16 results on '"Stuart, Samuel"'
Search Results
2. Gait measurement in chronic mild traumatic brain injury: A model approach
- Author
-
Stuart, Samuel, Parrington, Lucy, Morris, Rosie, Martini, Douglas N., Fino, Peter C., and King, Laurie A.
- Published
- 2020
- Full Text
- View/download PDF
3. Monitoring multiple cortical regions during walking in young and older adults: Dual-task response and comparison challenges
- Author
-
Stuart, Samuel, Alcock, Lisa, Rochester, Lynn, Vitorio, Rodrigo, and Pantall, Annette
- Published
- 2019
- Full Text
- View/download PDF
4. Staying UpRight in Parkinson's disease: A pilot study of a novel wearable postural intervention.
- Author
-
Stuart, Samuel, Godfrey, Alan, and Mancini, Martina
- Subjects
- *
PARKINSON'S disease , *WEARABLE technology , *WALKING , *POSTURAL balance , *PHYSICAL therapy - Abstract
• Neck posture improved immediately with the UpRight in Parkinson's disease (PD) during sitting and standing. • Neck, trunk and low back posture did not improve with the UpRight during walking in PD. • Gait was worse when walking with the UpRight device compared to without in PD. • Postural improvement related to attentional capabilities of people with PD. • Self-reported feedback suggests that participants felt the UpRight was beneficial. This interventional pilot study aimed to 1) examine whether a novel wearable vibro-tactile feedback device ('UpRight Go') is effective and feasible to improve postural alignment in Parkinson's disease (PD); 2) explore relationships between postural alignment and attention in PD; 3) explore effect of vibro-tactile device on balance and gait; and 4) gain initial feedback on the use of the vibro-tactile device in the laboratory and at home. 25 people with PD sat, stood and walked for two-minutes without and with the UpRight device attached to their upper backs to provide feedback on postural alignment in the laboratory. A sub-group (n = 12) wore the UpRight device at home for 60 min. per day for 7-days of postural feedback. Subjective feedback on use of the device was obtained in the laboratory and at the end of the 7-day period. The primary outcome for this study was posture measured by verticality of inertial measurement units (IMUs) at the neck, trunk and low back, which was done with and without the UpRight device. Secondary outcomes included clinical measures of posture, subjective feedback on the device, computerized attention measures, gait and balance. Neck postural alignment in PD was significantly improved (reduced neck flexion) with the UpRight during sitting and standing in both clinical measures (p = 0.005) and IMU outcomes (p = 0.046), but trunk and low back posture did not change. There was no change in postural alignment during walking with the UpRight. Postural alignment response was related to attentional capabilities. Many subjects (68 %) reported that they felt a benefit from the UpRight and most participants reported that the device was acceptable (Lab use; 72 %, Home use; 75 %). The UpRight Go feedback device may improve neck/upper-back posture in PD during sitting and standing, but not during walking. Postural alignment response to the device may depend on attentional mechanisms. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
5. Staying UpRight in Parkinson's disease: A pilot study of a novel wearable postural intervention.
- Author
-
Stuart, Samuel, Godfrey, Alan, and Mancini, Martina
- Abstract
Objectives: This interventional pilot study aimed to 1) examine whether a novel wearable vibro-tactile feedback device ('UpRight Go') is effective and feasible to improve postural alignment in Parkinson's disease (PD); 2) explore relationships between postural alignment and attention in PD; 3) explore effect of vibro-tactile device on balance and gait; and 4) gain initial feedback on the use of the vibro-tactile device in the laboratory and at home.Methods: 25 people with PD sat, stood and walked for two-minutes without and with the UpRight device attached to their upper backs to provide feedback on postural alignment in the laboratory. A sub-group (n = 12) wore the UpRight device at home for 60 min. per day for 7-days of postural feedback. Subjective feedback on use of the device was obtained in the laboratory and at the end of the 7-day period. The primary outcome for this study was posture measured by verticality of inertial measurement units (IMUs) at the neck, trunk and low back, which was done with and without the UpRight device. Secondary outcomes included clinical measures of posture, subjective feedback on the device, computerized attention measures, gait and balance.Results: Neck postural alignment in PD was significantly improved (reduced neck flexion) with the UpRight during sitting and standing in both clinical measures (p = 0.005) and IMU outcomes (p = 0.046), but trunk and low back posture did not change. There was no change in postural alignment during walking with the UpRight. Postural alignment response was related to attentional capabilities. Many subjects (68 %) reported that they felt a benefit from the UpRight and most participants reported that the device was acceptable (Lab use; 72 %, Home use; 75 %).Conclusion: The UpRight Go feedback device may improve neck/upper-back posture in PD during sitting and standing, but not during walking. Postural alignment response to the device may depend on attentional mechanisms. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
6. Changes in prefrontal cortical activity and turning in response to dopaminergic and cholinergic therapy in Parkinson's disease: A randomized cross-over trial.
- Author
-
Vitorio, Rodrigo, Stuart, Samuel, Giritharan, Andrew, Quinn, Joseph, Nutt, John G., and Mancini, Martina
- Subjects
- *
PARKINSON'S disease , *CROSSOVER trials , *NEAR infrared spectroscopy , *PREFRONTAL cortex , *DOPA - Abstract
Introduction: Cholinergic dysfunction contributes to mobility deficits in Parkinson's disease (PD). People with PD rely on limited prefrontal executive-attentional resources for the control of locomotion, including turning. Cortical and behavioral responses to cholinergic augmentation during turning remains unclear. We examined prefrontal cortex (PFC) activity while turning-in-place and spatiotemporal measures of turns in response to usual dopaminergic medication and adjunct cholinergic augmentation.Methods: This study consisted of a single-site, randomized, double-blind crossover trial. Twenty PD participants were assessed in the levodopa-off state and then randomized to either levodopa + donepezil (5 mg) or levodopa + placebo treatments for two weeks followed by a 2-week washout before crossover. The primary outcome was change from off state in PFC activity while turning-in-place (assessed with functional near-infrared spectroscopy). Secondary outcomes were changes in spatiotemporal turning measures (assessed with body-worn inertial measurement units) and accuracy in the secondary task.Results: Nineteen participants completed the trial. While levodopa + placebo had no effect on PFC activity when turning-in-place with a dual-task, levodopa + donepezil led to a large reduction in PFC activity (effect size, -0.82). Spatiotemporal measures of turning improved with both treatments, with slightly greater effect sizes observed for levodopa + donepezil. Additionally, the accuracy in the concurrent cognitive task improved only with levodopa + donepezil (effect size, 0.63).Conclusion: The addition of cholinergic therapy with donepezil (5 mg/day for 2 weeks) to standard dopaminergic therapy reduced the burden on prefrontal executive-attentional resources while turning with a dual-task and improved secondary task accuracy and turning. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
7. Concussion in contact sport: A challenging area to tackle
- Author
-
Stuart, Samuel, Hickey, Aodhan, Morris, Rosie, O'Donovan, Karol, and Godfrey, Alan
- Published
- 2017
- Full Text
- View/download PDF
8. The Association between Prefrontal Cortex Activity and Turning Behavior in People with and without Freezing of Gait.
- Author
-
Belluscio, Valeria, Stuart, Samuel, Bergamini, Elena, Vannozzi, Giuseppe, and Mancini, Martina
- Subjects
- *
PREFRONTAL cortex , *NEAR infrared spectroscopy , *PARKINSON'S disease , *IMPULSE control disorders - Abstract
Turning elicits Freezing of Gait (FoG) episodes in people with Parkinson's disease (PD) and is thought to require higher cortical control compared to straight ahead gait. Functional near infrared spectroscopy (fNIRS) has been used to examine prefrontal cortex (PFC) activity while walking, but the relationship between PFC activity and turn performance remains unclear. The aim of this pilot study was to examine PFC activity during turning in PD and healthy controls, and to investigate the association between PFC activity and turning. Thirty-two subjects, 15 freezers (PD + FoG) and 17 non-freezers (PD − FoG), and 8 controls were asked to perform a 2-min turning-in-place test under single-task (ST) and dual-task (DT) conditions. Each participant wore an fNIRS system to measure changes in oxyhemoglobin, as measure of PFC activity, and inertial sensors to quantify turning. Our results show a significant group (p =.050), task (p =.039), and interaction (p =.047) for the PFC activity during turning. Specifically, PD + FoG show higher PFC during turning compared to the other groups; PFC activity during DT is overall different compared to ST with an opposite trend in PD + FoG compared to controls and PD − FoG. In addition, higher PFC is associated with worse FoG in PD + FoG (r = 0.57, p =.048) and with lower number of turns in PD − FoG (r = − 0.70, p =.002). The increased PFC activity in PD and the association between higher PFC activity and poorer turning performance may be a sign of poor movement automaticity in PD. Although further investigations are required, these pilot findings may guide development of personalized treatments to improve motor automaticity in PD. • Turning tends to require larger pre-frontal cortex activation in PD compared to controls. • Higher pre-frontal cortex activity during turning is related to more severe FoG. • Worse visuo-spatial ability is related to higher pre-frontal cortex activity during turning. • Wearable sensors-based characteristics of turning differ between people with PD and controls. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
9. Do people with Parkinson’s disease look at task relevant stimuli when walking? An exploration of eye movements.
- Author
-
Hunt, David, Stuart, Samuel, Nell, Jeremy, Hausdorff, Jeffrey M., Galna, Brook, Rochester, Lynn, and Alcock, Lisa
- Subjects
- *
PARKINSON'S disease , *EYE movement disorders , *STIMULUS & response (Psychology) , *WALKING , *AGE factors in disease , *PSYCHOLOGY - Abstract
Eye movements are impaired by Parkinson’s disease (PD) although limited research has explored if PD affects the relevance of visual fixations when walking. Visual fixations may provide crucial contextual information for safe navigation and important insights into fall risk. This study aimed to: investigate visual fixations made while walking under a range of conditions in PD; identify their task relevance; and explore their relationship with clinical features. Thirty-eight people with mild-moderate PD and forty age-matched control participants completed a straight walk with (i) no additional stimuli and (ii) with additional stimuli (visual cues or a high contrast obstacle), whilst wearing a mobile eye-tracker. Fixations were extracted and classified by location and relevance. PD participants made proportionally fewer task-relevant fixations (floor, walls and additional stimuli ahead), caused by significantly more task-irrelevant fixations (floor, walls and ceiling away from waking path) during normal walking ( p = 0.014). These group differences were not apparent with visual cues ( p = 0.359). During obstacle crossing trials, PD made significantly more task-relevant fixations than controls ( p = 0.007). Reduced bilateral visual acuity was associated with fewer fixations in PD. Our findings suggest that people with PD visually explore complex environments less efficiently likely owing to underlying PD pathology. Visual exploration improved with the addition of salient stimuli (for example visual cues or an obstacle) and thus developing and optimising visual interventions could prove critical to improving locomotor safety and reducing falls risk in home environments. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
10. Cortical activity during walking and balance tasks in older adults and in people with Parkinson's disease: A structured review.
- Author
-
Stuart, Samuel, Vitorio, Rodrigo, Morris, Rosie, Martini, Douglas N., Fino, Peter C., and Mancini, Martina
- Subjects
- *
WALKING , *PARKINSON'S disease , *INFRARED spectroscopy , *ELECTROENCEPHALOGRAPHY , *EVOKED potentials (Electrophysiology) , *CEREBRAL cortex , *POSTURAL balance , *GAIT in humans , *NEAR infrared spectroscopy , *RESEARCH funding - Abstract
An emerging body of literature has examined cortical activity during walking and balance tasks in older adults and in people with Parkinson's disease, specifically using functional near infrared spectroscopy (fNIRS) or electroencephalography (EEG). This review provides an overview of this developing area, and examines the disease-specific mechanisms underlying walking or balance deficits. Medline, PubMed, PsychInfo and Scopus databases were searched. Articles that described cortical activity during walking and balance tasks in older adults and in those with PD were screened by the reviewers. Thirty-seven full-text articles were included for review, following an initial yield of 566 studies. This review summarizes study findings, where increased cortical activity appears to be required for older adults and further for participants with PD to perform walking and balance tasks, but specific activation patterns vary with the demands of the particular task. Studies attributed cortical activation to compensatory mechanisms for underlying age- or PD-related deficits in automatic movement control. However, a lack of standardization within the reviewed studies was evident from the wide range of study protocols, instruments, regions of interest, outcomes and interpretation of outcomes that were reported. Unstandardized data collection, processing and reporting limited the clinical relevance and interpretation of study findings. Future work to standardize approaches to the measurement of cortical activity during walking and balance tasks in older adults and people with PD with fNIRS and EEG systems is needed, which will allow direct comparison of results and ensure robust data collection/reporting. Based on the reviewed articles we provide clinical and future research recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
11. Safety of pitch-side care provision in community contact sport within England.
- Author
-
Stuart, Samuel, O'Shaughnessy, Cillian, Armstrong, Michael, Brennan, Sam, Marr, Sophie, Turnell, Daniel, and Marshall, Steven J.
- Published
- 2018
- Full Text
- View/download PDF
12. Gait in Parkinson’s disease: A visuo-cognitive challenge.
- Author
-
Stuart, Samuel, Lord, Sue, Hill, Elizabeth, and Rochester, Lynn
- Subjects
- *
PARKINSON'S disease , *GAIT in humans , *VISUAL cortex , *COGNITION , *NEUROSCIENCES , *OLDER people - Abstract
Vision and cognition have both been related to gait impairment in Parkinson’s disease (PD) through separate strands of research. The cumulative and interactive effect of both (which we term visuo-cognition) has not been previously investigated and little is known about the influence of cognition on vision with respect to gait. Understanding the role of vision, cognition and visuo-cognition in gait in PD is critical for data interpretation and to infer and test underlying mechanisms. The purpose of this comprehensive narrative review was to examine the interdependent and interactive role of cognition and vision in gait in PD and older adults. Evidence from a broad range of research disciplines was reviewed and summarised. A key finding was that attention appears to play a pivotal role in mediating gait, cognition and vision, and should be considered emphatically in future research in this field. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
13. The measurement of visual sampling during real-world activity in Parkinson's disease and healthy controls: A structured literature review.
- Author
-
Stuart, Samuel, Alcock, Lisa, Galna, Brook, Lord, Sue, and Rochester, Lynn
- Subjects
- *
PARKINSON'S disease , *CONTROL groups , *VOLUNTEERS' health , *COGNITION , *BRAIN physiology ,MEDICAL literature reviews - Abstract
Highlights: [•] Techniques for objective measurement of visual sampling lack consistency. [•] Reliability and validity of instruments has not been yet established. [•] Testing recommendations include assessment of basic visual function and cognition. [•] This review informs the development of robust protocols. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
14. Relating Parkinson freezing and balance domains: A structural equation modeling approach.
- Author
-
Peterson, Daniel S., Van Liew, Charles, Stuart, Samuel, Carlson-Kuhta, Patricia, Horak, Fay B., and Mancini, Martina
- Subjects
- *
STRUCTURAL equation modeling , *FREEZING , *LATENT variables , *DYNAMIC balance (Mechanics) - Abstract
Background: People with PD who exhibit freezing of gait (FOG) also exhibit poor balance compared to those who do not freeze. However, balance is a broad construct that can be subdivided into subdomains that include dynamic balance (gait), anticipatory postural adjustments (APAs) & gait initiation, postural sway in stance, and automatic postural responses (e.g., reactive stepping). Few studies have provided a robust investigation on how each of these domains is impacted by FOG, and no studies have compared balance across groups while rigorously controlling for disease severity.Methods: Structural equation modeling was used to evaluate the relationships between FOG and balance domains constructed as latent variables and controlling for disease severity. Domains included: dynamic balance (gait), APAs, postural sway, and reactive stepping. Models were run relating domains to both the presence and severity of FOG.Results: Latent variables reflecting domains of Gait and APAs, but not postural sway or reactive stepping, were significantly related to the severity of FOG. Models for presence of FOG showed the same results, as Gait and APAs, but not postural sway or reactive stepping, were related to presence of FOG.Conclusion: These results are consistent with hypotheses that balance deficits in people with PD who freeze are most pronounced in gait and anticipatory postural adjustments. Reactive stepping and postural sway domains are less effected in PD patients who freeze compared to those who do not. These findings suggest that rehabilitative strategies focused on gait and APAs may be most effective for people with PD who freeze. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
15. iVOMS: Instrumented Vestibular / Ocular motor screen in healthy controls and mild traumatic brain injury.
- Author
-
Graham, Lisa, Powell, Dylan, Campbell, Kody R., Morris, Rosie, Vitorio, Rodrigo, Parrington, Lucy, Antonellis, Prokopios, Godfrey, Alan, King, Laurie A., and Stuart, Samuel
- Subjects
- *
BRAIN injuries , *EYE tracking , *VISUAL perception , *EYE movements , *TRACKING algorithms , *SACCADIC eye movements , *TASK performance , *PHYSICIANS - Abstract
• The vestibular/ocular motor screening (VOMS) is used to assess individuals post-mTBI and relies on self-reported symptoms. • Instrumenting the VOMS (iVOMS) with technology may allow for more objective assessment and better reflect actual deficits. • This study shows that the iVOMS is analytically and clinically valid in mTBI and controls. • Further work is required to examine the sensitivity of iVOMS outcomes across the mTBI spectrum. Objective Vestibular/ocular deficits occur with mild traumatic brain injury (mTBI). The vestibular/ocular motor screening (VOMS) tool is used to assess individuals post-mTBI, which primarily relies upon subjective self-reported symptoms. Instrumenting the VOMS (iVOMS) with technology may allow for more objective assessment post-mTBI, which reflects actual task performance. This study aimed to validate the iVOMS analytically and clinically in mTBI and controls. Methods Seventy-nine people with sub-acute mTBI (<12 weeks post-injury) and forty-four healthy control participants performed the VOMS whilst wearing a mobile eye-tracking on a one-off visit. People with mTBI were included if they were within 12 weeks of a physician diagnosis. Participants were excluded if they had any musculoskeletal, neurological or sensory deficits which could explain dysfunction. A series of custom-made eye tracking algorithms were used to assess recorded eye-movements. Results The iVOMS was analytically valid compared to the reference (ICC 2,1 0.85–0.99) in mTBI and controls. The iVOMS outcomes were clinically valid as there were significant differences between groups for convergence, vertical saccades, smooth pursuit, vestibular ocular reflex and visual motion sensitivity outcomes. However, there was no significant relationship between iVOMS outcomes and self-reported symptoms. Conclusion The iVOMS is analytically and clinically valid in mTBI and controls, but further work is required to examine the sensitivity of iVOMS outcomes across the mTBI spectrum. Findings also highlighted that symptom and physiological issue resolution post-mTBI may not coincide and relationships need further examination. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. A consensus guide to using functional near-infrared spectroscopy in posture and gait research.
- Author
-
Menant, Jasmine C., Maidan, Inbal, Alcock, Lisa, Al-Yahya, Emad, Cerasa, Antonio, Clark, David J., de Bruin, Eling D., Fraser, Sarah, Gramigna, Vera, Hamacher, Dennis, Herold, Fabian, Holtzer, Roee, Izzetoglu, Meltem, Lim, Shannon, Pantall, Annette, Pelicioni, Paulo, Peters, Sue, Rosso, Andrea L., St George, Rebecca, and Stuart, Samuel
- Subjects
- *
NEAR infrared radiation , *POSTURE , *BRAIN damage , *WALKING , *HEMODYNAMICS , *SCIENTIFIC community , *CONSENSUS (Social sciences) , *NEAR infrared spectroscopy , *GAIT in humans ,RESEARCH evaluation - Abstract
Background: Functional near-infrared spectroscopy (fNIRS) is increasingly used in the field of posture and gait to investigate patterns of cortical brain activation while people move freely. fNIRS methods, analysis and reporting of data vary greatly across studies which in turn can limit the replication of research, interpretation of findings and comparison across works.Research Question and Methods: Considering these issues, we propose a set of practical recommendations for the conduct and reporting of fNIRS studies in posture and gait, acknowledging specific challenges related to clinical groups with posture and gait disorders.Results: Our paper is organized around three main sections: 1) hardware set up and study protocols, 2) artefact removal and data processing and, 3) outcome measures, validity and reliability; it is supplemented with a detailed checklist.Significance: This paper was written by a core group of members of the International Society for Posture and Gait Research and posture and gait researchers, all experienced in fNIRS research, with the intent of assisting the research community to lead innovative and impactful fNIRS studies in the field of posture and gait, whilst ensuring standardization of research. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.