29 results on '"Rocha, Paula"'
Search Results
2. Optimal operation of combined heat and power under uncertainty and risk aversion
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Maurovich-Horvat, Lajos, Rocha, Paula, and Siddiqui, Afzal S.
- Published
- 2016
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3. Improving energy efficiency via smart building energy management systems: A comparison with policy measures
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Rocha, Paula, Siddiqui, Afzal, and Stadler, Michael
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- 2015
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4. Nickel-doped small pore zeolite bifunctional catalysts: A way to achieve high activity and yields into olefins
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Ferreira, Anna Danielli F., Maia, Aline J., Guatiguaba, Bianca, Herbst, Marcelo H., Rocha, Paula T.L., Pereira, Marcelo M., and Louis, Benoit
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- 2014
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5. Multistage stochastic portfolio optimisation in deregulated electricity markets using linear decision rules
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Rocha, Paula and Kuhn, Daniel
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- 2012
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6. HEREDITARY HEMORRHAGIC TELANGIECTASIA IN MUCOSA AND FACE.
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SILVA, Rubens Signoretti Oliveira, OLIVEIRA, Sicília Rezende, ROCHA, Paula Alves da Silva, SANTANA, Nayara Conceição Marcos, BERNARDES, Vanessa Fátima, de MESQUITA, Ricardo Alves, and da SILVA, Tarcília Aparecida
- Abstract
Hereditary Hemorrhagic Telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is a rare autosomal dominant disease characterized by mucosal, visceral, and dermal telangiectasias. This study details the case of a 68-year-old individual diagnosed with HHT since 2007. The patient has reported a progressive onset of telangiectasias on the face, oral mucosa, lips, palate, and tongue. In 2014 and 2018, the patient developed cerebral abscesses 15 days after dental manipulation for endodontic treatment. Additionally, episodes of epistaxis and gingival bleeding were noted, leading to sessions of vascular sclerotherapy on the oral mucosa under antibiotic prophylaxis. In 2022, the patient experienced hypovolemic shock necessitating volume resuscitation due to recurrent epistaxis and gingival bleeding. Following recovery, further sclerotherapy sessions were conducted. The patient is currently under follow-up, with plans for additional sclerotherapy sessions, and has not reported recent episodes of buccal bleeding. This case highlights the challenges and complications associated with HHT, emphasizing the importance of ongoing management and interventions to address the vascular manifestations of the syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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7. Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test
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Boettcher, Melanie, Grund, Stefanie, Keiter, Steffen, Kosmehl, Thomas, Reifferscheid, Georg, Seitz, Nadja, Rocha, Paula Suares, Hollert, Henner, and Braunbeck, Thomas
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- 2010
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8. THE IMPORTANCE OF IMAGING AND HISTOLOGICAL EVALUATION FOR THE DIAGNOSIS OF LYMPHANGIOMAS.
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ROCHA, Paula Alves da Silva, FRAGA, Marina Guimarães, SANTANA, Nayara Conceição Marcos, TAVARES, Thalita Soares, da COSTA, Adriana Aparecida Silva, OLIVEIRA, Sicília Rezende, and SILVA, Tarcília Aparecida
- Abstract
Lymphangiomas are benign formations of the lymphatic system characterized by dilated vascular channels filled with lymphatic fluid. The case refers to a 31-years-old man presented with an asymptomatic submandibular swelling that had been evolving for 8 years. Ultrasonography revealed irregular hypoechoic compartments in the right submandibular region suggestive of cystic lesions with retention of mucus or lymph. An incisional biopsy was performed and microscopic analysis revealed fibrous connective tissue fragments exhibiting discreet mononuclear inflammatory infiltration and vascular spaces of different calibers partially covered by a single layer of cells. The vascular wall presented disorganized bundles of muscle fibers and vascular-nerve bundles. Complete surgical resection was performed. Although lymphangiomas are rare in adults, they should be considered in the evaluation of cystic neck masses. This case highlights the importance of imaging and histological evaluation for accurate diagnosis and appropriate treatment of these lesions. [ABSTRACT FROM AUTHOR]
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- 2024
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9. THE IMPORTANCE OF ORAL CAVITY SURVEILLANCE IN PATIENTS WITH FANCONI ANEMIA FOR EARLY DIAGNOSIS OF ORAL CANCER.
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ROCHA, Paula Alves da Silva, SANTANA, Nayara Conceição Marcos, VENDRUSCOLO, Joana Letícia, PASCOAL, Thaís Pimenta, TORRES-PEREIRA, Cassius Carvalho, and SILVA, Tarcília Aparecida
- Abstract
Fanconi Anemia (FA) is a rare genetic disorder known for its bone marrow impact and increased cancer risk, particularly oral squamous cell carcinoma. In this case, a 36-year-old female patient with FA exhibited hypothenar facies, café-au-lait spots, pancytopenia, and multiple leukoplakias in the oral mucosa. Initial clinical examination revealed variable thickness white plaques on the hard and soft palate, leading to incisional biopsies and diagnoses of hyperkeratosis with mild and moderate epithelial dysplasia, respectively. After three months, new diffuse lesions emerged on the hard and soft palate, tongue, and buccal mucosa, accompanied by erythematous areas. Subsequent biopsies on the hard and soft palate confirmed severe and moderate epithelial dysplasia, respectively. This rapid transformation underscores the importance of closely monitoring FA patients to facilitate early detection of oral squamous cell carcinoma. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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10. Markov properties for systems described by PDEs and first-order representations
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Rocha, Paula and Willems, Jan C.
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- 2006
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11. Strong controllability and extendibility of discrete multidimensional behaviors
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Rocha, Paula and Zerz, Eva
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- 2005
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12. Two Brazilian archaeological sites investigated by GPR: Serrano and Morro Grande
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da Silva Cezar, Glória, Ferrucio da Rocha, Paula Lucia, Buarque, Angela, and da Costa, Ariovaldo
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- 2001
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13. Safety-promoting interventions for the older person with hip fracture on returning home: A systematic review.
- Author
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Rocha, Paula, Baixinho, Cristina Lavareda, Marques, Andrea, and Henriques, Maria Adriana
- Abstract
Older adults with a prior history of falls that results in hip fractures have difficulties in regaining pre-fracture functional capacity. Scientific evidence has shown benefits of the implementation of multidimensional rehabilitation programs, but this evidence is not systematized with regard to continuity of care after hospital discharge. To identify interventions that promote safety and functional recovery of older adults with hip fractures after hospital discharge. A systematic review was carried out according to Cochrane methodology. The research strategy was predefined for the MEDLINE and CINAHL databases. The identified articles were screened according to the eligibility criteria by two independent reviewers. The articles included in the bibliographic sample were evaluated for risk of bias. Of the 10,036 articles found, 10 were included in this systematic review. The safety-promoting interventions identified were: exercise training, occupational therapy/activities of daily living training, transfer and gait training, strengthening exercises, education on assistive device use, fall prevention education, nutritional assessment, environmental modifications/adjustments at home, use of an app, medication, self-care education, and support and counseling. In eight studies analyzed, exercise training emerged as the most effective intervention for promoting the safety of older adults after hip fractures on returning home. Three studies associated two or more interventions, which focused on exercise training, occupational therapy/training of activities of daily living, and conventional postoperative rehabilitation with transfer and gait training, strengthening exercises, education on assistive device use and discharge planning, aiming to achieve muscle strengthening and safe gait, associated with the performance of activities of daily living. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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14. Energy-efficient building retrofits: An assessment of regulatory proposals under uncertainty.
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Rocha, Paula, Kaut, Michal, and Siddiqui, Afzal S.
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ENERGY consumption of buildings , *ENERGY conservation in buildings , *ELECTRICITY pricing , *STOCHASTIC programming - Abstract
Improving energy efficiency in European Union buildings will require retrofitting much of the existing stock due to limited new construction opportunities. Given uncertainty in energy prices and technology costs stemming from deregulation, a stochastic optimisation framework is desirable for long-term decision support. We synthesise treatment of uncertainty and risk management to obtain insights about the impact of retrofits on energy consumption, costs, CO 2 emissions, and risk at real buildings in Austria and Spain. The optimal strategy for the Spanish site is to invest in photovoltaic and solar thermal technologies. This lowers expected costs by 8.5% and reduces expected primary energy consumption and CO 2 emissions by 20% relative to using existing equipment. By limiting exposure to volatile energy prices, the strategy also yields a nearly 10% reduction in risk. We obtain similar results also for the Austrian site. Via this framework, tradeoffs among competing objectives and the effectiveness of proposed regulation may be assessed. Specifically, we find that more stringent restrictions on energy efficiency are economically viable if regulation also facilitates enhanced operational decision support for buildings. Indeed, primary energy consumption can be lowered only through more on-site generation such as combined heat and power, which is more complex for building managers to deploy. [ABSTRACT FROM AUTHOR]
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- 2016
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15. Algebraic tools for the study of quaternionic behavioral systems
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Pereira, Ricardo, Rocha, Paula, and Vettori, Paolo
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UNIVERSAL algebra , *ABSTRACT algebra , *SYSTEMS theory , *POLYNOMIAL rings - Abstract
Abstract: In this paper we study behavioral systems whose trajectories are given as solutions of quaternionic difference equations. As happens in the commutative case, it turns out that quaternionic polynomial matrices play an important role in this context. Therefore we pay special attention to such matrices and derive new results concerning their Smith form. Based on these results, we obtain a characterization of system theoretic properties such as controllability and stability of a quaternionic behavior. [Copyright &y& Elsevier]
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- 2005
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16. <atl>Feedback control of multidimensional behaviors
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Rocha, Paula
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FEEDBACK control systems , *ADAPTIVE control systems - Abstract
In this paper, we consider the problem of controlling an
n D system by means of a feedback connection. First, we characterize the system interconnections that can be implemented as feedback connections by means of a suitable choice of input/output structures. Then, we give a necessary and sufficient condition for the possibility of obtaining a desired control performanceBd⊂B from a givenn D behaviorB by a feedback connection with a suitable controller in case both the input/output structures ofB andBd are a priori imposed. Our results generalize those obtained in Willems (IEEE Trans. Automat. Control 42(4) (1997) 458) for the 1D case. [Copyright &y& Elsevier]- Published
- 2002
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17. Feedback control of multidimensional behaviors
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Rocha, Paula
- Published
- 2002
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18. Placental model as an important tool to study maternal-fetal interface.
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Gonçalves, Bianca M., Graceli, Jones B., da Rocha, Paula B., Tilli, Helena P., Vieira, Ester M., de Sibio, Maria T., Peghinelli, Vinícius V., Deprá, Igor C., Mathias, Lucas S., Olímpio, Regiane M.C., Belik, Virgínia C., and Nogueira, Célia R.
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TROPHOBLAST , *FETAL development , *DEVELOPMENTAL toxicology , *ENDOCRINE disruptors , *PLACENTA , *PRENATAL exposure , *POISONS - Abstract
The placenta is a temporary organ that plays critical roles at the maternal-fetal interface. Normal development and function of the placenta is dependent on hormonal signaling pathways that make the placenta a target of endocrine disrupting chemical (EDC) action. Studies showing association between prenatal exposure, hormone disruption, and reproductive damage indicate that EDCs are developmentally toxic and can impact future generations. In this context, new placental models (trophoblast-derived cell lines, organotypic or 3D cell models, and physiologically based kinetic models) have been developed in order to create new approach methodology (NAM) to assess and even prevent such disastrous toxic harm in future generations. With the widespread discouragement of conducting animal studies, it has become irrefutable to develop in vitro models that can serve as a substitute for in vivo models. The goal of this review is to discuss the newest in vitro models to understand the maternal-fetal interface and predict placental development, physiology, and dysfunction generated by failures in molecular hormone control mechanisms, which, consequently, may change epigenetic programming to increase susceptibility to metabolic and other disorders in the offspring. We summarize the latest placental models for developmental toxicology studies, focusing mainly on three-dimensional (3D) culture models. • New placental models are available for in vitro maternal-fetal interface studies. • Developmental toxicity is an emerging growth area and needs to be addressed. • In vitro studies to assess risk of developmental damage can reduce disease development in adulthood. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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19. Penetration Profiles of a Class IV Therapeutic Laser and a Photobiomodulation Therapy Device in Equine Skin.
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Luna, Stelio Pacca Loureiro, Schoen, Allen, Trindade, Pedro Henrique Esteves, and Rocha, Paula Barreto da
- Abstract
Photobiomodulation therapy (PBMT) effects depend on the energy settings and laser penetration. We investigated the penetration time profiles of two different light therapy devices, at the dark and light skin regions in horses. Six light skin and six dark skin adult clinically healthy Arab and Quarter horses were used. A cutometer was used to measure the width of the skin fold from both sides of the cervical area, followed by three measurements of the thickness of the same skin fold by transversal and longitudinal ultrasonography (US). The depth of light penetration was compared based on the percentage of penetration versus power, between a portable PBMT device versus a class IV laser device. The laser mean power output was measured with an optical power meter system for 120 seconds after penetrating the skin. Skin width and laser penetration were compared among equipment by paired "t" test. There was no difference in the width of the skin fold between measurements acquired by the cutometer against either longitudinal or transversal US or between the US measurements at cervical versus metacarpus area. Light penetration was greater in both kinds of skins in the PBMT (0.01303 ± 0.00778) versus class IV laser (0.00122 ± SD 0.00070) (P <.001). The PBMT device provided a greater energy penetration than the class IV laser in unclipped light and dark skin, suggesting that the former may produce a better therapeutic effect. The color of the skin changes penetration profiles of PBMT. • Energy penetration laser equipment in unclipped skin. • The color of the skin changes penetration profiles of photobiomodulation therapy. • In vivo model for evaluation of the depth of light penetration. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Oral cancer and oral potentially malignant disorders in patients with Fanconi anemia – A systematic review.
- Author
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Santana, Nayara Conceição Marcos, de Sena, Ana Carolina Velasco Pondé, Rocha, Paula Alves da Silva, de Arruda, José Alcides Almeida, Torres-Pereira, Cassius Carvalho, Abreu, Lucas Guimarães, Fournier, Benjamin P.J., Warnakulasuriya, Saman, and Silva, Tarcília Aparecida
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FANCONI'S anemia , *ORAL cancer , *SQUAMOUS cell carcinoma , *SYMPTOMS , *YOUNG adults , *MUCOSITIS - Abstract
• The review summarizes the available published data on OSCC/OPMD in FA patients. • May provide useful information for clinicians. • Lesions occur more frequently in young adult women. • Most OSCC/OPMD are treated with surgical resection. • High death rates are observed within a short period time. The purpose of the present study was to perform a systematic review focusing on oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) in Fanconi anemia (FA) individuals. Electronic searches were undertaken in five databases supplemented by manual scrutiny and gray literature. Case reports and/or cases series were included. The searches yielded 55 studies describing 112 cases of OSCC (n = 107) and/or OPMD (n = 5) in FA individuals. The mean age at diagnosis of OSCC/OPMD was 27.1 (±9.6) years, and females (51.8 %) were slightly more affected. Ulcer (n = 37) or mass (n = 25) were described as clinical presentations for OSCC and OPMD. White lesions (n = 4) were the most common manifestation in OPMD. Tongue (47.2 %) was the most frequent location. Sixty-one (54.5 %) individuals underwent HSCT. Surgical resection (n = 75) was the main treatment adopted. The estimated rate of OPMD malignant transformation was 1.8 % and recurrences following OSCC excision occurred in 26.8 % of individuals. Overall, at 60 months of follow-up, the probability of survival fell to 25.5 % and at 64 months the probability of recurrence increased to 63.2 %. The present data support the need for strict surveillance of patients with FA, even in the absence of OPMD, for early OSCC detection and reduction of mortality. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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21. Controller design for neuromuscular blockade level tracking based on optimal control.
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Almeida, Juliana, Mendonça, Teresa, Rocha, Paula, and Rodrigues, Luís
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NEUROMUSCULAR blocking agents , *OPTIMAL control theory , *STATE feedback (Feedback control systems) , *MUSCLE relaxants , *SEMIDEFINITE programming , *INFINITY (Mathematics) - Abstract
The contribution of this paper is to present and compare two state-feedback design methods for the automatic control of the Neuromuscular Blockade Level (NMB) based on optimal control. For this purpose a parsimoniously parameterized model is used to describe the patient's response to a muscle relaxant. Due to clinical restrictions the controller action begins when the patient recovers after an initial drug bolus . The NMB control problem, typically consisting of tracking a constant NMB reference level, can be associated with an optimal control problem (OCP) with a positivity constraint in the input signal. Due to the complexity associated with the introduction of a positivity constraint in the input, approximate solutions to this OCP will be found in this paper using two methods. In the first method, the optimal control problem is relaxed into a Semi-Definite Program (SDP) using a change of variables, whereas in the second method the OCP is approximated by an infinite horizon constrained Linear Quadratic Regulator (LQR) problem. These two controllers are compared with a classical PI controller in simulation. The PI exhibits a slightly worse performance in terms of the control magnitude but it was not optimized taking this magnitude into account. The simulation results show that the SDP relaxation and the saturated LQR methods lead to the same controller gains and therefore the same trajectory tracking using parameters from a patient's database, thus encouraging its application and validation in clinical trials. Although the performance of the proposed controllers can be compared in terms of how they work when applied to the patient's database models, the two proposed methods cannot be compared from an optimal control theoretical point of view because they correspond to the solution of two different relaxations of the original control problem using two different functions of merit. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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22. Nonlinear controller for bispectral index tracking: Robustness and on-line retuning.
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N. Nogueira, Filipa, Mendonça, Teresa, and Rocha, Paula
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REMIFENTANIL , *ELECTRONIC control , *NONLINEAR analysis , *MATHEMATICAL models , *MATHEMATICAL statistics - Abstract
In this paper, the performance of a control law designed for the automatic administration of propofol and of remifentanil in order to track a desired level for the bispectral index (BIS), used as a measure of the depth of anesthesia, is analyzed under the presence of model parameters uncertainties. It is theoretically proved and illustrated by simulations that under these circumstances the controller has a very good performance as the BIS converges to a value contained in a neighborhood of the desired BIS level. A retuning strategy in order to improve the BIS tracking under the presence of uncertainties was also theoretically deduced. Simulations show that this strategy leads to BIS tracking improvement. The performance of the controller in clinical environment is illustrated by a clinical case. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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23. Time-relevant stability of 2D systems
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Napp, Diego, Rapisarda, Paolo, and Rocha, Paula
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SYSTEMS theory , *STABILITY (Mechanics) , *MATRIX inequalities , *QUADRATIC differentials , *MATHEMATICAL forms , *DIFFERENCE equations , *POLYNOMIALS - Abstract
Abstract: For many 2D systems, one of the independent variables plays a distinct role in the evolution of the trajectories; since often this special independent variable is time, we call such systems ‘time-relevant’. In this paper, we introduce a stability notion for time-relevant systems described by higher-order difference equations. We give algebraic tests in terms of the location of the zeros of the determinant of a polynomial matrix describing the system. We also give an LMI characterization of time-relevant stability involving only constant matrices. [Copyright &y& Elsevier]
- Published
- 2011
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24. Hopfield neural networks for on-line parameter estimation
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Alonso, Hugo, Mendonça, Teresa, and Rocha, Paula
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ARTIFICIAL neural networks , *ROBUST control , *PARAMETER estimation , *STABILITY (Mechanics) , *PERTURBATION theory , *CASE studies - Abstract
This paper addresses the problem of using Hopfield Neural Networks (HNNs) for on-line parameter estimation. As presented here, a HNN is a nonautonomous nonlinear dynamical system able to produce a time-evolving estimate of the actual parameterization. The stability analysis of the HNN is carried out under more general assumptions than those previously considered in the literature, yielding a weaker sufficient condition under which the estimation error asymptotically converges to zero. Furthermore, a robustness analysis is made, showing that, under the presence of perturbations, the estimation error converges to a bounded neighbourhood of zero, whose size decreases with the size of the perturbations. The results obtained are illustrated by means of two case studies, where the HNN is compared with two other methods. [Copyright &y& Elsevier]
- Published
- 2009
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25. A hybrid method for parameter estimation and its application to biomedical systems
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Alonso, Hugo, Mendonça, Teresa, and Rocha, Paula
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COMPUTERS in medicine , *PARAMETER estimation , *COMPUTER algorithms , *ARTIFICIAL neural networks , *NEUROMUSCULAR diseases , *THERAPEUTICS - Abstract
A general version of a hybrid method for parameter estimation is presented with a theoretical support and an illustrative example of application. This method consists of a curve fitting algorithm that takes the initial estimate of the parameterization from an artificial neural network. The idea is to improve the convergence of the algorithm to the sought parameterization using a close initial estimate. The motivation arises from biomedical problems where one is interested in obtaining a meaningful estimate so that it can be used for both description and prediction purposes. Two strategies are proposed for the application of the hybrid method: one is of general applicability, the other is intended for systems defined by the series connection of various blocks. The feasibility of the method is illustrated with a case study related to the neuromuscular blockade of patients undergoing general anaesthesia. [Copyright &y& Elsevier]
- Published
- 2008
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26. Representations and structural properties of periodic systems
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Aleixo, José Carlos, Polderman, Jan Willem, and Rocha, Paula
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DIGITAL control systems , *AUTOMATIC control systems , *COMPUTERS , *SYSTEM analysis - Abstract
Abstract: We consider periodic behavioral systems as introduced in [Kuijper, M., & Willems, J. C. (1997). A behavioral framework for periodically time-varying systems. In Proceedings of the 36th conference on decision & control (Vol. 3, pp. 2013–2016). San Diego, California, USA, 10–12 December 1997] and analyze two main issues: behavioral representation/controllability and autonomy. More concretely, we study the equivalence and the minimality of kernel representations, and introduce latent variable (and, in particular, image) representations. Moreover we relate the controllability of a periodic system with the controllability of an associated time-invariant system known as lifted system, and derive a controllability test. Further, we prove the existence of an autonomous/controllable decomposition similar to the time-invariant case. Finally, we introduce a new concept of free variables and inputs, which can be regarded as a generalization of the one adopted for time-invariant systems, but appears to be more adequate for the periodic case. [Copyright &y& Elsevier]
- Published
- 2007
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27. Evidence of sexual dimorphism of HTR1B gene on major adult ADHD comorbidities.
- Author
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Müller, Diana, Grevet, Eugenio H., Panzenhagen, Alana C., Cupertino, Renata B., da Silva, Bruna S., Kappel, Djenifer B., Mota, Nina R., Blaya-Rocha, Paula, Teche, Stefania P., Vitola, Eduardo S., Rohde, Luis A., Contini, Verônica, Rovaris, Diego L., Schuch, Jaqueline B., and Bau, Claiton H.D.
- Subjects
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ATTENTION-deficit hyperactivity disorder , *SEXUAL dimorphism , *MENTAL illness , *PATHOLOGICAL psychology , *SEROTONINERGIC mechanisms , *TREATMENT of attention-deficit hyperactivity disorder , *GENETICS - Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a very common psychiatric disorder across the life cycle and frequently presents comorbidities. Since ADHD is highly heritable, several studies have focused in the underlying genetic factors involved in its etiology. One of the major challenges in this search is the phenotypic heterogeneity, which could be partly attributable to the sexual dimorphism frequently seen in psychiatric disorders. Taking into account the well-known sexual dimorphic effect observed in serotonergic system characteristics, we differentially tested the influence of HTR1B SNPs (rs11568817, rs130058, rs6296 and rs13212041) on ADHD susceptibility and on its major comorbidities according to sex. The sample comprised 564 adults with ADHD diagnosed according to DSM-IV criteria and 635 controls. There was no association of any HTR1B SNPs tested in relation to ADHD susceptibility. As for the comorbidities evaluated, after correction for multiple tests, significant associations were observed for both rs11568817 and rs130058 with substance use disorders (P corr = 0.009 and P corr = 0.018, respectively) and for rs11568817 with nicotine dependence (P corr = 0.025) in men with ADHD. In women with ADHD, the same rs11568817 was associated with generalized anxiety disorder (P corr = 0.031). The observed effects of rs11568817 G allele presence conferring risk to either substance use disorders or generalized anxiety disorder according to sex, suggest an overall scenario where a higher transcriptional activity of HTR1B , resulting from the presence of this allele, is related to externalizing behaviors in men and internalizing behaviors in women. These results are consistent with and expand previous evidence of sexual dimorphism of the serotoninergic system. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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28. MO08 Severe neonatal epilepsies with supression-burst: one more case of hyperglycinaemia without ketosis
- Author
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Chorão, Rui, Carrilho, Inês, Rocha, Paula, Santos, Manuela, and Cardoso, Maria Luís
- Published
- 2008
- Full Text
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29. Fluoxetine chronic exposure affects growth, behavior and tissue structure of zebrafish.
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de Farias, Natália Oliveira, Oliveira, Rhaul, Moretti, Patrícia Natália Silva, e Pinto, Joana Mona, Oliveira, Ana Clara, Santos, Viviani Lara, Rocha, Paula Suares, Andrade, Thayres Sousa, and Grisolia, Cesar Koppe
- Subjects
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FISH physiology , *FLUOXETINE , *SEWAGE disposal plants , *FISH locomotion , *WEIGHT gain , *ZEBRA danio , *TISSUES , *FISH morphology - Abstract
Fluoxetine (FLX) is among the top 100 pharmaceutical prescribed annually worldwide and consequently is often detected in wastewater treatment plant effluent and surface waters, in concentrations up to 2.7 and 0.33 μg/L, respectively. Despite the presence of FLX in surface waters, little is known about its chronic effects in fish. Thus, this study aimed at investigating the chronic toxicity of FLX to Danio rerio adults. Rate of weight gain, behavior (feeding and swimming activity) and tissue organization (liver and intestine) were evaluated, after 30 days exposure. A lower rate of weight gain was observed at 100 μg/L FLX. The food intake time decreased, showing a decrease in fish appetite. The preference for the upper aquarium layer was observed at 10 and 100 μg/L of FLX, indicating an inhibition of the stress level (anxiolytic effect). Mild to moderate damage of hepatic tissue and a decrease epithelium height and increase in villus height of intestine were observed in fish exposed to concentrations as low as 0.01 μg/L. Based on obtained results, chronic exposure of fish to FLX could affect swimming and feeding behavior and alter morphological structure of liver and intestine tissues at environmental levels. Unlabelled Image • Chronic effects of fluoxetine were evaluated in zebrafish adults exposed for 30 days. • No mortality was recorded in fish exposed to highest tested concentration (100 μg/L). • Alterations on weight gain rate and feeding behavior were observed at 100 μg/L • Fluoxetine induced anti-anxiety swimming behavior at 10 μg/L. • Damage in hepatic tissue and alterations in the intestines were observed at 0.01 μg/L. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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