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• Cognitive impairments may be developed post nerve injuries of upper limb. • There is no cognitive impairment post musculoskeletal injuries to upper limb without nerve damage. • Cognitive impairments appear within one month post traumatic upper limb injuries. The purpose of this study was to investigate the association between cognitive impairments and traumatic upper limb injuries of the acute phase. A cross-sectional observational study was conducted with three groups: a nerve-injury group, a without nerve injury group, and a control group (uninjured participants). Demographic characteristics (e.g. age, sex, body mass index, and education) and traumatic characteristics (duration since injury, injury side, pain, light touch sensation, hand motor function) were recorded. Short-term memory and executive functions were assessed using Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT, including SIECT and SIECN), respectively. The study comprised 43 participants in the nerve-injury group, 30 participants in the group without nerve injury, and 104 participants in the control group. Generalized linear model was applied to explore the difference of cognitive functions among three groups with impactors. Significantly poorer performance on the RAVLT was observed in the nerve-injury group compared to the other two groups, and lower score of SIECT in nerve-injury group was lower compared to the control group. However, there was no significant difference of SIECN among three groups. In addition, traumatic characteristics did not significantly impact RAVLT and SIECT (p > 0.05) in all injured participants. Traumatic nerve injury to the upper limb appears to be associated with both short-term memory and executive function impairment, whereas musculoskeletal injuries without nerve damage showed no cognitive impairment. Therefore, it is important to monitor cognitive function following upper limb nerve injuries. [ABSTRACT FROM AUTHOR]

The apnea-hypopnea index (AHI) is the current diagnostic parameter for diagnosing and estimating the severity of obstructive sleep apnea (OSA). It is, however, poorly associated with the main clinical symptom of OSA, excessive daytime sleepiness, and with the often-seen cognitive decline among OSA patients. To better evaluate OSA severity, novel hypoxic load parameters have been introduced that consider the duration and depth of oxygen saturation drops associated with apneas or hypopneas. The aim of this paper was to compare novel hypoxic load parameters and traditional OSA parameters to verbal memory and executive function in OSA patients. A total of 207 adults completed a one-night polysomnography at sleep laboratory and two neuropsychological assessments, the Rey Auditory Verbal Learning Test and Stroop test. Results : Simple linear regression analyses were used to evaluate independent associations between each OSA parameter and cognitive performance. Associations were found between immediate recall and arousal index, hypoxia <90 %, average SpO 2 during sleep, and DesSev100+RevSev100. Total recall was associated with all OSA parameters, and no associations were found with the Stroop test. Subsequently, sex, age, and education were included as covariates in multiple linear regression analyses for each OSA parameter and cognitive performance. The main findings of the study were that average SpO 2 during sleep was a significant predictor of total recall (p <.007, β = −.188) with the regression model explaining 21.2 % of performance variation. Average SpO 2 during sleep was also a significant predictor of immediate recall (p <.022, β = −.171) with the regression model explaining 11.4 % of performance variation. Neither traditional OSA parameters nor novel hypoxic load parameters predicted cognitive performance after adjustment for sex, age, and education. The findings validate that the AHI is not an effective indicator of cognitive performance in OSA and suggest that average oxygen saturation during sleep may be the strongest PSG predictor of cognitive decline seen in OSA. The results also underline the importance of considering age when choosing neurocognitive tests, the importance of including more than one test for each cognitive domain as most tests are not pure measures of a single cognitive factor, and the importance of including tests that cover all cognitive domains as OSA is likely to have diffuse cognitive effects. • The currently used diagnostic tool for obstructive sleep apnea, the apnea-hypopnea index, is not associated with verbal memory and executive function. • Novel hypoxic load parameters are not associated with verbal memory or executive function in obstructive sleep apnea. • Average oxygen saturation during sleep is the strongest predictor of verbal memory in obstructive sleep apnea. [ABSTRACT FROM AUTHOR]

Obsessive-compulsive disorder (OCD) has been associated with neurocognitive impairments. The present study examined the effect of treatment on neurocognitive performance in OCD and the relationship between neurocognitive change and symptom change. The present study also examined polymorphisms influencing brain derived neurotrophic factor (BDNF) as predictors of neurocognitive change. Method: Treatment-seeking participants with OCD (N = 125) were assigned to cognitive behavioural therapy (CBT) alone, CBT combined with regular physical exercise, exercise alone, or a waitlist control group. Measures of OCD symptom severity and a neuropsychological battery were completed pre- and post-treatment. Blood or saliva samples were used to genotype the BDNF Val66Met polymorphism. Results: OCD symptom severity was not cross-sectionally associated with neurocognitive performance. Several neurocognitive measures improved over treatment. The BDNF Val66Met polymorphism was significantly associated with worse performance on the Stroop test but did not significantly predict change in neurocognitive performance over time. Limitations: Limitations include lack of a healthy control group. Conclusion: Improvement in neurocognitive performance corresponded to symptomatic improvement and was independent of the BDNF Val66Met genotype. • Several neurocognitive measures improved following CBT for OCD. • Val66met polymorphism significantly associated with worse Stroop test performance. • Val66Met polymorphism did not predict neurocognitive performance over time. [ABSTRACT FROM AUTHOR]

Sympathetic and blood pressure (BP) hyper-reactivity to stress may contribute to increased cardiovascular disease (CVD) risk in adults with major depressive disorder (MDD); however, whether this is evident in young adults with MDD without comorbid disease remains unclear. We hypothesized that acute stress-induced increases in muscle sympathetic nerve activity (MSNA) and BP would be exaggerated in young adults with MDD compared to healthy non-depressed young adults (HA) and that, in adults with MDD, greater symptom severity would be positively related to MSNA and BP reactivity. In 28 HA (17 female) and 39 young adults with MDD of mild-to-moderate severity (unmedicated; 31 female), MSNA (microneurography) and beat-to-beat BP (finger photoplethysmography) were measured at rest and during the cold pressor test (CPT) and Stroop color word test (SCWT). There were no group differences in resting MSNA (p = 0.24). Neither MSNA nor BP reactivity to either the CPT [MSNA: ∆24 ± 10 HA vs. ∆21 ± 11 bursts/min MDD, p = 0.67; mean arterial pressure (MAP): ∆22 ± 7 HA vs. ∆21 ± 10 mmHg MDD, p = 0.46)] or the SCWT (MSNA: ∆-4 ± 6 HA vs. ∆-5 ± 8 bursts/min MDD, p = 0.99; MAP: ∆7 ± 8 HA vs ∆9 ± 5 mmHg MDD; p = 0.82) were different between groups. In adults with MDD, symptom severity predicted MAP reactivity to the CPT (β = 0.78, SE = 0.26, p = 0.006), but not MSNA (p = 0.42). The mild-to-moderate symptom severity reflects only part of the MDD spectrum. Neither sympathetic nor BP stress reactivity are exaggerated in young adults with MDD; however, greater symptom severity may amplify BP reactivity to stress, thereby increasing CVD risk. • Greater blood pressure (BP) reactivity to stress predicts cardiovascular risk. • BP reactivity to stress is not exaggerated in young adults with depression. • Symptom severity predicted BP reactivity to stress in young adults with depression. [ABSTRACT FROM AUTHOR]

In the current study, it was aimed to evaluate neurotrophic factor levels and their relationship with executive functions in high-risk children and adolescents (high-risk group) whose parents were diagnosed with bipolar disorder (BD) but not affected by any psychiatric disease,and in order to determine possible vulnerability factors related to the disease. The study sample consisted of 32 high-risk group and 34 healthy controls. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version-Turkish Adaptation (KSADS-PL-T), Stroop Test, Serial Digit Learning Test (SDLT) and Cancellation Test to evaluate executive functions were administered to all participants by the clinician.Serum levels of neurotrophic factors were measured using commercial enzyme linked immunosorbent assay kits. Serum BDNF, NT-3, NT-4 levels and SDLT scores were significantly lower in the high-risk group for BD compared to the healthy control group. A moderate negative correlation was found between BDNF levels and the Cancellation Test scores in the high-risk group. In addition to these results, the odds ratios of age, NT-4, SDLT scores for being in the risky group in terms of BD diagnosis were 1.26, 0.99 and 0.86 respectively. This was a cross-sectional study. Causality between study results is therefore difficult to establish. The relatively small sample size of the study is another limitation. The results of the present study suggest that BDNF, NT-3, NT-4 may play a role in the physiopathology of BD and may be associated with impaired executive function areas such as attention and response inhibition in the high-risk group. • Neurotrophic factors may play a role in the pathophysiology of bipolar disorder. • Neurotrophic factors may be associated with impaired executive functions. • Examination of the offspring of bipolar parents provides an opportunity to investigate early changes. [ABSTRACT FROM AUTHOR]

Impaired cognition has been demonstrated in pediatric bipolar disorder (PBD). The subcortical limbic structures play a key role in PBD. However, alternations of anatomical and functional characteristics of subcortical limbic structures and their relationship with neurocognition of PBD remain unclear. Thirty-six PBD type I (PBD-I) (15.36 ± 0.32 years old), twenty PBD type II (PBD-II) (14.80 ± 0.32 years old) and nineteen age-gender matched healthy controls (HCs) (14.16 ± 0.36 years old) were enlisted. Primarily, the volumes of the subcortical limbic structures were obtained and differences in the volumes were evaluated. Then, these structures served as seeds of regions of interest to calculate the voxel-wised functional connectivity (FC). After that, correlation analysis was completed between volumes and FC of brain regions showing significant differences and neuropsychological tests. Compared to HCs, both PBD-I and PBD-II patients showed a decrease in the Stroop color word test (SCWT) and digit span backward test scores. Compared with HCs, PBD-II patients exhibited a significantly increased volume of right septal nuclei, and PBD-I patients presented increased FC of right nucleus accumbens and bilateral pallidum, of right basal forebrain with right putamen and left pallidum. Both the significantly altered volumes and FC were negatively correlated with SCWT scores. The study revealed the role of subcortical limbic structural and functional abnormalities on cognitive impairments in PBD patients. These may have far-reaching significance for the etiology of PBD and provide neuroimaging clues for the differential diagnosis of PBD subtypes. Distinctive features of neural structure and function in PBD subtypes may contribute to better comprehending the potential mechanisms of PBD. • Increased volume of the right septal nuclei. • Aberrated functional connectivity of subcortical limbic structures. • Alternations of structural and functional characteristics were negatively correlated with Stroop color word test scores in pediatric bipolar disorder subtypes. [ABSTRACT FROM AUTHOR]

Cognitive impairment remains understudied in generalized anxiety disorder (GAD), despite the high prevalence and substantial burden associated with this disorder. We aimed to assess cognitive impairment in patients with GAD and evaluate the ability of cognitive tests to detect this disorder. Because of its high rate of comorbidity, we also examined how other anxiety disorders and current major depressive episodes affected our results. We tested 263 consecutive general practice outpatients. We used the GAD-7 and the Mini International Neuropsychiatric Interview (MINI) to detect anxiety and mood disorders. We assessed cognitive performance with the Stroop test, a facial emotion recognition test, and the trail-making test (TMT). Compared to patients without GAD, patients with GAD were significantly slower to complete the TMT (B-A) and faster to recognize emotions, especially negative ones such as disgust and anger. When controlling for other anxiety disorders and current major depressive episode, GAD retained a significant effect on the TMT (B-A) , but not on the emotion recognition test. The TMT (B-A) could detect GAD with good accuracy (area under the curve (AUC) = 0.83, maximal Youden's index = 0.56), which was by no means comparable to the GAD-7 (AUC = 0.97, Youden's index = 0.81). While it is not efficient enough to replace the GAD-7 as a diagnostic tool, the capacity of the TMT (B-A) to detect GAD emphasizes the importance of cognitive flexibility impairment in GAD. [ABSTRACT FROM AUTHOR]

Research has shown the diagnostic potential of optical coherence tomography (OCT) and OCT angiography (OCTA) in various psychiatric disorders. However, there is few research focusing on changes specific to Major Depressive Disorder (MDD), and the diagnostic value of OCT combined with OCTA parameters for MDD remains unclear. In this study, we investigated microvascular and morphology changes in the retina of MDD patients using a combination of OCTA and OCT parameters, and to examine their correlation with MDD mood and cognitive function in order to assess their diagnostic capability. Our findings revealed a significant decline in macular vessel density (MVD) in the superficial retinal capillary plexus (SRCP) across all subfields, except the NO area. We also observed a significant positive correlation between fovea and Stroop-1, as well as between temporal inner (TI) and Stroop-3 in MDD patients. Furthermore, we identified a negative correlation between fovea and Self-Rating Depression Scale, as well as between Superior outer (SO) and Difficulties in Emotion Regulation Scale-C in MDD patients. The sample size was small. Anatomical variables in blood flow may contribute to variability between subjects and outcomes. The diagnostic value of OCTA suggests their potential as valuable tools for monitoring and diagnosing MDD. • A significant decrease in macular vessel density in the superficial retinal capillary plexus in MDD compared to healthy controls. • Positive correlation between fovea/ temporal inner and Stroop Color-Word Test in MDD. • Negative correlation between fovea and depressive symptom in MDD • The combined diagnostic potential of OCT and OCTA suggests their utility as valuable tools for diagnosing MDD. [ABSTRACT FROM AUTHOR]

Cognitive impairment often occurs in major depressive disorder (MDD). Studies suggest that these cognitive deficits may be associated with inflammatory biomarkers, but data are limited. Therefore, this study aims to investigate the relationship between 48 peripheral blood cytokines and cognitive performance in patients with severe depressive disorder. One hundred consecutive hospitalized adult patients with severe depression who participated in the Depression long-term Augsburg (DELTA) study were included in the present analysis. To test working memory (WM) the Wechsler Adult Intelligence Scale (WAIS) IV and to assess interference control (IC) the Stroop Color and Word Test (SCWT) were performed. The serum concentrations of the biomarkers were measured using the Bio-Plex Pro™ Human Cytokine Screening Panel 1. Multiple linear regression models adjusted for possible confounders were fitted to examine associations. WM was impaired in 11% of the patients. IC was impaired in 1%–3% of the cases depending on the subtest. Eotaxin, IL-1β, IL-4, MCP-1, G-CSF, and PGF-BB were negatively associated with the WM. Eotaxin, IL-1β, IL-4, IL-16, IL-18, MCP-1, G-CSF, SCF, and MIP-1α were negatively associated with IC. None of these associations remained significant after adjustment for multiple testing. The present study identified eotaxin, IL-1β, IL-4, IL-16, IL-18, MCP-1, G-CSF, SCF, PGF-BB and MIP-1α as being associated with cognitive performance. After confirmation of these results in further studies, these cytokines may be potential targets for new treatments. • At least mild impairment of working memory was found in 33% of patients with severe depression. • Eotaxin, IL-1β, IL-4, MCP-1, G-CSF, and PGF-BB were associated with impaired working memory. • Eotaxin, IL-1β, IL-4, IL-16, IL-18, MCP-1, G-CSF, SCF, and MIP-1α were associated with impaired interference control. [ABSTRACT FROM AUTHOR]

In this study, we investigated the effect of 24-h total sleep deprivation on subjective time perception. Twenty-five participants aged 18–35 years (13 female and 12 male) were recruited. Time perception and cognitive assessments were performed twice: after a regular night's sleep and following a 24-h sleep deprivation. The retrospective and prospective tasks were used to measure time perception. In order to prevent order effect, the test orders were randomized. The Stroop test and the Wechsler Memory Scale-III were used to evaluate attention, processing speed, and memory. The repeated measures ANOVA was used to examine gender-by-sleep deprivation interactions on time perception. We found that retrospective time perception was significantly prolonged after sleep deprivation (p < 0.05). Women had a shorter prospective time estimation rate after adequate sleep than men, but this difference disappeared after sleep deprivation. The Stroop test showed improvement in cognitive flexibility after sleep deprivation (p < 0.05), and short-term or working memory appeared unaffected by one night of sleep deprivation. There was a negative correlation between sleepiness rate and working memory function in female subgroup. The results suggest that even short-term sleep deprivation can significantly affect time perception, which may have important implications in critical situations. • Retrospective time perception is prolonged after 24-h sleep deprivation. • Women reported shorter prospective time perception and quicker time flow under adequate sleep conditions. • After sleep deprivation, there was an improvement in inhibition and cognitive flexibility capabilities. • One day sleep deprivation didn't affect short-term and working memory. [ABSTRACT FROM AUTHOR]

Short-sleep is becoming increasingly common and may negatively affect brain function including cognitive ability. Physical exercise has been proved to improve cognitive function while intensity matters. This study was conducted to examine the effects of 12-week exercise interventions on cognitive performance and prefrontal cortex activation related to task performance in short-sleep young adults. A total of 50 subjects (23.62 ± 5.28 years and 24 men) with regular short-sleep conditions (<7 h per night) participated in this study and were divided into three groups: control, moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT) group. As task performance (congruent and incongruent Stroop) was monitored, changes in prefrontal oxygenated hemoglobin (oxyHb), an indicator of cortical activation, were measured using functional near-infrared spectroscopy (fNIRS) to explore the hemodynamics mechanism. Post 12-week intervention, significant differences in reaction time for congruent [β (95%CI): −0.045 (−0.088, −0.002), p = 0.039] and incongruent Stroop tests [β (95%CI): −0.058 (−0.113, −0.003), p = 0.038] were found only in the MICT intervention group. However, HIIT did not show significant improvements in cognitive function. Left middle frontal gyrus (Frontal Mid L) and right dorsolateral superior frontal gyrus (Frontal Sup R) were both stimulated by MICT and HIIT. Moreover, left dorsolateral superior frontal gyrus (Frontal Sup L) was stimulated by MICT. The findings indicated that 12-week MICT improved cognition by significantly increasing cortical activity across more brain regions. Thus, we suggested that maintaining moderate-intensity exercise could benefit cognitive function despite short sleep. [Display omitted] • 12-week MICT can improve cognitive performance in short-sleep young adults. • 12-week HIIT has little effect on cognition in short-sleep young adults. • MICT improves cognition by activating more brain regions than HIIT. • A longitudinal study design is applied and sleep duration is objectively measured. [ABSTRACT FROM AUTHOR]

• We explored the brain regions activated in a rodent version of the Stroop task. • Our data revealed novel involvement of cortical and striatal regions. • The dorsomedial striatum, infralimbic and retrosplenial cortices are implicated. • These data have implications for people with neurological conditions. The Stroop test is a widely used neuropsychological test measuring attention and conflict resolution, which shows sensitivity across a range of diseases, including Alzheimer's, Parkinson's and Huntington's diseases. A rodent analogue of the Stroop test, the Response-Conflict task (rRCT), allows for systematic investigation of the neural systems underpinning performance in this test. Little is known about the involvement of the basal ganglia in this neural process. The aim of this study was to use the rRCT to determine whether striatal subregions are recruited during conflict resolution processing. To achieve this, rats were exposed to Congruent or Incongruent stimuli in the rRCT and the expression patterns of the immediate early gene Zif268 were analysed throughout cortical, hippocampal and basal ganglia subregions. The results confirmed the previously reported involvement of prefrontal cortical and hippocampal regions, as well as identifying a specific role for the dysgranular (but not granular) retrosplenial cortex in conflict resolution. Finally, performance accuracy correlated significantly with reduced neural activation in the dorsomedial striatum. Involvement of the basal ganglia in this neural process has not previously been reported. These data demonstrate that the cognitive process of conflict resolution requires not only prefrontal cortical regions, but also recruits the dysgranular retrosplenial cortex and the medial region of the neostriatum. These data have implications for understanding the neuroanatomical changes that underpin impaired Stroop performance in people with neurological disorders. [ABSTRACT FROM AUTHOR]

Previous studies have shown that people implicitly associate the emotional valence of abstract words with vertical position (i.e., positive words up , negative words down), resulting in the so-called valence-space congruency effect. Research has demonstrated that there is a valence-space congruency effect when it comes to emotional words. It's interesting to see that whether the emotional pictures with different levels of valence are mapped to distinct vertical space positions. Here, the event-related potential (ERP) and time-frequency techniques were employed to investigate the neural basis of the valence-space congruency effect of emotional pictures in a spatial Stroop task. Firstly, this study showed that the reaction time of the congruent condition (i.e., positive pictures in the top and negative pictures in the bottom of the screen) was significantly shorter than that of the incongruent condition (i.e., positive pictures in the bottom and negative pictures in the top of the screen), suggesting that exposure to stimuli with positive or negative valence, regardless of whether these stimuli were comprised of words or pictures, would be enough to invoke the vertical metaphor. Moreover, we found that the congruency between the vertical position and the valence of emotional pictures could significantly modulate the amplitude of the P2 component and the Late Positive Component (LPC) in ERP waveforms, as well as the post-stimulus alpha-ERD in the time-frequency plane. This study has conclusively demonstrated the presence of a space-valence congruency effect in emotional pictures and has elucidated the underlying neurophysiological mechanisms associated with the valence-space metaphor. • Exposure to pictures with positive or negative valence would be enough to invoke the valence-space congruency effect. • The valence-space congruency could significantly modulate the amplitude of the P2 and LPC in ERP waveform. • The post-stimulus alpha-ERD is closely linked to the valence-space congruency effect. [ABSTRACT FROM AUTHOR]

• The Ruff 2 & 7 and Stroop Color-Word tests are two reliable paper-pencil measures. • The Multitasking test shows the best reliability of the selected CANTAB tests. • Paper-pencil tests are more reliable than computerized tests (CANTAB) in DM1. • The lack of variability in many tests resulted in lower reliability. Myotonic dystrophy type 1 (DM1) is a multisystemic inherited neuromuscular disease leading to central nervous system symptoms, including cognitive impairments, among multiple other symptoms. However, information is presently lacking regarding the psychometric properties of neuropsychological tests and promising computerized cognitive tests, such as the Cambridge Neuropsychological Test Automated Battery (CANTABⓇ). This type of information is critical to improve clinical trial readiness and provide knowledge of DM1 natural history. The aims of the present study were (1) to document the intrarater reliability of classic paper-pencil tests assessing visuospatial working memory, cognitive flexibility, attention, episodic memory and apathy, and (2) to compare these findings with their equivalent computerized automated tests from the CANTABⓇ. Thirty participants were seen twice at four-week intervals. Results showed that the Stroop Color and Word Test (ICC = 0.741–0.869) and the Ruff 2 & 7 (ICC = 0.703–0.871) appear to be reliable paper-and-pencil tests in the DM1 population. For the CANTABⓇ, a similar observation was made for the Multitasking test (ICC = 0.588–0.792). Further studies should explore the applicability and concurrent validity of the CANTAB® and classic neuropsychological assessments in additional cohorts of DM1 patients. [ABSTRACT FROM AUTHOR]

Cognitive impairment is one of the major symptoms of individuals with bipolar disorder (BD). Purine system disorders may play an important role in cognitive dysfunction. So far, the relationship between cognitive deficits and purinergic metabolism in BD has been seldom discussed in previous studies. This study aims to explore its relevance and potential biological mechanisms. In this cross-sectional study, 205 first time diagnosed drug-naive individuals with BD and 97 healthy volunteers were recruited. The uric acid(UA) level was measured using automatic biochemical analyzer, and cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Stroop color-word test. In addition, general information and clinical symptoms were collected and evaluated. In this study, the UA level of BD group (U = 8475.000, p = 0.038) was found to be significantly higher than that of the healthy controls, but the scores of RBANS (t = −11.302, p < 0.001) and Stroop color-word test (t = −6.962, p < 0.001) were significantly lower than that of the healthy controls. In gender subgroup analysis, females had lower UA level and higher RBANS scores. In correlation analysis, the cognitive function of individuals with BD was found to present a significant negative correlation with UA level in attention (r = −0.23, p = 0.001) and delayed memory(r = −0.16, p = 0.022). This is a cross-sectional design. Elevated UA levels may be a potential mechanism of cognitive impairment in BD. This provides a new possible strategy for the prevention and treatment of cognitive impairment in BD. • The level of acid uric in drug-naive individuals with bipolar disorder is higher than that of the healthy controls. • Individuals with bipolar disorder have poorer cognitive function, and there are gender differences. • Uric acid level negatively correlated with cognitive function in drug-naive individuals with bipolar disorder. [ABSTRACT FROM AUTHOR]

Transcranial direct current stimulation (tDCS) is a promising technique for enhancement of executive functions in healthy as well as neurologically disturbed patients. However, the evidence regarding the neuropsychological and behavioral change with neurophysiological shifts as well as the mechanism of tDCS action as evidenced by activation of neuronal sources important for executive functions have remained unaddressed. The study thereby endeavors to (1) determine the neuropsychological, behavioral, and neurophysiological change induced with five sessions of bilateral tDCS stimulation and (2) identify putative neuronal sources related to the executive functions responsible for neuropsychological and behavioral change. For this single blinded study, a total of 40 healthy participants, randomly allocated to active (n = 19) or sham (n = 21) groups completed five sessions of 2 mA tDCS stimulation administered over Dorso-Lateral Prefrontal Cortex (DLPFC) (F3 as anode, F4 as cathode). Repeated measure analysis was performed on neuropsychological (Everyday Memory Questionnaire and Mindful Attention Awareness Scale), and behavioral assessment (n-Back and Stroop tests) to investigate within and between group differences. Pre and post neurophysiological (Electroencephalogram) results showed that bilateral tDCS stimulation activates cortical regions responsible for executive functions including updation (working memory) and inhibition (interference control or attention). Multiple sessions of bilateral tDCS stimulation results in a significant increase in theta, alpha, and beta-band activity in the DLPFC, cingulate and parietal cortex. This study provides evidence that tDCS can be used for performance enhancement of executive functions in able-bodied people. • Bilateral tDCS (F3/F4) influenced cortical regions responsible for executive functions including working memory and attention • Multiple tDCS sessions increase theta, alpha, and beta-band activity in the DLPFC, cingulate and parietal cortex respectively • Findings provide evidence for the use of tDCS to augment executive functions. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool for bipolar and unipolar disorders while performing cognitive tasks. 150 participants were divided into three groups including bipolar, unipolar disorder, and healthy controls (50:50:50), matched by age, gender, and family history of mood disorder. Hemodynamics in the frontal cortex were monitored by fNIRS during the Stroop Color-Word Test and Verbal Fluency Test. The GLM compared the differences in oxy-hemoglobin levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area. For people with BD group, the area under the ROC curve (AUC) for the left orbitofrontal cortex was maximal during the VFT [AUC = 0.727, 95%CI = 0.617–0.824]. The Youden's index reached a peak (0.40) at the optimal cut-point value (HbO2 cutoff <0.180 μmol/ml for BD) in which the sensitivity was 82 %; specificity was 58 %; PPV was 0.66; NPV was 0.76 and correct classification rate was 70 %. Regarding the UD group, during VFT, the highest value AUC [AUC = 0.822, 95%CI = 0.740–0.903] was recorded in the left dorsolateral prefrontal cortex with the optimal cut-off value (HbO2cutoff ≥0.163 μmol/ml for healthy controls; <0.163 for unipolar disorder), the sensitivity was 72 %; specificity was 82 %; PPV was 0.80; NPV was 0.75, correct classification rate was 77 %, and the Youden's index was 0.54. Assessing hemodynamics during VFT using portable fNIRS offers the potential as an adjunct diagnostic tool for mood disorders in low-resource environments. [ABSTRACT FROM AUTHOR]

Background: The pathophysiological mechanism of cognitive impairments of bipolar disorder (BD) has not yet been completely revealed. It is well known that Vitamin D and physical activity (PA) are associated with BD. However, specific links between Vitamin D and cognitive deficits in BD are still unclear.Method: The serum levels of vitamin D were measured. The cognitive performances of 102 first-diagnosed and drug-naïve BD patients were evaluated for analysis. The repeatable battery for the assessment of neuropsychological status (RBANS) and the Stroop Color-Word test was used in this study. PA was collected by international physical activity questionnaire.Result: Patients with BD had high levels of serum vitamin D. Furthermore, immediate and delayed memory was negatively associated with vitamin D levels in patients' group. The serum levels of vitamin D in patients with low PA were positively associated with memory. However, increased PA attenuated the protective effect of vitamin D on executive cognition.Conclusion: It is concluded that the increased levels of vitamin D were observed in the serum of patients with BD. Thus, it is found that more PA is less beneficial to cognition of patients with BD than longer resting. [ABSTRACT FROM AUTHOR]

• High schizotypy individuals showed significantly decreased N170 and N2 amplitudes in reactive control of emotional conflict. • No significant differences in N170 or N2 were found between groups in proactive control of emotional conflict. • A dissociation in the reactive and proactive control of emotional conflict was found in high schizotypy individuals. The present study aimed to examine how individuals with high schizotypy, a high risk group of schizophrenia patients, resolve emotional conflict in proactive and reactive control and the underlying neural mechanisms. Thirty-two individuals with high schizotypy and 30 matched individuals with low schizotypy completed an emotional face–word Stroop task with electroencephalographic data recorded. The proportion of incongruent trials was manipulated in the task to induce proactive control (mostly incongruent trials context, MI context) or reactive control (mostly congruent trials context, MC context). Two event-related potential (ERP) components (N170 and N2) were examined, which represent face processing and cognitive control processes, respectively. In the MC context, significantly decreased N2 and N170 amplitudes were found in high schizotypy individuals compared with low schizotypy individuals, suggesting abnormal neural activity of reactive control in high schizotypy individuals. No significant differences were found between the two groups in the MI context. These results provide initial evidence for dissociation of neural activity of proactive and reactive control on emotional conflict in individuals with high schizotypy. The current findings provide important insight into the emotional conflict resolution in the schizophrenia spectrum. [ABSTRACT FROM AUTHOR]

Consistent with cognitive models of social anxiety, socially anxious individuals show cognitive biases that magnify their perceived level of threat in the environment. The first objective was to determine whether attentional bias for socially threatening stimuli occurs after concomitant depression has been controlled. The second objective was to test the effectiveness of the Attention Control Training Program for Social Anxiety (ACTP-SA) for reducing social anxiety attentional bias and improving therapeutic indices in people with social anxiety. In the first study, socially anxious (N = 30) and non-anxious individuals (N = 30) completed the Beck Depression Inventory-II, Spielberger's State-Trait Anxiety Inventory, Conner's Social Phobia Inventory, a social-anxiety Stroop test, and a clinical interview. In the second study, individuals with social anxiety (N = 30) were randomly assigned to an experimental group that received 4 sessions of ACTP-SA, or to a sham-intervention control condition. At the post-test and a 3-month follow-up, both groups completed the same measures as in Study 1. In Study 1, socially anxious individuals showed higher attentional bias for threatening stimuli than the controls, after depression had been controlled for. In Study 2, participants in the experimental group, compared with the controls, showed greater reductions in attentional bias, social anxiety, and trait anxiety at post-test and follow-up. The results underscore the importance of information processing biases in social anxiety and the benefits of attentional bias training as a complementary intervention for modifying symptoms of social anxiety. • Social Anxiety Attentional Bias (AB) is independent of depression and rumination. • We tested the effectiveness of an attention re-training program to reduce social anxiety AB and the social anxiety symptoms. • Participants trained with SA-ACTP reduced their social anxiety AB, social anxiety, and trait anxiety. • We suggest that SA-ACTP can be used as a complementary intervention in the treatment of social anxiety. [ABSTRACT FROM AUTHOR]

Background: Cognitive inhibition impairment is one of the causes of impulsive behaviors in individuals with borderline personality disorder (BPD). This study aimed to investigate the effect of emotional working memory training (EWMT) on cognitive inhibition in individuals with a clinically significant borderline personality trait.Methods: In a randomized, parallel-group trial, 40 individuals with borderline personality trait, were selected out of 1000 screened individuals and were randomly assigned to the experimental (N = 20) and waiting-list control (N = 20) groups based on the score on the Borderline Personality Scale and the follow-up Structured Clinical Interview for DSM-IV Personality Disorders. The experimental group underwent 10 sessions of EWMT and the control group did not receive any intervention (waiting list). Participants completed the Stroop Color and Word Test (SCWT) and Go/No-Go task Before and after the intervention.Results: EWMT significantly reduced reaction time of incongruent trials in the SCWT and commission errors in the Go/No-Go task after the intervention only in the experimental group. Furthermore, the interference score in SCWT and commission error rate at the post-intervention time were significantly lower for the experimental vs the waitlist group.Limitations: The single-blind design and absence of follow-up measures.Conclusions: EWMT can improve cognitive inhibition in individuals with borderline personality trait and could be used for therapeutic purposes of impulsivity behavior in BPD. [ABSTRACT FROM AUTHOR]

Contrary to popular belief, the cerebellum is involved not only in motor planning, balance, and coordination but also in cognitive processes. The present study aimed to investigate executive functions (EFs), intellectual capacity, and psychiatric disorders in adults with type 1 Chiari malformation, which is defined as a hindbrain anomaly that involves the cerebellum. The study included 62 adults, with 29 in the CM group and 33 in the control group. EFs were evaluated using the Stroop test, number sequence learning test, and standardized mini-mental state examination (SMMSE). The intelligence quotient (IQ) was measured using the Kent EGY and Porteus maze tests, and psychiatric disorders were evaluated using the Structured Clinical Interview for DSM-5, Clinician Version (DSM-5-CV). The CM group took longer than the control to complete the Stroop test for each section (P < 0.005). Although the mean IQ scores of both groups were within the normal range, the CM group had a lower mean IQ score than the control group (P < 0.005). Although the mean SMMSE scores of both groups were within the normal range, the CM group had a lower mean SMMSE score than the control group (P < 0.005). The CM group had a higher rate of psychiatric comorbidities than the control group (P < 0.005). The study found that subjects with type 1 Chiari malformation performed worse in EFs than healthy controls and had a higher prevalence of psychiatric disorders. [ABSTRACT FROM AUTHOR]

Research suggests that symptoms of anxiety may result in atypical alpha activity associated with cognitive functioning. It is well documented that symptoms of anxiety are often comorbid with symptoms of depression. However, the combined influence of these symptoms on alpha activity changes between engaged attention states and rest is poorly understood. We therefore aimed to investigate the specific added contribution depressive symptoms may have in predicting alpha power compared to anxiety alone. We measured the disparity in alpha power between a selective attention state compared to a resting state using EEG. Selective attention was engaged using the Eriksen flanker task. Our results show that alpha disparity was predicted significantly better when symptoms of depression were incorporated into the model, compared to trait anxiety alone. Also, both symptoms were significant predictors of alpha power change, but in opposite directions. Alpha disparity increased between rest and attention as trait anxiety symptoms increased, while disparity was negatively correlated with increased symptoms of depression. Clinical symptoms did not predict flanker task performance during incongruent trials, but did strongly relate to global executive dysfunction. Given that clinical symptoms were related to alpha change between attention and rest but not behavioral performance on the flanker task, it is possible that these neural patterns could reflect a compensatory strategy. These results further emphasize the importance of examining how the compounded influence symptoms of anxiety and depression manifest in executive abilities, and add to the growing body of evidence that there is a neurological differentiation between these disorders. • Symptoms of depression and anxiety together predicted alpha change. • Predicting alpha disparity was significantly improved with depression symptoms. • Alpha change was related to clinical symptoms in opposite directions. • Trait anxiety and depressive symptoms predicted general executive dysfunction. • The flanker effect was not predicted by clinical symptoms. [ABSTRACT FROM AUTHOR]

• AUD subjects exhibit attentional bias towards alcohol cues. • AUD subjects exhibit general attentional bias (generalized control issue). • Alcohol-specific bias improve during alcohol abstinence (from 1 to 6 months) • Alcohol attentional bias may reverse in abstinence (value-based decision process) • General attentional bias remains stable during six months of abstinence. Alcohol Use Disorder (AUD) is linked to an attentional bias towards alcohol-related cues (e.g. images, smells), which acquire incentive properties and promote continued consumption. We investigated how the general and alcohol attentional bias evolved longitudinally in AUD patients along two periods of abstinence: t = 0 (baseline, 1–3 months of abstinence) and t = 1 (follow-up; 6 months of abstinence), as well as their relationship with alcohol-related variables. General and alcohol-specific attentional bias were evaluated by the Classic and the Alcohol Stroop tests (neutral and alcohol conditions) in abstinent AUD patients and controls. At t = 0, the AUD group exhibited both general and alcohol-specific attentional biases, with greater effect in the general bias. At t = 1, alcohol-specific attentional bias decreased specifically in the AUD group and reached control levels (with interference index levels increasing from 1-3 months to 6 months). However, general attentional bias showed a trend toward improvement but it did not significantly change through abstinence process (linear mixed models, controlling for age, BMI, sex and education). In AUD patients, general and alcohol attentional biases exhibit different trajectories during abstinence, with the attentional bias toward alcohol improving significantly throughout this process whereas general attentional bias is maintained. [ABSTRACT FROM AUTHOR]

• A novel sequence coding-based 1D-GLCM method was proposed. • The recognition accuracy for mild mental stress increased from 88.57% to 98.57%. • The Energy feature is more discriminating compared with other texture features. Mild mental stress, which represents the type of stress that occurs in daily life without a specific time limit, can accumulate and eventually lead to many physical and psychological disorders. Moreover, the overall heart rate fluctuations induced by mild mental stress are less significant, posing a great challenge to stress detection. However, current traditional methods have the drawback of limited ability to quantify local details and spatial variations in the pattern of autonomic fluctuations during early mental stress. To address these issues, in this study, a novel inter-beat interval-based analysis model is proposed, which is comprised of sequence coding-based transformation and construction of gray level co-occurrence matrix (GLCM). The inter-beat intervals were first mapped into binary symbolic sequences, and then the word sequences were constructed. Then four texture features, i.e., Contrast, Correlation, Energy, and Homogeneity, were extracted from the derived GLCM constructed from the word sequences. Additionally, other classic multi-domain features were also extracted. Statistical analysis and Spearman correlation analysis were then performed, respectively. After feature selection by recursive feature elimination, different feature subsets were fed into the support vector machine to identify whether subjects were suffering from mental stress. The results showed that Energy was not only statistically different but also associated with altered mental states. The accuracy using only classic features was 88.57%, while combining classic and texture features increased the highest accuracy to 98.57%. This study provides promising methodology to detecting mild mental stress and potential insight into the mechanisms underlying its pathophysiology. [ABSTRACT FROM AUTHOR]

An executive overload model of obsessive-compulsive disorder (OCD) posits that broad difficulties with executive functioning in OCD result from an overload on the executive system by obsessive thoughts. It implies that, if individuals with OCD "snap out" of their obsessive thoughts, their performance on neurocognitive tasks will improve. We test this prediction using the revised Attention Network Test, ANT-R, and distinct subsamples of data from unmedicated OCD and healthy controls (HC). ANT-R includes Simon and Flanker tasks; in both, incongruent trials take longer to resolve ('conflict costs'). On some trials, a warning cue helps participants to respond faster ('alerting benefits'). In OCD (N = 34) and HC (N = 46), matched on age, IQ, and sex, we tested (1) the effect of OCD on alerting benefits, and (2) the effect of OCD on warning cue related reductions in conflict costs. In a distinct subsample of OCD (N = 32) and HC (N = 51), we assessed whether alerting benefits and cue-related reductions in conflict costs are associated differently with different OCD symptoms. A warning cue can help individuals with OCD more than HC to improve performance on Simon and Flanker tasks. This effect is positively associated with severity of contamination symptoms. This study did not directly assess how distracted participants are by obsessive thoughts. It relied on the ANT-R subtraction measures. Symptom severity was assessed using self-report measures. Difficulties in resolving conflict during decision-making in OCD can be modulated by a warning cue presented immediately before an attentional task. [Display omitted] • Internal preoccupations negatively impact executive function in OCD. • Externally orienting cues improve readiness to respond to external stimuli in OCD. • Externally orienting cues improve efficacy of conflict processing in OCD. • Effects of externally orienting cues vary across obsessive-compulsive themes. [ABSTRACT FROM AUTHOR]

The Neurovisceral Integration Model posits a link between resting vagally mediated heart rate variability (vmHRV) and cognitive control. Empirical support for this link is mixed, potentially due to coarse performance metrics such as mean response time (RT). To clarify this issue, we tested the relationships between resting vmHRV and refined estimates of cognitive control- as revealed by the ex-Gaussian model of RT and, to a greater extent, the drift diffusion model (DDM, a computational model of two-choice performance). Participants (N = 174) completed a five-minute resting baseline while ECG was collected followed by a Simon spatial conflict task. The root mean square of successive differences in interbeat intervals was calculated to index resting vmHRV. Resting vmHRV was unrelated to Simon mean RT and accuracy rates, but was inversely related to the ex-Gaussian parameter reflecting slow RTs (tau); however, this finding was attenuated after adjustment for covariates. High resting vmHRV was related to faster drift rates and slower non-decision times, DDM parameters reflecting goal-directed cognition and sensorimotor processes, respectively. The DDM effects survived covariate adjustment and were specific to incongruent trials (i.e., when cognitive control demands were high). Findings suggest a link between vmHRV and cognitive control vis-a-vis drift rate, and potentially, a link between vmHRV and motoric inhibition vis-a-vis non-decision time. These cognitive correlates would have been missed with reliance on traditional performance. Findings are discussed with respect to the inhibitory processes that promote effective performance in high vmHRV individuals. • The links between vmHRV and cognitive control can be clarified with the drift diffusion model (DDM). • Resting vmHRV was positively related to drift rate and non-decision time under high cognitive control demands. • The association between vmHRV and drift rate suggests a link between cardiac vagal function and cognitive inhibition [ABSTRACT FROM AUTHOR]

Background: Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment. However, there are limited comparative working memory (WM) and neuroimaging studies on these two disorders. Therefore, we investigated the characteristics of WM and neurometabolic changes in patients with OCD and MDD.Methods: A total of 64 unmedicated patients (32 OCD and 32 MDD), and 33 healthy controls (HC) were included to conduct WM assessment comprising Digit Span Test (DST), 2-back task and Stroop Color and Word Test (SCWT). Additionally, all subjects underwent protons magnetic resonance spectroscopy (1H-MRS) to collect neurometabolic ratios of N-acetyl aspartate (NAA) and choline-containing compounds (Cho) to creatine (Cr) in the prefrontal cortex (PFC) and lentiform nucleus (LN). Finally, differential and correlation analysis were conducted to investigate their characteristics and relationships.Results: Compared with HC, both OCD and MDD patients exhibited a lower accuracy rate in the 2-back task, and only MDD patients performed worse in DST scores and longer reaction times in SCWT (all p < 0.05). Both OCD and MDD patients had lower NAA/Cr ratios in bilateral PFC (all p < 0.05). And the decreased NAA/Cr ratios in right PFC were positively correlated to DST scores in MDD group (r = 0.518, p = 0.003).Conclusions: Both OCD and MDD showed WM impairment and neurometabolic alterations in PFC. Besides, MDD performed more severe and broader WM impairment compared to OCD. Moreover, the dysfunction of PFC may underlie the neural basis of WM impairment in MDD. [ABSTRACT FROM AUTHOR]

Medial prefrontal cortex (MPC) has been associated with a wide range of cognitive functions; however, its specific role in interference control is not fully understood. The current study investigates the role of MPC in interference control by externally stimulating it with an electric current and studying associated behavioral and neurophysiological markers. Participants randomly assigned to experimental and sham groups were administered with a high-definition transcranial direct current stimulation (HD-tDCS) of 2 mA for 15 min. They performed a classic color-word Stroop task before, during, and immediately after the stimulation, while electroencephalography (EEG) was acquired throughout the experiment. A decrease in reaction time (RT) for incongruent and neutral trials of the Stroop task was observed in the experimental group compared to the sham group with a significant reduction in the Stroop Effect after stimulation; however, no significant change was observed in the amplitude and latency of N200, P200, and N450 event related potentials. Furthermore, the resting state complexity of the neural signals in the medial frontal region was decreased in the experimental group with a decrease in theta frequency band during the Stroop task. We conclude that the stimulation of MPC increases its efficiency in resolving the conflict by reducing theta power during the Stroop task, which is also reflected in the reduced complexity in the resting state EEG. (ClinicalTrials.gov Identifier: NCT04318522) • Stroop task performance is modulated by the stimulation of Medial Prefrontal Cortex. • Stimulation results in the reduction of EEG theta power during Stroop task. • Resting state complexity of EEG signals is reduced during stimulation. [ABSTRACT FROM AUTHOR]

Background: Neuroimaging studies on depersonalization / derealization disorder (DPD) have revealed that there are structural and functional alterations across numerous brain regions. However, to date, the exact white matter abnormalities that are associated with different clinical symptoms and cognitive impairments in first-episode, drug-naïve patients with DPD remain unclear.Methods: Overall, 25 first-episode, drug-naïve patients with DPD and 23 healthy controls were recruited and underwent DTI scans. The tract-based spatial statistics analysis was conducted in order to determine white matter microstructural changes between the two groups. Correlation analysis was conducted between the fractional anisotropy (FA) of abnormal WM fibers and the total score of the 30-item Cambridge Depersonalization Scale (CDS-30), cognitive assessments.Results: Patients with DPD demonstrated higher FA in the right corpus callosum (CC), and posterior corona radiate (CR), compared to healthy controls. The FA in the right CC demonstrated a positive correlation with total score of CDS-30, numbing, unreality of self, perceptual alterations, and temporal disintegration, respectively. FA in the right CR region indicated a positive correlation with the total score of CDS-30, unreality of self, perceptual alterations, and temporal disintegration, respectively. Furthermore, FA in the right CR region was found to be negatively correlated with the Continuous Performance Test and the Stroop color-word test.Conclusion: The altered white matter microstructure and cognitive impairments of medication naïve DPD patients were observed. Abnormalities in the integrity of CC and CR were associated with severity of symptoms and cognitive impairments, which may provide a potential biomarker for clinical studies on DPD. [ABSTRACT FROM AUTHOR]

The study aims to compare neurological soft signs and executive functions between Toxocara -seropositive and seronegative groups in children with attention-deficit/hyperactivity disorder. The study included 60 boys with ADHD, aged 7–12. After blood samples were taken, the Stroop Color Word Test and Judgment of Line Orientation test (JLOT) were implemented to measure executive functions. Neurological soft signs were evaluated with Physical and Neurological Examination for Subtle Signs (PANESS). Serological tests were positive for Toxocara antibodies in 20 cases. There was no significant difference between Toxocara seropositive and seronegative regarding age, socioeconomic status, developmental stages, and ADHD severity. However, Toxocara -seropositive children had higher Stroop time and Stroop interference scores and lower JLOT scores than Toxocara -seronegative children. Furthermore, Toxocara -seropositive children exhibited more neurological soft signs, such as gait and station abnormalities, dysrhythmia, and a longer total time in timed movements compared to Toxocara -seronegative children. Our study indicates a link between Toxocara -seropositivity and impaired neurological soft signs and executive functions in ADHD. Further research is needed to understand ADHD mechanisms, develop practical treatments considering immunological factors, and thoroughly evaluate how Toxocara seropositivity affects executive functions and motor skills in children with ADHD. • Toxocara -seropositive children exhibited poorer attention and visuospatial skills. • Toxocara antibody-positive children exhibit increased neurological soft signs. • Toxocara indicated potential impairments in motor skills and executive functions. • The impact of Toxocara on ADHD suggests the need for further immunological research. [ABSTRACT FROM AUTHOR]

• Alterations in audiovisual speech processing in CI users mostly deprivation induced. • Audiovisual speech processing is influenced by the attentional focus. • CI users rely stronger on visual cues in audiovisual speech perception than NH. Limited auditory input, whether caused by hearing loss or by electrical stimulation through a cochlear implant (CI), can be compensated by the remaining senses. Specifically for CI users, previous studies reported not only improved visual skills, but also altered cortical processing of unisensory visual and auditory stimuli. However, in multisensory scenarios, it is still unclear how auditory deprivation (before implantation) and electrical hearing experience (after implantation) affect cortical audiovisual speech processing. Here, we present a prospective longitudinal electroencephalography (EEG) study which systematically examined the deprivation- and CI-induced alterations of cortical processing of audiovisual words by comparing event-related potentials (ERPs) in postlingually deafened CI users before and after implantation (five weeks and six months of CI use). A group of matched normal-hearing (NH) listeners served as controls. The participants performed a word-identification task with congruent and incongruent audiovisual words, focusing their attention on either the visual (lip movement) or the auditory speech signal. This allowed us to study the (top-down) attention effect on the (bottom-up) sensory cortical processing of audiovisual speech. When compared to the NH listeners, the CI candidates (before implantation) and the CI users (after implantation) exhibited enhanced lipreading abilities and an altered cortical response at the N1 latency range (90–150 ms) that was characterized by a decreased theta oscillation power (4–8 Hz) and a smaller amplitude in the auditory cortex. After implantation, however, the auditory-cortex response gradually increased and developed a stronger intra-modal connectivity. Nevertheless, task efficiency and activation in the visual cortex was significantly modulated in both groups by focusing attention on the visual as compared to the auditory speech signal, with the NH listeners additionally showing an attention-dependent decrease in beta oscillation power (13–30 Hz). In sum, these results suggest remarkable deprivation effects on audiovisual speech processing in the auditory cortex, which partially reverse after implantation. Although even experienced CI users still show distinct audiovisual speech processing compared to NH listeners, pronounced effects of (top-down) direction of attention on (bottom-up) audiovisual processing can be observed in both groups. However, NH listeners but not CI users appear to show enhanced allocation of cognitive resources in visually as compared to auditory attended audiovisual speech conditions, which supports our behavioural observations of poorer lipreading abilities and reduced visual influence on audition in NH listeners as compared to CI users. [ABSTRACT FROM AUTHOR]

This study explores the impact of movement-outcome congruency and motor dominance on the action-associated modulations of early visual event-related potentials (ERPs). Employing the contingent paradigm, participants with varying degrees of motor dominance were exposed to stimuli depicting left or right human hands in the corresponding visual hemifields. Stimuli were either passively observed or evoked by voluntary button-presses with the dominant or non-dominant hand, in a manner that was either congruent or incongruent with stimulus laterality and hemifield. Early occipital responses (C1 and P1 components) revealed modulations consistent with sensory attenuation (SA) for self-evoked stimuli. Our findings suggest that sensory attenuation during the initial stages of visual processing (C1 component) is a general phenomenon across all degrees of handedness and stimulus/movement combinations. However, the magnitude of C1 suppression was modulated by handedness and movement-stimulus congruency, reflecting stronger SA in right-handed participants for stimuli depicting the right hand, when elicited by actions of the corresponding hand, and measured above the contralateral occipital lobe. P1 modulation suggested concurrent but opposing influences of attention and sensory prediction, with more pronounced suppression following stimulus-congruent button-presses over the hemisphere contralateral to movement, especially in left-handed individuals. We suggest that effects of motor dominance on the degree of SA may stem from functional/anatomical asymmetries in the processing of body parts (C1) and attention networks (P1). Overall, our results demonstrate the modulating effect of hand dominance and movement-outcome congruency on SA, underscoring the need for deeper exploration of their interplay. Additional empirical evidence in this direction could substantiate a premotor account for action-associated modulation of early sensory processing in the visual domain. • Explored the impact of movement-outcome congruency and handedness on sensory attenuation. • Action-associated modulation of the visual C1, P1 and N1 ERPs was assessed. • Sensory attenuation of the C1 component was a general phenomenon. • Attention and sensory prediction modulated the P1 component in an opposing manner. • Handedness and movement-stimulus congruency modulated the suppression of C1 and P1. [ABSTRACT FROM AUTHOR]

The color-word reverse Stroop (RS) effect still represents an interesting puzzle for cognitive researchers as an interference between incongruent ink colors and the meaning of the words is not always found. Here, we examined whether an unfamiliar and complex visuomotor task would produce a RS effect. Forty inexperienced shooters carried out a simulated shooting task. To test if the RS effect is related to the stimuli processing or to a late processing of the color (early and late time-windows), electroencephalographic global field power (GFP) variations were recorded with a high-impedance system (32 channels configuration in a standard monopolar montage, referenced to FCz and grounded to FPz). The color-word RS effect was reflected in the performance of 32 participants, suggesting that the strength of the association between the target and the specific response requested might be central to the RS interference. This behavioral result was paralleled by GFP modulations in 20 participants. A significant increase of the GFP for the congruent trials (e.g., the word "red" written in red ink) was recorded after stimulus presentation (conflict detection), followed by an increase for the incongruent trials (e.g., the word "red" written in green ink) just before the shooting (conflict resolution). Despite the limitations of the study, such as the inclusion of a low number of channels in the GFP analyses, the results suggest that the RS interference is easily elicited in tasks requiring an unfamiliar response, which supports the strength of association hypothesis. Moreover, as implied by the GFP modulations, the interference might occur early in time, but also in a later stage, closer to the response. • The reverse Stroop (RS) effect is an interesting puzzle for cognitive researchers. • Participants performed an unfamiliar and complex simulated handgun task. • Shooting performance and participants' electroencephalographic GFP were collected. • RS effect modulated both variables. • RS effect would occur at the stimulus processing stage and closer to the response. [ABSTRACT FROM AUTHOR]

Synaptic dysfunctions precede cognitive decline in Alzheimer's disease by decades, affect executive functions, and can be detected by quantitative electroencephalography (qEEG). We used quantitative electroencephalography combined with Stroop testing to identify changes of inhibitory controls in cognitively healthy individuals with an abnormal versus normal ratio of cerebrospinal fluid (CSF) amyloid/total-tau. We studied two groups of participants (60–94 years) with either normal (CH-NAT or controls, n = 20) or abnormal (CH-PAT, n = 21) CSF amyloid/tau ratio. We compared: alpha event-related desynchronization (ERD), alpha spectral entropy (SE), and their relationships with estimated cognitive reserve. CH-PATs had more negative occipital alpha ERD, and higher frontal and occipital alpha SE during low load congruent trials, indicating hyperactivity. CH-PATs demonstrated fewer frontal SE changes with higher load, incongruent Stroop testing. Correlations of alpha ERD with estimated cognitive reserve were significant in CH-PATs but not in CH-NATs. These results suggested compensatory hyperactivity in CH-PATs compared to CH-NATs. We did not find differences in alpha ERD comparisons with individual CSF amyloid(A), p-tau(T), total-tau(N) biomarkers. [ABSTRACT FROM AUTHOR]

• ERPs evoked by interface errors with congruent and incongruent sensory feedback. • Comparison of ERPs and visual vs proprioceptive sensory effects. • Incongruent sensory feedback on motion error evokes Stroop effect. • Brain computer interface (BCI) aspects. • Realistic experiment environment and motion task. The manipulation of remote agents such as robotic arms in remote surgery or in BCI-wheelchair control are prone to errors. Some of these are related to user intent misclassification or other interface system errors, which lead to an incorrect movement. Here we focused on errors originating from unpredicted interface movements violating user intent and producing sensory conflicts. In addition, we examined effects of incongruent/congruent sensory stimuli induced by interface errors, focusing on haptic and visual cues in the system. The overarching goal was to identify the prototypical patterns of electroencephalogram (EEG) error signals associated with two types of interface errors rising when the visual and proprioceptive feedback are congruent or incongruent. For purposes of comparison validity, both types of errors were recorded in the same 3D virtual game environment. The comparison of congruent and incongruent interface errors revealed significant and marginally significant differences in EEG potentials with respect to profile, latencies, scalp distribution and sources. Different EEG time–frequency combinations had high power content. Incongruence between visual and proprioceptive feedback in interface errors not only elicited distinct EEG signal characteristics, but also produced a marginally significant Stroop effect. Incongruency in visuo-haptic feedback modalities cause a delayed user response. This effect is of major importance for the design of controlling interfaces and can provide designers with crucial information when aiming to control human response time. [ABSTRACT FROM AUTHOR]

Emotion's influence on source memory has proven more elusive and the lack of studies investigates the effect of the congruent emotional contexts on source memory. Here, we investigated these issues using event-related potentials (ERPs) to assess emotional-induced neural correlates. During encoding, congruent word-picture (a word 'shoes' - a picture described shoes) and incongruent word-picture (a word 'pepper' - a picture described shoes) with a prompt (Common? or Natural?) were presented. At retrieval, participants indicated which prompts were concomitantly presented with the word during encoding. Behavioral results revealed that source memory accuracy was enhanced in the neutral contexts compared to the negative contexts, and enhanced in the incongruent condition relative to the congruent condition, suggesting that emotional contexts impaired source memory performance, and incongruent information enhanced source memory. ERPs results showed that early P2 old/new effect (150–250 ms) and FN400 old/new effect (300–450 ms) were observed for words with correct source that had been encoded in the congruent emotional contexts, and that a larger parietal old/new effect, between 500 and 700 ms, was observed for words with correct source that had been encoded in the incongruent condition than in the congruent condition, irrespective the nature of context. The ERPs results indicate that retrieval of source details for the associated emotionally congruent information supports the idea that emotional events could attract more attentional resources, and reflects the contribution of familiarity-based process. Meanwhile, retrieval of source details for the associated incongruent information reflects a stronger contribution of recollection-based process. • Emotional contexts impaired source memory performance. • Incongruent information enhanced source memory. • Familiarity-based and recollection-based process was contributed to source recognition. [ABSTRACT FROM AUTHOR]

Objectives: Cognitive impairment and abnormal glycolipid metabolism are common clinical features of bipolar disorder (BD). The purpose of this study was to investigate the relationship between conventional glycolipid metabolism indicators and cognitive impairment in patients with BD.Methods: A total of 132 drug-naïve patients with BD and 129 healthy controls (HC) were recruited in the study. Five serum glycolipid metabolism indicators were measured and cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Stroop Color-Word Test (Stroop test) for each participant.Results: The scores of immediate memory, attention, language and delayed memory in BD group were significantly lower than those in HC group (P < 0.05). The triglyceride (TG) level in BD group was higher than that in HC group (P = 0.011), and the total cholesterol and high-density lipoprotein cholesterol (HDL) levels were lower than those in HC group (P = 0.026; P = 0.001). Regression analysis showed that TG level was significantly correlated with RBANS total score (β = 0.245, P = 0.008), attention (β = 0.289, P = 0.03) and delayed memory (β = 0.221, P = 0.023). Fasting blood glucose (FBG) level was significantly correlated with language subscale score (β = -0.187, P = 0.046) in BD.Limitations: Cross-sectional design and limited control variables.Conclusions: Elevated FBG and TG levels may be associated with cognitive dysfunction in BD patients. Improving glycolipid metabolism in patients with BD may help to improve certain domain-specific cognitive functions. [ABSTRACT FROM AUTHOR]

The Stroop task, which examines an aspect of executive function/cognitive control, the ability to inhibit prepotent responses, has been relatively little examined in schizophrenia, and the findings have been inconsistent. Whether performance of this task is associated with failure of de-activation in the disorder is also uncertain. We examined 42 schizophrenic patients and 61 healthy controls during performance of an fMRI-adapted version of the Stroop task, the counting Stroop task. Task-related activations (incongruent > congruent condition) and de-activations (baseline > incongruent) were examined using whole-brain, voxel-based methods. In the healthy controls, task performance was found to be associated with activations in the left dorsolateral prefrontal cortex and the dorsal anterior cingulate cortex, among other regions. De-activations were seen in the medial frontal cortex, the middle and posterior cingulate gyrus and cuneus, the parahippocampal gyrus and the hippocampus. The schizophrenic patients did not show reduced activation compared to the healthy controls. They did, however, show failure of de-activation in the medial frontal cortex. Our negative finding with respect to hypoactivation during performance of a task requiring inhibition of prepotent responses suggests that brain functional abnormality in schizophrenia may not affect all aspects of executive function/cognitive control. The finding of medial frontal cortex failure of de-activation adds to existing findings of default mode network dysfunction in the disorder. [ABSTRACT FROM AUTHOR]

Background: Bipolar disorder (BD) is a severe mental illness that affects more than 1% the world's population with high recurrence rates and a series of comorbidities. Cognitive dysfunction is an endophenotype of BD, but sex influences in cognitive impairment remains unclear.Method: We evaluated the performance of 139 patients with first-diagnosed, drug-naïve BD (44 males and 95 females) and 92 healthy controls (24 males and 68 females) using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scale and the Stroop color-word test.Result: Immediate memory, visuospatial/constructional ability, language, attention, delayed memory, total RBANS score, and Stroop color-word scores were significantly lower in patients with first-diagnosed, drug-naïve BD than healthy participants. Thus, male patients had worse attention and delayed memory scores compared with female patients with BD. Importantly, a worse performance in visuospatial/constructional ability was negatively associated with the Young Mania Rating Scale score in male patients only.Conclusion: Male patients with first-diagnosed, drug-naïve bipolar disorder had worse cognitive dysfunction than female patients in attention and delayed memory. Cognitive deficits were correlated with mania severity only in male patients. These findings reveal the sexual dimorphism in the cognitive deficits of early BD patients with mild and moderated symptoms for further pathophysiological exploration. [ABSTRACT FROM AUTHOR]

• N450 still can be detected when distracters of Stroop tasks were encoded consciously. • Emotional conflict control inhibited memory retrieval on Stroop tasks' distractors. • The 300–400 ms old/new effect regulated by congruency may be a subcomponent of FN400. • The LPN component was also offline regulated by the congruency factor. Evidence is mounting that emotional conflict is mainly resolved by the rostral anterior cingulate inhibiting the processing of emotional distractors. However, this theory has not been verified from the perspective of memory retrieval. This experiment aimed to explore the offline effect of emotional conflict processing on memory retrieval. We adopted a modified encoding-retrieval paradigm to explore this issue. Participants' electroencephalography (EEG) signal were also collected. A face-word Stroop task was used to create the congruency factor. In addition, an old/new judgment task was used to evaluate the recognition performance. During the retrieval phase, the response time of the incongruent condition was longer and the recognition accuracy was lower compared with congruent and neutral conditions in the behavioral data. For event-related potentials (ERP), we detected two well-established old/new effects related to memory retrieval under both neutral and emotional conditions: the frontal negativity (FN400) related to familiarity-driven recognition and the late posterior negativity (LPN) related to reconstructive processing or evaluation of retrieval outcomes. More importantly, the old/new effects were missing for incongruent condition during the early stage of FN400 (300–400 ms). Besides, for LPN (700–900 ms), the old/new effects of the incongruent condition are greater than the congruent condition. The results prove that the encoding phase's emotional congruency factor has a regulatory effect on the retrieval phase's early familiarity processing and evaluation of retrieval outcomes. Our data confirm the inhibitory effect of emotional conflict control on memory retrieval and support the emotional conflict control mechanism found in previous studies. [ABSTRACT FROM AUTHOR]

Background: Dual-task is the concurrent performance of two independent single tasks (ST) that have distinct goals. Daily variations in performance of singular cognitive or motor tasks are reported in the literature.Research Question: To investigate whether performance of a dual-task (DT) varies based on the time of day and whether there is interference between the motor and cognitive aspect of DT.Methods: Participants performed a 10 Meter Walk Test (10MWT) for motor and a Stroop Test for cognitive task. The DT activity combined both STs. All participants performed three trials for all three conditions at three different times of the day (morning, noon, afternoon), on separate testing days.Results: Data were collected on 42 participants. Most participants were female (28/42), average age of 27.95 ± 9.28 years, and BMI of 25.58 ± 4.49 Kg/m2. Walking velocities in ST were consistently faster than in DT, p < .0005. In DT conditions, the participants walked faster at noon (1.21 ± 0.13 m/s) compared to the morning (1.16 ± 0.15 m/s, p = 0.01) or the afternoon (1.16 ± 0.18 m/s, p = 0.04). The participants' score on the DT-Stroop test were only different at noon (11.43 ± 2.28) when compared to morning (10.67 ± 1.34, p = 0.006). The percentage DT-Cognitive interference effect was 26.1 % in the morning, 11.8 % at noon and 13.4 % in the afternoon. The Motor interference was -14.6 % in the morning, -12.2 % at noon and -13.8 % in the afternoon.Significance: Noon is the best time to perform a dual task condition. Noon consistently exhibited the least motor or cognitive interference. Conversely, the maximum boost in cognitive performance was observed in the mornings. [ABSTRACT FROM AUTHOR]

Background: A wide variety of psychiatric conditions are associated with social cognitive deficits. The relationship between social cognition and many factors, especially executive functions (EF), has been examined, but there is no study examining sleep and social cognition in children with attention deficit activity disorder (ADHD). It is important to find new approaches and intervention areas to improve their social cognitive skills. The main hypothesis of our study was that sleep disturbance would predict lower social cognition scores. We hypothesized that sleep disturbances and EF impairment could predict lower social cognitive performance.Methods: Eighty-five children aged 7-12 years with drug-naïve ADHD were included in the study. Reading the Mind in the Eyes Test (RMET) and Faux Pas Recognition Test (FPRT) were used for social cognition performance; Stroop test was used for executive function performance. Sleep disturbance was evaluated with Children's Sleep Habits Questionnaire (CSHQ), ADHD severity with Conners Parent Rating Scale (CPRS). Hierarchical multiple regression analyses were performed to determine predictive factors of the FPRT and RMET.Results: Age, gender, and comorbidity were included at step 1, CPRS-RS score was included at step 2, Stroop test part V score was included at step 3, CSHQ total score and sleep duration were included at step 4. Lower sleep disturbance score on CSHQ was associated with higher social cognition FPRT score (p = 0.014). There was no significant relationship between CSHQ and social cognition RMET score. Lower EF score on Stroop test part V was associated with higher social cognition FPRT score (p = 0.002) and higher social cognition RMET score (p < 0.001).Conclusion: These results showed that sleep disturbance and EF are both associated with social cognitive impairment, sleep particularly with the cognitive component. Identifying sleep problems in children with ADHD may provide helpful information in understanding and treating social cognitive impairments. This study is the first to draw attention to the relationship between sleep and social cognition. [ABSTRACT FROM AUTHOR]

Humans express volition by making voluntary choices which, relative to forced choices, can motivate cognitive performance in a variety of tasks. However, a task that requires the generation of motor responses on the basis of external sensory stimulation involves complex underlying cognitive processes, e.g., pre-response processing, response selection, and response execution. The present study investigated how these underlying processes are facilitated by voluntary choice-making. In five experiments, participants were free or forced to choose a task-irrelevant picture from two alternatives, and then completed a conflict task, i.e., Flanker, Stroop, Simon, Stroop-Simon, or Flanker-Simon task, where the conflict effect could occur at different processing levels. Results consistently showed that responses in all tasks were generally faster after voluntary (vs. forced) choices. Importantly, the conflict effect at the response-execution level (i.e., the Simon effect), but not the conflict effect at the pre-response and response-selection levels (i.e., the Flanker and Stroop effects), was reduced by the voluntary choice-making. Model fitting revealed that the peak amplitude of automatic motor activations in the response-execution conflict was smaller after voluntary (vs. forced) choices. These findings suggest that volition motivates subsequent cognitive performance at the response-execution level by attenuating task-irrelevant motor activations. • A task-irrelevant voluntary choice can generally enhance the following performance across various conflict tasks. • Making a voluntary choice can facilitate conflict resolution at the response-execution level (i.e., the Simon effect). • The peak amplitude of the automatic motor activation in the Simon conflict can be attenuated after a voluntary choice. [ABSTRACT FROM AUTHOR]

Conflict adaptation can be expressed as greater performance (shorter response time and lower error rate) after incongruent trials when compared to congruent trials. It has been observed in designs that minimize confounding factors, i.e., feature integration, contingency learning, and temporal learning. Our current study aimed to further elucidate the temporal evolution mechanisms of conflict adaptation. To address this issue, the current study employed a combination of behavioral, univariate, and multivariate analysis (MVPA) methods in a modified color-word Stroop task, where half of the trials required button presses (DO trials), and the other half only required observation (LOOK trials). Both behavioral and the ERP results (N450 and SP) in the LOOK-DO transition trials revealed significant conflict adaptation without feature integration, contingency learning, and temporal learning, providing support for the conflict monitoring theory. Furthermore, during the LOOK trials, significant Stroop effect in the N450 and SP components were observed, indicating that conflict monitoring occurred at the stimulus level and triggered reactive control adjustments. The MVPA results decoded the congruent-incongruent and incongruent-incongruent conditions during the conflict adjustment phase but not during the conflict monitoring phase, emphasizing the unique contribution of conflict adjustment to conflict adaptation. The current research findings provided more compelling supporting evidence for the conflict monitoring theory, while also indicating that future studies should employ the present design to elucidate the specific processes of conflict adaptation. • Conflict adaptation can be triggered by observing conflict. • Conflict monitoring can detect conflicts at lower processing levels and trigger conflict adjustment. • MVPA successfully decoded the conflict adaptation during the conflict adjustment stage. • The operation of conflict observation can effectively eliminate known confounding factors in conflict adaptation. [ABSTRACT FROM AUTHOR]

Cognitive processes are fundamentals of safety behavior of construction workers. Exposure to hypoxia may impair their cognitive abilities and increase their susceptibility to cognitive failure. However, the high-altitude effect on the cognitive abilities of construction workers remains unclear. This study assessed the cognitive impairment experienced by construction workers on high-altitude construction sites. Ten practitioners engaged in high-altitude construction project were recruited to assess four cognitive abilities: sustained attention, selective attention, working memory, and executive ability using the Simple Reaction Time Test, the Color Word Stroop Test, the 2-Back Test, and the Go-Nogo Test through a baseline and plateau follow-up test. Results showed that hypoxia exposure reduced each of the four cognitive abilities by 11–31% and caused sustained impairment in working memory. In addition, electroencephalogram was used to monitor pre-service fatigue marked by cognitive impairment, achieving an accuracy rate of 91%. This study provides insights to protect and improve occupational safety and health of highland construction practitioners. • Cognitive abilities impairment in workers at plateau environments is assessed. • A cognitive ability test battery was administered to ten participants. • Participants completed a low-altitude baseline and plateau follow-up tests. • Deep learning and EEG help identify pre-service fatigue induced at the working site. • Results shed light on fatigue management and safety practices in plateau projects. [ABSTRACT FROM AUTHOR]

The paper proposes an induced stress classification algorithm that uses features from the Doppler spectrum. In this approach, a reference signal source is used to obtain the quadrature and in-phase components of the EEG signal. The higher frequency components from the in-phase and quadrature are then eliminated using a pair of low-pass filters. The Doppler spectrum was then constructed from which the Doppler frequency features are then estimated. The features that were thus obtained are trained using an ensemble 1 D -CNN (one-dimensional Convolutional neural network) which uses two sections of 1 D -CNN. The first section 1D-CNN trains the features based on the EEG signal classes namely Stroop test, arithmetic task, and mirror tasks, while the second 1 D -CNN section trains the features based on the EEG signal intense classes namely high, low, and medium stress. We also propose a linear-cosine-linear (LCL) activation function for the ensemble 1 D -CNN which was derived from the cosine signal. The proposed stress classification scheme was evaluated using the SAM-40 datasets with induced stress classes namely arithmetic task, Stroop color-word test, and mirror image recognition task with stress levels namely high, low, and medium with the evaluation metrics such as precision, F1-score, accuracy, specificity, and recall. The proposed stress classification scheme attains an average accuracy, precision, and recall of 95.25 % , 95.22 % , and 92.9 % when evaluated in 9 classes of EEGs. [ABSTRACT FROM AUTHOR]

Leading hypotheses of oxytocin's (OT) role in human cognition posit that it enhances salience attribution. However, whether OT exerts its effects predominantly in social (vs non-social) contexts remains debatable, and the time-course of intranasal OT's effects' on salience attribution processing is still unknown. We used the social Salience Attribution Task modified (sSAT) in a double-blind, placebo-controlled intranasal OT (inOT) administration, between-subjects design, with 54 male participants, to test existing theories of OT's role in cognition. Namely, we aimed to test whether inOT would differently affect salience attribution processing of social stimuli (expressing fearfulness) and non-social stimuli (fruits) made relevant via monetary reinforcement, and its neural processing time-course. During electroencephalography (EEG) recording, participants made speeded responses to emotional social (fearful faces) and non-emotional non-social (fruits) stimuli - which were matched for task-relevant motivational salience through their (color-dependent) probability of monetary reinforcement. InOT affected early (rather than late, P3b and LPP) EEG components, increasing N170 amplitude (p =.041) and P2b latency (p.001; albeit not of P1), regardless of stimuli's (emotional) socialness or reinforcement probability. Fear-related socialness affected salience attribution processing EEG (p.05) across time (N170, P2b and P3b), being later modulated by reinforcement probability (LPP). Our data suggest that OT's effects on neural activity during early perception, may exist irrespective of fear-related social- or reward-contexts. This partially supports the tri-phasic model of OT (which posits OT enhances salience attribution in an early perception stage regardless of socialness), and not the social salience nor the general approach-withdrawal hypotheses of OT, for early salience processing event-related potentials. • Intranasal OT affected early ERPs regardless of (fearful) social or reward contexts. • OT's role in fear-related early salience attribution, may be social/reward-independent • Our results partially support the tri-phasic model of OT [ABSTRACT FROM AUTHOR]

Patients with somatic symptom disorder (SSD) may have declined parasympathetic activity and selective attention to negative information. We combined Stroop tasks and heart rate variability (HRV) measurements to explore the brain mechanism of SSD. 104 SSD patients (64 women) and 100 healthy adults (76 women) received three Stroop tasks (the "cognitive" color-word Stroop, "emotional" emotion Stroop, and "cognitive and emotional" face-word Stroop) with low and high interference conditions. The key HRV indexes included high-frequency power (HF) and standard deviation of normal to normal RR intervals (SDNN). The generalized estimating equation model was used to examine the effects of SSD on three Stroop tasks performance (accuracy and reaction time) and HRV (HF and SDNN) controlling for sex, age, body mass index, and the levels of anxiety and depression. For Stroop tasks, the significant group difference in emotion Stroop task with the high level of interference (SSD patients had lower accuracy than healthy ones) was only found in women. As for HRV, only men during color-word Stroop, women during emotion Stroop revealed significant between-group differences; SDNN in SSD men was higher than healthy men, and HF in SSD women was lower than healthy women controlling for the confounding factors. The significantly longer reaction time in SSD women than in healthy women diminished in the adjusted analysis. Emotion Stroop task and HRV helps distinguish SSD patients from healthy adults, particularly in women. Sex-specific measures for early detection and intervention for SSD are suggested. • Women with SSD revealed lower HF and less accuracy in emotion Stroop with high interference than healthy women. • During color-word Stroop with high interference, SDNN was higher in men with SSD than in healthy men. • Emotion Stroop task and HRV help distinguish SSD patients from healthy adults. • The magnitude of longer reaction time in SSD women than healthy women diminished after controlling depression/anxiety. [ABSTRACT FROM AUTHOR]

Background: Previous studies claimed that transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) improves cognition in neuropsychiatric patients with cognitive impairment, schizophrenia, organic hypersomnia, etc, but few studies evaluated the effects of tDCS on cognitive improvement following sleep deprivation. The objective of this study was to determine whether tDCS (anode on the left DLPFC and cathode on the right DLPFC with a 2-mA current for 30 min) improves cognition following sleep deprivation.Methods: Seven participants received active tDCS and eight participants received sham tDCS when their cognition declined during at least 30 h of sleep deprivation. All participants completed the psychomotor vigilance task, Trail Making Tests A and B, digit cancellation test, Stroop color word test, the Brief Visuospatial Memory Test-Revised and a procedural game every 2 h during the sleep deprivation and after recovery sleep.Results: Compared to the sham stimulation, active tDCS (anode on the left DLPFC and cathode on the right DLPFC at a 2-mA current for 30 min) had beneficial effects on attention, memory, executive function, processing speed, and the ability to inhibit cognitive interference, and improved in subjective drowsiness and fatigue following sleep deprivation. The lasting effect of a single tDCS on cognition during sleep deprivation was greater than 2 h. In all participants, tDCS did not disturb recovery sleep, and cognitive performance recovered to the baseline levels after recovery sleep.Conclusions: The study results indicate that tDCS can improve cognition following sleep deprivation and does not disturb recovery sleep or cognitive performance after recovery sleep. The possible pathophysiological mechanisms might be related to the modulation of the corticothalamic pathway. We believe that tDCS can be applied in the treatment of sleep disorders involving sleepiness.Trial Registration Number: ChiCTR2000029420.Date Of Registration: 2020-1-31. [ABSTRACT FROM AUTHOR]