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SERPINB5 is a mammary serine protease inhibitor, which is involved in various cellular functions. The aberrant expression of SERPINB5 is reported in many cancers along with GBC but limited information is available about its role in genetic predisposition for GBC. We carried out case-control study in 206 cases and 219 controls. Promoter SNPs were genotyped by Sanger's sequencing. In - silico promoter analysis and luciferase reporter assay were done to elucidate the role of promoter variants in regulation of SERPINB5 expression. Out of four SNPs, three SERPINB5 promoter variants showed association with GBC in different models. The 'C' allele of variant rs17071138 was found to be significantly associated with GBC (p = 0.017). The 'T' allele of rs3744940 significantly increased the risk for GBC in dominant (p = 0.035) and additive models (p = 0.005). Also, rs3744941 'T' allele increased the risk for GBC by dominant (p = 0.042) as well as additive models (p = 0.016). In - silico promoter analysis and luciferase reporter assay revealed the probable regulatory role of the SERPINB5 promoter variant rs17071138 on the expression. Overall, our study reveals the genetic association of SERPINB5 promoter variants with GBC and possible role of rs17071138 in the regulation of expression. [ABSTRACT FROM AUTHOR]

Abstract: Thin films of a-Se80Te20− x Cu x (where x=2, 6, 8 and 10) were deposited on glass substrates by vacuum evaporation technique. The absorbance, reflectance and transmittance of as-deposited thin films were measured in the wavelength region 400–1000nm. The optical band gap and optical constants of amorphous thin films have been studied as a function of photon energy. The optical band gap increases on incorporation of copper in Se80Te20− x Cu x system. The value of refractive index (n) decreases while the value of the extinction coefficient (k) increases with increasing photon energy. The results are interpreted in terms of concentration of localized states. [Copyright &y& Elsevier]

In the present work, a detailed conformational study of cladrin (3-(3,4-dimethoxy phenyl)-7-hydroxychromen-4-one) has been done by using spectroscopic techniques (FT-IR/FT-Raman/UV-Vis/NMR) and quantum chemical calculations. The optimized geometry, wavenumber and intensity of the vibrational bands of the cladrin in ground state were calculated by density functional theory (DFT) employing 6-311++G(d,p) basis sets. The study has been focused on the two most stable conformers that are selected after the full geometry optimization of the molecule. A detailed assignment of the FT-IR and FT-Raman spectra has been done for both the conformers along with potential energy distribution for each vibrational mode. The observed and scaled wavenumber of most of the bands has been found to be in good agreement. The UV-Vis spectrum has been recorded and compared with calculated spectrum. In addition, 1H and 13C nuclear magnetic resonance spectra have been also recorded and compared with the calculated data that shows the inter or intramolecular hydrogen bonding. The electronic properties such as HOMO-LUMO energies were calculated by using time-dependent density functional theory. Molecular electrostatic potential has been plotted to elucidate the reactive part of the molecule. Natural bond orbital analysis was performed to investigate the molecular stability. Non linear optical property of the molecule have been studied by calculating the electric dipole moment (µ) and the first hyperpolarizability (β) that results in the nonlinearity of the molecule. [ABSTRACT FROM AUTHOR]

Abstract: The crystallization kinetics of Se80Te20−x Zn x with x =0.5, 1.0, 1.5, 2.0 and 2.5 chalcogenide glasses were investigated using non-isothermal crystallization approach. The glass transition temperature (T g ) and crystallization temperature (T c ) of these glasses were determined using the differential scanning calorimeter at different heating rates. The dependence of T g and T c on the heating rate (β) has been used for the determination of the activation energy of crystallization (E c), the activation energy of structural relaxation (E t), crystallization enthalpy (ΔH c) and the Avrami exponent (n). It was found that the enthalpy released is minimum at 2.5% of Zn, hence, the glass with 2.5% of Zn is most stable in the Se80Te20−x Zn x system. The crystallization kinetics for the glasses was studied by using the modified Kissinger and Ozawa equations. [Copyright &y& Elsevier]

Abstract: Results of differential scanning calorimetric (DSC) under non-isothermal condition of bulk amorphous semiconducting alloys of Se80Te20− x Cu x (x=2, 4, 6, 8 and 10) glasses with different heating rates are reported and discussed. The glass transition temperature, crystallization temperature at different heating rates and structural change during glass transition have been determined from an empirical relation. The dependence of the glass transition temperature (T g), crystallization temperature (T c), the activation energy for structural relaxation (ΔE t), the activation energy of crystallization (ΔE c) and the order parameter (n) are calculated at different heating rates. On the basis of the obtained experimental data, the temperature difference T c−T g is found to be maximum for Se80Te16Cu4 glass, which indicates that this glass is the thermally most stable in the composition range of investigation. [Copyright &y& Elsevier]