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The hygrothermal behaviour of an outdoor ventilated crawl space with two different designs of the floor structure was investigated. The first design had 250 mm insulation and visible wooden beams towards the crawl space. The second design had 300 mm insulation and no visible wooden beams. One year of measurements was compared with simulations of temperature and moisture condition in the floor structure and crawl space. The measurements showed that the extra 50 mm insulation placed below the beams reduced moisture content in the beams below 20 weight% all year. A reasonable agreement between the measurements and simulations was found; however, the evaporation from the soil was a dominant parameter affecting the hygrothermal response in the crawl space and floor structure. [ABSTRACT FROM AUTHOR]

BNC2 is an extremely conserved zinc finger protein with important functions in the development of craniofacial bones and male germ cells. Because disruption of the Bnc2 gene in mice causes neonatal lethality, the function of the protein in adult animals has not been studied. Until now BNC2 was considered to have a wider tissue distribution than its paralog, BNC1, but the precise cell types expressing Bnc2 are largely unknown. We identify here the cell types containing BNC2 in the mouse and we show the unexpected presence of BNC1 in many BNC2-containing cells. BNC1 and BNC2 are colocalized in male and female germ cells, ovarian epithelial cells, sensory neurons, hair follicle keratinocytes and connective cells of organ capsules. In many cell lineages, the two basonuclins appear and disappear synchronously. Within the male germ cell lineage, BNC1 and BNC2 are found in prospermatogonia and undifferentiated spermatogonia, and disappear abruptly from differentiating spermatogonia. During oogenesis, the two basonuclins accumulate specifically in maturing oocytes. During the development of hair follicles, BNC1 and BNC2 concentrate in the primary hair germs. As follicle morphogenesis proceeds, cells possessing BNC1 and BNC2 invade the dermis and surround the papilla. During anagen, BNC1 and BNC2 are largely restricted to the basal layer of the outer root sheath and the matrix. During catagen, the compartment of cells possessing BNC1 and BNC2 regresses, and in telogen, the two basonuclins are confined to the secondary hair germ. During the next anagen, the BNC1/BNC2-containing cell population regenerates the hair follicle. By examining Bnc2 −/− mice that have escaped the neonatal lethality usually associated with lack of BNC2, we demonstrate that BNC2 possesses important functions in many of the cell types where it resides. Hair follicles of postnatal Bnc2 −/− mice do not fully develop during the first cycle and thereafter remain blocked in telogen. It is concluded that the presence of BNC2 in the secondary hair germ is required to regenerate the transient segment of the follicle. Postnatal Bnc2 −/− mice also show severe dwarfism, defects in oogenesis and alterations of palatal rugae. Although the two basonuclins possess very similar zinc fingers and are largely coexpressed, BNC1 cannot substitute for BNC2. This is shown incontrovertibly in knockin mice expressing Bnc1 instead of Bnc2 as these mice invariably die at birth with craniofacial abnormalities undistinguishable from those of Bnc2 −/− mice. The function of the basonuclins in the secondary hair germ is of particular interest. [ABSTRACT FROM AUTHOR]

Appropriate window solutions are decisive for the design of ‘nearly zero-energy’ buildings with healthy and comfortable indoor environment. This paper focuses on the relationship between size, orientation and glazing properties of façade windows for different side-lit room geometries in Danish ‘nearly zero-energy’ houses. The effect of these parameters on space heating demand, daylighting and thermal environment is evaluated by means of EnergyPlus and DAYSIM and presented in charts illustrating how combinations of design parameters with minimum space heating demand can be selected within a solution space defined by targets for daylighting and thermal comfort. In contrast with existing guidelines, the results show an upper limit for energy savings and utilisation of solar gains in south-oriented rooms. Instead, low U -values are needed in both north- and south oriented rooms before large window areas lead to reductions in space heating demand. Furthermore, windows in south-oriented rooms have to be carefully designed to prevent overheating. Design options for prevention of overheating, however, correspond well with options for low space heating demand. Glazings with solar control coating are therefore obvious alternatives to dynamic solar shadings. Regarding room geometry, deep or narrow south-oriented rooms show difficulties in reaching sufficient daylight levels without overheating. [ABSTRACT FROM AUTHOR]

In the design of very well-insulated homes, there is a need for a more nuanced design that takes into account winter and summer conditions. In this paper, we compare a traditional design for a typical Danish single-family house with large glazing areas oriented towards the south and smaller glazing areas towards the north, and a design with an even window distribution where the glazing-to-floor ratio is the same for each room. We found that the use of solar gains through south-oriented windows is not as important as is traditionally believed because, in well-insulated homes, space heating demand is not reduced much by having larger south-facing windows. Furthermore, we found that there is a g-value above which the additional solar gains through south-oriented windows do not help reduce space heating demand, and it becomes important to use solar shading or glazing with solar-control coating as a cheaper alternative to reduce overheating. Maximum window sizes from an overheating perspective were identified that are larger than the optimal window sizes for space heating demand. However, we show that the difference in space heating demand with optimal window size and with larger window sizes is small, so it is up to the building owner to decide whether or not he wants larger glazing areas to allow for more daylight. And windows can be positioned in the façade with considerable architectural freedom. However, we do recommend an even distribution of the glazing-to-floor ratio, because this generally provides an improved thermal indoor environment in south-oriented rooms and will ensure a better daylight level especially in north-oriented rooms. We also show that the optimal window size is influenced by thermal zone configuration and that there is a need for models in which a difference is made between zones with direct and with non-direct solar gains. [ABSTRACT FROM AUTHOR]

Abstract: Basonuclin 1 and the recently discovered basonuclin 2 are vertebrate proteins with multiple paired C2H2 zinc fingers. It has long been known that the zinc fingers of basonuclin 1 closely resembled those of the Drosophila disconnected and discorelated proteins, two proteins essential for head development, but the relation between the basonuclins and the disco proteins has remained unclear because the putative function of basonuclin 1 in the control of keratinocyte growth potential appeared unrelated to that of disco and there was no resemblance between basonuclin 1 and Drosophila disco outside of the zinc fingers. The recent generation of a basonuclin-2 knockout has demonstrated that basonuclin 2 shares with disco a function in head development and the availability of new arthropod genome sequences has shown that the basonuclins are the vertebrate orthologs of the insect disco proteins. All these proteins are thought to be transcription factors, and it will have to be determined to what extent they share similar targets. [ABSTRACT FROM AUTHOR]

Abstract: In Nordic countries significant primary energy saving potential exists in houses built before 1980. These old houses need to be renovated, which provides an opportunity for implementation of energy efficiency measures. However, there are several economic and market hindrances and the renovation markets are dominated by handicraft-based individual solutions. In this paper we have analyzed the opportunities for implementation of one-stop-shop business models where an overall contractor offers full-service renovation packages including consulting, independent energy audit, renovation work, follow-up (independent quality control and commissioning) and financing. A comparative assessment of emerging business models in the Nordic countries shows that different types of actors can provide such a service. Financing is included in some models. There are differences in how customers are contacted, while the similarities are on how the service is provided. Even though there is strong business potential for one-stop-shop energy renovation concept, still it has been somewhat difficult to start or run such a business. Various options to overcome the hindrances to promote energy efficient renovation of detached houses are discussed. [Copyright &y& Elsevier]