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This exploratory study was designed to identify potential time windows of exposure to air pollution before and during early pregnancy that are more likely to be associated with GDM across age and body mass index (BMI) classes. The studied women were living in the urban region of Dijon (France) and delivered between 2005 and 2009. Data were obtained from medical records. Outdoor NO 2 and PM 1 0 cumulative home exposures were modelled over sliding 4-week exposure windows from 7 months before the last menstrual period to the 24th week of gestation. Logistic regression models estimating the odds ratio (OR) for GDM per 10 μg/m3 increase in pollutant concentrations were applied to two age classes and four prepregnancy BMI classes. Among the 5218 women, 311 women under 35 years of age and 136 women over 35 years old developed GDM. The number of women who developed GDM in the underweight, normal weight, overweight and obese classes was 21 (6.1 %), 251 (7.4 %), 96 (10.6 %) and 65 (25.3 %), respectively. When considering PM 10 exposure, ORs of up to 2.03 were observed in women under 35 years of age. The highest ORs were associated with the [-09; −06], [-13; −10] and [-15; −12] windows in underweight, overweight, and obese women, respectively. The ORs were nearly all centred on one for NO 2. For women living in an urban environment, our results suggest that critical 4-week windows of exposure to air pollution in both the pre- and postconception periods are associated with the development of GDM. • We used an iterative method to explore the air pollution-GDM relationship. • We highlight pre-conceptional critical windows of exposure to particles. • The potential critical windows could be modulated by age and BMI of mothers. • Our findings help strengthen women's health promotion in an urban environment. [ABSTRACT FROM AUTHOR]

The chronology of landslides of Valles Marineris, the equatorial trough system of Mars, has been investigated by a crater population study. Valles Marineris landslides have widespread debris aprons which offer a remarkable opportunity to study the crater population with high resolution images from Mars Orbiter Camera (MOC) and from Mars Odyssey Thermal Emission Imaging System (THEMIS). Sixty-six ages were determined within Valles Marineris including 56 landslide ages and 10 ages of the canyon floor. Results reveal that landslides of Valles Marineris system of canyons occurred during a widespread period of time between 3.5 Gy and 50 My. In some locations, the canyon floor has an apparent age of 3.5 Gy suggesting that at least locally within Valles Marineris no major refreshing processes have occurred for 3.5 Gy. The temporal repetitivity of landslides implies that the triggering mechanisms of the landslides are reproducible in time. Landslides have the same features whatever their age. The dynamic of these landslides is probably the same either with intervention of water up to recently (the last 100 My) or without water since 3.5 Gy. Keywords: Mars; Surface; Landslide; Cratering chronology

While bariatric surgery has demonstrated physical and psychological benefits, a risk of suicide and non-fatal self-harm has also been shown. The aim of this study was to compared the rate of hospitalization for self-harm during a three-year observational follow-up period between adolescents/young adults who underwent bariatric surgery in France in 2013–2014 and two control groups. All individuals aged 12–25 years old who underwent bariatric surgery in France between January 1st, 2013, and December 31st, 2014, were identified with a validated algorithm from the French national hospital database, and compared to a healthy sample of the general population matched for age and gender. Information relative to hospitalizations, including for self-harm (ICD-10 codes X60-84), were extracted i) between 2008 and the surgery, and ii) for a three-year follow-up period. A second unmatched control group with obesity but no bariatric surgery was also identified. Survival analyses with adjustments for confounding variables were used. In 2013–2014, 1984 youths had bariatric surgery in France. During follow-up, 1.5% were hospitalized for self-harm vs. 0.3% for controls (p < 0.0001). After adjustment, subsequent hospitalization for self-harm was associated with bariatric surgery (HR 3.64, 95% CI 1.70–7.81), prior psychiatric disorders (HR 7.76, 95% CI 3.76–16.01), and prior self-harm (HR 4.43, 95% CI 1.75–11.24). When compared to non-operated youths with obesity, bariatric surgery was not associated with self-harm while prior mental disorders and self-harm were. Mortality reached 0.3% after surgery. Bariatric surgery is associated with an increased risk of self-harm, mainly in relation to preexisting psychological conditions. Vigilance and appropriate care are thus warranted in vulnerable individuals. [ABSTRACT FROM AUTHOR]

Abstract Ultramafic derived soils are characterized by low nutrient soils, a low Ca:Mg ratio, and high metal contents such as Ni, Co and Cr. The vegetation growing on these soils is highly adapted and includes both Ni hyperaccumulator and accumulator species. Today, approximately 530 Ni hyperaccumulator species are listed worldwide and the Ni concentration can be extremely high, e.g. up to 25% in latex from Pycnandra acuminata (Sapotaceae), a tree found in New Caledonia. The aim of this study is to identify the potential role of Ni hyperaccumulator plants in the Ni biogeochemical cycle at the soil surface by using Ni isotopes. A set of Ni hyperaccumulator and Ni accumulator plants as well as topsoils were sampled on the Barro Alto and Niquelândia ultramafic complexes (Goiás State, Brazil). Three Ni hyperaccumulator plants were collected: Justicia lanstyakii, Heliotropium aff. salicoides, Cnidoscolus aff. urens , as well as one Ni accumulator plant, Manihot sp. The isotopic compositions of the whole plants were determined and compared to those of the bulk topsoils and DTPA-extractable Ni. The topsoils exhibited δ60Ni values ranging from −0.30 ± 0.06‰ to 0.16 ± 0.05‰. The DTPA-extractable Ni in the topsoils ranged from 94 to 623 mg kg−1, i.e. 0.9–4.9% of the total soil Ni and was found to be isotopically heavier than the corresponding topsoil (from −0.30 ± 0.05‰ to 0.34 ± 0.08‰). The δ60Ni values for the Ni accumulator plants showed an enrichment in heavy Ni isotopes in the aerial parts of the plant compared to the roots, whereas similar δ60Ni values for the roots, stems and aerial parts suggested that no significant fractionation results from Ni uptake and translocation in Ni hyperaccumulator plants. Moreover, the aerial parts (i.e. leaves and flowers) from all of the plants analyzed showed the highest Ni concentrations and the heaviest δ60Ni values up to 1.21 ± 0.05‰. The enrichment in heavy Ni isotopes in the leaves (0.09 ± 0.06‰ < Δ60Ni leaves-soil < 1.06 ± 0.03‰) may result in a heavy Ni input in the litter during organic matter restitution. There is a non-negligible amount of Ni uptake by Ni accumulator and Ni hyperaccumulator plants and this may modify both the Ni isotope composition at the soil-plant interface and the overall cycle of Ni in surface soils. Highlights • DTPA extractable Ni in topsoil is isotopically heavier than the total Ni pool. • Ni-accumulators exhibit enrichment in Ni heavy isotopes in aerial parts. • Similar δ60Ni values for each plant compartment are observed for Ni-hyperaccumulators. • Enrichment in heavy Ni isotopes in leaves may lead to a heavy Ni input in the litter. [ABSTRACT FROM AUTHOR]

Objective: To study the association between the results of water samples and Pseudomonas aeruginosa healthcare-associated cases in a French university hospital.Methods: Generalized Estimating Equations were used on complete case and imputed datasets. The spatial unit was the building and the time unit was the quarter.Results: For the period 2004-2013, 2932 water samples were studied; 17% were positive for P. aeruginosa. A higher incidence of P. aeruginosa cases was associated with a higher proportion of positive water samples (P=0.056 in complete case analysis and P=0.031 with the imputed dataset). The association was no longer observed when haematology and intensive care units were excluded, but was significant in analyses of data concerning intensive care units alone (P<0.001).Conclusion: This study suggests that water outlet contamination in hospitals can lead to an increase in healthcare-associated P. aeruginosa cases in wards dealing with susceptible patients, but does not play a significant role in other wards. [ABSTRACT FROM AUTHOR]

Nickel isotope ratios were measured in ores, fly ash, slags and FeNi samples from two metallurgical plants located in the Goiás State, Brazil (Barro Alto, Niquelândia). This allowed investigating the mass-dependent fractionation of Ni isotopes during the Ni-laterite ore smelting and refining. Feeding material exhibits a large range of δ 60 Ni values (from 0.02 ± 0.10‰ to 0.20 ± 0.05‰, n = 7), explained by the diversity of Ni-bearing phases, and the average of δ 60 Ni feeding materials was found equal to 0.08 ± 0.08‰ (2SD, n = 7). Both δ 60 Ni values of fly ash (δ 60 Ni = 0.07 ± 0.07‰, n = 10) and final FeNi produced (0.05 ± 0.02‰, n = 2) were not significantly different from the feeding materials ones. These values are consistent with the very high production yield of the factories. However, smelting slags present the heaviest δ 60 Ni values of all the smelter samples, with δ 60 Ni ranging from 0.11 ± 0.05‰ to 0.27 ± 0.05‰ (n = 8). Soils were also collected near and far from the Niquelândia metallurgical plant, to evaluate the potential of Ni isotopes for tracing the natural vs anthropogenic Ni in soils. The Ni isotopic composition of the non-impacted topsoils developed on ultramafic rocks ranges from −0.26 ± 0.09‰ to −0.04 ± 0.05‰ (n = 20). On the contrary, the Ni isotopic composition of the non-ultramafic topsoils, collected close to the plant, exhibit a large variation of δ 60 Ni, ranging from −0.19 ± 0.13‰ up to 0.10 ± 0.05‰ (n = 4). This slight but significant enrichment in heavy isotopes highlights the potential impact of smelting activity in the surrounding area, as well as the potential of Ni isotopes for discerning anthropogenic samples (heavier δ 60 Ni values) from natural ones (lighter δ 60 Ni values). However, given the global range of published δ 60 Ni values (from −1.03 to 2.5‰) and more particularly those associated to natural weathering of ultramafic rocks (from −0.61 to 0.32‰), the use of Ni isotopes for tracing environmental contamination from smelters will remain challenging. [ABSTRACT FROM AUTHOR]

Objectives : Teleassistance is defined as the help provided through a telemedicine network by a practitioner to another one faced with a difficult situation. Beyond securing communication, another main issue is to provide evidence that some data have been exchanged in order to determine the liabilities of each practitioner involved in a telemedicine session in case of litigation. Material and methods : The purpose of this work is the definition of a teleassistance protocol that allows achieving these goals. To do so, we first identify needs in terms of security and evidence considering the example of the French legislation and then propose a secure teleassistance protocol that takes advantage of the Joint Watermarking–Encryption (JWE) approach. The originality of this approach is that it offers watermarking functionalities in both encrypted and decrypted domains and is compliant with the DICOM standard. Results : We describe the functioning of the proposed teleassistance protocol. This protocol is able to secure exchanged data and bring evidence that an exchange took place and that data have been communicated. The security analysis of our protocol shows that it is resistant to non-repudiation issues and collusion attacks. Conclusion : The use of joint watermarking–encryption allows i) ensuring confidentiality of exchanged data while giving access to proofs of their integrity and of their origins even though data are encrypted; and ii) identifying which data were involved in a telemedicine session by means of secure links established between them. The proposed protocol is compliant with the DICOM standard. [ABSTRACT FROM AUTHOR]

Copyright of European Research in Telemedicine / La Recherche Européenne en Télémédecine is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We investigated temporal clusters of Pseudomonas aeruginosa cases between 2005 and 2014 in 1 French university hospital, overall and by ward, using the Kulldorff method. Clusters of positive water samples were also investigated at the whole hospital level. Our results suggest that water outlets are not closely involved in the occurrence of clusters of P aeruginosa cases. [ABSTRACT FROM AUTHOR]

Copyright of IRBM is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of IRBM is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of IRBM is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: The sources and the potential availability of chromium were investigated in ultramafic soils from Niquelândia (Goïas State, Brazil), with chemical extractions associated to mineralogical studies, in order to evaluate its bioavailability and its potential impact on the soil biodiversity. Cr contents are particularly high in the studied soils and its partitioning among the solid phase varies with the position in the landscape and depth. Most of the Cr is associated to Fe-oxides but the amount of exchangeable Cr(VI) is high, particularly in one soil profile. Cr availability is higher than expected, and Cr-tolerant vegetation is probably growing on these soils. [Copyright &y& Elsevier]

Abstract: A batch experiment was conducted to compare PAH degradation in a polluted river sediment under aerobic and anaerobic conditions, and to investigate whether input of fresh organic material (cellulose) could enhance such degradation. All measurements were checked against abiotic control treatments to exclude artifacts of sample preparation and non-biological processes like aging. Three- and four-ring PAHs could be degraded by the indigenous microbial community under aerobic conditions, but anaerobic metabolism based on iron and sulphate reduction was not coupled with PAH degradation of even the simplest 3-ring compounds like phenanthrene. Cellulose addition stimulated both aerobic and anaerobic respiration, but had no effect on PAH dissipation. We conclude that natural attenuation of PAHs in polluted river sediments under anaerobic conditions is exceedingly slow. Dredging and biodegradation on land under aerobic conditions would be required to safely remediate and restore polluted sites. [Copyright &y& Elsevier]

The walls of the Valles Marineris canyons are affected by about 45 landslides. The study of these landslides provides a test of the hypothesis of processes having affected Martian wallslopes after their formation. The dynamics of Valles Marineris landslides are controversial : either the landslides are interpreted as large debris flows or as dry rock avalanches. Their morphology and their topography are basic parameters to understand their dynamics. From topographic MOLA data and remote sensing images acquired with different spatial resolutions (Viking, THEMIS, MOC), the 3D geometry of 45 landslides of Valles Marineris has been studied. The landslides have been classified in 3 geomorphologic classes from the topography of the landslide deposits: the “chaotic” landslides without well identified structures, the “structured deposit without debris aprons” landslides with tectonic structures and small roughness at the deposit front and the “structured deposit with debris aprons” which display circular normal faults at the back of the deposit and several debris aprons at the front of the landslide. The spatial distribution of the three morphological types is in relation with the confinement of the canyons. The initial volume and the total deposited volume were also measured to compute volume balances. The deposited volumes range from 50 to . All volume balances display a maximum deficit ranging from 5% to 70%. The landslides with the largest deficits take place within an enclosed-canyon (Hebes Chasma). Lacking material exportation, these deficits could be interpreted as reflecting the porosity of the landslide source. This fact is in agreement with the hypothesis of a karstic origin of these enclosed-canyons. The Valles Marineris landslides have large mobilities (length/vertical drop) ranging from 1.8 to 12 implying low coefficients of friction and so fluidization mechanisms. The possible filling up of the porosity by volatile could be compatible with the fluidization patterns of Valles Marineris landslides. [Copyright &y& Elsevier]

: ObjectiveTo assess the role of recurrence in prognosis of colon cancer, we investigated several methodologic issues, including application of classic survival analysis and Markov model.: Study Design and SettingThe data were recorded by the Registry of Digestive Tumors of Coˆte d'Or, France, for 874 patients who had been treated by surgery between 1976 and 1984 and followed for up to 11 years. Survival analyses included the Cox proportional hazards model and its two generalizations that allow recurrence to be taken into account as a time-dependent covariate or as a competing outcome. The Markov model was used to analyze simultaneously recurrence and death.: ResultsThe competing risks approach is not appropriate because censoring is indisputably informative. The Markov model and the Cox model, with recurrence as a time-dependent covariate, provided similar results, demonstrating the impact of age and gender on recurrence and revealing a reduction in the effect of site and stage on mortality.: ConclusionA Markov multistate model seems to give new insights about the course of digestive cancer progression and into the role of recurrence in this process. [Copyright &y& Elsevier]

Soils and ore samples influenced by mining and metallurgical activity were collected in ultramafic soils (UM) complexes of Barro Alto and Niquelândia, in order to determine the contribution of each Ni bearing phases to the total exchangeable pool of Ni, and to point out if this pool was affected by anthropic activities. For this purpose, the IEK-model previously developed by the group (Zelano et al., submitted) was applied, on the basis of IEK experiments performed on pure typical Ni scavengers (serpentines, chlorite, smectite and iron oxydes) from ultramafic systems. For each typical scavenger, this model describes the percentage of Ni associated to exchangeable pool(s) as well as their corresponding kinetic constant(s) of exchange. The mineralogical composition of soil and ore samples and Ni solid speciation were first determined, and the IEK-model was applied on these bases. In almost all samples, an important contribution of serpentine to Ni exchangeable pool was highlighted, ranging between 10% and 45%. The important amount of organic matter (OM) in one of the studied soil samples, allowed to extrapolate generic OM E Ni and k parameters, which were introduced in the IEK-model to improve its predictive capability. Obtained results provided evidences of how even a small content (3 wt%) of organic carbon (OC), can represent an important contribution of OM to the total E Ni pool (60%). In the investigated ore samples, up to the 60% of E Ni was attribute to smectite, responsible for fast E Ni pool kinetic evolution. In addition, the model highlighted the role of the Fine Black Ash (FBA), by-products of the pyrometallurgical activity, detected into a soil sample, that is responsible for the 15% of E Ni . This approach allowed to determine, for the first time, the relative contribution of each Ni bearing phase to the total exchangeable pool, in terms of concentration and kinetics. [ABSTRACT FROM AUTHOR]

Objectives: To analyse published cost-of-illness studies that had assessed the cost of prematurity according to gestational age at birth. Methods: A review of the literature was carried out in March 2011 using the following databases: Medline, ScienceDirect, The Cochrane Library, Econlit and Business Source Premier, and a French Public-Health database. Key-word sequences related to 'prematurity' and 'costs' were considered. Studies that assessed costs according to the gestational age (GA) at the premature birth (<37 weeks of gestation) in industrialized countries and during the last two decades were included. Variations in the reported costs were analysed using a check-list, which allowed the studies to be described according to several methodological and contextual criteria. Results: A total of 18 studies published since 1990 were included. According to these studies, costs were assessed for different follow-up periods (short, medium or long-term), and for different degrees of prematurity (extreme, early, moderate and late). Results showed that whatever the follow-up period, costs correlated inversely with GA. They also showed considerable variability in costs within the same GA group. Differences between studies could be explained by the choices made, concerning i/the study populations, ii/contextual information, ill/and various economic criteria. Despite these variations, a global trend of costs was estimated in the short-term period using mean costs from four American studies that presented similar methodologies. Costs stand at over US$ 100,000 for extreme prematurity, between US$ 40,000 and US$100,000 for early prematurity, between US$10,000 and US$ 30,000 for moderate prematurity and below US$ 4500 for late prematurity. Conclusion: This review underlined not only the clear inverse relationship between costs and GA at birth, but also the difficulty to transfer the results to the French context. It suggests that studies specific to the French health system need to be carried out. [ABSTRACT FROM AUTHOR]

Résumé: La restriction de croissance intra-utérine indique qu’un fœtus n’a pu réaliser son potentiel individuel de croissance. Ce potentiel peut être approché par la customisation des courbes de croissance. Les courbes néonatales (références du poids mesuré à la naissance) et les courbes fœtales (références du poids estimé à partir de mesures biométriques chez le fœtus) ne sont pas équivalentes et ont des significations différentes pour l’épidémiologiste et pour le clinicien. Outre le poids, les courbes fœtales permettent d’estimer la vélocité de la croissance fœtale mais souffrent de l’imprécision des estimations. Les courbes néonatales incluent toute la population ou sont limitées aux naissances sans pathologie gestationnelle. La différence entre ces deux types de courbes néonatales est très nette aux faibles âges gestationnels car 30 % des prématurés naissent avec une restriction de croissance intra-utérine. Même si la restriction de croissance intra-utérine est un facteur de risque reconnu de la mortalité fœtale, de la mortalité néonatale et de la morbidité à court et long terme, la valeur prédictive d’une restriction de croissance intra-utérine identifiée chez un fœtus par les seules courbes de poids (personnalisées ou non) est insuffisante et améliorable par des explorations complémentaires. [ABSTRACT FROM AUTHOR]

Ultramafic (UM) rocks are known to be nickel (Ni) rich and to weather quickly, which makes them a good candidate to look at the Ni isotope systematics during weathering processes at the Earth’s surface. The present study aims at identifying the Ni solid speciation and discussing the weathering processes that produce Ni isotope fractionation in two deep laterite profiles under tropical conditions (Barro Alto, Goiás State, Brazil). While phyllosilicates and to a lower extent goethite are the main Ni-bearing phases in the saprolitic part of the profile, iron (Fe) oxides dominate the Ni budget in the lateritic unit. Nickel isotopic composition (δ 60 Ni values) has been measured in each unit of the regolith, i.e., rock, saprock, saprolite and laterite (n = 52). δ 60 Ni varies widely within the two laterite profiles, from −0.10 ± 0.05‰ to 1.43 ± 0.05‰, showing that significant Ni isotope fractionation occurs during the weathering of UM rocks. Overall, our results show that during weathering, the solid phase is depleted in heavy Ni isotopes due to the preferential sorption and incorporation of light Ni isotopes into Fe oxides; the same mechanisms likely apply to the incorporation of Ni into phyllosilicates (type 2:1). However, an isotopically heavy Ni pool is observed in the solid phase at the bottom of the saprolitic unit. This feature can be explained by two hypotheses that are not mutually exclusive: (i) a depletion in light Ni isotopes during the first stage of weathering due to the preferential dissolution of light Ni-containing minerals, and (ii) the sorption or incorporation of isotopically heavy Ni carried by percolating waters (groundwater samples have δ 60 Ni of 2.20 and 2.27‰), that were enriched in heavy Ni isotopes due to successive weathering processes in the overlying soil and laterite units. [ABSTRACT FROM AUTHOR]

Context: The evaluation of national cancer plans is an important aspect of their implementation. For this evaluation, the principal actors in the field (doctors, nurses, etc.) as well as decision-makers must have access to information that is reliable, synthetic and easy to interpret, and which reflects the implementation process in the field. We propose here a methodology to make this type of information available in the context of reducing inequalities with regard to access to healthcare for patients with lung cancer in the region of Burgundy. Methods: We used the national medico-administrative DRG-type database, which gathers together all hospital stays. By using this database, it was possible to identify and reconstruct the care management history of these patients. That is, by linking together all attended hospitals, sorted chronologically. Eligible patients were at least 18 years old, whatever the gender and had undergone surgery for their lung cancer. They had to be residents of Burgundy at the time of the first operation between 2006 and 2008. Patient's pathway was defined as the sequence of all attended hospitals (hospital stays) during the year of follow up linked together using an anonymised patient identifier. We then constructed a pathway typology of pathway using an unsupervised clustering method, and conducted a spatial analysis of this typology. Results: Between 2006 and 2008, we selected 495 patients in the 4 administrative departments of the Burgundy region. They accounted for a total of 3821 stays during the year of follow-up. There were 393 men (79%) and the mean age was 64 (95% confidence interval: 63-65) years. We reconstructed 94 pathways (about five per patient). Here, neighbourhood's cares accounted for 41% of them, while 44% included a surgical intervention outside the region of Burgundy. We constructed a pathway typology with five classes. Spatial analysis showed that the vast majority of initial surgeries took place in the major regional centres. Conclusion: The construction of a pathway typology leads to better understanding of the reasoning that lies behind the movements of patients. It opens the way for analysis of the collaboration between the different healthcares establishments attended, which should bring to light associations that need to be developed. [ABSTRACT FROM AUTHOR]

L’influence de la durée de conservation des CGR sur la mortalité après transfusion reste controversée. La survie des receveurs masculins pourrait être altérée après transfusion de CGR de donneuses. L’étude visait à estimer la survie des receveurs d’une première transfusion et à analyser l’effet pronostique de la conservation et du sexe du donneur sur la survie, en particulier après chirurgie cardiovasculaire (CCV). Les données EFS et hospitalières des patients adultes receveurs d’une première transfusion de CGR entre 2007 et 2011 aux CHU de Besançon et Dijon ont été compilées. Le statut vital provenait du registre des personnes physiques. La survie après transfusion a été estimée pour l’ensemble des receveurs. L’influence de la conservation du plus ancien CGR et du sexe du donneur sur la survie à un an après CCV ont été analysés par modèle de Cox avec ajustement sur l’âge, le sexe du receveur, le nombre de CGR, et le type de CCV codé dans le système d’information hospitalier (SIH). Parmi les 12 700 patients analysés, 72,2 % d’entre eux étaient en vie à un an, alors que 85,1 % des 2716 patients ayant subi une CCV étaient en vie à un an. Dans ces résultats préliminaires, la durée de conservation des CGR et une discordance du sexe donneur/receveur semblaient avoir un effet négatif sur la survie après CCV en analyse univariée ( p < 0,0001), mais ces effets n’étaient pas significatifs après ajustement. Il s’agit de la première étude française de survie après transfusion. Nous proposons une méthode innovante pour étudier l’influence des caractéristiques des CGR à l’aide de données du SIH. Une limite de la méthode est qu’elle requiert un croisement nominatif au sein des hôpitaux. [ABSTRACT FROM AUTHOR]