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Summary: Central vascular catheters (CVC) are used extensively in critical care for monitoring and therapy. They can become colonised with viable micro-organisms within 24h of insertion, which can rapidly form biofilm. This colonisation is a precursor of catheter-related bloodstream infections (CR-BSI), which are associated with substantial morbidity, mortality, prolonged hospital stay and increased cost. Antimicrobials have been incorporated into the bulk material of CVC or applied to their surfaces as a coating in an attempt to reduce the incidence of CVC colonisation and infection. This study examines the effect of a silver zeolite-impregnated catheter on catheter-related colonisation and infection in adult critical care patients. The study was conducted in adult Intensive Care Units (ICU) at three acute hospitals over 14 months and involved 246 CVC insertions (122 silver-impregnated and 124 non-impregnated). CVC tip colonisation was detected by the Maki Roll culture and CR-BSI by differential time-to-positivity of blood cultures. Overall colonisation rate was significantly lower in the silver zeolite-impregnated CVC tips (58%) as compared with the control CVC tips (73%) (p <0.025). In addition, there was a lower rate (34%) of tip colonisation by coagulase negative staphylococci in the silver zeolite-impregnated CVC tips as compared with the control CVC tips (47%) (p <0.05). Four episodes of CR-BSI were detected in each arm by differential time-to-positivity in a subset of patients. This study indicates that the silver zeolite-impregnated catheter is superior to non-impregnated catheter in reducing the rate of CVC colonisation but it showed no difference in the rates of CR-BSI in the two arms. Larger prospective randomised control studies are required to evaluate its role in the prevention of CR-BSI. [Copyright &y& Elsevier]

Abstract: The equations for a -structure with torsion on a product are studied in relation to the induced -structure on . All solutions are found in the case when the Lee-form of the -structure is non-zero and is a six-dimensional nilmanifold with half-integrable -structure. Special properties of the torsion of these solutions are discussed. [Copyright &y& Elsevier]

Gray and Hervella gave a classification of almost Hermitian structures (g,I) into 16 classes. We systematically study the interaction between these classes when one has an almost hyper-Hermitian structure (g,I,J,K). In general dimension we find at most 167 different almost hyper-Hermitian structures. In particular, we obtain a number of relations that give hyper-Kähler or locally conformal hyper-Kähler structures, thus generalising a result of Hitchin. We also study the types of almost quaternion-Hermitian geometries that arise and tabulate the results. [Copyright &y& Elsevier]

G2-manifolds with a cohomogeneity-one action of a compact Lie group G are studied. For G simple, all solutions with holonomy G2 and weak holonomy G2 are classified. The holonomy G2 solutions are necessarily Ricci-flat and there is a one-parameter family with SU(3)-symmetry. The weak holonomy G2 solutions are Einstein of positive scalar curvature and are uniquely determined by the simple symmetry group. During the proof the equations for G2-symplectic and G2-cosymplectic structures are studied and the topological types of the manifolds admitting such structures are determined. New examples of compact G2-cosymplectic manifolds and complete G2-symplectic structures are found. [Copyright &y& Elsevier]

• We study hypars with irregular tilings, enabling the integration of plate material with diverse polygonal shapes, sourced from wood production waste. • We propose an optimization process that can adapt to given material stocks with timber panels of self-similar shape, and give configurations that have a high variety of different quadrilateral pieces. • Non-uniform sub-tiling gives a better approximation for several particular shapes (rhombic, square or rectangular), which demonstrates that the optimization works when aiming for such geometry, with best results obtained for rectangles. Hyperbolic paraboloids, "hypars," are special types of ruled surfaces. Their geometric properties provide them with loadbearing and stabilizing capacities, as well as distinct esthetic qualities. These attributes become evident in numerous applications in buildings, in many of which concrete or timber is used for the construction of the hypars. Hypars could also be relevant in the context of circular construction and design for disassembly, and the upcycling of construction waste. Due to the geometric simplicity of straight lines, which generate ruled surfaces, hypar-based structures can be designed and built with relatively simple means. They can consist of self-similar or even identical elements, which could facilitate their reuse. Compared to other types of ruled surfaces, such as conoids, hypars have the advantage of being doubly ruled, meaning that structural grids of straight elements can be formed. This paper investigates another interesting property, which is the possibility of creating flat-quad meshes by diagonally connecting the intersection points of the generatrices. This property has been previously described by other scholars, some of which explored its applicability for glass-clad steel grid shells. In this research, we focus on its potential for segmented timber shells that can serve as stand-alone structures, or as modular and reusable building parts, such as façade or roof components. The reusability of such modular units could be achieved by using reversible joints between them. More specifically, our research investigates the design space of construction systems based on such components via computational design and optimization algorithms, such as the memory limited Broyden–Fletcher–Goldfarb–Shanno (LBFGS) algorithm with automatic computation of the gradient, within the Julia programming environment. By applying principles and methods of differential geometry, we study hypars with irregular tilings, enabling the integration of panels with diverse proportions, shapes and sizes, as they can occur in wood production waste. By reducing construction waste, the work aims at reducing the negative environmental impact of the building construction sector. Moreover, irregular tilings could enable a more customized design of acoustic qualities and offer visual variety in segmented hypar based timber structures. The here presented studies show that the proposed optimization method provides a good fit of many tiles to rhombi, particularly when the steepness is not too large. We also show that optimizing towards rectangles provides better results. Overall, the results support the initial assumption that irregular rulings could be a means of adapting to both homogeneous and diverse material stocks. [ABSTRACT FROM AUTHOR]