Search

Your search keyword '"Spooner, Neil"' showing total 7 results
Start Over Author "Spooner, Neil" Publisher elsevier b.v.
7 results on '"Spooner, Neil"'

2. The CYGNO experiment, a directional detector for direct Dark Matter searches

Author

Amaro, Fernando Domingues, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Cortez, André, Costa, Igor Abritta, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Imperio, Giulia, Iacoangeli, Francesco, Lima, Herman Pessoa, Jùnior, Lopes, Guilherme Sebastiao Pinheiro, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Pelosi, Sandro, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, da Cruz Roque, Rita Joanna, Rosatelli, Filippo, Russo, Alessandro, dos Santos, Joaquim Marques Ferreira, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, Tommasini, Sandro, and Torelli, Samuele

Published
2023
Full Text
View/download PDF

3. LIME — A gas TPC prototype for directional Dark Matter search for the CYGNO experiment

Author

Amaro, Fernando Domingues, Baracchini, Elisabetta, Benussi, Luigi, Bianco, Stefano, Capoccia, Cesidio, Caponero, Michele, Cardoso, Danilo Santos, Cavoto, Gianluca, Cortez, André, Costa, Igor Abritta, Dané, Emiliano, Dho, Giorgio, Di Giambattista, Flaminia, Di Marco, Emanuele, D’Imperio, Giulia, Iacoangeli, Francesco, Júnior, Herman Pessoa Lima, Lopes, Guilherme Sebastiao Pinheiro, Maccarrone, Giovanni, Mano, Rui Daniel Passos, Gregorio, Robert Renz Marcelo, Marques, David José Gaspar, Mazzitelli, Giovanni, McLean, Alasdair Gregor, Messina, Andrea, Monteiro, Cristina Maria Bernardes, Nobrega, Rafael Antunes, Pains, Igor Fonseca, Paoletti, Emiliano, Passamonti, Luciano, Pelosi, Sandro, Petrucci, Fabrizio, Piacentini, Stefano, Piccolo, Davide, Pierluigi, Daniele, Pinci, Davide, Prajapati, Atul, Renga, Francesco, da Cruz Roque, Rita Joanna, Rosatelli, Filippo, Russo, Alessandro, dos Santos, Joaquim Marques Ferreira, Saviano, Giovanna, Spooner, Neil John Curwen, Tesauro, Roberto, Tomassini, Sandro, and Torelli, Samuele

Published
2023
Full Text
View/download PDF

6. Quantitative bioanalysis of paracetamol in rats using volumetric absorptive microsampling (VAMS).

Author

Denniff, Philip, Parry, Simon, Dopson, Wesley, and Spooner, Neil

Subjects
*ACETAMINOPHEN, *DRIED blood spot testing, *HEMATOCRIT, *VOLUMETRIC analysis, *HEMORRHAGE, *LABORATORY rats
Abstract

Volumetric absorptive microsampling (VAMS) is a simple intuitive technique for collecting and quantitative analysis of dried blood samples. It enables the collection of an accurate blood volume (approximately 10 μL) regardless of blood hematocrit. A bioanalytical method for the determination of paracetamol in dried blood supported on VAMS samplers has been validated and used to support a toxicokinetic (TK) study in rat. The calculated TK parameters were comparable to those obtained from blood–water (1:1, v/v) samples. VAMS is demonstrated to be a robust method that simplifies both the blood sample collection and bioanalytical laboratory procedures and generates high quality quantitative data. However, problems were encountered with controlling the bleed rate during sample collection, resulting in the VAMS tips being flooded and highlighting the need for bleeding methods to be compatible with microsampling techniques to avoid wasting blood. Alternative sample collection procedures are discussed that minimize these issues. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

7. Overcoming the barriers to the uptake of nonclinical microsampling in regulatory safety studies.

Author

Chapman, Kathryn, Chivers, Simon, Gliddon, Dan, Mitchell, David, Robinson, Sally, Sangster, Tim, Sparrow, Susan, Spooner, Neil, and Wilson, Amanda

Subjects
*DRUG laws, *MEDICATION safety, *PHARMACOKINETICS, *DRUG toxicity, *DRUG side effects, *PHARMACEUTICAL industry, *DRUG analysis
Abstract

Highlights: [•] Toxicokinetic (TK) data allow correlation of drug exposure to adverse effects. [•] Pharmaceutical companies are investing in microsampling to improve TK data. [•] Workshop output on the challenges and benefits of microsampling. [•] Expert opinion on perceived regulatory and scientific hurdles for microsampling. [•] Perspective on the future of microsampling in the pharmaceutical industry. [Copyright &y& Elsevier]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results