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Start Over Author "Toba A" Publisher elsevier b.v.
444 results on '"Toba A"'

3. Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model

Author

Sasaki, Michihito, Sugi, Tatsuki, Iida, Shun, Hirata, Yuichiro, Kusakabe, Shinji, Konishi, Kei, Itakura, Yukari, Tabata, Koshiro, Kishimoto, Mai, Kobayashi, Hiroko, Ariizumi, Takuma, Intaruck, Kittiya, Nobori, Haruaki, Toba, Shinsuke, Sato, Akihiko, Matsuno, Keita, Yamagishi, Junya, Suzuki, Tadaki, Hall, William W., Orba, Yasuko, and Sawa, Hirofumi

Published
2024
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7. Clinical impact of optical coherence tomography findings after drug-coated balloon treatment for patients with acute coronary syndromes

Author

Yamamoto, Tetsuya, Kawamori, Hiroyuki, Toba, Takayoshi, Kakizaki, Shunsuke, Nakamura, Koichi, Fujimoto, Daichi, Sasaki, Satoru, Fujii, Hiroyuki, Hamana, Tomoyo, Osumi, Yuto, Iwane, Seigo, Naniwa, Shota, Sakamoto, Yuki, Matsuhama, Koshi, Fukuishi, Yuta, Kozuki, Amane, Shite, Junya, Iwasaki, Masamichi, Ishida, Akihiko, Hirata, Ken-ichi, and Otake, Hiromasa

Published
2023
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13. Cholesterol uptake capacity: A new measure of high-density lipoprotein functionality as a predictor of subsequent revascularization in patients undergoing percutaneous coronary intervention

Author

Fujimoto, Daichi, Otake, Hiromasa, Kawamori, Hiroyuki, Toba, Takayoshi, Nagao, Manabu, Nakano, Shinsuke, Tanimura, Kosuke, Takahashi, Yu, Fukuyama, Yusuke, Kakizaki, Shunsuke, Nakamura, Koichi, Harada, Amane, Murakami, Katsuhiro, Iino, Takuya, Toh, Ryuji, and Hirata, Ken-ichi

Published
2022
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21. Development of Pericardial Fat Count Images Using a Combination of Three Different Deep-Learning Models: Image Translation Model From Chest Radiograph Image to Projection Image of Three-Dimensional Computed Tomography.

Author

Matsunaga, Takaaki, Kono, Atsushi, Matsuo, Hidetoshi, Kitagawa, Kaoru, Nishio, Mizuho, Hashimura, Hiromi, Izawa, Yu, Toba, Takayoshi, Ishikawa, Kazuki, Katsuki, Akie, Ohmura, Kazuyuki, and Murakami, Takamichi

Abstract

Pericardial fat (PF)—the thoracic visceral fat surrounding the heart—promotes the development of coronary artery disease by inducing inflammation of the coronary arteries. To evaluate PF, we generated pericardial fat count images (PFCIs) from chest radiographs (CXRs) using a dedicated deep-learning model. We reviewed data of 269 consecutive patients who underwent coronary computed tomography (CT). We excluded patients with metal implants, pleural effusion, history of thoracic surgery, or malignancy. Thus, the data of 191 patients were used. We generated PFCIs from the projection of three-dimensional CT images, wherein fat accumulation was represented by a high pixel value. Three different deep-learning models, including CycleGAN were combined in the proposed method to generate PFCIs from CXRs. A single CycleGAN-based model was used to generate PFCIs from CXRs for comparison with the proposed method. To evaluate the image quality of the generated PFCIs, structural similarity index measure (SSIM), mean squared error (MSE), and mean absolute error (MAE) of (i) the PFCI generated using the proposed method and (ii) the PFCI generated using the single model were compared. The mean SSIM, MSE, and MAE were 8.56 × 10−1, 1.28 × 10−2, and 3.57 × 10−2, respectively, for the proposed model, and 7.62 × 10−1, 1.98 × 10−2, and 5.04 × 10−2, respectively, for the single CycleGAN-based model. PFCIs generated from CXRs with the proposed model showed better performance than those generated with the single model. The evaluation of PF without CT may be possible using the proposed method. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients

Author

Yamamoto, Hiroyuki, Yoshida, Naofumi, Shinke, Toshiro, Otake, Hiromasa, Kuroda, Masaru, Sakaguchi, Kazuhiko, Hirota, Yushi, Toba, Takayoshi, Takahashi, Hachidai, Terashita, Daisuke, Uzu, Kenzo, Tahara, Natsuko, Shinkura, Yuto, Kuroda, Kouji, Nagasawa, Yoshinori, Nagano, Yuichiro, Tsukiyama, Yoshiro, Yanaka, Ken-ichi, Emoto, Takuo, Sasaki, Naoto, Yamashita, Tomoya, Ogawa, Wataru, and Hirata, Ken-ichi

Published
2018
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24. The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography

Author

Nagasawa, Yoshinori, Shinke, Toshiro, Toh, Ryuji, Ishida, Tatsuro, Otake, Hiromasa, Takaya, Tomofumi, Sugiyama, Daisuke, Toba, Takayosi, Kuroda, Masaru, Takahashi, Hachidai, Terashita, Daisuke, Tahara, Natsuko, Shinkura, Yuto, Uzu, Kenzo, Kashiwagi, Daiji, Kuroda, Koji, Nagano, Yuichiro, Yamamoto, Hiroyuki, Yanaka, Kenichi, Tsukiyama, Yoshiro, and Hirata, Ken-ichi

Published
2017
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26. Effectiveness of surveillance by echocardiography for cancer therapeutics-related cardiac dysfunction of patients with breast cancer.

Author

Okushi, Yuichiro, Saijo, Yoshihito, Yamada, Hirotsugu, Toba, Hiroaki, Zheng, Robert, Seno, Hiromitsu, Takahashi, Tomonori, Ise, Takayuki, Yamaguchi, Koji, Yagi, Shusuke, Soeki, Takeshi, Wakatsuki, Tetsuzo, Sata, Masataka, and Kusunose, Kenya

Abstract

Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-human epidermal growth factor receptor type 2 (HER2) antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients. We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in global longitudinal strain of 15 % were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint. The mean age was 59 ± 12 years. During the follow-up period of 15 months (12–17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1 % vs. 5.5 %, adjusted odds ratio: 0.28, 95 % confidential intervals: 0.09–0.94; p = 0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group. The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer. [Display omitted] • Cancer therapeutics-related cardiac dysfunction (CTRCD) affects the prognosis of patients with breast cancer. • Echocardiographic surveillance showed effectiveness for CTRCD. • Further research is needed on the effectiveness of tailoring surveillance. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Cholesterol uptake capacity: A new measure of high-density lipoprotein functionality as a predictor of subsequent revascularization in patients undergoing percutaneous coronary intervention

Author

Daichi Fujimoto, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Manabu Nagao, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Shunsuke Kakizaki, Koichi Nakamura, Amane Harada, Katsuhiro Murakami, Takuya Iino, Ryuji Toh, and Ken-ichi Hirata

Subjects
Secondary prevention, Cholesterol, HDL, Cholesterol efflux capacity, Coronary artery disease, Functionality of high-density lipoprotein, Cholesterol, Percutaneous Coronary Intervention, Treatment Outcome, Risk Factors, Humans, High-density lipoprotein, Lipoproteins, HDL, Cardiology and Cardiovascular Medicine, Cholesterol uptake capacity, Retrospective Studies
Abstract

Background and aims High-density lipoprotein (HDL) functionality is an important determinant of coronary artery disease (CAD) development. We recently developed cholesterol-uptake capacity (CUC), a rapid cell-free assay system that directly evaluates the capacity of HDL to accept additional cholesterol. We aimed to evaluate the association between CUC and revascularization in patients who have undergone percutaneous coronary intervention (PCI). Methods We retrospectively reviewed patients who underwent PCI with subsequent revascularization or coronary angiography (CAG) without revascularization. The patients who had frozen blood samples for which CUC were measurable at the index PCI and follow-up were enrolled. Results We finally enrolled 74 patients who underwent subsequent revascularization and 183 patients who underwent follow-up CAG without revascularization. The serum CUC level at the index PCI was significantly lower in the revascularization group than that in the non-revascularization group (84.3 [75.2–98.9] vs. 92.0 [81.6–103.3 A U.]; p = 0.004). Multivariate logistic regression analysis revealed that decreased serum CUC level at the index PCI was independently associated with subsequent revascularization (odds ratio, 0.98; 95% confidence interval, 0.969–1.000). After adjusting for 16 cardiovascular risk factors, the serum CUC level at the index PCI and follow-up and the absolute change in serum CUC level from the index PCI to follow-up were significantly lower in the revascularization group than those in the non-revascularization group. Conclusions Serum CUC level at index PCI was independently associated with subsequent revascularization after PCI. Continuous assessment of HDL functionality by CUC might help predict subsequent revascularization after PCI.

Published
2022

30. Association of acute improvement in left ventricular longitudinal function after transcatheter aortic valve implantation with outcomes for severe aortic stenosis and preserved ejection fraction.

Author

Takeuchi, Kimikazu, Yamauchi, Yuki, Shiraki, Hiroaki, Sumimoto, Keiko, Shono, Ayu, Suzuki, Makiko, Yamashita, Kentaro, Toba, Takayoshi, Kawamori, Hiroyuki, Otake, Hiromasa, Hirata, Ken-ichi, and Tanaka, Hidekazu

Abstract

Global longitudinal strain (GLS) is reportedly a sensitive marker for early subtle abnormalities in left ventricular (LV) performance of asymptomatic patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). For symptomatic patients with severe AS and preserved LVEF, however, the association of immediate improvement in GLS after transcatheter aortic valve implantation (TAVI) with long-term outcomes remains uncertain. This study concerned 151 symptomatic patients with severe AS and preserved LVEF who had undergone TAVI. Echocardiography was performed before TAVI and 7 (7–9) days after TAVI. GLS was determined by means of a two-dimensional speckle-tracking strain using current guidelines. The primary endpoint was defined as a composite endpoint comprising cardiovascular death or re-hospitalization for HF after TAVI over a median follow-up period of 27.7 (11.9–51.4) months. Mean LVEF and GLS were 65 ± 7 % and 12.8 ± 3.4 %, respectively. The Kaplan-Meier curve indicated that patients with acute improvement in GLS after TAVI experienced fewer cardiovascular events than those without such improvement (log-rank P = 0.02). Multivariate analysis showed that non-acute improvement in GLS after TAVI was independently associated with worse outcomes as well as deterioration of the mean transaortic pressure gradient. Assessment of GLS immediately after TAVI is a valuable additional parameter for better management of symptomatic patients with severe AS and preserved LVEF who are scheduled for TAVI. [Display omitted] • Patients with acute improvement in GLS after TAVI experienced favorable outcome. • Acute improvement in GLS after TAVI was independently associated with outcome. • Assessment of GLS immediately after TAVI is a valuable additional parameter. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Pharmacokinetic Approach for the Elucidation of Elevated Plasma Small Extracellular Vesicle (sEV) Concentration in Cancer.

Author

Yamamoto, Aki, Toba, Mihiro, Takahashi, Yuki, and Takakura, Yoshinobu

Subjects
*EXTRACELLULAR vesicles, *PHARMACOKINETICS, *DETECTION limit, *LABORATORY mice, *ANIMAL disease models
Abstract

The abundance of circulating plasma small extracellular vesicles (sEVs) has been reported to be elevated in cancer; however, the underlying mechanism remains unclear. In this study, a pharmacokinetic approach was used to determine the factors contributing to elevated plasma sEV levels during cancer in a tumor-bearing mouse model. Mouse plasma-derived sEVs (MP-sEVs) isolated from tumor-bearing mice showed increased protein concentrations and physicochemical characteristics comparable to MP-sEVs isolated from healthy mice. The steady-state concentration of sEVs is determined by the balance between the MP-sEV production and clearance. Thus, to determine whether tumorigenesis influences sEV clearance, isolated MP-sEVs were intravenously administered to either tumor-bearing or healthy mice. The results showed minimal differences in sEV clearance rates, suggesting that sEV production is the driving force of elevated MP-sEV concentrations. Lastly, CD63-gLuc stably expressing B16BL6-bearing mice were used to estimate the contribution of tumor cell-derived sEVs in the plasma. The gLuc activity of the MP-sEVs isolated was below the limit of detection, and it was estimated that the tumor cell-derived sEVs comprised at most 0.5% of the total MP-sEVs. Taken together, these results suggest that cells other than tumor cells contribute to elevated plasma sEV levels in cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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