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The globalization process of the last half century entailed a growing trade in agricultural and food products. As a result, water has been transferred among countries, embodied in these goods. This paper studies the evolution of virtual water flows over the long term, analyzing the main driving factors through Decomposition Analysis. It contributes to the existing literature by offering a dynamic and economic interpretation of the historical changes in virtual water trade flows. In particular, this study points to a gradual increase in virtual water exchange, related to the upsurge of agricultural and food products trade in the world from 1965 to 2010. Although the origins and destinations of virtual water have changed, North America stands out as the primary net exporter of virtual water. Europe and Asia, on the other hand, with a high dependency on foreign water resources, appear as net importers of virtual water. Despite improvements in agricultural yields and the reallocation of production, the virtual water trade continues to increase globally via these significant commercial exchanges. [ABSTRACT FROM AUTHOR]

Highlights: [•] DON concentrations of 560ng/ml and higher were detrimental to the survival of PRRSV permissive cells, MARC-145 and PAM. [•] DON concentrations between 140 and 280ng/ml reduced the cytopathic effect caused by PRRSV in permissive cells. [•] Early activation of pro-inflammatory genes and apoptosis may be detrimental to PRRSV survival in DON-exposed permissive cells. [ABSTRACT FROM AUTHOR]

The literature on business models and sustainability is vast but fragmented across many studies. This article seeks to unify the diverse contributions, proposing a sustainable business model archetype. With a sample of 411 Spanish wineries and using the Mann-Whitney U test, we have detected a difference between wineries in terms of their sustainability, identifying two business models, one of high sustainability and another of low sustainability. The high sustainability business model is based on the ownership of a vineyard, the production of bottled wine, sales in retail stores, supermarkets or through intermediaries, a better online position than the competition, a positioning in the premium segment and exports. The business model of a less sustainable winery is based on the sale of bulk wine in the low-price segment and an unawareness of where the wine is sold. • The joint analysis of sustainability and the business model of wineries has been conducted by very few researchers. • The business model of a winery determines its degree of sustainability. • The difference in the integration of sustainability in wineries gives rise to two business models. • The key elements of each business model have been identified. [ABSTRACT FROM AUTHOR]

This study was performed to characterize the influence of consuming DON naturally contaminated feeds on pig's intestinal immune defenses, antibody response and cellular immunity. Sixteen 4-week-old piglets were randomly allocated to two dietary treatments: control diet or diet contaminated with 3.5 mg DON/kg. At days 7 and 21, animals were immunized with ovalbumin (OVA). On day 42, intestinal samples were collected for measurement of gene expression involved in immune response, oxidative status and barrier function. Primary IgG antibody response to OVA was increased in pigs fed DON diet compared to control animals. In the ileum of pigs fed DON diet, claudin, occludin, and vimentin genes involved in integrity and barrier function were down-regulated compared to controls. Results also revealed that expression of two chemokines (IL-8, CXCL10), interferon-γ, and major antioxidant glutathione peroxidase 2 (GPX-2) were up-regulated whereas expression of genes encoding enzymatic antioxidants including GPX-3, GPX-4 and superoxide dismutase 3 (SOD-3) were down-regulated in pigs fed DON-contaminated diet. These results strongly suggest that ingestion of DON naturally contaminated feed impaired intestinal barrier and immunological functions by modulating expression of genes coding for proteins involved in tight junctions, tissue remodelling, inflammatory reaction, oxidative stress reaction and immune response. [ABSTRACT FROM AUTHOR]