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Your search keyword '"Ritacco G"' showing total 94 results
Start Over Author "Ritacco G" Publisher elsevier b.v.
94 results on '"Ritacco G"'

1. RIFM fragrance ingredient safety assessment β-Patchoulene, CAS Registry Number 514-51-2.

Author

Api, A.M., Belsito, D., Botelho, D., Browne, D., Bruze, M., Jr.Burton, G.A., Buschmann, J., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., La Cava, S., Lapczynski, A., Liebler, D.C., O'Brien, D., Parakhia, R., Patel, A., Penning, T.M., Ritacco, G., and Romine, J.

Subjects
*VOLATILE organic compound analysis, *GENETIC toxicology, *DOSE-response relationship in biochemistry, *FOOD toxicology, *FOOD safety
Published
2018
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2. RIFM fragrance ingredient safety assessment, menthyl acetate (isomer unspecified), CAS Registry Number 16409-45-3.

Author

Api, A.M., Botelho, D., Browne, D., Date, M., Deodhar, C., Francis, M., Joshi, K., La Cava, S., Lapczynski, A., O'Brien, D., Parakhia, R., Patel, A., Ritacco, G., Romine, J., Salvito, D., Thakkar, Y., Theophilus, E.H., Tiethof, A.K., Tsang, S., and Wahler, J.

Subjects
*RECORDING & registration, *FOOD additives, *CHEMICALS, *METHYL acetate
Published
2017
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7. RIFM fragrance ingredient safety assessment, Ethyl 2,3,6-trimethylcyclohexyl carbonate, CAS Registry Number 93981-50-1.

Author

Api, A.M., Botelho, D., Browne, D., Date, M., Deodhar, C., Francis, M., Joshi, K., La Cava, S., Lapczynski, A., O'Brien, D., Parakhia, R., Patel, A., Ritacco, G., Romine, J., Salvito, D., Thakkar, Y., Theophilus, E.H., Tiethof, A.K., Tsang, S., and Wahler, J.

Subjects
*RECORDING & registration, *FOOD additives, *CHEMICALS, *ORGANIC compounds
Published
2017
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13. RIFM fragrance ingredient safety assessment, 1-methyl-3-methoxy-4-isopropylbenzene, CAS Registry Number 1076-56-8.

Author

Api, A.M., Botelho, D., Browne, D., Date, M., Deodhar, C., Francis, M., Joshi, K., La Cava, S., Lapczynski, A., O'Brien, D., Parakhia, R., Patel, A., Ritacco, G., Romine, J., Salvito, D., Thakkar, Y., Theophilus, E.H., Tiethof, A.K., Tsang, S., and Wahler, J.

Subjects
*RECORDING & registration, *FOOD additives, *CHEMICALS, *CUMENE
Published
2017
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31. RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 2,2,4-trimethyl-4-phenyl-butane-nitrile CAS Registry Number 75490-39-0.

Author

Api, A.M., Botelho, D., Browne, D., Date, M., Deodhar, C., Joshi, K., La Cava, S., Lapczynski, A., O'Brien, D., Parakhia, R., Patel, A., Ritacco, G., Romine, J., Salvito, D., Thakkar, Y., Tsang, S., Wahler, J., Penning, T.M., Schultz, T.W., and Sipes, I.G.

Subjects
*CHEMICALS, *RECORDING & registration, *PHENYL compounds, *BUTANE, *NITRILES
Published
2017
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44. RIFM fragrance ingredient safety assessment, cyclohexanecarboxylic acid, 1,4-dimethyl-, methyl ester, trans- CAS Registry Number 23250-42-2.

Author

Api, A.M., Botelho, D., Browne, D., Date, M., Deodhar, C., Francis, M., Joshi, K., La Cava, S., Lapczynski, A., O'Brien, D., Parakhia, R., Patel, A., Ritacco, G., Romine, J., Salvito, D., Thakkar, Y., Theophilus, E.H., Tiethof, A.K., Tsang, S., and Wahler, J.

Subjects
*CARBOXYLIC acids, *ETHANES, *METHYL formate, *CYCLOHEXANE, *CHEMICAL laws
Published
2017
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46. RIFM fragrance ingredient safety assessment, Isopulegol, CAS Registry Number 89-79-2.

Author

Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Penning, T.M., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., and Sipes, I.G.

Subjects
*GENETIC toxicology, *DEVELOPMENTAL toxicology, *ENVIRONMENTAL protection, *SKIN inflammation, *ULTRAVIOLET spectrometers, *REPRODUCTIVE toxicology
Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework. [ABSTRACT FROM AUTHOR]

Published
2016
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47. RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0.

Author

Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Miyachi, Y., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., and Sipes, I.G.

Subjects
*LINALOOL, *GENETIC toxicology, *DEVELOPMENTAL toxicology, *REPRODUCTIVE toxicology, *SKIN inflammation, *ENVIRONMENTAL protection, *LABORATORY rats
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable. [ABSTRACT FROM AUTHOR]

Published
2016
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48. RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8.

Author

Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., Sipes, I.G., and Wall, B.

Subjects
*TOXICOLOGICAL chemistry, *GENETIC toxicology, *REPRODUCTIVE toxicology, *DEVELOPMENTAL toxicology, *ENVIRONMENTAL protection
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework. [ABSTRACT FROM AUTHOR]

Published
2016
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49. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3.

Author

Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Miyachi, Y., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., and Sipes, I.G.

Subjects
*IONONES, *GENETIC toxicology, *DRUG dosage, *DEVELOPMENTAL toxicology, *REPRODUCTIVE toxicology, *LABORATORY rats
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable. [ABSTRACT FROM AUTHOR]

Published
2016
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50. RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3.

Author

Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Politano, V.T., Ritacco, G., Salvito, D., Schultz, T.W., Shen, J., Sipes, I.G., and Wall, B.

Subjects
*TOXICOLOGICAL chemistry, *GENETIC toxicology, *DEVELOPMENTAL toxicology, *REPRODUCTIVE toxicology, *ENVIRONMENTAL protection, *ULTRAVIOLET spectrometers
Abstract

Summary : The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2). [ABSTRACT FROM AUTHOR]

Published
2016
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