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Your search keyword '"Singh, Shambhu Nath"' showing total 1 results
Start Over Author "Singh, Shambhu Nath" Publisher elsevier b.v.
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1. Cu-mediated 1,3-dipolar cycloaddition of azomethine ylides with dipolarophiles: a faster access to spirooxindoles of potential pharmacological interest.

Author

Singh, Shambhu Nath, Regati, Sridhar, Paul, Abir Kumar, Layek, Mohosin, Jayaprakash, Sarva, Reddy, K. Venkateshwara, Deora, Girdhar Singh, Mukherjee, Soumita, and Pal, Manojit

Subjects
*ZWITTERIONS, *RING formation (Chemistry), *OXINDOLES, *PHARMACOLOGY, *MULTIPHASE flow, *COPPER, *IN vitro studies
Abstract

Abstract: CuI facilitated three-component reaction of isatin derivatives, l-proline and terminal alkynes containing an amide or ester functional group. The multi-component reaction (MCR) afforded a faster and practical synthesis of spirooxindole derivatives. A range of novel spirooxindoles were synthesized by using this straightforward and one-pot efficient methodology. A representative compound showed significant inhibition of PDE4B enzyme in vitro and good interactions with this protein in silico. [Copyright &y& Elsevier]

Published
2013
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