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Lysosome associated membrane protein 3 (LAMP3), a highly glycosylated protein, is one member of the LAMPs family. LAMPs family plays a critical role in the autolysosome fusion process. Autophagy was recently confirmed to regulate hepatic lipolysis. However, the physiological function of LAMP3 in lipid metabolism is not clear. In the current study, we discovered that the LAMP3 expression level was higher in the liver tissues of non-alcoholic fatty liver disease (NAFLD) patients and high-fat diet and ob/ob mice than in the matched control groups. LAMP3 expression was also obviously increased in hepatocellular carcinoma (HCC) cells treated with free fatty acids. Moreover, marked accumulation of intracellular lipid droplets and triglycerides (TG) was observed after LAMP3 overexpression in HCC cells. Further study showed that LAMP3 overexpression activated Akt and upregulated the expression of the lipogenic enzymes FASN and SCD-1 in HepG2 cells. Additionally, the increased TG content induced by LAMP3 overexpression was attenuated by treatment with a PI3K/Akt pathway inhibitor. Our findings demonstrated that LAMP3 is an important regulator of hepatic lipid metabolism, which provides a line of evidence for taking LAMP3 as a drug target in lipid metabolism disorder-associated diseases, such as NAFLD and obesity. [ABSTRACT FROM AUTHOR]

Abstract: Novel lotus root slice-like self-assembled hierarchical In2O3 microspheres with porous structure are fabricated successfully by a facile, template-free solvent-thermal method. X-ray diffraction (XRD) and scanning electron microscopy (SEM) are employed to characterize their structures and morphologies. The results reveal that the as-synthesized microspheres after calcination are cubic phase In2O3 and subunits are lotus root slice-like nanosheets with porous structure benefiting enhancement of gas sensing. The sensing properties of the sensors based on the In2O3 microspheres are investigated. The sensors show fast and excellent response to NO2. We think this higher response more than that of In2O3 nanoparticles is attributed to unique hierarchical and porous structures. Furthermore, the obtained NO2 sensor has a prominent long-term stability. [Copyright &y& Elsevier]

Abstract: In this paper, by using the center manifold reduction method, together with the eigenvalue analysis, we made bifurcation analysis for the Kuramoto–Sivashinsky equation, and proved that the Kuramoto–Sivashinsky equation with constraint condition bifurcates an attractor as crossed the first critical value under the two cases. Our analysis was based on a new and mature attractor bifurcation theory developed by Ma and Wang (2005) . [Copyright &y& Elsevier]

Abstract: In this paper, by using an iteration procedure, regularity estimates for the linear semigroups and a classical existence theorem of global attractor, we prove that a modified Swift–Hohenberg equation possesses a global attractor in Sobolev space for all , which attracts any bounded subset of in the -norm. [Copyright &y& Elsevier]

Abstract: In this paper, we use the iteration technique for regularity estimates, combining with the classical existence theorem of global attractors, to derive that for any the semilinear parabolic equation possesses a global attractor in , which attracts any bounded subset of in the -norm. [Copyright &y& Elsevier]

Abstract: In this paper, a kind of nonlinear delayed differential equations which can describe a two species predator–prey system with stage structure is discussed. The stability of the equilibria of the system and the existence of Hopf bifurcations are given. And the stability and the direction of the Hopf bifurcation are determined by applying the normal form theory and the center manifold theorem. [Copyright &y& Elsevier]

In this work, CdIn 2 O 4 nanofibers with diameter about 100 nm have been synthesized successfully through an electrospinning method with the assistance of poly (vinyl pyrrolidone) (PVP) followed by calcinating in air at 800 °C. The morphology, structure and composition of the as-prepared products were characterized by powder X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). The characterization results indicated that high-purity CdIn 2 O 4 nanofibers could be obtained by using the electrospinning method with optimal Cd/In molar-ratio. By using as-prepared CdIn 2 O 4 nanofibers as sensing material, semiconductor-type gas sensors were constructed and used to detect ethanol vapor at ppm level. Compared to CdIn 2 O 4 materials with conventional particulate shape, the as-prepared CdIn 2 O 4 nanofibers sensing material exhibited improved sensing performance in sensitivity and long-term stability. [ABSTRACT FROM AUTHOR]

Abstract: In this paper, we considered an important nonlinear reaction-diffusion equations describing a two-species ratio-dependent predator–prey system with diffusion terms and stage structure. By using the linearized method, we investigated the locally asymptotical stability of the nonnegative equilibria of the above mentioned system and obtained the locally stable conditions. And by combining the approach introduced by J. Canosa (see [J. Canosa, On a nonlinear diffusion equation describing population growth, IBM J. Res. Deve. 17 (1973) 307–313]) with the method of upper and lower solutions, we proved that the traveling wavefronts which connect the zero solution with the positive constant equilibrium of the system exist and appear to be monotone. Finally, we gave a conclusion to summarize the achievements of the work. [Copyright &y& Elsevier]