1. Osteonecrosis of the jaw related oral solitary myeloid sarcoma.
- Author
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Fushimi, Mao, Ohbayashi, Yumiko, Takao, Kenjiro, Higuchi, Saki, Nakai, Yasuhiro, Nakai, Fumi, Iwasaki, Akinori, Uemura, Makiko, Imataki, Osamu, and Miyake, Minoru
- Abstract
Myeloid sarcoma (MS) is a myeloblast-derived neoplasm that develops in areas other than the bone marrow, and MS associated with chronic myelomonocytic leukemia (CMML) has rarely been reported. Documentation of the initial symptoms of myeloid sarcoma in the oral cavity is also extremely rare. Most cases of osteonecrosis of the jaw (ONJ) have been reported to be iatrogenic, with origins such as osteoradionecrosis and treatment with bisphosphonates. We provide herein the first case report of MS with osteonecrosis of the mandible as a clinical manifestation of acute transformation of CMML. The patient was a 39-year-old Japanese man in whom necrosis of the mandibular bone marrow was caused by a rapid proliferation of myeloblasts. Patients with hematological disorders should always be monitored for the appearance of oral lesions, and thorough examinations and oral hygiene management may be necessary to prevent the exacerbation of infection. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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