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Start Over Author "Sartorelli, Vittorio" Publisher elsevier b.v.
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1. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

Author

Hamamori, Yasuo, Sartorelli, Vittorio, Ogryzko, Vasily, Puri, Pier Lorenzo, Wu, Hung-Yi, Wang, Jean Y.J., Nakatani, Yoshihiro, and Kedes, Larry

Subjects
Histones -- Research, Proteins -- Research, Genetic transcription -- Research, Transferases -- Research, Biological sciences
Abstract

The regulation of the p300 and p300/CBP-associated factor (PCAF) histone acetyltransferases (HAT) was investigated. Results showed that the basic helix-loop-helix protein Twist directly binds two independent HAT domains and regulates the HAT activities of p300 and PCAF. It was also found that the N terminus of the Twist is the primary domain interacting with p300 and PCAF and that the effects of the Twist are imitated by the adenovirus E1A protein.

Published
1999

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