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Start Over Author "Shutter, John R." Publisher elsevier b.v.
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1. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Author

Veis, Deborah, J., Sorenson, Christine M., Shutter, John R., and Korsmeyer, Stanley J.

Subjects
Dwarfism -- Genetic aspects, Mice -- Research, Embryology -- Research, Mortality -- Genetic aspects, Biological sciences
Abstract

Growth retardation and postnatal mortality accompanies embryogenesis in bcl-2-l-mice characterized by the absence of the oncogene, bcl-2. Polycystic kidney disease, fulminant apoptosis of the thymus and spleen and cell death in thymocytes commonly prevail in the bcl-2-l-mice. Programmed cell death is ascribed to the function of oxygen-induced free radicals. Bcl-2 is characterized by a death repressor molecular activity which proceeds through an antioxidant pathway.

Published
1993

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