1. Effect of propofol on cortico-cortical evoked potentials: findings of intraoperative dorsal language pathway monitoring
- Author
-
Sei Nishida, Rika Inano, Yukihiro Yamao, Takayuki Kikuchi, Akio Ikeda, Takuro Nakae, Yoshiki Arakawa, Riki Matsumoto, Takeharu Kunieda, Kazumichi Yoshida, Susumu Miyamoto, and Sumiya Shibata
- Subjects
Adult ,Male ,Dorsum ,Adolescent ,Intraoperative Neurophysiological Monitoring ,Remifentanil ,050105 experimental psychology ,White matter ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Neural Pathways ,medicine ,Humans ,Hypnotics and Sedatives ,0501 psychology and cognitive sciences ,Evoked Potentials ,Propofol ,Aged ,Language ,Cortico-cortical evoked potential ,Cerebral Cortex ,Dorsal language pathway ,Brain Neoplasms ,business.industry ,Waveform correlation ,05 social sciences ,Middle Aged ,White Matter ,Sensory Systems ,Awake craniotomy ,medicine.anatomical_structure ,Neurology ,Anesthesia ,Electrical stimulation ,Female ,Neurology (clinical) ,business ,Craniotomy ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objective In order to evaluate the clinical utility even under general anesthesia, the present study aimed to clarify the effect of anesthesia on the cortico–cortical evoked potentials (CCEPs). Methods We analyzed 14 patients’ data in monitoring the integrity of the dorsal language pathway by using CCEPs both under general anesthesia with propofol and remifentanil and awake condition, with the main aim of clarifying the effect of anesthesia on the distribution and waveform of CCEPs. Results The distribution of larger CCEP response sites, including the locus of the maximum CCEP response site, was marginally affected by anesthesia. With regard to similarity of waveforms, the mean waveform correlation coefficient indicated a strong agreement. CCEP N1 amplitude increased by an average of 25.8% from general anesthesia to waking, except three patients. CCEP N1 latencies had no correlation in changes between the two conditions. Conclusions We demonstrated that the distribution of larger CCEP responses was marginally affected by anesthesia and that the CCEP N1 amplitude had tendency to increase from general anesthesia to the awake condition. Significance The CCEP method provides the efficiency of intraoperative monitoring for dorsal language white matter pathway even under general anesthesia.
- Published
- 2021