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This work quantifies the financial impact of the mean and the variability of production and shipping lead times on multi-echelon supply chains. We combine agent-based modelling and Taguchi methods, through which we develop a framework for supporting entrepreneurial investment decisions. A throughput-based analysis reveals that decreasing mean lead times improves the internal operation of production and distribution systems, while reducing lead time variability enhances the satisfaction of consumers. In this regard, we contrast traditional and collaborative supply chains. We find that the latter are not only more profitable than the former, but also more robust to variations in lead times. [ABSTRACT FROM AUTHOR]

• We investigate the dynamics induced by quantity discounts in supply chains. • We explore key operational and performance metrics via analytical and numerical methods. • The discount tends to exacerbate the Bullwhip Effect and reduce inventory performance. • Offerors of discounts need to explore the non-immediate consequences of pricing decisions. • We study how several parameters should affect the buyer's willingness to pursue the discount. Quantity discounts are a common pricing mechanism to stimulate large orders. We explore their impact on the dynamic behaviour of production and distribution systems by studying key operational and economic metrics. In a three-echelon supply chain, we observe that the discount generally increases the Bullwhip Effect, which especially harms the manufacturer. The discount also reduces the retailer's purchase costs, but increases its inventory- and capacity-related costs. A key trade-off thus emerges, which manifests itself through a U-shaped relationship between the total cost and the discount acceptance parameter. In the light of this trade-off, we discuss how key factors should affect the retailer's willingness to pursue the discount. We observe that managers that need to deal with tougher environmental conditions, such as high demand uncertainty and long lead times, should be less reluctant to increase orders up to the discount quantity. We also discuss in detail other valuable insights for professionals, both from the perspective of sellers and buyers. [ABSTRACT FROM AUTHOR]