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Your search keyword '"Reddy, Ratnakar"' showing total 3 results
Start Over Author "Reddy, Ratnakar" Publisher elsevier b.v.
3 results on '"Reddy, Ratnakar"'

2. Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.

Author

Markwalder, Jay A., Balog, Aaron J., Williams, David K., Nara, Susheel J., Reddy, Ratnakar, Roy, Saumya, Kanyaboina, Yadagiri, Li, Xin, Johnston, Kathy, Fan, Yi, Lewis, Hal, Marsilio, Frank, Yan, Chunhong, Critton, David, Newitt, John A., Traeger, Sarah C., Wu, Dauh-Rurng, Jure-Kunkel, Maria N., Jayaraman, Lata, and Lin, Tai-An

Subjects
*BIOSYNTHESIS, *ALKYL ethers, *PREGNANE X receptor, *INDOLEAMINE 2,3-dioxygenase, *ION channels, *POTASSIUM channels
Abstract

[Display omitted] Starting from the dialkylaniline indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor lead 3 (IDO1 HeLa IC 50 = 7.0 nM), an iterative process of synthesis and screening led to cyclized analog 21 (IDO1 HeLa IC 50 = 3.6 nM) which maintained the high potency of 3 while addressing issues of lipophilicity, cytochrome P450 (CYP) inhibition, hERG (human potassium ion channel Kv11.1) inhibition, Pregnane X Receptor (PXR) transactivation, and oxidative metabolic stability. An x-ray crystal structure of a biaryl alkyl ether 11 bound to IDO1 was obtained. Consistent with our earlier results, compound 11 was shown to bind to the apo form of the enzyme. [ABSTRACT FROM AUTHOR]

Published
2023
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3. High plasma concentrations of polychlorinated biphenyls and phthalate esters in women with endometriosis: a prospective case control study

Author

Reddy, B. Satyanarayana, Rozati, Roya, Reddy, Suguna, Kodampur, Shankarappa, Reddy, Pardhasaradhi, and Reddy, Ratnakar

Subjects
*ETIOLOGY of diseases, *ENDOMETRIOSIS, *POLYCHLORINATED biphenyls, *PHTHALATE esters, *ESTERS, *FERTILITY, *WOMEN'S health
Abstract

The objective of this study was to detect the probable association between polychlorinated biphenyls (PCBs) and phthalate esters (PEs), and the occurrence of endometriosis in a prospective case control study. We found that PCBs and PEs may be instrumental in the etiology of endometriosis. [ABSTRACT FROM AUTHOR]

Published
2006
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