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Background: The incidence of total knee replacements (TKRs) in young patients is increasing. Few reports described encouraging results and acceptable survival rates. However, many concerns still persist, in particular about the high rates of infection and aseptic loosening. Aim of this article was to investigate the survival of TKRs in patients aged 45 years or younger in a registry population.Methods: The Emilia-Romagna registry RIPO was enquired about TKRs in patients ≤45 years; 238 TKRs were evaluated at a mean follow-up of 5.4 years (range 0-15.6 years), examining the features of the patients involved, the survival rate, and the reasons for revision of the knee implants.Results: The TKRs were generally performed in men, in private hospitals, and almost in half of the cases for other causes rather than primary osteoarthritis. The mean age was 40 years. Bicompartmental, cemented posterior-stabilized implants with fixed bearing were preferred. The survival rate was higher than 90% in the first 7 years, and then it decremented. The choice of implant did not apparently influence the survivorship. The final outcomes were acceptable, substantially in line with the previous literature about young patients. Twenty-one revisions occurred (8.8%), in particular 8 cases for aseptic loosening and 7 TKRs for infection. The rate of revision was higher than in overall population and even in some young cohorts.Conclusion: TKRs in patients aged 45 years or younger seem a promising procedure, although the high rates of septic and aseptic loosening should be carefully evaluated. Prospective, well-designed studies are required to confirm and investigate these preliminary findings. [ABSTRACT FROM AUTHOR]

Abstract: This work discusses the wear behaviour of two different ultra-high-molecular-weight-polyethylene tibial component designs. Mobile and fixed bearings were tested on a knee wear simulator for 5 million cycles using bovine calf serum as lubricant. We correlated the wear results with the chemical characterisation of the investigated materials: Fourier Transformed Infra Red Spectroscopy analyses, Differential Scanning Calorimetry and cross-link density measurements were used to assess the chemical features of this polyethylene. Mobile and fixed polyethylene inserts showed a different wear behaviour: the mobile designs components showed lower weight losses than the fixed components (109±6mg and 163±80mg, respectively). Significant statistical differences were observed in wear rate (P =0.035, Kolmogorov–Smirnov Test for two samples). From a molecular point of view, typical radiation-induced oxidation profiles were observed in all the tested polyethylene samples, but the overall degradation was more significant in the fixed bearing inserts and this is likely to play a role on the wear performances. [Copyright &y& Elsevier]

Background The repair of the myotendinous junction following total hip arthroplasty is challenging as this region is the weakest part of the muscle structure. This study investigated the mechanical behaviour and the mode of failure of different suturing techniques of the myotendinous junction. A new asymmetrical stitch was compared to two widely used techniques, i.e. the simple stitch (two loops in parallel) and the figure-of-eight stitch. Methods The ovine triceps brachii myotendinous junction was selected as the experimental model. Each technique was sewn in muscle belly on one side and in a polyester belt (no-tendon configuration) or in thin tendon (full configuration) on the other side. The former was chosen to determine the grasping power of the stitch on the muscle despite the tendon quality, the latter to simulate a very thin gluteus medius tendon. Findings The new stitch showed a higher ultimate strength (+ 40%) compared to the two controls in the no-tendon configuration. In the full configuration, no significant increase was observed, although failure of the new stitch always occurred at the tendon side. Furthermore, the new stitch does not alter the stiffness of repair. Interpretation The new stitch has a higher grasping power on muscle belly than the single passing-through stitches thanks to the multiple fixation points, which better distribute the load in the tissue. However, such performance can be fully exploited only in the presence of good quality tendons. [ABSTRACT FROM AUTHOR]

Abstract: Small and large sized-mobile inserts (i.e. size #2 and size #6) were tested on a knee wear simulator for 2 million cycles, using bovine calf serum as lubricant. Gravimetric and micro-Raman spectroscopic analyses were performed on polyethylene inserts. Roughness analysis was performed on the metallic components. The larger size, i.e. #6, had almost twice weight loss with respect to the smaller one, i.e. #2 (37.8±2.8mg and 19.46±0.93mg, respectively). Significant statistical differences were observed in wear rates (p=0.001, Kolmogorov–Smirnov test for two samples). Raman spectroscopy showed a greater increase in crystallinity for the smaller inserts: upon wear, the orthorhombic content (α o) significantly increased at the expense of the third phase content (α b). [Copyright &y& Elsevier]

Abstract: Preoperative diagnosis of septic loosening hip prosthesis is often challenging. Culture test on joint samples obtained during revision surgery is the diagnostic gold standard while the role of preoperative hip aspiration is still controversial. The aims of this prospective randomized study were to compare the sensitivity, specificity and accuracy of preoperative ultrasound-guided and fluoroscopic-guided aspiration, and to identify associated laboratory parameters or scintigraphy that could help in predicting septic loosing hip prosthesis. Sixty patients affected by persistent pain after hip prosthesis randomly received fluoroscopic-guided or ultrasound-guided hip aspiration before revision surgery. The results of culture tests of joint fluid presurgically and at surgery were compared. In addition, associated blood inflammatory markers and scintigraphy were evaluated. Ultrasound-guided aspiration showed a better sensitivity (69% vs. 27%), specificity (94% vs. 75%) and accuracy (83% vs. 40%) than fluoroscopic-guided aspiration. The combination of ultrasound-guided aspiration and C-reactive protein represents the best model to predict septic loosening hip prosthesis preoperatively. [Copyright &y& Elsevier]