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CoFe 2 O 4 &V 2 CT x hybrid material was synthesized as a high volumetric performance anode in lithium-ion batteries by an in-situ hydrothermal method. Multilayered V 2 CT x in the hybrid acts as a superior host for homogenous loading CoFe 2 O 4 nanoparticles due to the opened two-dimensional structure of MXene, favorable electrical conductivity and low Li+ diffusion barrier. XRD results confirmed CoFe 2 O 4 &V 2 CT x hybrid had been formed, and SEM images showed the spherical CoFe 2 O 4 nanoparticles were randomly deposited on the surface of accordion-like morphology MXene. Being an anode material, it exhibited a good reversible capacity of 638.6 mAh g−1 with 97.8 % coulombic efficiency after 100 cycles at 1 C. In addition, ex-situ X-ray photoelectron spectra revealed that a redox reaction was involved in the Li+ ions extraction/insertion process. Our work provides further insight into the hybrid application of the binary metal & layered MXene hybrids as high-performance anode electrodes for lithium-ion batteries. [Display omitted] • CFO&V 2 CT x hybrid material were prepared the by in-situ hydrothermal method. • CFO&V 2 CT x hybrid exhibited a reversible capacity of 638.6 mAh g−1 after 100 cycles at 1 C. • Ex-situ XPS revealed a redox reaction was involved in the Li+ ions extraction/insertion process. [ABSTRACT FROM AUTHOR]

The Liver is the most common organ for metastasis for various cancers, including uveal melanoma, the most common primary intraocular tumor. Uveal melanoma metastasizes to the liver in ~90% of patients, and results in death in almost all cases due to late detection and lack of effective treatment. There is a pressing unmet medical need to develop MRI contrast agents and imaging methodologies with desired sensitivity and specificity to overcome the high heterogeneous background and in vivo properties as well as reduced toxicity. Herein, we report the development of a collagen targeting protein contrast agent (ProCA32.collagen1), since collagen is a diagnostic biomarker and therapeutic target for many types of primary and metastatic cancers and the tumor microenvironment. In addition to a strong affinity to collagen I, ProCA32.collagen1 possesses high relaxivities (r 1 and r 2 are 68.0 ± 0.25 and 100.0 ± 0.32 mM−1 s−1 at 1.4 T, respectively, and 42.6 ± 1.0 and 217 ± 2.4 mM−1s−1 at 7.0 T per particle). ProCA32.collagen1 also has strong serum stability against degradation, resistance to transmetallation, and 102 and 1013-fold higher metal selectivity for Gd3+ over Ca2+ and Zn2+, respectively, compared to clinical contrast agents. ProCA32.collagen1 does not exhibit any cell toxicity for various cell lines. Sensitive detection of liver lesions in animal models can be achieved using multiple imaging methodologies, taking advantage of the dual relaxation property of ProCA32.collagen1. ProCA32.collagen1 enables sensitive and early stage detection of hepatic micrometastasis as small as 0.144 mm2 and two different tumor growth patterns. Further development of ProCA32.collagen1 has the potential to greatly facilitate non-invasive, early detection and staging of primary and metastatic liver cancers, and devising effective treatments. [ABSTRACT FROM AUTHOR]