were included. Prolonged opioid use was defined as continued use ≥3 months following surgery, and study quality was evaluated using the Newcastle-Ottawa Scale. Random-effects meta-analysis was performed to calculate pooled odds ratios and confidence intervals. The initial search yielded 648 studies. Following duplicate removal, 492 titles and abstracts were screened. After full-text review of 68 studies, 19 final studies including 168,961 patients were eligible for meta-analysis. Newcastle-Ottawa Scale scores ranged from 6 to 9. Meta-analysis assessed 17 risk factors for long-term opioid use. Preoperative opioid use, depression, depression and/or anxiety, drug abuse or dependency, female gender, fibromyalgia, lower back pain, tobacco use, and chronic pulmonary disease were found to be statistically significant risk factors for prolonged opioid use. Several patient-level factors may play a role in the tendency to persistently use opioids after spine surgery. By preoperatively identifying these characteristics, clinicians may be better able to identify patients who are at risk and employ methods to mitigate potential long-term opioid use. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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