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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.childyouth.2008.09.008 Byline: Linda van den Dries, Femmie Juffer, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg Keywords: Meta-analysis; Adoption; Attachment; Parent-child relationships; Institutional care; Foster care Abstract: Adopted children are hypothesized to be at risk of insecure attachment relationships because of their background of institutional care, maltreatment and neglect. We conducted two series of meta-analyses, one using only observational assessments of attachment and one using both observational and self-report assessments. Observational assessments showed that children who were adopted before 12 months of age were as securely attached as their non-adopted peers, whereas children adopted after their first birthday showed less attachment security than non-adopted children (d =0.80, CI =0.49-1.12). Regarding the overall effect for attachment security, adoptees were comparable to foster children. Adopted children showed more disorganized attachments compared to their non-adopted peers (trimmed d =0.36, CI =0.04-0.68), but again were comparable to foster children (trimmed d =0.35, CI =0.02-0.67). Compared to institutionalized children, adoptees were less often disorganized attached. When self-report measures of attachment were included no difference was found between adoptees and their non-adopted counterparts (trimmed d =0.12, CI =-0.02-0.26, 39 studies, N =2912 adopted children). Compared to institutionalized children, (early) adoption proves to be an effective intervention in the domain of attachment. Author Affiliation: Centre for Child and Family Studies, Leiden University, The Netherlands Article History: Received 30 May 2008; Revised 8 September 2008; Accepted 14 September 2008 Article Note: (footnote) [star] This study was funded by the Netherlands Organization for Scientific Research (NWO 400-03-208), and additional support was received from VSBfonds, Fonds Psychische Gezondheid, and Stichting Kinderpostzegels Nederland to Femmie Juffer and Marinus van IJzendoorn in cooperation with the Adoptie Driehoek Onderzoeks Centrum [Adoption Triad Research Center] (www.adoptionresearch.nl). Femmie Juffer is supported by Wereldkinderen. Marinus van IJzendoorn and Marian Bakermans-Kranenburg are supported by the Netherlands Organization for Scientific Research (SPINOZA Prize and VIDI grant, respectively).

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jecp.2007.06.004 Byline: Renske Gilissen, Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn, Rene van der Veer Keywords: Fear; Children; Physiological reactivity; Temperament; Parent-child relationship; Differential susceptibility Abstract: Recent studies have supported the intriguing hypothesis that highly reactive infants are most susceptible to the effect of parenting. This study replicates and extends an earlier study on 4-year-olds concerning higher susceptibility of more fearful children to the quality of their relationships with their mothers, as shown by their physiological reactions to fear-inducing film clips. Two groups of children (4- and 7-year-olds) were shown the same fear-inducing and neutral film clips. During the film clips, their skin conductance and heart rate variability were measured. Both 4- and 7-year-olds responded to the fear-inducing film clips with increases in skin conductance and decreases in heart rate variability. A secure relationship affected the reactivity to fearful stimuli in temperamentally more fearful children but not in less fearful children irrespective of children's ages. Our findings add to the growing literature showing that children high in negative emotion are more susceptible to positive as well as negative rearing influences for better and for worse. Author Affiliation: Centre for Child and Family Studies, Leiden University, 2300 RB Leiden, The Netherlands Article History: Received 20 April 2007; Revised 19 June 2007

Highlights • Hippocampus modulates oxytocin (OT) level increases after OT administration. • A larger hippocampus appears to be related to increases of salivary OT level. • The hippocampus may underlie individual differences in sensitivity to intranasal OT. Abstract Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration. [ABSTRACT FROM AUTHOR]

Abstract Experiencing and observing social exclusion and inclusion, as well as prosocial behavior, are important aspects of social relationships in childhood. However, it is currently unknown to what extent these processes and their neural correlates differ in heritability. We investigated influences of genetics and environment on experiencing social exclusion and compensating for social exclusion of others with the Prosocial Cyberball Game using fMRI in a twin sample (aged 7–9; N = 500). Neuroimaging analyses (N = 283) revealed that experiencing possible self-exclusion resulted in activity in inferior frontal gyrus and medial prefrontal cortex, which was influenced by genetics and unique environment. Experiencing self-inclusion was associated with activity in anterior cingulate cortex, insula and striatum, but this was not significantly explained by genetics or shared environment. We found that children show prosocial compensating behavior when observing social exclusion. Prosocial compensating behavior was associated with activity in posterior cingulate cortex/precuneus, and showed unique environmental effects or measurement error at both behavioral and neural level. Together, these findings show that in children neural activation for experiencing possible self-exclusion and self-inclusion, and for displaying prosocial compensating behavior, is accounted for by unique environmental factors and measurement error, with a small genetic effect on possible self-exclusion. [ABSTRACT FROM AUTHOR]

Learning to control behavior when receiving feedback underlies social adaptation in childhood and adolescence, and is potentially strengthened by environmental support factors, such as parents. This study examined the neural development of responding to social feedback from childhood to adolescence, and effects of parental sensitivity on this development. We studied these questions in a 3-wave longitudinal fMRI sample (ages 7–13 years, n = 512). We measured responses to feedback using the fMRI Social Network Aggression Task through noise blasts following peer feedback and associated neural activity, and parental sensitivity using observations of parent-child interactions during Etch-a-Sketch. Results revealed largest reductions in noise blasts following positive feedback between middle and late childhood and following negative feedback between late childhood and early adolescence. Additionally, brain-behavior associations between dorsolateral prefrontal cortex activation and noise blast durations became more differentiated across development. Parental sensitivity was only associated with noise blast duration following positive feedback in childhood, but not in adolescence. There was no relation between parental sensitivity and neural activity. Our findings contribute to our understanding of neural development and individual differences in responding to social feedback, and the role of parenting in supporting children's adaption to social feedback. • Three-wave longitudinal fMRI study on development of responses to social feedback from childhood to adolescence. • Developmental trajectories differed for behavioral responses following positive, neutral and negative peer feedback. • Inhibition of aggressive responses was more strongly associated with DLPFC activation during childhood than adolescence. • Children with more sensitive parents showed more inhibition following positive feedback in middle childhood. [ABSTRACT FROM AUTHOR]

Childhood adversity is associated with brain morphology and poor psychological outcomes, and evidence of protective factors counteracting childhood adversity effects on neurobiology is scarce. We examined the interplay of childhood adversity with protective factors in relation to brain morphology in two independent longitudinal cohorts, the Generation R Study (N = 3008) and the Mannheim Study of Children at Risk (MARS) (N = 179). Cumulative exposure to 12 adverse events was assessed across childhood until age 9 years in Generation R and 11 years in MARS. Protective factors (temperament, cognition, self-esteem, maternal sensitivity, friendship quality) were assessed at various time-points during childhood. Global brain volumes and volumes of amygdala, hippocampus, and the anterior cingulate, medial orbitofrontal and rostral middle frontal cortices were assessed with anatomical scans at 10 years in Generation R and at 25 years in MARS. Childhood adversity was related to smaller cortical grey matter, cerebral white matter, and cerebellar volumes in children. Also, no buffering effects of protective factors on the association between adversity and the brain outcomes survived multiple testing correction. We found no robust evidence for an interaction between protective factors and childhood adversity on broad brain structural measures. Small interaction effects observed in one cohort only warrant further investigation. [ABSTRACT FROM AUTHOR]

Background: Parental feeding practices are associated with children's body mass index (BMI). It has been generally assumed that parental feeding determines children's eating behaviors and weight gain, but feeding practices could equally be a parent's response to child weight. Objective: In longitudinal analyses, we assessed the directionality in the relation between selected controlling feeding practices and BMI in early childhood. Design: Participants were 4166 children from the population-based Generation R Study. BMI was measured at ages 2 and 6 y. With the use of the Child Feeding Questionnaire, parents reported on restriction, monitoring, and pressure to eat (child age: 4 y). BMI and feeding-behavior scales were transformed to SD scores. Results: With the use of linear regression analyses, there was an indication that a higher BMI at age 2 y predicted higher levels of parental restriction (adjusted β = 0.07; 95% CI: 0.04, 0.10) and lower levels of pressure to eat (adjusted β = -0.20; 95% CI: -0.23, -0.17) 2 y later. Restriction at age 4 y positively predicted child BMI at 6 y of age, although this association attenuated to statistical nonsignificance after accounting for BMI at age 4 y (β = 0.01; 95% CI: -0.01, 0.03). Pressure to eat predicted lower BMI independently of BMI at age 4 y (β = -0.02; 95% CI: -0.04, -0.01). For both restriction and pressure to eat, the relation from BMI to parenting was stronger than the reverse (Wald's test for comparison: P = 0.03 and < 0.001, respectively). Monitoring predicted a lower child BMI, but this relation was explained by confounding factors. Conclusions: Although the feeding-BMI relation is bidirectional, the main direction of observed effects suggests that parents tend to adapt their controlling feeding practices in response to their child's BMI rather than the reverse. Therefore, some components of current programs aimed at preventing or treating unhealthy child weight may need to be carefully scrutinized, especially those targeting parental food-related restriction and pressure to eat. [ABSTRACT FROM AUTHOR]

Abstract: Background: Postnatal depression is common and negatively affects the mother–baby relationship; oxytocin has been found to have positive effects on parenting behavior. We hypothesize that intranasal administration of oxytocin to mothers with depression will influence their parenting related expressed emotion, creating a better basis for sensitive parenting. Methods: Twenty-five postnatally depressed mothers with infants less than one year participated in a randomized, double-blind, placebo controlled within-subject clinical study in 2011. Mothers attended an out-patient perinatal psychiatry setting in NSW, Australia. They received 24IU of oxytocin alternating with placebo approximately one week apart in random order, prior to completing outcome measures. The outcome measures were the Five Minute Speech Sample, the Self-Assessment Manikin and the Controlled Oral Word Association Test. Results: In the oxytocin condition mothers were sadder (p =.01), and they more often initially described their babies as difficult (p =.038), but they reported that the quality of their relationship with their infant was more positive (p =.036). Limitations: Despite an adequate sample size to answer our central hypothesis, a larger sample may have elucidated a moderating effect of childhood trauma. Conclusion: Oxytocin did not make depressed mothers happier but their perception of the relationship with their baby improved. Treatment with intranasal oxytocin might show some unwanted side-effects in depressed individuals. [Copyright &y& Elsevier]

Summary: The neuropeptide oxytocin has a popular reputation of being the ‘love’ hormone. Here we test meta-analytically whether experiments with intranasal administration of oxytocin provide support for the proposed effects of oxytocin. Three psychological effects were subjected to meta-analysis: facial emotion recognition (13 effect sizes, N =408), in-group trust (8 effect sizes, N =317), and out-group trust (10 effect sizes; N =505). We found that intranasal oxytocin administration enhances the recognition of facial expressions of emotions, and that it elevates the level of in-group trust. The hypothesis that out-group trust is significantly decreased in the oxytocin condition was not supported. It is concluded that a sniff of oxytocin can change emotion perception and behavior in trusting relationships. [ABSTRACT FROM AUTHOR]

Abstract: Does the experience of stress during child care lead to downregulation of the immune system, in particular in low-quality care? Saliva was collected from 68 toddlers attending center or family child care at home and at child care, and assayed for secretory IgA (SIgA). Caregiver sensitivity was used as an index of quality of care and was observed during three videotaped episodes of 10min. Diurnal patterns of SIgA showed a steep fall in the morning followed by a flattening out. SIgA was not associated with type of care, but lower caregiver sensitivity was associated with lower SIgA levels in both types of care. Quality of child care is associated with a non-specific secretory component of children''s mucosal immunity with well established protective effects against upper respiratory infections. [Copyright &y& Elsevier]

Abstract: It is unclear whether there is hemispheric specialization for prosodic perception and, if so, what the nature of this hemispheric asymmetry is. Using the lesion-approach, many studies have attempted to test whether there is hemispheric specialization for emotional and linguistic prosodic perception by examining the impact of left vs. right hemispheric damage on prosodic perception task performance. However, so far no consensus has been reached. In an attempt to find a consistent pattern of lateralization for prosodic perception, a meta-analysis was performed on 38 lesion studies (including 450 left hemisphere damaged patients, 534 right hemisphere damaged patients and 491 controls) of prosodic perception. It was found that both left and right hemispheric damage compromise emotional and linguistic prosodic perception task performance. Furthermore, right hemispheric damage degraded emotional prosodic perception more than left hemispheric damage (trimmed g =−0.37, 95% CI [−0.66; −0.09], N =620 patients). It is concluded that prosodic perception is under bihemispheric control with relative specialization of the right hemisphere for emotional prosodic perception. [Copyright &y& Elsevier]

Summary: Recent correlational studies showed that oxytocin is associated with parenting style in humans as in other mammals. Here the first double-blind, placebo-controlled, within-subject experiment with intranasal oxytocin administration is presented. Subjects were 17 fathers with their toddler, observed in two play sessions of 15min each with an intervening period of 1 week. In the oxytocin condition fathers were more stimulating of their child''s exploration than in the placebo condition, and they tended to show less hostility. Parent training experiments might be combined with intranasal oxytocin administration to test differential and cumulative effects of traditional, interaction-focused versus pharmaceutical treatments. [Copyright &y& Elsevier]

Abstract: To study the effect of institutional rearing on physical growth and stress regulation we examined 16 institution-reared children (3–6 years old) in Ukraine and compared them with 18 native family-reared children pair-matched on age and gender. Physical growth trajectories were examined on the basis of archival medical records and current measurements of height, weight, and head circumference. Stress regulation was studied on the basis of diurnal salivary cortisol sampled six times during 1 day. 31% of institution-reared children were stunted at 48 months whereas none of the family-reared children were. Substantial delays in physical growth were observed in institution-reared children especially during the first year of life. From 24 months onwards a tendency for improvement in physical growth was evident among the temporarily stunted institution-reared children, with complete catch-up in weight and partial catch-up in height by the time of assessment. Chronically stunted institution-reared children demonstrated persistent severe growth delays. Institution-reared and family-reared children showed similar patterns of diurnal cortisol production with decreases over the day. However, temporarily stunted institution-reared children had a significantly higher total daily cortisol production than both chronically stunted institution-reared children and family-reared children. These data confirm previous findings regarding physical growth delays and stress dysregulation associated with institutional care, but also point to differences in cortisol production between stunted and non-stunted institution-reared children. [Copyright &y& Elsevier]

Abstract: We reviewed nine studies in which children''s cortisol levels at center daycare were assessed. Our first hypothesis, concerning intraindividual differences in cortisol levels across home and daycare settings, was also tested in a meta-analysis. Our main finding was that at daycare children display higher cortisol levels compared to the home setting. Diurnal patterns revealed significant increases from morning to afternoon, but at daycare only. The combined effect size for seven pertinent studies (n =303) was r =.18 (CI .06–.29, p =.003). We examined all papers on possible associations between cortisol levels and quality of care, and the influences of age, gender, and children''s temperament. Age appeared to be the most significant moderator of this relation. It was shown that the effect of daycare attendance on cortisol excretion was especially notable in children younger than 36 months. We speculate that children in center daycare show elevated cortisol levels because of their stressful interactions in a group setting. [Copyright &y& Elsevier]

The development of social-cognitive abilities in infancy is subject to an intricate interaction between maturation of neural systems and environmental input. We investigated the role of infants' attachment relationship quality in shaping infants' neural responses to observed social interactions. One-hundred thirty 10-month-old infants participated in an EEG session while they watched animations involving a distressing separation event that ended with either comforting or ignoring behavior. Frontal asymmetry (FA) in the alpha range - which is indicative of approach-withdrawal tendencies - was measured with EEG. Attachment quality was assessed using the Strange Situation procedure at 12 months. Overall, infants with disorganized attachment showed a lack of right-sided – withdrawal related – FA compared to secure and insecure infants. Furthermore, only avoidant infants exhibited reduced right-sided FA responses following the separation. Contrary to our expectations, the type of response (comforting vs. ignoring) did not elicit differences in FA patterns, and attachment quality did not moderate the effects of the type of response on frontal asymmetry. Implications for research on attachment-related biases in social information processing and on the neural underpinnings of prosocial behaviors are discussed. [ABSTRACT FROM AUTHOR]

Scientific research can be categorized into: a) descriptive research, with the main goal to summarize characteristics of a group (or person); b) predictive research , with the main goal to forecast future outcomes that can be used for screening, selection, or monitoring; and c) explanatory research , with the main goal to understand the underlying causal mechanism, which can then be used to develop interventions. Since each goal requires different research methods in terms of design, operationalization, model building and evaluation, it should form an important basis for decisions on how to set up and execute a study. To determine the extent to which developmental research is motivated by each goal and how this aligns with the research designs that are used, we evaluated 100 publications from the Consortium on Individual Development (CID). This analysis shows that the match between research goal and research design is not always optimal. We discuss alternative techniques, which are not yet part of the developmental scientist's standard toolbox, but that may help bridge some of the lurking gaps that developmental scientists encounter between their research design and their research goal. These include unsupervised and supervised machine learning, directed acyclical graphs, Mendelian randomization, and target trials. [ABSTRACT FROM AUTHOR]

Background: Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences? Methods: DNA was obtained from growth phase entrained Epstein-Barr Virus (EBV) transformed lymphoblast cell lines from 143 adopted participants. Genotype of the serotonin transporter linked polymorphic region (5HTTLPR) was determined, and methylation ratios for each of the C-phosphate-G (CpG) residues were assessed using quantitative mass spectroscopy. Unresolved loss or trauma was established using the Berkeley Adult Attachment Interview. Results: Higher levels of methylation of the 5HTT promoter associated CpG island were associated with increased risk of unresolved responses to loss or other trauma in carriers of the usually protective 5HTTLPR ll variant. The ss variant of 5HTTLPR predicted more unresolved loss or trauma, but only in case of lower levels of methylation. Higher levels of methylation of the ss variant were associated with less unresolved loss or other trauma. Conclusions: Associations between 5HTTLPR polymorphisms and psychological problems are significantly altered by environmentally induced methylation patterns. Methylation may serve as the interface between adverse environment and the developing organism. [ABSTRACT FROM AUTHOR]

In this study, we aimed to develop a behavioral task that measures pro-social decision making in rats. A fully automated, operant pro-social two-choice task is introduced that quantifies pro-social preferences for a mutual food reward in a set-up with tightly controlled task contingencies. Pairs of same-sex adult Wistar rats were placed in an operant chamber divided into two compartments (one rat per compartment), separated by a transparent barrier with holes that allowed the rats to see, hear, smell, but not touch each other. Test rats could earn a sucrose pellet either for themselves (own reward) or for themselves and the partner (both reward) by means of lever pressing. On average, male rats showed a 60 % preference for the lever that yielded a food reward for both themselves and their partner. In contrast, females did not show lever preference, regardless of the estrous cycle phase. Next, the impact of juvenile environmental factors on male rat social decision making was studied. Males were group-housed from postnatal day 26 onwards in complex housing Marlau™ cages that provided social and physical enrichment and stimulation in the form of novelty. Complex housed males did not show a preference for the pro-social lever. [ABSTRACT FROM AUTHOR]

The transition period between early childhood and late adolescence is characterized by pronounced changes in social competence, or the capacity for flexible social adaptation. Here, we propose that two processes, self-control and prosociality, are crucial for social adaptation following social evaluation. We present a neurobehavioral model showing commonalities in neural responses to experiences of social acceptance and rejection, and multiple pathways for responding to social context. The Leiden Consortium on Individual Development (L-CID) provides a comprehensive approach towards understanding the longitudinal developmental pathways of, and social enrichment effects on, social competence, taking into account potential differential effects of such enrichment. Using Neurosynth based brain maps we point towards the medial prefrontal cortex as an important region integrating social cognition, self-referential processing and self-control for learning to respond flexibly to changing social contexts. Based on their role in social evaluation processing, we suggest to examine medial prefrontal cortex connections with lateral prefrontal cortex and the ventral striatum as potential neural differential susceptibility markers, in addition to previously established markers of differential susceptibility. [ABSTRACT FROM AUTHOR]

Prosocial behavior and empathy are important aspects of developing social relations in childhood. Prior studies showed protracted structural development of social brain regions associated with prosocial behavior. However, it remains unknown how structure of the social brain is influenced by genetic or environmental factors, and whether overlapping heritability factors explain covariance in structure of the social brain and behavior. The current study examined this hypothesis in a twin sample (aged 7–9-year; N = 512). Bilateral measures of surface area and cortical thickness of the medial prefrontal cortex (mPFC), temporo-parietal junction (TPJ), posterior superior temporal sulcus (pSTS), and precuneus were analyzed. Results showed genetic contributions to surface area and cortical thickness for all brain regions. We found additional shared environmental influences for TPJ, suggesting that this region might be relatively more sensitive to social experiences. Genetic factors also influenced parent-reported prosocial behavior (A = 45%) and empathy (A = 59%). We provided initial evidence that the precuneus shares genetically determined variance with empathy, suggesting a possible small genetic overlap (9%) in brain structure and empathy. These findings show that structure of the social brain and empathy are driven by a combination of genetic and environmental factors, with some factors overlapping for brain structure and behavior. [ABSTRACT FROM AUTHOR]

• We meta-analyzed the association between parenting and testosterone. • Studies on male participants were included (k = 50 studies, N = 7,080). • The combined effect size for parental status was a Hedges g = 0.22. • P-hacking seemed absent, but publication bias might have inflated the effect. • Effect sizes for parenting quality and reactivity were weak. In fathers testosterone levels are suggested to decrease in the context of caregiving, but results seem inconsistent. In a meta-analysis including 50 study outcomes with N = 7,080 male participants we distinguished three domains of research, relating testosterone levels to parental status (Hedges' g = 0.22, 95% CI: 0.09 to 0.35; N = 4,150), parenting quality (Hedges' g = 0.14, 95% CI: 0.03 to 0.24; N = 2,164), and reactivity after exposure to child stimuli (Hedges' g = 0.19, 95% CI: -0.03 to 0.42; N = 766). The sets of study outcomes on reactivity and on parenting quality were both homogeneous. Parental status and (higher) parenting quality were related to lower levels of testosterone, but according to conventional criteria combined effect sizes were small. Moderators did not significantly modify combined effect sizes. Results suggest that publication bias might have inflated the meta-analytic results, and the large effects of pioneering but small and underpowered studies in the domains of males' parental status and parenting quality have not been consistently replicated. Large studies with sufficient statistical power to detect small testosterone effects and, in particular, the moderating effects of the interplay with other endocrine systems and with contextual determinants are required. [ABSTRACT FROM AUTHOR]

Poor quality of the early infant-parent bond predicts later child problems. Infant-parent attachment has been suggested to influence brain development, but this association has hardly been examined. In adults, larger amygdala volumes have been described in relation to early attachment disorganization; neuroimaging studies of attachment in children, however, are lacking. We examined the association between infant-parent attachment and brain morphology in 551 children from a population-based cohort in the Netherlands. Infant-parent attachment was observed with the Strange-Situation Procedure at age 14 months and different brain measures were collected with magnetic resonance imaging at mean age 10 years. Children with disorganized infant attachment had larger hippocampal volumes than those with organized attachment patterns. This finding was robust to the adjustment for confounders and consistent across hemispheres. The association was not explained by cognitive or emotional and behavioral problems. Disorganized attachment did not predict any other difference in brain morphology. Moreover, children with insecure organized infant attachment patterns did not differ from those who were securely attached in any brain outcome. Causality cannot be inferred, but our findings in this large population-based study provide novel evidence for a long-term association between the quality of infant-parent attachment and specific brain differences in childhood. [ABSTRACT FROM AUTHOR]

This preregistered randomized controlled study investigated the effects of Video-Feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD) on parents' secure base script knowledge (SBSK). Furthermore, we examined whether effects of VIPP-SD on sensitive caregiving and sensitive discipline behavior and parents' attitudes toward these behaviors were moderated by SBSK at baseline. Families (n = 445) with pre- and school-aged children (n = 890) were randomized to receive VIPP-SD or telephone calls. Results showed no effects of VIPP-SD on SBSK. Furthermore, there was no moderation of effects on sensitive caregiving or sensitive discipline behavior by SBSK. VIPP-SD promoted positive attitudes toward sensitive caregiving and sensitive discipline behavior. The latter effect was moderated by SBSK: parents with lower SBSK showed the strongest improvements in positive attitudes toward sensitive discipline behavior. This effect was driven by a subgroup of younger children. These findings highlight the potential importance of tailoring interventions to meet the specific needs of parents with varying levels of SBSK. • We found no effects of VIPP-SD on parental secure base script knowledge (SBSK). • SBSK moderates effects of VIPP-SD on discipline attitudes. • Parents with lower SBSK benefit most from VIPP-SD. • VIPP-SD is effective in promoting positive attitudes toward sensitivity. • Effects on promoting positive attitudes toward sensitivity are independent of SBSK. [ABSTRACT FROM AUTHOR]

The neuropeptide oxytocin plays an important role in social behavior, parenting, and affectionate touch and there is some evidence that oxytocin release can be stimulated by massage or affectionate touch. We examined the effects of massage applied by a massage seat cover on salivary oxytocin levels in two exploratory studies using within-subject designs. In Study 1 massage effects on oxytocin levels were examined in a sample of N = 20 healthy female participants. Effects of a 15-min massage session were compared to a control condition during which participants sat on a comfortable chair without a massage seat cover. Salivary oxytocin levels were measured at baseline and up to three hours after the session. We found that massage attenuated oxytocin decreases over time, indicating that massage stimulates oxytocin release. In Study 2, we examined whether effects of massage in N = 46 healthy male participants depend on experiences of emotional maltreatment. In addition, we examined whether enhanced oxytocin levels after massage affect the use of excessive handgrip force in response to infant crying and laughter as measured with a handgrip dynamometer. Our findings show that massage results in elevated oxytocin levels compared to a control condition, but that the effects of massage are dependent on experiences of emotional maltreatment. Men with experiences of emotional maltreatment showed lower oxytocin levels, which did not increase after massage. Furthermore, we found that high oxytocin levels after massage were related to reduced handgrip force during exposure to infant crying and laughter, indicating that massage stimulates a sensitive response to infant signals by stimulating oxytocin release. Although massage did not affect oxytocin levels in individuals with experiences of maltreatment, it reduced the use of handgrip force in response to infant crying and laughter in these individuals. Our findings indicate that emotional maltreatment is associated with atypical responding to stimulation of endogenous oxytocin release. [ABSTRACT FROM AUTHOR]

Temperament involves stable behavioral and emotional tendencies that differ between individuals, which can be first observed in infancy or early childhood and relate to behavior in many contexts and over many years.1 One of the most rigorously characterized temperament classifications relates to the tendency of individuals to avoid the unfamiliar and to withdraw from unfamiliar people, objects, and unexpected events. This temperament is referred to as behavioral inhibition or inhibited temperament (IT).2 IT is a moderately heritable trait1 that can be measured in multiple species.3 In humans, levels of IT can be quantified from the first year of life through direct behavioral observations or reports by caregivers or teachers. Similar approaches as well as self-report questionnaires on current and/or retrospective levels of IT1 can be used later in life. [ABSTRACT FROM AUTHOR]

The associations between attachment representations of adopted young adults and their experiential and physiological arousal to infant crying were examined. Attachment representations were assessed with the Attachment Script Assessment (ASA), and the young adults listened to infant cries, during which ratings of cry perception were collected and physiological reactivity was measured. Secure adoptees showed a well-integrated response to infant distress: heart-rate increases and respiratory sinus arrhythmia (RSA) withdrawal were coupled with heightened perception of urgency in these individuals. In insecure adoptees RSA withdrawal was absent, and a combination of lowered perceived urgency and heightened sympathetic arousal was found, reflecting a deactivating style of emotional reactivity. Overall, our findings support the idea that internal working models of attachment explain individual differences in the way attachment-related information is processed. [ABSTRACT FROM AUTHOR]

The neuropeptide oxytocin facilitates parental caregiving and is involved in the processing of infant vocal cues. In this randomized-controlled trial with functional magnetic resonance imaging we examined the influence of intranasally administered oxytocin on neural activity during emotion recognition in infant faces. Blood oxygenation level dependent (BOLD) responses during emotion recognition were measured in 50 women who were administered 16 IU of oxytocin or a placebo. Participants performed an adapted version of the Infant Facial Expressions of Emotions from Looking at Pictures (IFEEL pictures), a task that has been developed to assess the perception and interpretation of infants' facial expressions. Experimentally induced oxytocin levels increased activation in the inferior frontal gyrus (IFG), the middle temporal gyrus (MTG) and the superior temporal gyrus (STG). However, oxytocin decreased performance on the IFEEL picture task. Our findings suggest that oxytocin enhances processing of facial cues of the emotional state of infants on a neural level, but at the same time it may decrease the correct interpretation of infants' facial expressions on a behavior level. This article is part of a Special Issue entitled Oxytocin and Social Behav . [ABSTRACT FROM AUTHOR]

This study examined whether neural processing of infant cry sounds changes across the transition to fatherhood (i.e., from the prenatal to postnatal period), and examined whether an interaction-based prenatal intervention modulated these changes. Furthermore, we explored whether postnatal activation in brain regions showing transition or intervention effects was associated with sensitive care and involvement. In a randomized controlled trial, 73 first-time expectant fathers were enrolled, of whom 59 had at least 1 available fMRI scan. Intervention and transition effects on cry processing were analyzed in the amygdala and superior frontal gyrus (SFG) using linear mixed effect models with all available data and with intent-to-treat analyses. Further, exploratory whole-brain analyses were performed. ROI analyses suggest that the transition to fatherhood is characterized by decreasing activation in response to cry vs control sounds in the amygdala but not SFG. Exploratory whole-brain analyses also show a decrease in activation over the transition to fatherhood in the sensorimotor cortex, superior lateral occipital cortex, hippocampus, and regions of the default mode network. In the putamen and insula, larger decreases were found in fathers with more adverse childhood caregiving experiences. In regions showing transitional changes, higher postnatal activation was associated with more concurrent parenting sensitivity. No effects of the intervention were found. The decrease in activation from the pre- to postnatal period may reflect fathers' habituation to cry sounds over repeated exposures. The positive association between postnatal neural activation and paternal sensitive care suggest that continued sensitivity to cry sounds may be conducive to parenting quality. • We examined the effect of a prenatal intervention for fathers on neural cry processing. • From the pre- to-postnatal period, fathers showed decreased activation to cries. • Higher postnatal activation to cries was associated with increased sensitive parenting. • No effects of the intervention were found. [ABSTRACT FROM AUTHOR]

Abstract: The current study examined professional caregivers’ perceived and physiological stress, and associations with the quality of care they provide. Participants were 55 female caregivers from childcare homes and 46 female caregivers from childcare centers in the Netherlands. In both types of settings, equivalent measures and procedures were used. On non-work days, caregivers’ salivary cortisol levels decreased between 11am and 3pm, whereas on work days, caregivers’ cortisol levels remained at the same level during this period. Caregivers’ cortisol levels and perceived stress did not differ across the two types of settings. In home-based childcare, caregivers offered higher-quality caregiving, compared to caregivers in center-based childcare. In home-based childcare – but not in center care – caregivers’ negative appraisal was associated with less positive caregiver behavior. These findings suggest that work at childcare influences cortisol secretion in professional caregivers, and that perceived stress but not cortisol is associated with quality of care. [Copyright &y& Elsevier]

Background: Selective attention to negative information has been strongly implicated in the etiology and maintenance of anxiety and offered as a potential intermediate phenotype for anxiety disorders. Attention biases have been studied in relation to a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) offering equivocal findings. The present meta-analysis tested whether the extant published data support the notion that variation in the 5-HTTLPR genotype modulates selective attention to negative information. Methods: Eleven relevant samples from 10 published articles were identified through a systematic literature search (total n = 807). Relevant attention bias and 5-HTTLPR data were extracted based on specific coding rules, and Cohen''s d effect size index was used to calculate all outcome measures. Publication bias was assessed using various methods. Results: Carriers of the low (SS, SLG, LGLG) transmission efficacy genotype display attentional vigilance toward negatively valenced stimuli, a pattern not found in the intermediate (SLA, LALG) and high (LALA) efficacy genotypes. This phenomenon emerges as of medium effect size. Conclusions: The meta-analysis supports the notion that allele variants of the 5-HTTLPR are associated with selective attention to negative stimuli. More studies are needed to fully establish the consistency of this effect. Future studies applying systematic attention bias modification may shed further light on the role of 5-HTTLPR in the development of anxiety disorders and in the prediction of clinical response to attention bias modification treatments. [Copyright &y& Elsevier]

Abstract: The central question in this study is whether individual variability in children''s cortisol levels and wellbeing at childcare can be explained by indices of quality of care and child characteristics. Participants were 71 children from childcare homes and 45 children from childcare centers in the age range of 20–40 months. In both types of settings equivalent measures and procedures were used. In home-based childcare, children experienced higher caregiver sensitivity, lower noise levels, and showed higher wellbeing compared to children in childcare centers. Caregiver sensitivity in home-based childcare – but not in center care – was positively associated with children''s wellbeing. Additionally, children displayed higher cortisol levels at childcare than at home, irrespective of type of care. In home-based childcare, lower caregiver sensitivity was associated with higher total production of salivary cortisol during the day. In center-based childcare, lower global quality of care was associated with a rise in cortisol between 11AM and 3PM during the day. Quality of care is an important factor in young children''s wellbeing and HPA stress reactivity. [Copyright &y& Elsevier]

Abstract: Recent studies have emphasized the negative impact of attachment insecurities for prosocial behavior. We examined the unique contribution of attachment insecurities to volunteerism and motives for volunteering beyond the explanatory power of high-order personality traits and assessed the potential roles of motives for volunteering in mediating and moderating the links between attachment insecurities and volunteering. One-hundred fifty-nine Dutch undergraduates completed scales tapping attachment insecurities, engagement in volunteer activities, motives for volunteering, and high-order personality traits. Findings show that attachment insecurities made a unique contribution to volunteerism beyond the explanatory power of personality traits. In addition, self-focused motives for volunteering were found to moderate the link between anxious attachment and volunteering behavior. The discussion focused on the psychological mechanisms by which attachment insecurities affect volunteerism. [Copyright &y& Elsevier]

In this study, the concept of ‘goodness-of-fit’ between the child’s temperament and the environment, introduced by Thomas and Chess [Temperament and Development, Brunner/Mazel, New York, 1977], is applied within the setting of center day care. Mothers and primary professional caregivers of 186 children, aged 6–30 months, participated in this study. The child’s problem behaviors were assessed with the CBCL Teacher Report Form [Achenbach, T.M., Guide for the Caregiver–Teacher Report Form for Ages 2–5, Department of Psychiatry, University of Vermont, Burlington, VT, 1997]. The child’s socio-emotional well-being in day care was measured with the Leiden Inventory for the Child’s Well-Being in Day Care. The Infant Characteristics Questionnaire measured the child’s temperament. Children with an easier temperament showed less internalizing and total problem behavior and more well-being. The results suggest that for children with a more difficult temperament, several parallel care arrangements interfere with the process of adapting to the day care setting. Also, our results indicate that in the group of children with greater availability of trusted caregivers, a more easy-going temperament was associated with more well-being. The association between temperament and well-being was not found in the group of children with less access to trusted caregivers. [Copyright &y& Elsevier]

In two studies in daycare centers, we investigated a newly developed index for flexible child care describing parents’ use of evening care and flexible attendance scheduling for their child. We examined the relation between this index together with stability in care, mother’s stress and the child’s temperament on the one hand, and quality of caregivers’ behavior and a child’s socio-emotional functioning in day care on the other. In Study I, the mothers and caregivers of 186 children (aged 6–30 months) participated in a survey. In Study II, approximately 18 months later, 52 children from Study I were observed in their daycare setting. Children showed more well-being in day care when they had few parallel care arrangements, and when there was more daily stability in staffing and grouping patterns. Unexpectedly, caregivers in groups with more stability in staffing and grouping patterns, showed less positive caregiving behavior. When staff turnover rate was higher, positive caregiving behavior was lower. Finally, children in more flexible child care showed more non-compliance. [Copyright &y& Elsevier]

This multi-sample study investigated the main and interactive effects of parenting (responsiveness, overreactivity) and young adolescents' personality traits (negative-affectivity: irritability and anxiety; and orienting-sensitivity) on behaviour problems during adolescence. Data from two samples (N1 = 222; girls 45.5%; Mean age = 11.54 years; N2 = 252; girls 50.4%; Mean age = 10.85 years) were analysed using a multivariate approach. Parenting and young adolescents' personality traits were assessed at Time-1 and behaviour problems were assessed 2 to 3 years later. Mothers rated their overreactive parenting practices with the Parenting-Scale (both samples); parental responsiveness was measured with the Louvain-Adolescent-Perceived-Parenting-Scale (sample-1) and the Parenting-Practices-Questionnaire (sample-2). Adolescents reported on their behaviour problems with the overlapping items of the Brief-Problem-Monitor (sample-1) and the Youth-Self-Report (sample-2). Young adolescents' personality traits were measured with the Hierarchical-Personality-Inventory-for-Children rated by mothers in sample-1 and by fathers in sample-2. No evidence supporting diathesis stress or differential susceptibility was found. Analyses revealed one interaction suggesting that adolescents with high irritability (≥1.4 SD; 9%) with more overreactive mothers presented less internalizing behaviour, when their mothers used less overreactive parenting they showed more internalizing behaviour. High-anxiety predicted internalizing behaviour. High-irritability and low-anxiety predicted externalizing behaviour. High-irritability and orienting sensitivity predicted attention problems. No main effects of parenting on behaviour problems were observed. • Early adolescence showed not to be a sensitive period for differential susceptibility to parenting. • Parenting does not have main effects on behaviour problems. • Irritability and orienting sensitivity in adolescents predicted attention problems 2–3 years later. • Irritability and low-anxiety in adolescents predicted externalizing behaviour 2–3 years later. • Anxiety in adolescents is a risk factor for developing internalizing behaviour 2–3 years later. [ABSTRACT FROM AUTHOR]

Objective: Co-occurrence of behavioral and emotional problems in childhood is widespread, and previous studies have suggested that this reflects vulnerability to experience a range of psychiatric problems, often termed a general psychopathology factor. However, the neurobiological substrate of this general factor is not well understood. We tested the hypothesis that lower overall white matter microstructure is associated with higher levels of the general psychopathology factor in children and less with specific factors.Method: Global white matter microstructure at age 10 years was related to general and specific psychopathology factors. These factors were estimated using a latent bifactor model with multiple informants and instruments between ages 6 and 10 years in 3,030 children from the population-based birth cohort Generation R. The association of global white matter microstructure and the psychopathology factors was examined with a structural equation model adjusted for sex, age at scan, age at psychopathology assessment, parental education/income, and genetic ancestry.Results: A 1-SD increase of the global white matter factor was associated with a β = -0.07SD (standard error [SE] = 0.02, p < .01) decrease in general psychopathology. In contrast, a 1-SD increase of white matter microstructure predicted an increase of β = +0.07 SD (SE = 0.03, p < .01) specific externalizing factor levels. No association was found with the specific internalizing and specific attention factor.Conclusion: The results suggest that general psychopathology in childhood is related to white matter structure across the brain and not only to specific tracts. Taking into account general psychopathology may also help reveal neurobiological mechanisms behind specific symptoms that are otherwise obscured by comorbidity. [ABSTRACT FROM AUTHOR]