1. Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: Role of aspirin and platelet glycoprotein IIIa polymorphism
- Author
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Morawski, W., Sanak, M., Cisowski, M., Szczeklik, M., Szczeklik, W., Dropinski, J., Waclawczyk, T., Ulczok, R., and Bochenek, A.
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Aspirin -- Genetic aspects ,Coronary artery bypass -- Genetic aspects ,Thrombin -- Genetic aspects ,Cardiac patients -- Genetic aspects ,Surgery -- Genetic aspects ,Health - Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2005.02.041 Byline: W. Morawski (a), M. Sanak (b), M. Cisowski (a), M. Szczeklik (a), W. Szczeklik (b), J. Dropinski (b), T. Waclawczyk (a), R. Ulczok (a), A. Bochenek (a) Abstract: The presence of the glycoprotein IIIa allele Pl.sup.A2 is associated with enhanced thrombin formation and an impaired antithrombotic action of aspirin, which could favor coronary thrombosis. We wondered whether Pl.sup.A1/A2 genetic polymorphism could affect the postoperative bleeding in patients undergoing coronary artery bypass grafting. We also aimed to assess the effects of aspirin pretreatment and to ascertain the value of platelet function studies as predictors of postoperative bleeding. Author Affiliation: (a) First Cardiac Surgery Department, Medical University of Silesia, Katowice, Poland (b) Department of Medicine, Jagellonian University School of Medicine, Krakow, Poland. Article History: Received 30 November 2004; Revised 12 February 2005; Accepted 24 February 2005 Article Note: (footnote) Supported by KBN (State Committee for Scientific Research).
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- 2005